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VANPRAGQPAQPEDLVDLPHLVTAYYSIEPDPDDLAQQVAFGTSGHRGSALTGTFNELHILAITQAIVEY RAAQGTTGPLFIGRDTHGLSEPAWVSALEVLAANQVVAVVDSRDRYTPTPAISHAILTYNRGRTEALADG IVVTPSHNPPSDGGIKYNPPNGGPADTAATTAIAKRANEILLARSMVKRLPLARALRTAQRHDYLGHYVD DLPNVVDIAAIREAGVRIGADPLGGASVDYWGEIAHRHGLDLTVVNPLVDATWRFMTLDTDGKIRMDCSS PDAMAGLIRTMFGNRERYQIATGNDADADRHGIVTPDEGLLNPNHYLAVAIEYLYTHRPSWPAGIAVGKT VVSSSIIDRVVAGIGRQLVEVPVGFKWFVDGLIGATLGFGGEESAGASFLRRDGSVWTTDKDGIIMALLA AEILAVTGATPSQRYHALAGEYGGPCYARIDAPADREQKARLARLSADQVSATELAGEPITAKLTTAPGN GAALGGLKVTTANAWFAARPSGTEDVYKIYAESFRGPQHLVEVQQTAREVVDRVIG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv3068c | pgmA | - | 100% (547) | phosphoglucomutase |
M. tuberculosis H37Rv | Rv3308 | pmmB | 2e-18 | 27.66% (517) | phosphomannomutase |
M. tuberculosis H37Rv | Rv3441c | glmM | 1e-05 | 26.00% (427) | phospho-sugar mutase / MRSA protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3095c | pgmA | 0.0 | 100.00% (547) | phosphoglucomutase |
M. gilvum PYR-GCK | Mflv_4406 | - | 0.0 | 79.71% (547) | phosphoglucomutase |
M. leprae Br4923 | MLBr_00706 | pmmB | 9e-19 | 25.91% (552) | putative phospho-sugar mutase |
M. abscessus ATCC 19977 | MAB_3450c | - | 0.0 | 75.32% (547) | phosphoglucomutase |
M. marinum M | MMAR_1591 | pgmA | 0.0 | 88.48% (547) | phosphoglucomutase PgmA |
M. avium 104 | MAV_4286 | - | 8e-17 | 26.73% (520) | phosphoglucomutase/phosphomannomutase |
M. smegmatis MC2 155 | MSMEG_2136 | pgm | 0.0 | 80.29% (548) | phosphoglucomutase |
M. thermoresistible (build 8) | TH_2260 | pmmB | 2e-20 | 26.92% (561) | PROBABLE PHOSPHOMANNOMUTASE PMMB (PHOSPHOMANNOSE MUTASE) |
M. ulcerans Agy99 | MUL_3442 | pgmA | 0.0 | 87.20% (547) | phosphoglucomutase |
M. vanbaalenii PYR-1 | Mvan_1950 | - | 0.0 | 78.60% (556) | phosphoglucomutase |
CLUSTAL 2.0.9 multiple sequence alignment Rv3068c|M.tuberculosis_H37Rv -----------------MVANPRAGQPAQPEDLVDLPHLVTAYYSIEPDP Mb3095c|M.bovis_AF2122/97 -----------------MVANPRAGQPAQPEDLVDLPHLVTAYYSIEPDP MMAR_1591|M.marinum_M -----------------MVANPRAGQPAQPEDLVDLSHLVTAYYTIEPDP MUL_3442|M.ulcerans_Agy99 -----------------MVANPRAGQPAQPEDLVDLSHLVTAYYTIEPDP Mflv_4406|M.gilvum_PYR-GCK MPTRGVPCGRWASRINGMAANPRAGQPAQPEDLIDVASVVTAYYTVSPDP Mvan_1950|M.vanbaalenii_PYR-1 MASR-------HSRINTMAANPRAGQPAQSEDLIDVAAVVTAYYTVAPDP MSMEG_2136|M.smegmatis_MC2_155 -----------------MSANPRAGQPAQPEDLIDVAHVVTAYYTRRPDP MAB_3450c|M.abscessus_ATCC_199 ------------------MSNARAGQPAQPEDLIDIAHVVTAYYAIEPDP MLBr_00706|M.leprae_Br4923 ------------------MKAAVTPEEWITHDPDPQTAAELAACDPDELA MAV_4286|M.avium_104 ----------------------MTPEEWIAHDPDPRTAAELAACDAAELA TH_2260|M.thermoresistible__bu ---------------MTAQRTSSAVQDWIAHDPDPVTAAELRACSPEELE : : ..* . Rv3068c|M.tuberculosis_H37Rv DDLAQQVAFGTSGHRGSALTG--TFNELHILAITQAIVEYRAAQGTTG-- Mb3095c|M.bovis_AF2122/97 DDLAQQVAFGTSGHRGSALTG--TFNELHILAITQAIVEYRAAQGTTG-- MMAR_1591|M.marinum_M DDVAQQVVFGTSGHRGSALNG--AFNEAHILAITQAIVEYRAARGTTG-- MUL_3442|M.ulcerans_Agy99 DDVAQQVVFGTSGHRGSALNA--AFNEAHILAITQAIVEYRAGRGTTG-- Mflv_4406|M.gilvum_PYR-GCK DNVDQQVTFGTSGHRGSSLDA--AFNEAHILATTQAIVEYRAAQGITG-- Mvan_1950|M.vanbaalenii_PYR-1 DNVDQQVTFGTSGHRGSSLDA--AFNEAHILATTQAIVEYRAAQGTTG-- MSMEG_2136|M.smegmatis_MC2_155 EDVAQQVAFGTSGHRGSSLDT--AFNEAHILATTQAIVEYRAAQGITG-- MAB_3450c|M.abscessus_ATCC_199 ANVAQQVAFGTSGHRGSSLDA--AFNEAHIVATTAAIVEYRNAQGISG-- MLBr_00706|M.leprae_Br4923 ARFTRALRFGTSGLRGPVRGGPDAMNLAVVLRATWAVAQVLLQRAGSRPA MAV_4286|M.avium_104 ARFARPLRFGTAGLRGPVRGGPDAMNVAVVSRASWALAQVLKRRGPAG-A TH_2260|M.thermoresistible__bu RRFARPLRFGTAGLRGPLRGGPAGMNLAVVLRATWAVAQVLKARGHAG-S . : : ***:* **. :* : : *:.: :. : Rv3068c|M.tuberculosis_H37Rv PLFIGRDTHGLSEPAWVSALEVLAANQVVAVVDSRDRYTPTPAISHAILT Mb3095c|M.bovis_AF2122/97 PLFIGRDTHGLSEPAWVSALEVLAANQVVAVVDSRDRYTPTPAISHAILT MMAR_1591|M.marinum_M PLFIGRDTHGLSEPAWVSALEVLAGNNVVTMIDSADRYTPTPAVSHAILT MUL_3442|M.ulcerans_Agy99 QLFIGRDTHGLSEPAWVSALEVLAGNNVVTMIDSADRYTPTPAVSHAILT Mflv_4406|M.gilvum_PYR-GCK PLFIGRDTHALSEPAWVSALEVLAANDVVTHIDSADRFTPTPAVSHAILA Mvan_1950|M.vanbaalenii_PYR-1 PLFIGRDTHALSEPAWSTALEVLAANDVVAMIDSAERYTPTPAVSHAILS MSMEG_2136|M.smegmatis_MC2_155 PLFIGRDTHALSEPAWASALEVLAANDVVAMIDSGDRYTPTPAVSHAILT MAB_3450c|M.abscessus_ATCC_199 PLFIGRDTHALSEPAWTSALEVLVANNVVVAIDSRDRYTPTPAVSHAILR MLBr_00706|M.leprae_Br4923 TVIVGRDSRHGSAAFVAATAEVLAAEGFSVLLLPN--PAPTPVVAFAVRN MAV_4286|M.avium_104 RVIVGRDARHGSAVFATVAAEVIAAQGFSVLLLPG--PAPTPVVAFAVRH TH_2260|M.thermoresistible__bu GVIVGRDARHHSDEFALAAAEVLAAEGFSVTLMFT--AVPTPVLAFAVRH :::***:: * : **:..: . . : .***.::.*: Rv3068c|M.tuberculosis_H37Rv YNRGRT---------EALADGIVVTPSHNPPSDGGIKYNPPNGGPADTAA Mb3095c|M.bovis_AF2122/97 YNRGRT---------EALADGIVVTPSHNPPSDGGIKYNPPNGGPADTAA MMAR_1591|M.marinum_M YNRGRT---------EALADGIVVTPSHNPPPDGGFKYNPPNGGPADTDA MUL_3442|M.ulcerans_Agy99 YNRGRT---------EALADGIVVTPSHNSPPDGGFKYNPPNGGPADTDA Mflv_4406|M.gilvum_PYR-GCK YNRGRE---------GNLADGIVVTPSHNPPRDGGFKYNPPNGGPADTDA Mvan_1950|M.vanbaalenii_PYR-1 FNRGRDSGSTSSSRAGDLADGIVVTPSHNPPRDGGFKYNPPNGGPADTDA MSMEG_2136|M.smegmatis_MC2_155 FNRGRE---------GDLADGIVVTPSHNPPRDGGFKYNPPNGGPADSDA MAB_3450c|M.abscessus_ATCC_199 HNRGNP---------AGRADGIVVTPSHNPPRDGGFKYNPPHGGPADTDA MLBr_00706|M.leprae_Br4923 TG---------------AAAGIQITASHNPPTDNGYKVYFDGGIQIISPI MAV_4286|M.avium_104 TG---------------AAAGVQITASHNPPTDNGYKVYDGGGIQIVSPT TH_2260|M.thermoresistible__bu NR---------------AAAGIQITASHNPATDNGYKVYFEGGLPIVSPV * *: :*.***.. *.* * * : Rv3068c|M.tuberculosis_H37Rv TTAIAKRANEILLAR-SMVKRLPLARALRTAQRHDYLGHYVDDLPNVVDI Mb3095c|M.bovis_AF2122/97 TTAIAKRANEILLAR-SMVKRLPLARALRTAQRHDYLGHYVDDLPNVVDI MMAR_1591|M.marinum_M TNAIAKRANEILRDG-AGVARTPLARALRSAQRHDYLGNYVDDLPNVVDI MUL_3442|M.ulcerans_Agy99 TNAIAKRANEILRDG-AGVARMPLARALRSAQRHDYLGNYVDDLPNVVDI Mflv_4406|M.gilvum_PYR-GCK TGAIAKRANEILRDGLKGVHRVPLARAMRSVHRHDYLNAYVDDLPNVVDL Mvan_1950|M.vanbaalenii_PYR-1 TSVIAKRANEILRDGLKAVKRIPLARALNTAQRHDYLESYVADLPNVVDL MSMEG_2136|M.smegmatis_MC2_155 TSVIAKRANEILADNLKAVKRMPLARALQTVHRYDYLDAYVADLPNVVNL MAB_3450c|M.abscessus_ATCC_199 TGAIAARANEILRDGWRSVKRVPLAQALKSVRRYDFQQAYVDDLINVVDL MLBr_00706|M.leprae_Br4923 DHQIENAMAAAPLAD--QITRKPVNPSEN--SASDLVDHYIQRAAAVRRS MAV_4286|M.avium_104 DHQIEAAMADAPPAD--EIRRTPVPP-----AHTDLVQRYIERAAGVRRG TH_2260|M.thermoresistible__bu DREIEEAMADAPHAD--EISRRPVEP-----SGVDVIQRYVERAAHVRRT * : * *: * *: * Rv3068c|M.tuberculosis_H37Rv AAIREAGVRIGADPLGGASVDYWGEIAHRHGLD-LTVVNPLVDATWRFMT Mb3095c|M.bovis_AF2122/97 AAIREAGVRIGADPLGGASVDYWGEIAHRHGLD-LTVVNPLVDATWRFMT MMAR_1591|M.marinum_M AAIREAGVRIGADPLGGASVDYWGEIASRHGLA-LSVVNPLVDATWRFMT MUL_3442|M.ulcerans_Agy99 AAIREAGVRIGADPLGGASVGYWGEIASRHGLA-LSVVNPLVDATWRFMT Mflv_4406|M.gilvum_PYR-GCK HAISAEKIRIGADPLGGASVDYWGAIAERHNLQ-LTVVNPLVDATWRFMT Mvan_1950|M.vanbaalenii_PYR-1 HAISAEGIRIGADPLGGASVDYWAAISERHNLQ-LTVVNPLVDATWRFMT MSMEG_2136|M.smegmatis_MC2_155 HAIRAEGVRIGADPLGGASVDYWGAIAERHQID-LTVVNPLVDATWRFMT MAB_3450c|M.abscessus_ATCC_199 DAIKGAGIRIGADPLGGASVDYWAAIADRWSLE-LTVVNPLVDATWRFMT MLBr_00706|M.leprae_Br4923 NGS----VRVALTPMHGVGGAVAVETLRRTGFDDVHTVAAQFEPDPDFPT MAV_4286|M.avium_104 TGS----VRVALTALHGVGGTVAVDALHRAGFGRIHTVASQFAPDPDFPT TH_2260|M.thermoresistible__bu HDP----VRVALTPLHGVGGEFVMDALVRAGCTDVHVVESQFAPDPDFPT :*:. .: *.. * : .* . . . * * Rv3068c|M.tuberculosis_H37Rv LDTDGKIRMDCSSPDAMAGLIRTMFGNRERYQIATGNDADADRHGIVTPD Mb3095c|M.bovis_AF2122/97 LDTDGKIRMDCSSPDAMAGLIRTMFGNRERYQIATGNDADADRHGIVTPD MMAR_1591|M.marinum_M LDHDGKIRMDCSSPDAMASLI----ANRDHYQIATGNDADADRHGIVTPD MUL_3442|M.ulcerans_Agy99 LDHDGKIRMDCSSPDAMASLI----ANRDHYQIATGDDADADRHGIVTPD Mflv_4406|M.gilvum_PYR-GCK LDTDGKIRMDCSSPNAMASLI----ANRESFQIATGNDADSDRHGIVTPD Mvan_1950|M.vanbaalenii_PYR-1 LDTDGKIRMDCSSPNAMAGLI----ANRDKYQVATGNDADSDRHGIVTPD MSMEG_2136|M.smegmatis_MC2_155 LDTDGKIRMDCSSPNAMASLI----ANRDAYQIATGNDADSDRHGIVTPD MAB_3450c|M.abscessus_ATCC_199 LDHDGKIRMDCSSPDAMASLV----ASRDKYQIATGNDADSDRHGIVTPD MLBr_00706|M.leprae_Br4923 VAFP-----NPEEPGATDALLA--LAAHVGADVAIALDPDADRCAVGIPT MAV_4286|M.avium_104 VAFP-----NPEEPGATDALLT--LAADVDADVAIALDPDADRCAVGIPD TH_2260|M.thermoresistible__bu VPSP-----NPEEPAAVEAVLK--LAAEVDAEIAIALDPDADRCAVGIPT : : ..* * .:: . ::* . *.*:** .: * Rv3068c|M.tuberculosis_H37Rv EG---LLNPNHYLAVAIEYLYTHRPS--WPAGIAVGKTVVSSSIIDRVVA Mb3095c|M.bovis_AF2122/97 EG---LLNPNHYLAVAIEYLYTHRPS--WPAGIAVGKTVVSSSIIDRVVA MMAR_1591|M.marinum_M EG---LLNPNHYLAVAIDYLYTHRPS--WPAGIAVGKTAVSSSIIDRVVA MUL_3442|M.ulcerans_Agy99 EG---LLNPNHYLAVAIDYLYTHRPS--WPAGIAVGKTAVSSSIIDRVVA Mflv_4406|M.gilvum_PYR-GCK GG---LLNPNHFLAVAIDYLFAHRPE--WAAETAVGKTAVSSSIIDRVVA Mvan_1950|M.vanbaalenii_PYR-1 GG---LLNPNHYLAVAIDYLFTHRPE--WATGTAVGKTAVSSSIIDRVVA MSMEG_2136|M.smegmatis_MC2_155 GG---LLNPNHYLAVAIDYLYTHRPD--WPQSTAVGKTAVSSSIIDRVVA MAB_3450c|M.abscessus_ATCC_199 AG---LMNPNHYLAVAIDYLFSHRGG--WAAQTAVGKTLVSSSIIDRVVA MLBr_00706|M.leprae_Br4923 NSGWRMLSGDETGWLLGDYILSQTDK---PETAVVASTVVSSRMLPAIAT MAV_4286|M.avium_104 ASGWRMLSGDETGWLLGDYLLSQPQR---ADRPVVASTVVSSRMLSAIAA TH_2260|M.thermoresistible__bu PTGWRMLSGDETGWLLGDYILAQLDDGPVTTSTLVASTVVSSRMLAAIAD ::. :. : :*: :: . *..* *** :: :. Rv3068c|M.tuberculosis_H37Rv GIGRQLVEVPVGFKWFVDG---LIGATLGFGGEESAGASFLRRDGSVWTT Mb3095c|M.bovis_AF2122/97 GIGRQLVEVPVGFKWFVDG---LIGATLGFGGEESAGASFLRRDGSVWTT MMAR_1591|M.marinum_M GIGRELVEVPVGFKWFVDG---LIGGTIGFGGEESAGASFLRRDGSVWTT MUL_3442|M.ulcerans_Agy99 GIGRELVEVPVGFKWFVDG---LIGGTIGFGGEESAGASFLRRDGSVWTT Mflv_4406|M.gilvum_PYR-GCK GLGRTLVEVPVGFKWFVGG---LLDGTIGFGGEESAGASFLRRDGSVWTT Mvan_1950|M.vanbaalenii_PYR-1 GLGRTLVEVPVGFKWFVDG---LIGGSIGFGGEESAGASFLRRDGSVWTT MSMEG_2136|M.smegmatis_MC2_155 GLERKLVEVPVGFKWFVDG---LVGGSIGFGGEESAGASFLRTDGTVWTT MAB_3450c|M.abscessus_ATCC_199 GLGRTLIEVPVGFKWFVNG---LIDGTIGFGGEESAGASFLRRDGSVWTT MLBr_00706|M.leprae_Br4923 HYNAVHVETLTGFKWLARADANLPG-TLVYAYEEAIGHCVDP----TAVR MAV_4286|M.avium_104 RHGAVHVETLTGFKWLARADAEVPGGTLVYAYEEAIGHCVDP----AAVR TH_2260|M.thermoresistible__bu AHGARHVETLTGFKWLVRADADLPGSSLVYAYEEAIGHCVDP----SAVR :*. .****:. . : . :: :. **: * .. . Rv3068c|M.tuberculosis_H37Rv DKDGIIMALLAAEILAVT---GATPSQRYHALAGEYGGPCYARIDAPAD- Mb3095c|M.bovis_AF2122/97 DKDGIIMALLAAEILAVT---GATPSQRYHALAGEYGGPCYARIDAPAD- MMAR_1591|M.marinum_M DKDGIIMALLAAEILAVT---GATPSQRYRALADQYGAPTYARVDAPAN- MUL_3442|M.ulcerans_Agy99 DKDGIIMALLAAEILAVT---GATPSQRYRALADQYGAPTYAWVDAPAN- Mflv_4406|M.gilvum_PYR-GCK DKDGIILALLASEILAVT---GSTPSQRYAELAETYGAPTYARIDAPAD- Mvan_1950|M.vanbaalenii_PYR-1 DKDGIILALLASEILAVT---GSTPSQRYAELAGKYGAPTYARIDAPAN- MSMEG_2136|M.smegmatis_MC2_155 DKDGIILALLASEIFAVT---GKTPSQRYAELAEQYGAPSYARIDAPAD- MAB_3450c|M.abscessus_ATCC_199 DKDGIIAALLASEILAVT---GVTPSQRYVQLTEKYGAPTYARVDAPAS- MLBr_00706|M.leprae_Br4923 DKDGISAAVLVCDLVAALHKQGRSVPDMLDQLALRHGVHDVTAISRRIGP MAV_4286|M.avium_104 DKDGISAAVLVCDLVAALIARGGSVSGRLDELARRHGVHDVAAVSRRVG- TH_2260|M.thermoresistible__bu DKDGISAAVLCCDLVAALRAQGRTVLDALDDLARRFGVHTTTASSRRVE- ***** *:* .::.*. * : *: .* : . Rv3068c|M.tuberculosis_H37Rv --------REQKARLARLSADQVSATELAGEPITAKLTTAPGNGAALGGL Mb3095c|M.bovis_AF2122/97 --------REQKARLARLSADQVSATELAGEPITAKLTTAPGNGAALGGL MMAR_1591|M.marinum_M --------RDQKARLAKLSPDQVSATELAGEPITAKLTQAPGNGAPLGGL MUL_3442|M.ulcerans_Agy99 --------RDQKARLAKLSPDQVSATELAGEPITAKLTQAPGNGAPLGGL Mflv_4406|M.gilvum_PYR-GCK --------REQKARLAKLSPEQVTATELAGEPITAKLTAAPGNGAPLGGL Mvan_1950|M.vanbaalenii_PYR-1 --------REQKARLGKLSPEQVTATELAGDPITAKLTTAPGNGAPLGGL MSMEG_2136|M.smegmatis_MC2_155 --------REQKARLSKLSPEQVTATELAGEPITAKLTAAPGNGAALGGL MAB_3450c|M.abscessus_ATCC_199 --------REQKAVLSKLAPEQVSVTELAGEPIVAKLTNAPGNGAPIGGL MLBr_00706|M.leprae_Br4923 KQTGVDEAVDLIQRLRAAPPSQLAGFTATTTDIT--------DALIFTGG MAV_4286|M.avium_104 ----TDGAAELMRRLRTSPPETLAGFGVALTDIT--------DALIFTGG TH_2260|M.thermoresistible__bu ---DPDQAAAMLDRLRRRPPTELTGFPVTVTDLARAEGARRTDALIFEGG * .. :: : :. :. : * Rv3068c|M.tuberculosis_H37Rv KVTTANAWFAARPSGTEDVYKIYAESFR---GPQHLVEVQQTAREVVDRV Mb3095c|M.bovis_AF2122/97 KVTTANAWFAARPSGTEDVYKIYAESFR---GPQHLVEVQQTAREVVDRV MMAR_1591|M.marinum_M KVTTANAWFAARPSGTEDVYKIYAESFN---GPAHLAEVQKTAREVVNQV MUL_3442|M.ulcerans_Agy99 KVTTANAWFAARPSGTEDVYKIYAESFN---GPAHLAEVQKTAREVVNQV Mflv_4406|M.gilvum_PYR-GCK KVTTENAWFAARPSGTEDVYKIYAESFR---GPEHLAEVQDAARDVVSKV Mvan_1950|M.vanbaalenii_PYR-1 KVTTQNAWFAARPSGTEDVYKIYAESFL---GADHLAEVQDAAREVVTKV MSMEG_2136|M.smegmatis_MC2_155 KVTTENAWFAARPSGTEDVYKIYAESFK---GPEHLAEVQQAAKDVVNTV MAB_3450c|M.abscessus_ATCC_199 KVVTENAWFAARPSGTEDVYKIYAESFL---GAEHLNQVQDAAREVVSAV MLBr_00706|M.leprae_Br4923 DDDTW-VRVVVRLSGTEPKLKCYLEVR--CSVAGNLPSTRQRARVLRDEL MAV_4286|M.avium_104 DDDTS-VRLVVRPSGTEPKVKCYLEIR--CAPSDDLASSRRRARALRELL TH_2260|M.thermoresistible__bu TADTA-VRVVVRPSGTEPKVKFYFEVRRSCHDDEDLDIARARARELQDEL * . ...* **** * * * .* : *: : : Rv3068c|M.tuberculosis_H37Rv IG----- Mb3095c|M.bovis_AF2122/97 IG----- MMAR_1591|M.marinum_M IG----- MUL_3442|M.ulcerans_Agy99 IG----- Mflv_4406|M.gilvum_PYR-GCK IS----- Mvan_1950|M.vanbaalenii_PYR-1 IS----- MSMEG_2136|M.smegmatis_MC2_155 IG----- MAB_3450c|M.abscessus_ATCC_199 IG----- MLBr_00706|M.leprae_Br4923 VTLVQQW MAV_4286|M.avium_104 VATVRSW TH_2260|M.thermoresistible__bu VATVDQW :