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GRLFGTDGVRGVANRELTAELALALGAAAARRLSRSGAPGRRVAVLGRDPRASGEMLEAAVIAGLTSEGV DALRVGVLPTPAVAYLTGAYDADFGVMISASHNPMPDNGIKIFGPGGHKLDDDTEDQIEDLVLGVSRGPG LRPAGAGIGRVIDAEDATERYLRHVAKAATARLDDLAVVVDCAHGAASSAAPRAYRAAGARVIAINAEPN GRNINDGCGSTHLDPLRAAVLAHRADLGLAHDGDADRCLAVDANGDLVDGDAIMVVLALAMKEAGELACN TLVATVMSNLGLHLAMRSAGVTVRTTAVGDRYVLEELRAGDYSLGGEQSGHIVMPALGSTGDGIVTGLRL MTRMVQTGSSLSDLASAMRTLPQVLINVEVVDKATAAAAPSVRTAVEQAAAELGDTGRILLRPSGTEPMI RVMVEAADEGVAQRLAATVADAVSTAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3441c | mrsA | - | 100% (448) | PROBABLE PHOSPHO-SUGAR MUTASE / MRSA PROTEIN HOMOLOG |
| M. tuberculosis H37Rv | Rv3257c | manB | 1e-34 | 29.48% (458) | phosphomannomutase/phosphoglucomutase |
| M. tuberculosis H37Rv | Rv3308 | pmmB | 1e-17 | 26.71% (513) | phosphomannomutase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3471c | glmM | 0.0 | 100.00% (448) | phospho-sugar mutase / MRSA protein |
| M. gilvum PYR-GCK | Mflv_4947 | glmM | 0.0 | 79.10% (445) | phosphoglucosamine mutase |
| M. leprae Br4923 | MLBr_00366 | glmM | 0.0 | 87.64% (445) | phosphoglucosamine mutase |
| M. abscessus ATCC 19977 | MAB_3750c | - | 1e-173 | 71.88% (441) | phosphoglucosamine mutase MrsA |
| M. marinum M | MMAR_1108 | glmM | 0.0 | 84.56% (447) | phosphomannomutase, MrsA |
| M. avium 104 | MAV_4384 | glmM | 0.0 | 86.61% (448) | phosphoglucosamine mutase |
| M. smegmatis MC2 155 | MSMEG_1559 | glmM | 0.0 | 79.03% (453) | phosphoglucosamine mutase |
| M. thermoresistible (build 8) | TH_1199 | - | 0.0 | 79.15% (446) | PROBABLE PHOSPHO-SUGAR MUTASE / MRSA PROTEIN HOMOLOG |
| M. ulcerans Agy99 | MUL_0866 | glmM | 0.0 | 84.56% (447) | phosphomannomutase, MrsA |
| M. vanbaalenii PYR-1 | Mvan_1472 | glmM | 0.0 | 79.69% (448) | phosphoglucosamine mutase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3441c|M.tuberculosis_H37Rv MGRLFGTDGVRGVANRELTAELALALGAAAARRLSR-SGAPG-------R
Mb3471c|M.bovis_AF2122/97 MGRLFGTDGVRGVANRELTAELALALGAAAARRLSR-SGAPG-------R
MLBr_00366|M.leprae_Br4923 MGRLFGTDGVRGVANRELTPELVLALGAAAARCLAN-SGEPG-------R
MAV_4384|M.avium_104 MGRLFGTDGVRGVANRELTAELALALGAAAARQLAS-GSAPG-------R
MMAR_1108|M.marinum_M MGRLFGTDGVRGVANRELTAELALALGAATAQHLAS-STGPG-------R
MUL_0866|M.ulcerans_Agy99 MGRLFGTDGVRGVANRELTAELALALGAATAQHLAS-STGPG-------R
Mflv_4947|M.gilvum_PYR-GCK MARLFGTDGVRGVANRELTPELAMALGSAAARRLGR-AGATR-------R
Mvan_1472|M.vanbaalenii_PYR-1 MARLFGTDGVRGVANRELTAELAMALGAAAARRLGR-TGAAR-------R
TH_1199|M.thermoresistible__bu MGRLFGTDGVRGVANRDLTAELALSVAAAAARRLTAPTGRTG-------R
MSMEG_1559|M.smegmatis_MC2_155 MARLFGTDGVRGVANRDLTAELALALGSAAARRLSTITTATATDSAERAR
MAB_3750c|M.abscessus_ATCC_199 MG-LFGTDGVRGVANADLTAELAMALGAAAARSLGR------------AH
*. ************ :**.**.:::.:*:*: * :
Rv3441c|M.tuberculosis_H37Rv RVAVLGRDPRASGEMLEAAVIAGLTSEGVDALRVGVLPTPAVAYLTGAYD
Mb3471c|M.bovis_AF2122/97 RVAVLGRDPRASGEMLEAAVIAGLTSEGVDALRVGVLPTPAVAYLTGAYD
MLBr_00366|M.leprae_Br4923 RVAVIGRDPRASGEMLEAAVIAGLTSAGVDALRVGVLPTPAVAYLTGAYD
MAV_4384|M.avium_104 RVAVIGRDPRASGEMLEAAVIAGLTSQGVDALRVGVLPTPAVAYLTGAYD
MMAR_1108|M.marinum_M RVAVVGRDPRASGEMLEAAVIAGLTSQGVDALRVGVLPTPAVAYLTGAYD
MUL_0866|M.ulcerans_Agy99 RVAVVGRDPRASGEMLEAAVIAGLTSQGVDALRVGVLPTPAVAYLTGAYD
Mflv_4947|M.gilvum_PYR-GCK RVAVVGRDPRASGEMLEAAVIAGIAGEGVDTLRVGILPTPAVAYLTSAYD
Mvan_1472|M.vanbaalenii_PYR-1 RVAVVGRDPRASGEMLEAAVIAGIASEGVDTLRVGVLPTPAVAYLTSAYD
TH_1199|M.thermoresistible__bu RVAVVGRDPRASGEMLEAAVIAGLTAEGVDAWRVGVLPTPAVAYLTSAYD
MSMEG_1559|M.smegmatis_MC2_155 RVAVVGRDPRASGEMLEAAVIAGLTSEGVDALRVGVLPTPAVAYLTSAYD
MAB_3750c|M.abscessus_ATCC_199 AVAVVGRDPRASGEMLEAAVVAGIAAEGVDVLRVGVLPTPAVAYLTGAYG
***:***************:**::. ***. ***:**********.**.
Rv3441c|M.tuberculosis_H37Rv ADFGVMISASHNPMPDNGIKIFGPGGHKLDDDTEDQIEDLVLGVSRGPGL
Mb3471c|M.bovis_AF2122/97 ADFGVMISASHNPMPDNGIKIFGPGGHKLDDDTEDQIEDLVLGVSRGPGL
MLBr_00366|M.leprae_Br4923 ADFGVMISASHNPMVDNGIKIFGPGGHKLDDDTEDQIEDLVTG---GPGL
MAV_4384|M.avium_104 ADFGVMISASHNPMPDNGIKIFGPGGHKLDDGTEDRIEALVGD----AGP
MMAR_1108|M.marinum_M ADFGVMISASHNPMPDNGIKIFGPGGHKLDDATEDRIESLVAA---GPGL
MUL_0866|M.ulcerans_Agy99 ADFGVMISASHNPMPDNGIKIFGPGGHKLDDATENRIESLVAA---GPGL
Mflv_4947|M.gilvum_PYR-GCK ADFGVMISASHNPMPDNGIKIFGPGGHKLDDATEDRIEELVHQ---GPGE
Mvan_1472|M.vanbaalenii_PYR-1 ADFGVMISASHNPMPDNGIKIFGPGGHKLDDATEDRIEELVHQ---GPGS
TH_1199|M.thermoresistible__bu ADFGVMISASHNPMPDNGIKLFGPGGHKLDDAAEDRIEELVNQ---GPGN
MSMEG_1559|M.smegmatis_MC2_155 ADFGVMISASHNPMPDNGIKIFGPGGHKLDDATEDRIEELVHA---GAVA
MAB_3750c|M.abscessus_ATCC_199 AAFGVMISASHNPMPDNGIKIFGVGGHKLDDDAEAAIEAQLEA----LSI
* ************ *****:** ******* :* ** :
Rv3441c|M.tuberculosis_H37Rv RPAGAGIGRVIDAEDATERYLRHVAKAATARLDDLAVVVDCAHGAASSAA
Mb3471c|M.bovis_AF2122/97 RPAGAGIGRVIDAEDATERYLRHVAKAATARLDDLAVVVDCAHGAASSAA
MLBr_00366|M.leprae_Br4923 RPAGVAIGRVIDAEDATERYLRHVGKASTIRLDGLTVVVDCAHGAASSAA
MAV_4384|M.avium_104 RPVGAGIGRVIDAEDAADRYLRHLSKASTLRLDGLTVVVDCAHGAASSVA
MMAR_1108|M.marinum_M RPVGSEIGRVIDAEDAADRYLRHVSKACTTRLDGLTVVVDCAHGAASEVG
MUL_0866|M.ulcerans_Agy99 RPVGSEIGRVIDAEDAADRYLRHVSKACTTRLDGLTVVVDCAHGAASEVG
Mflv_4947|M.gilvum_PYR-GCK RPTGAGIGRVVDAEDALERYLRHVGKAATTRLDPLTVVVDCAHGAASVAA
Mvan_1472|M.vanbaalenii_PYR-1 RPTGAGIGRVVDAEDALERYLRHVGKAATTRLDALTVVVDCAHGAASLAA
TH_1199|M.thermoresistible__bu RPVGAAIGRIVDAEDAMDRYLRHVAKAVTTRLDGLTVVVDCANGAASTVA
MSMEG_1559|M.smegmatis_MC2_155 RPTGTGIGRVLDAEDALDRYLRHAGKAVTTRLDGLTVVVDCAHGAAWAAA
MAB_3750c|M.abscessus_ATCC_199 RPTGGGIGRVRDAVDALDRYLHHVENAGTHPLSGVTVVVDCAHGAASDAA
**.* ***: ** ** :***:* :* * *. ::******:*** ..
Rv3441c|M.tuberculosis_H37Rv PRAYRAAGARVIAINAEPNGRNINDGCGSTHLDPLRAAVLAHRADLGLAH
Mb3471c|M.bovis_AF2122/97 PRAYRAAGARVIAINAEPNGRNINDGCGSTHLDPLRAAVLAHRADLGLAH
MLBr_00366|M.leprae_Br4923 PRAYRAAGARVIAINADPNGININDRCGSTDLGSLRSAVLAHRADLGLAH
MAV_4384|M.avium_104 PRAYRAAGARVIAINADPNGLNINDNCGSTHLDSLRAAVVAHRADLGLAH
MMAR_1108|M.marinum_M PRAYRAAGARVIEINADPNGLNINDDCGSTHLEAIRAAVLAHGADLGVAH
MUL_0866|M.ulcerans_Agy99 PRAYRAAGARVIEINADPNGLNINDDCGSTHLEAIRAAVLAHGADLGVAH
Mflv_4947|M.gilvum_PYR-GCK PRAYRAAGANVIPIHADPDGLNINDGCGSTHMESLRSAVVSYGADLGLAH
Mvan_1472|M.vanbaalenii_PYR-1 PRAYRAAGANVIPIHAEPDGLNINDNCGSTHMQALSAAVVSYGADLGLAH
TH_1199|M.thermoresistible__bu PRAYRAAGANVIPINAEPTGLNINDNCGSTHMESLQQAVVSYGADLGLAH
MSMEG_1559|M.smegmatis_MC2_155 PRAYRAAGANVIAINAEPTGLNINDNCGSTHMDVVRAAVVEHGADLGLAH
MAB_3750c|M.abscessus_ATCC_199 PLAYRAAGAHVVDINADPDGLNINDGCGSTHLGPLQEAVRAHGAHLGLAH
* *******.*: *:*:* * **** ****.: : ** : *.**:**
Rv3441c|M.tuberculosis_H37Rv DGDADRCLAVDANGDLVDGDAIMVVLALAMKEAGELACNTLVATVMSNLG
Mb3471c|M.bovis_AF2122/97 DGDADRCLAVDANGDLVDGDAIMVVLALAMKEAGELACNTLVATVMSNLG
MLBr_00366|M.leprae_Br4923 DGDADRCLAVDANGDLVDGDAIMVVLALAMQEAGELSSNTLVTTVMSNLG
MAV_4384|M.avium_104 DGDADRCLAVDADGNLVDGDHIMVVLALAMREAGELASDTLVTTVMSNLG
MMAR_1108|M.marinum_M DGDADRCLAVDANGDLVDGDAIMVVLALAMQEAGELASDTLVTTVMSNLG
MUL_0866|M.ulcerans_Agy99 DGDADRCLAVDANGDLVDGDAIMVVLALAMQEAGELASDTLVTTVMSNLG
Mflv_4947|M.gilvum_PYR-GCK DGDADRCLAVDAHGRVIDGDAIMVVLALAMQQSGELVSDTLVATVMSNMG
Mvan_1472|M.vanbaalenii_PYR-1 DGDADRCLAVDAHGRVIDGDAIMVVLALAMQEAGELASDTLVTTVMSNMG
TH_1199|M.thermoresistible__bu DGDADRCLAVDAHGRVIDGDAIMVVLALAMQEAGELSANTLVTTVMSNMG
MSMEG_1559|M.smegmatis_MC2_155 DGDADRCLAVDATGHVVDGDAIMVILALAMQEAGELAANTLVATVMSNLG
MAB_3750c|M.abscessus_ATCC_199 DGDADRCLAVDADGNVIDGDAIMVVLAAAMAEAGELTANTLVTTVMSNQG
************ * ::*** ***:** ** ::*** .:***:***** *
Rv3441c|M.tuberculosis_H37Rv LHLAMRSAGVTVRTTAVGDRYVLEELRAGDYSLGGEQSGHIVMPALGSTG
Mb3471c|M.bovis_AF2122/97 LHLAMRSAGVTVRTTAVGDRYVLEELRAGDYSLGGEQSGHIVMPALGSTG
MLBr_00366|M.leprae_Br4923 LHLAMRSVGVIVRTTDVGDRYVLEELRAGDFSLGGEQSGHIVMPALGSTG
MAV_4384|M.avium_104 LHLAMRSAGITVRTTGVGDRYVVEELRAGDYSLGGEQSGHIVMPALGSTG
MMAR_1108|M.marinum_M LHLAMREAGVNVRTTGVGDRYVLEELRAGDYSLGGEQSGHIVMPGLGSTG
MUL_0866|M.ulcerans_Agy99 LHLAMREAGVNVRTTGVGDRYVLEELRAGDYSLGGEQSGHIVMPGLGSTG
Mflv_4947|M.gilvum_PYR-GCK LHLAMRSADIEVRTTGVGDRYVLEELRAGQFSLGGEQSGHIVLPSFGTTG
Mvan_1472|M.vanbaalenii_PYR-1 LHLAMRSAGIEVRTTGVGDRYVLEELRAGLFSLGGEQSGHIVLPSFGTTG
TH_1199|M.thermoresistible__bu LHLAMRSAGIEVRTTAVGDRYVLEELRSGDYTLGGEQSGHIVMPTLGTTG
MSMEG_1559|M.smegmatis_MC2_155 LHLAMRAAGIDVRTTSVGDRYVLEELRSGEFSLGGEQSGHIVMPSFGTTG
MAB_3750c|M.abscessus_ATCC_199 LHIAMRAAGIDVKVTGVGDRYVLEELRAGQFALGGEQSGHIVLPSLATTG
**:*** ..: *:.* ******:****:* ::**********:* :.:**
Rv3441c|M.tuberculosis_H37Rv DGIVTGLRLMTRMVQTGSSLSDLASAMRTLPQVLINVEVVDKATAAAAPS
Mb3471c|M.bovis_AF2122/97 DGIVTGLRLMTRMVQTGSSLSDLASAMRTLPQVLINVEVVDKATAAAAPS
MLBr_00366|M.leprae_Br4923 DGIITGLRLMTRMVQTSSSLAALASAMRALPQVLINVEVADKTTAAAAPL
MAV_4384|M.avium_104 DGIVTGLRLMTRMAQTGSPLSDLASAMQTLPQVLINVTVADKATAATAPS
MMAR_1108|M.marinum_M DGIVTGLRLMTRMVATGASLAALASRMQTLPQVLINVQVTDKAAAAAAPS
MUL_0866|M.ulcerans_Agy99 DGIVTGLRLMTRMVATGASLAALASRMQTLPQVLINVQVTDKATAAAAPS
Mflv_4947|M.gilvum_PYR-GCK DGIVTGLRLMARMAQTGRSLADLAQPMQTLPQVLINVEVADKTTVADAPS
Mvan_1472|M.vanbaalenii_PYR-1 DGIVTGLRLMARMAQTGRSLAGLAEPMQTLPQVLINVEVADKATVADAQP
TH_1199|M.thermoresistible__bu DGIVTGLRLMSRMAQTGKTLAALAEPMRTLPQVLINVAVADKAAVAAAPA
MSMEG_1559|M.smegmatis_MC2_155 DGIVTGLRLMSRMAQTGSSLAELADAMHSLPQVLINVAVADKTTVAQAPS
MAB_3750c|M.abscessus_ATCC_199 DGIVTGLRLMSRMAQTGKSLAELASAMRSLPQTLINVPVSNKHTVAQAPE
***:******:**. *. .*: **. *::***.**** * :* :.* *
Rv3441c|M.tuberculosis_H37Rv VRTAVEQAAAELGDTGRILLRPSGTEPMIRVMVEAADEGVAQRLAATVAD
Mb3471c|M.bovis_AF2122/97 VRTAVEQAAAELGDTGRILLRPSGTEPMIRVMVEAADEGVAQRLAATVAD
MLBr_00366|M.leprae_Br4923 VQTAVETAEVELGNTGRILLRPSGTEPMIRVMVEAAEEDVAHRVATRVAA
MAV_4384|M.avium_104 VQTAVGQAAAELGDTGRILLRPSGTEPMIRVMVEAPEKDIAQRLATRVAE
MMAR_1108|M.marinum_M VQAAVDRAETELGDTGRILLRPSGTEPLIRVMVEAADEEAAHRLATSVAD
MUL_0866|M.ulcerans_Agy99 VQAAVDRAETELGDTGRILLRPSGTEPLIRVMVEAADEEAAHRLATSVAD
Mflv_4947|M.gilvum_PYR-GCK VRDAVAQVEAELGDTGRILLRPSGTEQVVRVMVEAADEDTARQMAVRVAD
Mvan_1472|M.vanbaalenii_PYR-1 VRDAVAQVEAELGDTGRILLRPSGTEQVVRVMVEAADEDTARQMAVRVAE
TH_1199|M.thermoresistible__bu VRTAVAAAEAELGDTGRILLRPSGTEQVVRVMVEAADEDTARQLAARVAE
MSMEG_1559|M.smegmatis_MC2_155 VRSAVAAAEAELGDTGRILLRPSGTEQVVRVMVEAADEDTARQVAARVAE
MAB_3750c|M.abscessus_ATCC_199 VLAAVAAVESELAGNGRILLRPSGTEQLVRVMVEADEQSTAQRLAERVAQ
* ** . **...*********** ::****** :: *:::* **
Rv3441c|M.tuberculosis_H37Rv AVSTAR------------------
Mb3471c|M.bovis_AF2122/97 AVSTAR------------------
MLBr_00366|M.leprae_Br4923 AVSAQGSPLRCWNPDAISGVELRL
MAV_4384|M.avium_104 AVSAAR------------------
MMAR_1108|M.marinum_M AVSAAG------------------
MUL_0866|M.ulcerans_Agy99 AVSAAG------------------
Mflv_4947|M.gilvum_PYR-GCK SVSAES------------------
Mvan_1472|M.vanbaalenii_PYR-1 SVSAQR------------------
TH_1199|M.thermoresistible__bu SVSAQGN-----------------
MSMEG_1559|M.smegmatis_MC2_155 SVSLQG------------------
MAB_3750c|M.abscessus_ATCC_199 VVGAV-------------------
*.