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VASRHSRINTMAANPRAGQPAQSEDLIDVAAVVTAYYTVAPDPDNVDQQVTFGTSGHRGSSLDAAFNEAH ILATTQAIVEYRAAQGTTGPLFIGRDTHALSEPAWSTALEVLAANDVVAMIDSAERYTPTPAVSHAILSF NRGRDSGSTSSSRAGDLADGIVVTPSHNPPRDGGFKYNPPNGGPADTDATSVIAKRANEILRDGLKAVKR IPLARALNTAQRHDYLESYVADLPNVVDLHAISAEGIRIGADPLGGASVDYWAAISERHNLQLTVVNPLV DATWRFMTLDTDGKIRMDCSSPNAMAGLIANRDKYQVATGNDADSDRHGIVTPDGGLLNPNHYLAVAIDY LFTHRPEWATGTAVGKTAVSSSIIDRVVAGLGRTLVEVPVGFKWFVDGLIGGSIGFGGEESAGASFLRRD GSVWTTDKDGIILALLASEILAVTGSTPSQRYAELAGKYGAPTYARIDAPANREQKARLGKLSPEQVTAT ELAGDPITAKLTTAPGNGAPLGGLKVTTQNAWFAARPSGTEDVYKIYAESFLGADHLAEVQDAAREVVTK VIS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_1950 | - | - | 100% (563) | phosphoglucomutase |
M. vanbaalenii PYR-1 | Mvan_1607 | - | 3e-19 | 26.58% (523) | phosphoglucomutase/phosphomannomutase alpha/beta/subunit |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3095c | pgmA | 0.0 | 78.60% (556) | phosphoglucomutase |
M. gilvum PYR-GCK | Mflv_4406 | - | 0.0 | 88.35% (558) | phosphoglucomutase |
M. tuberculosis H37Rv | Rv3068c | pgmA | 0.0 | 78.60% (556) | phosphoglucomutase |
M. leprae Br4923 | MLBr_00706 | pmmB | 4e-15 | 24.81% (540) | putative phospho-sugar mutase |
M. abscessus ATCC 19977 | MAB_3450c | - | 0.0 | 80.00% (550) | phosphoglucomutase |
M. marinum M | MMAR_1591 | pgmA | 0.0 | 81.70% (552) | phosphoglucomutase PgmA |
M. avium 104 | MAV_4286 | - | 4e-20 | 26.36% (535) | phosphoglucomutase/phosphomannomutase |
M. smegmatis MC2 155 | MSMEG_2136 | pgm | 0.0 | 86.23% (552) | phosphoglucomutase |
M. thermoresistible (build 8) | TH_2260 | pmmB | 2e-21 | 27.75% (537) | PROBABLE PHOSPHOMANNOMUTASE PMMB (PHOSPHOMANNOSE MUTASE) |
M. ulcerans Agy99 | MUL_3442 | pgmA | 0.0 | 80.80% (552) | phosphoglucomutase |
CLUSTAL 2.0.9 multiple sequence alignment Mb3095c|M.bovis_AF2122/97 -----------------MVANPRAGQPAQPEDLVDLPHLVTAYYSIEPDP Rv3068c|M.tuberculosis_H37Rv -----------------MVANPRAGQPAQPEDLVDLPHLVTAYYSIEPDP MMAR_1591|M.marinum_M -----------------MVANPRAGQPAQPEDLVDLSHLVTAYYTIEPDP MUL_3442|M.ulcerans_Agy99 -----------------MVANPRAGQPAQPEDLVDLSHLVTAYYTIEPDP Mvan_1950|M.vanbaalenii_PYR-1 MASR-------HSRINTMAANPRAGQPAQSEDLIDVAAVVTAYYTVAPDP Mflv_4406|M.gilvum_PYR-GCK MPTRGVPCGRWASRINGMAANPRAGQPAQPEDLIDVASVVTAYYTVSPDP MSMEG_2136|M.smegmatis_MC2_155 -----------------MSANPRAGQPAQPEDLIDVAHVVTAYYTRRPDP MAB_3450c|M.abscessus_ATCC_199 ------------------MSNARAGQPAQPEDLIDIAHVVTAYYAIEPDP MLBr_00706|M.leprae_Br4923 ------------------MKAAVTPEEWITHDPDPQTAAELAACDPDELA MAV_4286|M.avium_104 ----------------------MTPEEWIAHDPDPRTAAELAACDAAELA TH_2260|M.thermoresistible__bu ---------------MTAQRTSSAVQDWIAHDPDPVTAAELRACSPEELE : : ..* . Mb3095c|M.bovis_AF2122/97 DDLAQQVAFGTSGHRGSALTG--TFNELHILAITQAIVEYRAAQGTTG-- Rv3068c|M.tuberculosis_H37Rv DDLAQQVAFGTSGHRGSALTG--TFNELHILAITQAIVEYRAAQGTTG-- MMAR_1591|M.marinum_M DDVAQQVVFGTSGHRGSALNG--AFNEAHILAITQAIVEYRAARGTTG-- MUL_3442|M.ulcerans_Agy99 DDVAQQVVFGTSGHRGSALNA--AFNEAHILAITQAIVEYRAGRGTTG-- Mvan_1950|M.vanbaalenii_PYR-1 DNVDQQVTFGTSGHRGSSLDA--AFNEAHILATTQAIVEYRAAQGTTG-- Mflv_4406|M.gilvum_PYR-GCK DNVDQQVTFGTSGHRGSSLDA--AFNEAHILATTQAIVEYRAAQGITG-- MSMEG_2136|M.smegmatis_MC2_155 EDVAQQVAFGTSGHRGSSLDT--AFNEAHILATTQAIVEYRAAQGITG-- MAB_3450c|M.abscessus_ATCC_199 ANVAQQVAFGTSGHRGSSLDA--AFNEAHIVATTAAIVEYRNAQGISG-- MLBr_00706|M.leprae_Br4923 ARFTRALRFGTSGLRGPVRGGPDAMNLAVVLRATWAVAQVLLQRAGSRPA MAV_4286|M.avium_104 ARFARPLRFGTAGLRGPVRGGPDAMNVAVVSRASWALAQVLKRRGPAG-A TH_2260|M.thermoresistible__bu RRFARPLRFGTAGLRGPLRGGPAGMNLAVVLRATWAVAQVLKARGHAG-S . : : ***:* **. :* : : *:.: :. : Mb3095c|M.bovis_AF2122/97 PLFIGRDTHGLSEPAWVSALEVLAANQVVAVVDSRDRYTPTPAISHAILT Rv3068c|M.tuberculosis_H37Rv PLFIGRDTHGLSEPAWVSALEVLAANQVVAVVDSRDRYTPTPAISHAILT MMAR_1591|M.marinum_M PLFIGRDTHGLSEPAWVSALEVLAGNNVVTMIDSADRYTPTPAVSHAILT MUL_3442|M.ulcerans_Agy99 QLFIGRDTHGLSEPAWVSALEVLAGNNVVTMIDSADRYTPTPAVSHAILT Mvan_1950|M.vanbaalenii_PYR-1 PLFIGRDTHALSEPAWSTALEVLAANDVVAMIDSAERYTPTPAVSHAILS Mflv_4406|M.gilvum_PYR-GCK PLFIGRDTHALSEPAWVSALEVLAANDVVTHIDSADRFTPTPAVSHAILA MSMEG_2136|M.smegmatis_MC2_155 PLFIGRDTHALSEPAWASALEVLAANDVVAMIDSGDRYTPTPAVSHAILT MAB_3450c|M.abscessus_ATCC_199 PLFIGRDTHALSEPAWTSALEVLVANNVVVAIDSRDRYTPTPAVSHAILR MLBr_00706|M.leprae_Br4923 TVIVGRDSRHGSAAFVAATAEVLAAEGFSVLLLPN--PAPTPVVAFAVRN MAV_4286|M.avium_104 RVIVGRDARHGSAVFATVAAEVIAAQGFSVLLLPG--PAPTPVVAFAVRH TH_2260|M.thermoresistible__bu GVIVGRDARHHSDEFALAAAEVLAAEGFSVTLMFT--AVPTPVLAFAVRH :::***:: * : **:..: . . : .***.::.*: Mb3095c|M.bovis_AF2122/97 YNRGRT---------EALADGIVVTPSHNPPSDGGIKYNPPNGGPADTAA Rv3068c|M.tuberculosis_H37Rv YNRGRT---------EALADGIVVTPSHNPPSDGGIKYNPPNGGPADTAA MMAR_1591|M.marinum_M YNRGRT---------EALADGIVVTPSHNPPPDGGFKYNPPNGGPADTDA MUL_3442|M.ulcerans_Agy99 YNRGRT---------EALADGIVVTPSHNSPPDGGFKYNPPNGGPADTDA Mvan_1950|M.vanbaalenii_PYR-1 FNRGRDSGSTSSSRAGDLADGIVVTPSHNPPRDGGFKYNPPNGGPADTDA Mflv_4406|M.gilvum_PYR-GCK YNRGRE---------GNLADGIVVTPSHNPPRDGGFKYNPPNGGPADTDA MSMEG_2136|M.smegmatis_MC2_155 FNRGRE---------GDLADGIVVTPSHNPPRDGGFKYNPPNGGPADSDA MAB_3450c|M.abscessus_ATCC_199 HNRGNP---------AGRADGIVVTPSHNPPRDGGFKYNPPHGGPADTDA MLBr_00706|M.leprae_Br4923 TG---------------AAAGIQITASHNPPTDNGYKVYFDGGIQIISPI MAV_4286|M.avium_104 TG---------------AAAGVQITASHNPPTDNGYKVYDGGGIQIVSPT TH_2260|M.thermoresistible__bu NR---------------AAAGIQITASHNPATDNGYKVYFEGGLPIVSPV * *: :*.***.. *.* * * : Mb3095c|M.bovis_AF2122/97 TTAIAKRANEILLAR-SMVKRLPLARALRTAQRHDYLGHYVDDLPNVVDI Rv3068c|M.tuberculosis_H37Rv TTAIAKRANEILLAR-SMVKRLPLARALRTAQRHDYLGHYVDDLPNVVDI MMAR_1591|M.marinum_M TNAIAKRANEILRDG-AGVARTPLARALRSAQRHDYLGNYVDDLPNVVDI MUL_3442|M.ulcerans_Agy99 TNAIAKRANEILRDG-AGVARMPLARALRSAQRHDYLGNYVDDLPNVVDI Mvan_1950|M.vanbaalenii_PYR-1 TSVIAKRANEILRDGLKAVKRIPLARALNTAQRHDYLESYVADLPNVVDL Mflv_4406|M.gilvum_PYR-GCK TGAIAKRANEILRDGLKGVHRVPLARAMRSVHRHDYLNAYVDDLPNVVDL MSMEG_2136|M.smegmatis_MC2_155 TSVIAKRANEILADNLKAVKRMPLARALQTVHRYDYLDAYVADLPNVVNL MAB_3450c|M.abscessus_ATCC_199 TGAIAARANEILRDGWRSVKRVPLAQALKSVRRYDFQQAYVDDLINVVDL MLBr_00706|M.leprae_Br4923 DHQIENAMAAAPLAD--QITRKPVNPSEN--SASDLVDHYIQRAAAVRRS MAV_4286|M.avium_104 DHQIEAAMADAPPAD--EIRRTPVPP-----AHTDLVQRYIERAAGVRRG TH_2260|M.thermoresistible__bu DREIEEAMADAPHAD--EISRRPVEP-----SGVDVIQRYVERAAHVRRT * : * *: * *: * Mb3095c|M.bovis_AF2122/97 AAIREAGVRIGADPLGGASVDYWGEIAHRHGLD-LTVVNPLVDATWRFMT Rv3068c|M.tuberculosis_H37Rv AAIREAGVRIGADPLGGASVDYWGEIAHRHGLD-LTVVNPLVDATWRFMT MMAR_1591|M.marinum_M AAIREAGVRIGADPLGGASVDYWGEIASRHGLA-LSVVNPLVDATWRFMT MUL_3442|M.ulcerans_Agy99 AAIREAGVRIGADPLGGASVGYWGEIASRHGLA-LSVVNPLVDATWRFMT Mvan_1950|M.vanbaalenii_PYR-1 HAISAEGIRIGADPLGGASVDYWAAISERHNLQ-LTVVNPLVDATWRFMT Mflv_4406|M.gilvum_PYR-GCK HAISAEKIRIGADPLGGASVDYWGAIAERHNLQ-LTVVNPLVDATWRFMT MSMEG_2136|M.smegmatis_MC2_155 HAIRAEGVRIGADPLGGASVDYWGAIAERHQID-LTVVNPLVDATWRFMT MAB_3450c|M.abscessus_ATCC_199 DAIKGAGIRIGADPLGGASVDYWAAIADRWSLE-LTVVNPLVDATWRFMT MLBr_00706|M.leprae_Br4923 NGS----VRVALTPMHGVGGAVAVETLRRTGFDDVHTVAAQFEPDPDFPT MAV_4286|M.avium_104 TGS----VRVALTALHGVGGTVAVDALHRAGFGRIHTVASQFAPDPDFPT TH_2260|M.thermoresistible__bu HDP----VRVALTPLHGVGGEFVMDALVRAGCTDVHVVESQFAPDPDFPT :*:. .: *.. * : .* . . . * * Mb3095c|M.bovis_AF2122/97 LDTDGKIRMDCSSPDAMAGLIRTMFGNRERYQIATGNDADADRHGIVTPD Rv3068c|M.tuberculosis_H37Rv LDTDGKIRMDCSSPDAMAGLIRTMFGNRERYQIATGNDADADRHGIVTPD MMAR_1591|M.marinum_M LDHDGKIRMDCSSPDAMASLI----ANRDHYQIATGNDADADRHGIVTPD MUL_3442|M.ulcerans_Agy99 LDHDGKIRMDCSSPDAMASLI----ANRDHYQIATGDDADADRHGIVTPD Mvan_1950|M.vanbaalenii_PYR-1 LDTDGKIRMDCSSPNAMAGLI----ANRDKYQVATGNDADSDRHGIVTPD Mflv_4406|M.gilvum_PYR-GCK LDTDGKIRMDCSSPNAMASLI----ANRESFQIATGNDADSDRHGIVTPD MSMEG_2136|M.smegmatis_MC2_155 LDTDGKIRMDCSSPNAMASLI----ANRDAYQIATGNDADSDRHGIVTPD MAB_3450c|M.abscessus_ATCC_199 LDHDGKIRMDCSSPDAMASLV----ASRDKYQIATGNDADSDRHGIVTPD MLBr_00706|M.leprae_Br4923 VAFP-----NPEEPGATDALLA--LAAHVGADVAIALDPDADRCAVGIPT MAV_4286|M.avium_104 VAFP-----NPEEPGATDALLT--LAADVDADVAIALDPDADRCAVGIPD TH_2260|M.thermoresistible__bu VPSP-----NPEEPAAVEAVLK--LAAEVDAEIAIALDPDADRCAVGIPT : : ..* * .:: . ::* . *.*:** .: * Mb3095c|M.bovis_AF2122/97 EG---LLNPNHYLAVAIEYLYTHRPS--WPAGIAVGKTVVSSSIIDRVVA Rv3068c|M.tuberculosis_H37Rv EG---LLNPNHYLAVAIEYLYTHRPS--WPAGIAVGKTVVSSSIIDRVVA MMAR_1591|M.marinum_M EG---LLNPNHYLAVAIDYLYTHRPS--WPAGIAVGKTAVSSSIIDRVVA MUL_3442|M.ulcerans_Agy99 EG---LLNPNHYLAVAIDYLYTHRPS--WPAGIAVGKTAVSSSIIDRVVA Mvan_1950|M.vanbaalenii_PYR-1 GG---LLNPNHYLAVAIDYLFTHRPE--WATGTAVGKTAVSSSIIDRVVA Mflv_4406|M.gilvum_PYR-GCK GG---LLNPNHFLAVAIDYLFAHRPE--WAAETAVGKTAVSSSIIDRVVA MSMEG_2136|M.smegmatis_MC2_155 GG---LLNPNHYLAVAIDYLYTHRPD--WPQSTAVGKTAVSSSIIDRVVA MAB_3450c|M.abscessus_ATCC_199 AG---LMNPNHYLAVAIDYLFSHRGG--WAAQTAVGKTLVSSSIIDRVVA MLBr_00706|M.leprae_Br4923 NSGWRMLSGDETGWLLGDYILSQTDK---PETAVVASTVVSSRMLPAIAT MAV_4286|M.avium_104 ASGWRMLSGDETGWLLGDYLLSQPQR---ADRPVVASTVVSSRMLSAIAA TH_2260|M.thermoresistible__bu PTGWRMLSGDETGWLLGDYILAQLDDGPVTTSTLVASTVVSSRMLAAIAD ::. :. : :*: :: . *..* *** :: :. Mb3095c|M.bovis_AF2122/97 GIGRQLVEVPVGFKWFVDG---LIGATLGFGGEESAGASFLRRDGSVWTT Rv3068c|M.tuberculosis_H37Rv GIGRQLVEVPVGFKWFVDG---LIGATLGFGGEESAGASFLRRDGSVWTT MMAR_1591|M.marinum_M GIGRELVEVPVGFKWFVDG---LIGGTIGFGGEESAGASFLRRDGSVWTT MUL_3442|M.ulcerans_Agy99 GIGRELVEVPVGFKWFVDG---LIGGTIGFGGEESAGASFLRRDGSVWTT Mvan_1950|M.vanbaalenii_PYR-1 GLGRTLVEVPVGFKWFVDG---LIGGSIGFGGEESAGASFLRRDGSVWTT Mflv_4406|M.gilvum_PYR-GCK GLGRTLVEVPVGFKWFVGG---LLDGTIGFGGEESAGASFLRRDGSVWTT MSMEG_2136|M.smegmatis_MC2_155 GLERKLVEVPVGFKWFVDG---LVGGSIGFGGEESAGASFLRTDGTVWTT MAB_3450c|M.abscessus_ATCC_199 GLGRTLIEVPVGFKWFVNG---LIDGTIGFGGEESAGASFLRRDGSVWTT MLBr_00706|M.leprae_Br4923 HYNAVHVETLTGFKWLARADANLPG-TLVYAYEEAIGHCVDP----TAVR MAV_4286|M.avium_104 RHGAVHVETLTGFKWLARADAEVPGGTLVYAYEEAIGHCVDP----AAVR TH_2260|M.thermoresistible__bu AHGARHVETLTGFKWLVRADADLPGSSLVYAYEEAIGHCVDP----SAVR :*. .****:. . : . :: :. **: * .. . Mb3095c|M.bovis_AF2122/97 DKDGIIMALLAAEILAVT---GATPSQRYHALAGEYGGPCYARIDAPAD- Rv3068c|M.tuberculosis_H37Rv DKDGIIMALLAAEILAVT---GATPSQRYHALAGEYGGPCYARIDAPAD- MMAR_1591|M.marinum_M DKDGIIMALLAAEILAVT---GATPSQRYRALADQYGAPTYARVDAPAN- MUL_3442|M.ulcerans_Agy99 DKDGIIMALLAAEILAVT---GATPSQRYRALADQYGAPTYAWVDAPAN- Mvan_1950|M.vanbaalenii_PYR-1 DKDGIILALLASEILAVT---GSTPSQRYAELAGKYGAPTYARIDAPAN- Mflv_4406|M.gilvum_PYR-GCK DKDGIILALLASEILAVT---GSTPSQRYAELAETYGAPTYARIDAPAD- MSMEG_2136|M.smegmatis_MC2_155 DKDGIILALLASEIFAVT---GKTPSQRYAELAEQYGAPSYARIDAPAD- MAB_3450c|M.abscessus_ATCC_199 DKDGIIAALLASEILAVT---GVTPSQRYVQLTEKYGAPTYARVDAPAS- MLBr_00706|M.leprae_Br4923 DKDGISAAVLVCDLVAALHKQGRSVPDMLDQLALRHGVHDVTAISRRIGP MAV_4286|M.avium_104 DKDGISAAVLVCDLVAALIARGGSVSGRLDELARRHGVHDVAAVSRRVG- TH_2260|M.thermoresistible__bu DKDGISAAVLCCDLVAALRAQGRTVLDALDDLARRFGVHTTTASSRRVE- ***** *:* .::.*. * : *: .* : . Mb3095c|M.bovis_AF2122/97 --------REQKARLARLSADQVSATELAGEPITAKLTTAPGNGAALGGL Rv3068c|M.tuberculosis_H37Rv --------REQKARLARLSADQVSATELAGEPITAKLTTAPGNGAALGGL MMAR_1591|M.marinum_M --------RDQKARLAKLSPDQVSATELAGEPITAKLTQAPGNGAPLGGL MUL_3442|M.ulcerans_Agy99 --------RDQKARLAKLSPDQVSATELAGEPITAKLTQAPGNGAPLGGL Mvan_1950|M.vanbaalenii_PYR-1 --------REQKARLGKLSPEQVTATELAGDPITAKLTTAPGNGAPLGGL Mflv_4406|M.gilvum_PYR-GCK --------REQKARLAKLSPEQVTATELAGEPITAKLTAAPGNGAPLGGL MSMEG_2136|M.smegmatis_MC2_155 --------REQKARLSKLSPEQVTATELAGEPITAKLTAAPGNGAALGGL MAB_3450c|M.abscessus_ATCC_199 --------REQKAVLSKLAPEQVSVTELAGEPIVAKLTNAPGNGAPIGGL MLBr_00706|M.leprae_Br4923 KQTGVDEAVDLIQRLRAAPPSQLAGFTATTTDIT--------DALIFTGG MAV_4286|M.avium_104 ----TDGAAELMRRLRTSPPETLAGFGVALTDIT--------DALIFTGG TH_2260|M.thermoresistible__bu ---DPDQAAAMLDRLRRRPPTELTGFPVTVTDLARAEGARRTDALIFEGG * .. :: : :. :. : * Mb3095c|M.bovis_AF2122/97 KVTTANAWFAARPSGTEDVYKIYAESFR---GPQHLVEVQQTAREVVDRV Rv3068c|M.tuberculosis_H37Rv KVTTANAWFAARPSGTEDVYKIYAESFR---GPQHLVEVQQTAREVVDRV MMAR_1591|M.marinum_M KVTTANAWFAARPSGTEDVYKIYAESFN---GPAHLAEVQKTAREVVNQV MUL_3442|M.ulcerans_Agy99 KVTTANAWFAARPSGTEDVYKIYAESFN---GPAHLAEVQKTAREVVNQV Mvan_1950|M.vanbaalenii_PYR-1 KVTTQNAWFAARPSGTEDVYKIYAESFL---GADHLAEVQDAAREVVTKV Mflv_4406|M.gilvum_PYR-GCK KVTTENAWFAARPSGTEDVYKIYAESFR---GPEHLAEVQDAARDVVSKV MSMEG_2136|M.smegmatis_MC2_155 KVTTENAWFAARPSGTEDVYKIYAESFK---GPEHLAEVQQAAKDVVNTV MAB_3450c|M.abscessus_ATCC_199 KVVTENAWFAARPSGTEDVYKIYAESFL---GAEHLNQVQDAAREVVSAV MLBr_00706|M.leprae_Br4923 DDDTW-VRVVVRLSGTEPKLKCYLEVR--CSVAGNLPSTRQRARVLRDEL MAV_4286|M.avium_104 DDDTS-VRLVVRPSGTEPKVKCYLEIR--CAPSDDLASSRRRARALRELL TH_2260|M.thermoresistible__bu TADTA-VRVVVRPSGTEPKVKFYFEVRRSCHDDEDLDIARARARELQDEL * . ...* **** * * * .* : *: : : Mb3095c|M.bovis_AF2122/97 IG----- Rv3068c|M.tuberculosis_H37Rv IG----- MMAR_1591|M.marinum_M IG----- MUL_3442|M.ulcerans_Agy99 IG----- Mvan_1950|M.vanbaalenii_PYR-1 IS----- Mflv_4406|M.gilvum_PYR-GCK IS----- MSMEG_2136|M.smegmatis_MC2_155 IG----- MAB_3450c|M.abscessus_ATCC_199 IG----- MLBr_00706|M.leprae_Br4923 VTLVQQW MAV_4286|M.avium_104 VATVRSW TH_2260|M.thermoresistible__bu VATVDQW :