For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
KAAVTPEEWITHDPDPQTAAELAACDPDELAARFTRALRFGTSGLRGPVRGGPDAMNLAVVLRATWAVAQ VLLQRAGSRPATVIVGRDSRHGSAAFVAATAEVLAAEGFSVLLLPNPAPTPVVAFAVRNTGAAAGIQITA SHNPPTDNGYKVYFDGGIQIISPIDHQIENAMAAAPLADQITRKPVNPSENSASDLVDHYIQRAAAVRRS NGSVRVALTPMHGVGGAVAVETLRRTGFDDVHTVAAQFEPDPDFPTVAFPNPEEPGATDALLALAAHVGA DVAIALDPDADRCAVGIPTNSGWRMLSGDETGWLLGDYILSQTDKPETAVVASTVVSSRMLPAIATHYNA VHVETLTGFKWLARADANLPGTLVYAYEEAIGHCVDPTAVRDKDGISAAVLVCDLVAALHKQGRSVPDML DQLALRHGVHDVTAISRRIGPKQTGVDEAVDLIQRLRAAPPSQLAGFTATTTDITDALIFTGGDDDTWVR VVVRLSGTEPKLKCYLEVRCSVAGNLPSTRQRARVLRDELVTLVQQW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00706 | pmmB | - | 100% (538) | putative phospho-sugar mutase |
| M. leprae Br4923 | MLBr_00366 | glmM | 6e-18 | 24.95% (505) | phosphoglucosamine mutase |
| M. leprae Br4923 | MLBr_00763 | manB | 2e-10 | 28.15% (238) | phosphomannomutase/phosphoglucomutase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3336 | pmmB | 0.0 | 77.14% (538) | phosphomannomutase |
| M. gilvum PYR-GCK | Mflv_4831 | - | 0.0 | 64.79% (534) | phosphoglucomutase/phosphomannomutase alpha/beta/subunit |
| M. tuberculosis H37Rv | Rv3308 | pmmB | 0.0 | 76.95% (538) | phosphomannomutase |
| M. abscessus ATCC 19977 | MAB_3661 | - | 1e-176 | 61.15% (538) | phosphomannomutase PmmB |
| M. marinum M | MMAR_1218 | pmmB | 0.0 | 76.97% (534) | phosphomannomutase PmmB |
| M. avium 104 | MAV_4286 | - | 0.0 | 74.39% (535) | phosphoglucomutase/phosphomannomutase |
| M. smegmatis MC2 155 | MSMEG_1695 | - | 0.0 | 62.89% (547) | phosphoglucomutase/phosphomannomutase |
| M. thermoresistible (build 8) | TH_2260 | pmmB | 0.0 | 65.50% (545) | PROBABLE PHOSPHOMANNOMUTASE PMMB (PHOSPHOMANNOSE MUTASE) |
| M. ulcerans Agy99 | MUL_2674 | pmmB | 0.0 | 76.59% (534) | phosphomannomutase PmmB |
| M. vanbaalenii PYR-1 | Mvan_1607 | - | 0.0 | 65.73% (534) | phosphoglucomutase/phosphomannomutase alpha/beta/subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4831|M.gilvum_PYR-GCK -----MHTAVEEWLAHDPDPESAAELAACDDDELAERFAHTLTFGTAGLR
Mvan_1607|M.vanbaalenii_PYR-1 -MTPTVRTAVQEWLSHDPDPASAAELAGCSEDELAERFAQPLTFGTAGLR
MSMEG_1695|M.smegmatis_MC2_155 MTS--TATTAQEWIAHDPDPETAAELSACSPEELEHRFSHPLTFGTAGLR
TH_2260|M.thermoresistible__bu MTAQRTSSAVQDWIAHDPDPVTAAELRACSPEELERRFARPLRFGTAGLR
Mb3336|M.bovis_AF2122/97 -------MTPENWIAHDPDPQTAAELAACGPDELKARFSRPLAFGTAGLR
Rv3308|M.tuberculosis_H37Rv -------MTPENWIAHDPDPQTAAELAACGPDELKARFSRPLAFGTAGLR
MLBr_00706|M.leprae_Br4923 ---MKAAVTPEEWITHDPDPQTAAELAACDPDELAARFTRALRFGTSGLR
MMAR_1218|M.marinum_M -------MTPEEWIAHDPDPVTAAELAACDAQELAARFARPLAFGTAGLR
MUL_2674|M.ulcerans_Agy99 -------MTPEEWIAHDPDPVTAAELAACDAQELAARFARPLAFGTAGLR
MAV_4286|M.avium_104 -------MTPEEWIAHDPDPRTAAELAACDAAELAARFARPLRFGTAGLR
MAB_3661|M.abscessus_ATCC_1997 --MTVAAETIQEWIDHDPDPQTVAELRACSEDELAQRFSDPLVFGTAGLR
: ::*: ***** :.*** .*. ** **: .* ***:***
Mflv_4831|M.gilvum_PYR-GCK GPLRAGPNGMNLAVVIRATWAVARVLTDRSPAS-SQVVVGYDARHRSAEF
Mvan_1607|M.vanbaalenii_PYR-1 GPLRAGPNGMNLAVVLRATWAVARVLTDRGLGG-SQVVVGYDARHRSAEF
MSMEG_1695|M.smegmatis_MC2_155 GPLRGGPDGMNLAVVLRTTWAVAQVLKEHGLGE-SQVVVGRDARHKSDEF
TH_2260|M.thermoresistible__bu GPLRGGPAGMNLAVVLRATWAVAQVLKARGHAG-SGVIVGRDARHHSDEF
Mb3336|M.bovis_AF2122/97 GHLRGGPDAMNLAVVLRATWAVARVLTDRGLAG-SPVIVGRDARHGSPAF
Rv3308|M.tuberculosis_H37Rv GHLRGGPDAMNLAVVLRATWAVARVLTDRGLAG-SPVIVGRDARHGSPAF
MLBr_00706|M.leprae_Br4923 GPVRGGPDAMNLAVVLRATWAVAQVLLQRAGSRPATVIVGRDSRHGSAAF
MMAR_1218|M.marinum_M GPVRGGPDAMNLAVVLRATWAVARVLAEQTPAGPATVIVGRDARHGSASF
MUL_2674|M.ulcerans_Agy99 GPVRGGPDAMNLAVVLRATWAVARVLAEQTPAGPATVIVGRDARHGSASF
MAV_4286|M.avium_104 GPVRGGPDAMNVAVVSRASWALAQVLKRRGPAG-ARVIVGRDARHGSAVF
MAB_3661|M.abscessus_ATCC_1997 GPVRGGPNGMNLAVVLRTTYGLAKVLKDRCLGG-STVVVGRDARHGSEKF
* :*.** .**:*** *:::.:*:** : . : *:** *:** * *
Mflv_4831|M.gilvum_PYR-GCK GRAAAEVFAAQGFTVQLMSGPVPTPAVAFAVRHLGAAAGVQITASHNPPT
Mvan_1607|M.vanbaalenii_PYR-1 GRAAAEVFAAQGFSVTLMFAAVPTPAVAFAVRGTGAAAGVQITASHNPPQ
MSMEG_1695|M.smegmatis_MC2_155 ALAAAEVLAAEGFEVQLMLAAVPTPVVAFAVRHMPAVAGIQITASHNPKT
TH_2260|M.thermoresistible__bu ALAAAEVLAAEGFSVTLMFTAVPTPVLAFAVRHNRAAAGIQITASHNPAT
Mb3336|M.bovis_AF2122/97 AAAAAEVLAAAGFSVLLLPDPAPTPVVAFAVRHTGAAAGIQITASHNPAT
Rv3308|M.tuberculosis_H37Rv AAAAAEVLAAAGFSVLLLPDPAPTPVVAFAVRHTGAAAGIQITASHNPAT
MLBr_00706|M.leprae_Br4923 VAATAEVLAAEGFSVLLLPNPAPTPVVAFAVRNTGAAAGIQITASHNPPT
MMAR_1218|M.marinum_M ATATAEVLAAEGFQVVLLPEPLPTPIVAFAVRHSGAVAGIQITASHNPAT
MUL_2674|M.ulcerans_Agy99 ATATAEILAAEGFQVVLLPEPLPTPIVAFAVRHSGAVAGIQITASHNPVT
MAV_4286|M.avium_104 ATVAAEVIAAQGFSVLLLPGPAPTPVVAFAVRHTGAAAGVQITASHNPPT
MAB_3661|M.abscessus_ATCC_1997 ALGAAEVLAAEGFTVVLLPRPLPTPVLAFAVRQVDAAAGIQITASHNPPA
:**::** ** * *: . *** :***** *.**:********
Mflv_4831|M.gilvum_PYR-GCK DNGYKVYVTGGLQIVSPTDREIEAAIAAAPPADEIPRAPVEVPA---ADE
Mvan_1607|M.vanbaalenii_PYR-1 DNGYKVYFPGGLQIVSPTDRDIEHAIASAPPADEIPRSPVTASG---EDQ
MSMEG_1695|M.smegmatis_MC2_155 DNGYKVFVDGGMQITSPTDHEIEEAISRAPHADEITRAPVTTGG---LAQ
TH_2260|M.thermoresistible__bu DNGYKVYFEGGLPIVSPVDREIEEAMADAPHADEISRRPVEPSG---VDV
Mb3336|M.bovis_AF2122/97 DNGYKVYVDGGLQLLAPTDRQIEAAMATAPPADQIARKTVNPSENRASDL
Rv3308|M.tuberculosis_H37Rv DNGYKVYVDGGLQLLAPTDRQIEAAMATAPPADQIARKTVNPSENRASDL
MLBr_00706|M.leprae_Br4923 DNGYKVYFDGGIQIISPIDHQIENAMAAAPLADQITRKPVNPSENSASDL
MMAR_1218|M.marinum_M DNGYKVYLDGGIQIISPTDRKIEAAMAAAPPADQIARKAVTPAR---TDL
MUL_2674|M.ulcerans_Agy99 DNGYKVYLDGGIQIISPTDRKIEAAMAAAPPADQIARKPVTPAR---TDL
MAV_4286|M.avium_104 DNGYKVYDGGGIQIVSPTDHQIEAAMADAPPADEIRRTPVPPAH---TDL
MAB_3661|M.abscessus_ATCC_1997 DNGYKVYWSGGAQIISPTDREIEAATAAAPFADQIPRTPVEPTG---ESL
******: ** : :* *:.** * : ** **:* * .*
Mflv_4831|M.gilvum_PYR-GCK LRAYLERAASVRHAAGAARIALTPMHGVGGEFALDALALAGFADVHVVEE
Mvan_1607|M.vanbaalenii_PYR-1 VRAYLERAASVRRTTGPARIALTPMHGVGGEFALDALALAGFDDVHVVQR
MSMEG_1695|M.smegmatis_MC2_155 IKAYLERAARVRRRSDTVRVAFTPMHGVGGEFTLDAMALAGLDDVHVVES
TH_2260|M.thermoresistible__bu IQRYVERAAHVRRTHDPVRVALTPLHGVGGEFVMDALVRAGCTDVHVVES
Mb3336|M.bovis_AF2122/97 IDRYIQRAAGVRRCAGSVRVALTPLHGVGGAMAVETLRRAGFTEVHTVAT
Rv3308|M.tuberculosis_H37Rv IDRYIQRAAGVRRCAGSVRVALTPLHGVGGAMAVETLRRAGFTEVHTVAT
MLBr_00706|M.leprae_Br4923 VDHYIQRAAAVRRSNGSVRVALTPMHGVGGAVAVETLRRTGFDDVHTVAA
MMAR_1218|M.marinum_M VEHYIARAAGIRRCAGSVRVALTPMHGVGGTVAVETLRRAGFTDVHTVAT
MUL_2674|M.ulcerans_Agy99 VEHYIARAAGIRRCAGSVRVALTPMHGVGGTVAVATLRRAGFTDVHTVAT
MAV_4286|M.avium_104 VQRYIERAAGVRRGTGSVRVALTALHGVGGTVAVDALHRAGFGRIHTVAS
MAB_3661|M.abscessus_ATCC_1997 IDAYVQRAATVRRGAGNLRVVLTALHGVGGATAVATLNAAGITDIHLVDE
: *: *** :*: . *:.:*.:***** .: :: :* :* *
Mflv_4831|M.gilvum_PYR-GCK QFAPDPDFPTVAFPNPEEPGASDALLALAAGVDAEIAIALDPDADRCAIG
Mvan_1607|M.vanbaalenii_PYR-1 QFAPDPDFPTVAFPNPEEPGASDLLLALAADVDADIAIALDPDADRCAIG
MSMEG_1695|M.smegmatis_MC2_155 QFNPDPEFPTVEFPNPEEPGATDELLALAERVGAEIAIALDPDADRCAVG
TH_2260|M.thermoresistible__bu QFAPDPDFPTVPSPNPEEPAAVEAVLKLAAEVDAEIAIALDPDADRCAVG
Mb3336|M.bovis_AF2122/97 QFAPNPDFPTVTLPNPEEPGATDALLTLATDVDADVAIALDPDADRCAVG
Rv3308|M.tuberculosis_H37Rv QFAPNPDFPTVTLPNPEEPGATDALLTLATDVDADVAIALDPDADRCAVG
MLBr_00706|M.leprae_Br4923 QFEPDPDFPTVAFPNPEEPGATDALLALAAHVGADVAIALDPDADRCAVG
MMAR_1218|M.marinum_M QFEPDPDFPTVAFPNPEEPGATDALLELAAGVRADVAIALDPDADRCAVA
MUL_2674|M.ulcerans_Agy99 QFEPDPDFPTVAFPNPEEPGATDALLELAAGVRADVAIALDPDADRCAVA
MAV_4286|M.avium_104 QFAPDPDFPTVAFPNPEEPGATDALLTLAADVDADVAIALDPDADRCAVG
MAB_3661|M.abscessus_ATCC_1997 QFQPNPDFPTVEFPNPEERGASDAVLARAAEVDAALAIALDPDADRCAIG
** *:*:**** ***** .* : :* * * * :************:.
Mflv_4831|M.gilvum_PYR-GCK VPTPTGWRMLSGDETGWLLGDYVLSHADP-----THAVVASTVVSSRMLA
Mvan_1607|M.vanbaalenii_PYR-1 VPTPAGWRMLSGDETGWLLGDYILSDRQ------DKAVVASTVVSSRMLA
MSMEG_1695|M.smegmatis_MC2_155 IPTPDGWRMLSGDETGWLLGDYILSQIEPGMV-SESTVVASTVVSSRMLA
TH_2260|M.thermoresistible__bu IPTPTGWRMLSGDETGWLLGDYILAQLDDGPV-TTSTLVASTVVSSRMLA
Mb3336|M.bovis_AF2122/97 IPTVSGWRMLSGDETGWLLGDYILSQTDDRASPPETRVVASTVVSSRMLA
Rv3308|M.tuberculosis_H37Rv IPTVSGWRMLSGDETGWLLGDYILSQTDDRASPPETRVVASTVVSSRMLA
MLBr_00706|M.leprae_Br4923 IPTNSGWRMLSGDETGWLLGDYILSQTDK----PETAVVASTVVSSRMLP
MMAR_1218|M.marinum_M IPTSSGWRMLSGDETGWLLGDYILSKQPP-----GDWIVASTLVSSRMLA
MUL_2674|M.ulcerans_Agy99 IPTSSGWRMLSGDETGWLLGDYILSKQPS-----GDWIVASTLVSSRMLA
MAV_4286|M.avium_104 IPDASGWRMLSGDETGWLLGDYLLSQPQR----ADRPVVASTVVSSRMLS
MAB_3661|M.abscessus_ATCC_1997 VPTTTGWRMLSGDETGWLLGDYILSTQPDS---SIPPVVASTVVSSRMLA
:* *****************:*: :****:******.
Mflv_4831|M.gilvum_PYR-GCK SIAAAHGARHVETLTGFKWLARADEG-LDATLVYAYEEAIGHCVDPGAVR
Mvan_1607|M.vanbaalenii_PYR-1 SIAAAHGARHVETLTGFKWLARADEG-LDARLVYAYEEAIGHCVDPDAVR
MSMEG_1695|M.smegmatis_MC2_155 SIAAAHGAHHVETLTGFKWLARAGS--PGTTLVYAYEEAIGHCVDPSSVR
TH_2260|M.thermoresistible__bu AIADAHGARHVETLTGFKWLVRADADLPGSSLVYAYEEAIGHCVDPSAVR
Mb3336|M.bovis_AF2122/97 AIAAHHAAVHVETLTGFKWLARADANLPG-TLVYAYEEAIGHCVDPTAVR
Rv3308|M.tuberculosis_H37Rv AIAAHHAAVHVETLTGFKWLARADANLPG-TLVYAYEEAIGHCVDPTAVR
MLBr_00706|M.leprae_Br4923 AIATHYNAVHVETLTGFKWLARADANLPG-TLVYAYEEAIGHCVDPTAVR
MMAR_1218|M.marinum_M AIAADYGVVHVQTLTGFKWLARADADRPG-TLVYAYEEAIGHCVDPTAVR
MUL_2674|M.ulcerans_Agy99 AIAADYGVVHVQTLTGFKWLARADADRPG-TLVYAYEEAIGHCVDPTAVR
MAV_4286|M.avium_104 AIAARHGAVHVETLTGFKWLARADAEVPGGTLVYAYEEAIGHCVDPAAVR
MAB_3661|M.abscessus_ATCC_1997 RIAASLGARHVETLTGFKWLVRAADS----DLVYAYEEAIGHCVDPVAVR
** . **:********.** *************** :**
Mflv_4831|M.gilvum_PYR-GCK DKDGISAAVLACDLVVSLREQGRTLLDALDDLARRHGVHTTTAVTRRVR-
Mvan_1607|M.vanbaalenii_PYR-1 DKDGISAAVLACDLVVALRGRGRTVPDALDDLARRHGVHTTTAVTRRVD-
MSMEG_1695|M.smegmatis_MC2_155 DKDGITAAILACDLVAALRYQGRTIVDALDGLARAHGVHVTRAVSRQVS-
TH_2260|M.thermoresistible__bu DKDGISAAVLCCDLVAALRAQGRTVLDALDDLARRFGVHTTTASSRRVE-
Mb3336|M.bovis_AF2122/97 DKDGISAAVLVCDLVAALKGQGRSVTDALDELARCYGVHEVAALSRPVG-
Rv3308|M.tuberculosis_H37Rv DKDGISAAVLVCDLVAALKGQGRSVTDALDELARCYGVHEVAALSRPVS-
MLBr_00706|M.leprae_Br4923 DKDGISAAVLVCDLVAALHKQGRSVPDMLDQLALRHGVHDVTAISRRIGP
MMAR_1218|M.marinum_M DKDGISAAVLTCDLVASLERQGRSVPDVLDDLAHRYGVHEVGAVARRVA-
MUL_2674|M.ulcerans_Agy99 DKDGISAAVLTCDLVASLERQGRSVPDVLDDLAHRYGVHEVGAVARRVA-
MAV_4286|M.avium_104 DKDGISAAVLVCDLVAALIARGGSVSGRLDELARRHGVHDVAAVSRRVG-
MAB_3661|M.abscessus_ATCC_1997 DKDGISAAVLACDLVTHLRELGTSVEEKLENLAIRHGIHVTSQVSRRMD-
*****:**:* ****. * * :: *: ** .*:* . :* :
Mflv_4831|M.gilvum_PYR-GCK ---SPQDAAAMMSRLRAAPPEEIAGFAVTVTDLMP-----RTDALIFSGG
Mvan_1607|M.vanbaalenii_PYR-1 ---SPQDAAAMMTRLRAAPPDTIAGVAVTVADLQP-----RTDALVFTGG
MSMEG_1695|M.smegmatis_MC2_155 ---DADKAMG---RLRTQPPDELAGFTVAVEDLAERRGQQRTDALIFTGE
TH_2260|M.thermoresistible__bu ---DPDQAAAMLDRLRRRPPTELTGFPVTVTDLARAEGARRTDALIFEGG
Mb3336|M.bovis_AF2122/97 ---GAVETTDLMRRLREDPPRRLAGFPATVTDIGD--------TLILTGG
Rv3308|M.tuberculosis_H37Rv ---GAVETTDLMRRLREDPPRRLAGFPATVTDIGD--------TLILTGG
MLBr_00706|M.leprae_Br4923 KQTGVDEAVDLIQRLRAAPPSQLAGFTATTTDITD--------ALIFTGG
MMAR_1218|M.marinum_M ---DADQAAALMRRLRESPPDRLAGFTATVTDITD--------ALIFAGG
MUL_2674|M.ulcerans_Agy99 ---DADQAAALMRRLRESPPDRLAGFTATVTDITD--------ALIFAGG
MAV_4286|M.avium_104 ----TDGAAELMRRLRTSPPETLAGFGVALTDITD--------ALIFTGG
MAB_3661|M.abscessus_ATCC_1997 ---SLEDIEAMMTRLRQNIPAALSGFPITAEDLLERRGQQRTDAVVLSGE
*** * ::*. : *: :::: *
Mflv_4831|M.gilvum_PYR-GCK DSATSVRVVMRPSGTEPKLKSYIEIR----CTGEVATGRSHAADVQDAVA
Mvan_1607|M.vanbaalenii_PYR-1 DDAASVRVVIRPSGTEPKLKSYIEVR----CAGELAPGRARAAALQEAVA
MSMEG_1695|M.smegmatis_MC2_155 DGGTAVRIVVRPSGTEPKLKSYIEVR--CAPTDDLAAARERANRISDELC
TH_2260|M.thermoresistible__bu TADTAVRVVVRPSGTEPKVKFYFEVRRSCHDDEDLDIARARARELQDELV
Mb3336|M.bovis_AF2122/97 DDNMLVRVAVRPSGTEPKLKCYLEIR--CAVTGDLPAARQLVRARIDELS
Rv3308|M.tuberculosis_H37Rv DDNMLVRVAVRPSGTEPKLKCYLEIR--CAVTGDLPAARQLVRARIDELS
MLBr_00706|M.leprae_Br4923 DDDTWVRVVVRLSGTEPKLKCYLEVR--CSVAGNLPSTRQRARVLRDELV
MMAR_1218|M.marinum_M DDRTSVRVVVRPSGTEPKLKCYIEVR--CEVAGDLAATRQRAQELRRELA
MUL_2674|M.ulcerans_Agy99 DDRTSVRVVVRPSGTEPKLKCYIEVR--CEVAGDLAATRQRAQELRRELA
MAV_4286|M.avium_104 DDDTSVRLVVRPSGTEPKVKCYLEIR--CAPSDDLASSRRRARALRELLV
MAB_3661|M.abscessus_ATCC_1997 IGGSSIRLVLRPSGTEPKVKCYIEVR--EPVITDPTVARIWAGVVVSELE
:*:.:* ******:* *:*:* : * . :
Mflv_4831|M.gilvum_PYR-GCK AAIATWR
Mvan_1607|M.vanbaalenii_PYR-1 AAVRAWT
MSMEG_1695|M.smegmatis_MC2_155 RAAKGW-
TH_2260|M.thermoresistible__bu ATVDQW-
Mb3336|M.bovis_AF2122/97 ASVRRWW
Rv3308|M.tuberculosis_H37Rv ASVRRWW
MLBr_00706|M.leprae_Br4923 TLVQQW-
MMAR_1218|M.marinum_M STVSGW-
MUL_2674|M.ulcerans_Agy99 STVSGW-
MAV_4286|M.avium_104 ATVRSW-
MAB_3661|M.abscessus_ATCC_1997 AYARNI-