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MAVHGFLLERVSVVRDEATVLRQVSAHFPAGRCSAVRGASGSGKTTLLRLLNRLIDPTSGKVWLDGVPLT DLDVLVLRRRVGLVAQAPVVLTDAVLNEVRVGRPDLPEGRVTELLARLCLGQSAREAFLPHQRSALRTAL IPAIDSTKVVGLISLPGAMSGLILAGVDPLTAIRYQIVVMYLLLAATAVAALTCARLAERALFDRAHRLV SLPAATRRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3000 | - | - | 100% (219) | POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. tuberculosis H37Rv | Rv0194 | - | 1e-13 | 37.89% (95) | drugs-transport transmembrane ATP-binding protein ABC transporter |
| M. tuberculosis H37Rv | Rv1620c | cydC | 5e-12 | 37.93% (116) | cytochrome' transport transmembrane ATP-binding protein ABC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3025 | - | 1e-118 | 100.00% (219) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1748 | - | 2e-12 | 39.13% (92) | ABC transporter related |
| M. leprae Br4923 | MLBr_01113 | - | 2e-11 | 34.34% (99) | putative ABC transporter, ATP-binding component |
| M. abscessus ATCC 19977 | MAB_2569c | - | 6e-13 | 29.17% (216) | hypothetical protein MAB_2569c |
| M. marinum M | MMAR_4973 | - | 1e-20 | 41.18% (136) | hypothetical protein MMAR_4973 |
| M. avium 104 | MAV_0669 | - | 3e-20 | 43.36% (143) | hypothetical protein MAV_0669 |
| M. smegmatis MC2 155 | MSMEG_5659 | - | 5e-15 | 43.48% (92) | ABC transporter, ATP-binding protein |
| M. thermoresistible (build 8) | TH_3634 | - | 2e-13 | 36.96% (92) | PUTATIVE ABC transporter, ATP-binding protein |
| M. ulcerans Agy99 | MUL_4047 | - | 7e-21 | 41.18% (136) | hypothetical protein MUL_4047 |
| M. vanbaalenii PYR-1 | Mvan_5005 | - | 3e-12 | 38.04% (92) | ABC transporter-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3000|M.tuberculosis_H37Rv --------------------------------------------------
Mb3025|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5659|M.smegmatis_MC2_155 -MSVTDWRGRLQEEQDPNNDNLPIDESIPLRREARSLLISLLRPYRWIVA
TH_3634|M.thermoresistible__bu --------------------------------------------------
Mflv_1748|M.gilvum_PYR-GCK -MTETNWRGKFDESAD-----LPIDETVPRQREARALLGSLLRPYRWAVV
Mvan_5005|M.vanbaalenii_PYR-1 MSADGEWRGKYDEHTD-----LPIDETVPRRREARSLLYLLLRPYRWVVL
MLBr_01113|M.leprae_Br4923 -MTMATAPATRSCDFYCTIRRLLKQLVPQRRLSLTVITLGITGTAIGIIV
MMAR_4973|M.marinum_M --------------------------------------------------
MUL_4047|M.ulcerans_Agy99 --------------------------------------------------
MAV_0669|M.avium_104 --------------------------------------------------
MAB_2569c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3000|M.tuberculosis_H37Rv --------------------------------------------------
Mb3025|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5659|M.smegmatis_MC2_155 VLALVVIVENAARLSVPVLVQRGIDHGIPPILAGGPARELMVIVATLCAV
TH_3634|M.thermoresistible__bu --------------------------------------------------
Mflv_1748|M.gilvum_PYR-GCK LLAVVVVVENAARLSVPILVQKGIDDGIPPLLEGGPAITLMTIVATLCGV
Mvan_5005|M.vanbaalenii_PYR-1 ALAVVVVVENAARLSVPLLVQKGIDDGIPPLLAGERATTLLTIVAALCGV
MLBr_01113|M.leprae_Br4923 PWVLGHTTDLLFNGVIGRQLPKGISKTQAVAAARTRGDNALADLLSGMNL
MMAR_4973|M.marinum_M --------------------------------------------------
MUL_4047|M.ulcerans_Agy99 --------------------------------------------------
MAV_0669|M.avium_104 --------------------------------------------------
MAB_2569c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3000|M.tuberculosis_H37Rv --------------------------------------------------
Mb3025|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5659|M.smegmatis_MC2_155 VLVQATSRMFFLRRSGRVG---------------------QKVLLELRRR
TH_3634|M.thermoresistible__bu --------MYFLRRSGRIG---------------------QEVLLELRRR
Mflv_1748|M.gilvum_PYR-GCK VVVQAVGRMYFLRRSGRIG---------------------QKVLLELRRR
Mvan_5005|M.vanbaalenii_PYR-1 VVVQACSRMYFLRRSGRIG---------------------QKVLLELRRR
MLBr_01113|M.leprae_Br4923 VPGQGVDFVAVGRTLGLALSLYLVYTLLTWAQARLLNVTVQRIMFALRSD
MMAR_4973|M.marinum_M --------------------------------------------------
MUL_4047|M.ulcerans_Agy99 --------------------------------------------------
MAV_0669|M.avium_104 --------------------------------------------------
MAB_2569c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3000|M.tuberculosis_H37Rv --------------------------------------------------
Mb3025|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5659|M.smegmatis_MC2_155 VFRHFQRLDLAFHDRYTSGRVVSRSTNDVEAIQDMLETGFDSLITAVLTL
TH_3634|M.thermoresistible__bu LFRHFQRLDVAFHERYTSGRVVSRSTNDVEAIQDMLETGFDSLITAVLTL
Mflv_1748|M.gilvum_PYR-GCK VFRHFGRLDIAFHDRYTSGRVVSRSTNDVEAIQDMLETGFDSLITAVLTM
Mvan_5005|M.vanbaalenii_PYR-1 VFRHFGRLDIAFHDRYTSGRVVSRSTNDVEAIQDMLETGFDSLITAVLTL
MLBr_01113|M.leprae_Br4923 VEDKVHRLPLSYCDTRQRGELLSRVTNDIDNLQSSLSITLSQLLTSLLTV
MMAR_4973|M.marinum_M --------------------------------------------------
MUL_4047|M.ulcerans_Agy99 --------------------------------------------------
MAV_0669|M.avium_104 --------------------------------------------------
MAB_2569c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3000|M.tuberculosis_H37Rv --------------------------------------------------
Mb3025|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5659|M.smegmatis_MC2_155 FGTAVLLVVLDWRLGLMCLAAFPILVALVWWFRNESARTYRKVRESAALV
TH_3634|M.thermoresistible__bu GGTAILLVTLDVRLGLMCLGAFPVLIALVWWFREESAKTYRKVRESAALV
Mflv_1748|M.gilvum_PYR-GCK VGTAVLLVVLDVKLGLMCLVAFPVLVLLVWWFQRESSKTYREVREISALV
Mvan_5005|M.vanbaalenii_PYR-1 VGTAVLLVVLDVKLGLMCLAAFPILVLLVMWFRRESSKTYREVREISALV
MLBr_01113|M.leprae_Br4923 VAVLVVMVSVSPLLALVALLTVPMSLLATRAIAQRSQQLFVAQWTSAGRL
MMAR_4973|M.marinum_M --------------------------------------------------
MUL_4047|M.ulcerans_Agy99 --------------------------------------------------
MAV_0669|M.avium_104 --------------------------------------------------
MAB_2569c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3000|M.tuberculosis_H37Rv --------------------------------------------------
Mb3025|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5659|M.smegmatis_MC2_155 IVQFVETMTGIKAVQAYRREPRNQEIFSDIADDYREINEKTFKLLAIFMP
TH_3634|M.thermoresistible__bu IVQFVETMTGIKAVQAYRREPRNQEIFEQVADDYREINEKTLRLLAIFMP
Mflv_1748|M.gilvum_PYR-GCK IVQFVETMTGIKAVQAYRREPRNQQIFEDVADRYREINERTFKLLAVFMP
Mvan_5005|M.vanbaalenii_PYR-1 IVQFVETMTGIKAVQAYRREPRNQQIFEDIADRYRVINEKTFKLLAVFMP
MLBr_01113|M.leprae_Br4923 NAHIEETYSGLTVVKTFGHQTAAREQFRNVNNDVYQASFSAQFFSGLVSP
MMAR_4973|M.marinum_M -----------------------------MNGQIGWIGLATSLALVAFAA
MUL_4047|M.ulcerans_Agy99 -----------------------------MNGQIGWIGLATSLALVAFAA
MAV_0669|M.avium_104 -----------------------------MNGQVGWLGLATSLILVAFAG
MAB_2569c|M.abscessus_ATCC_199 --------------------------MNGSQLVLGPVLVSVCVVMVLASA
Rv3000|M.tuberculosis_H37Rv --------------------------------------------------
Mb3025|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5659|M.smegmatis_MC2_155 GVKLVGNITTGVVLIYGGYRVLNDQMTIGTLAAFLLYLRMFFEPMQEISQ
TH_3634|M.thermoresistible__bu GVRLVGNITTGVVLLYGGYLVLNDQMTIGTLTAFLLYLRMFFEPMQEISQ
Mflv_1748|M.gilvum_PYR-GCK GVKLVGNLTTGVVLLYGGYRALHGEMTIGTLTAFLLYLRMFFEPMQEISQ
Mvan_5005|M.vanbaalenii_PYR-1 GVKLVGNLTTGVVLLYGGYRVLHGEMTIGTLAAFLLYLRMFFEPMQEISQ
MLBr_01113|M.leprae_Br4923 ATMFISNLGYVVVAALGGLQVATGHITLGNIQAFIQYVRQFNMPLSQVAG
MMAR_4973|M.marinum_M AISLWQRLGLERQVVWAAARALVQLLLVG----------------GALTL
MUL_4047|M.ulcerans_Agy99 AISLWQRLGLERQVVWAAARALVQLLLVG----------------GALTL
MAV_0669|M.avium_104 AISLWRRLGLERQLLWAASRALVQLLLVG----------------GALTL
MAB_2569c|M.abscessus_ATCC_199 AVYRVAAIGSVWTVPWASLRGVVQLAAVAG-------------------V
Rv3000|M.tuberculosis_H37Rv ------------MAVHGFLLERVSVVR-----------------------
Mb3025|M.bovis_AF2122/97 ------------MAVHGFLLERVSVVR-----------------------
MSMEG_5659|M.smegmatis_MC2_155 FFNTFQSASSALEKLAGVLAQRPGIADPERPVA-----LHAVAGTITFDH
TH_3634|M.thermoresistible__bu FFNTFQSAASALEKLAGVLAEEPAIKDPQHPVSP----ARPVRGEIAFHG
Mflv_1748|M.gilvum_PYR-GCK FFNTFQSASSALEKLAGVLAEKPGISDPAKPVR-----VDEVRGEVALLD
Mvan_5005|M.vanbaalenii_PYR-1 FFNTFQSAASALEKLAGVLAEKPGISDPPHPVA-----LGEVRGEIALRD
MLBr_01113|M.leprae_Br4923 IYNTLQSGLASAERVFDLLDEPEELPDPMLALPPPHGQVPRINGRVEFQQ
MMAR_4973|M.marinum_M LFEPGRSLWWSWAWIAGMIG------------------------------
MUL_4047|M.ulcerans_Agy99 LFEPGRSLWWSWAWIAGMIG------------------------------
MAV_0669|M.avium_104 LFEPGRSLWWSWAWVAGMVG------------------------------
MAB_2569c|M.abscessus_ATCC_199 LVAAMARLWSSALVLAGMFV------------------------------
: ...
Rv3000|M.tuberculosis_H37Rv ------DEATVLRQVSAHFPAGRCSAVRGASGSGKTTLLRLLNRLIDPTS
Mb3025|M.bovis_AF2122/97 ------DEATVLRQVSAHFPAGRCSAVRGASGSGKTTLLRLLNRLIDPTS
MSMEG_5659|M.smegmatis_MC2_155 VHFAYAPGRPVLPDLTLTVPAGQTVALVGTTGAGKTTIAKLIARFYDPTS
TH_3634|M.thermoresistible__bu VQFAYVPGRPVIPELTLTVPAGQTVALVGTTGAGKTTIATLIARFYDPTA
Mflv_1748|M.gilvum_PYR-GCK VHFAYVPGRPVLPGLDLVIPAGQTVALVGTTGAGKTTIAKLITRFYDPGS
Mvan_5005|M.vanbaalenii_PYR-1 LTFEYVPGRPVLPGLDLVIPAGQTVALVGTTGAGKTTIAKLITRFYDPVA
MLBr_01113|M.leprae_Br4923 VSFAYRTGTPVIDDLSMVVEPGSTVAIVGPTGAGKTTLVNLLMRFYDVDS
MMAR_4973|M.marinum_M ------YAGDVARRRAPEVPRLALLAVAAFSAAAVLTLGVIFG------L
MUL_4047|M.ulcerans_Agy99 ------YAGDVARRRAPEVPRLALLAVAAFSAAAVLTLGVIFG------L
MAV_0669|M.avium_104 ------YAGDVARRRAPEVPRFAPLAVAAFAAAAVVTLGVLFG------L
MAB_2569c|M.abscessus_ATCC_199 -------VAGVTAAKRIGASRGAAWAVGALAVGWVSVLPLLLVS------
* *: . : . .: ::
Rv3000|M.tuberculosis_H37Rv GKVWLDGVPLTDLDVLVLRRRVGLVAQAPVVLTDAVLNEVRVGRPDLPEG
Mb3025|M.bovis_AF2122/97 GKVWLDGVPLTDLDVLVLRRRVGLVAQAPVVLTDAVLNEVRVGRPDLPEG
MSMEG_5659|M.smegmatis_MC2_155 GTVTLDGVDLRDLSQSELRRHVVMVTQENFMFEGTVADNIRFGRPDATDA
TH_3634|M.thermoresistible__bu GSVTLDGIDLRDIAQSELRRHVVMVTQENFMFDGTVADNIRFGRPEATDA
Mflv_1748|M.gilvum_PYR-GCK GTVSLDGVDLRDMSQADLRRHVVMVTQENFMFGGTIADNIRFGRPGATDD
Mvan_5005|M.vanbaalenii_PYR-1 GTVMLDEIDLRDVAQAELRRHVVMVTQENFMFGGTVADNIRFGRPDATDD
MLBr_01113|M.leprae_Br4923 GQILIDGVDITTVSRHALRSRIGMVLQDAWLFDGTIAENIAYGRPQASED
MMAR_4973|M.marinum_M GVFPLQARTVVPIAG----MMIGNSMTAMVLVARRLVDELRDKR------
MUL_4047|M.ulcerans_Agy99 GVFPLQARTVVPIAG----MMIGNSMTAMVLVARRLVDELRDKR------
MAV_0669|M.avium_104 RVFPLQGRTLVPVAG----MMIGNSMTAMVLVARRLVDELRDKR------
MAB_2569c|M.abscessus_ATCC_199 GAVPLTGVAVVPIAA----IVLGNAMTSISVAARLALDAIAARAG-----
. : : : : : : :
Rv3000|M.tuberculosis_H37Rv ---------RVTELLARLCLGQSAREAFLPHQRSALRTALIPAIDSTKVV
Mb3025|M.bovis_AF2122/97 ---------RVTELLARLCLGQSAREAFLPHQRSALRTALIPAIDSTKVV
MSMEG_5659|M.smegmatis_MC2_155 QVRAAAEAVGADRFIATLPEGYGTDVAKRGGRLSAGQRQLIAFARAFLAD
TH_3634|M.thermoresistible__bu EIAAAAEAVGADRFIAALPDGYHTDVAKRGSRLSAGQRQLIAFARAFLAD
Mflv_1748|M.gilvum_PYR-GCK EVRAAARAVGAHTFIDVLPDGYDTDVAKRGGRLSAGQRQLVAFARAFLAD
Mvan_5005|M.vanbaalenii_PYR-1 EVRAAARAVGAHTFIGALPDGYDTDVAKRGGRLSAGQRQLVAFARAFLAD
MLBr_01113|M.leprae_Br4923 EVMEAAKAAYVDRFVHTLSAGYQTRVSGDGDNISAGEKQLITIARAFLAR
MMAR_4973|M.marinum_M -----------DEVEARLALGQPSRQAAAPYLRTSLRSAISPQIETTKAT
MUL_4047|M.ulcerans_Agy99 -----------DEVEARLALGQPSRQAAAPYLRASLRSAISPQIETTKAT
MAV_0669|M.avium_104 -----------DEVEARLALGQPSGQAASPYLRIALRSAISPQIETTKAT
MAB_2569c|M.abscessus_ATCC_199 ------------EVEAALSLGMSQRDSRMGVIDQVAATSLLPTVDSTRTV
. * * : : . : .
Rv3000|M.tuberculosis_H37Rv GLISLPGAMSG--------LILAGVDPLTAIRYQIVVMYLLLAATAVAAL
Mb3025|M.bovis_AF2122/97 GLISLPGAMSG--------LILAGVDPLTAIRYQIVVMYLLLAATAVAAL
MSMEG_5659|M.smegmatis_MC2_155 PAVLILDEATSSLDIPSERMVQRALETVLADRTALVIAHRLSTVQIADRV
TH_3634|M.thermoresistible__bu PAVLILDEATSALDIPSERMVQRALRTVLADRTALVIAHRLSTVEIADRV
Mflv_1748|M.gilvum_PYR-GCK PAVLILDEATSSLDIPSERLVQRALETVLADRTAVVIAHRLSTVQIADRV
Mvan_5005|M.vanbaalenii_PYR-1 PAVLILDEATSSLDIPSERMVQRALETVLADRTAVVIAHRLSTVQIADRV
MLBr_01113|M.leprae_Br4923 PQLLILDEATSSIDTRTEALIARATHDLLQDRTSFIIAHHLPTIRDADHI
MMAR_4973|M.marinum_M GLVFLPGAMTG--------LILAGVSPLQAVLVQAVVMFLILGSVAATTV
MUL_4047|M.ulcerans_Agy99 GLVFLPGAMTG--------LILAGVSPLQAVLVQAVVMFLILGSVAATTV
MAV_0669|M.avium_104 GLVFLPGAMTG--------LILAGVPPLQAVLVQAVVMFLILGSVAATTV
MAB_2569c|M.abscessus_ATCC_199 GLVTLPGAFVG--------VLLSTGSAAQAAAVQILILIALLLSQTCAVA
: : . . :: :: :
Rv3000|M.tuberculosis_H37Rv TCARLAERALFDRAHRLVSLPAATRRA----------------
Mb3025|M.bovis_AF2122/97 TCARLAERALFDRAHRLVSLPAATRRA----------------
MSMEG_5659|M.smegmatis_MC2_155 LVLEHGRIIEDGSPADLIGRTDGAYAALHRAWVDSLA------
TH_3634|M.thermoresistible__bu LVLERGRVVEDGPPGELIRRGEGRYAALHHAWLESLG------
Mflv_1748|M.gilvum_PYR-GCK LVLEHGRIVEDGPPEELTAREGGHYAALHRSWVQSLA------
Mvan_5005|M.vanbaalenii_PYR-1 LVLEHGRIVEDGAPDELTARDHGHYAALHRSWVQSLA------
MLBr_01113|M.leprae_Br4923 LVVAAGKIVEQGSHAKLLARRGAYYRMTQA-------------
MMAR_4973|M.marinum_M VVGLGLVRLVFTRDHRLRPLRQPTGVHGGPSRARPSGRRATQR
MUL_4047|M.ulcerans_Agy99 VVGLGLVRLVFTRDHRLRPLRQPTGVHGGPSRARPSGRRATQR
MAV_0669|M.avium_104 VVALGIVRLVFTRDHRLRPLDQ-----------RPPD------
MAB_2569c|M.abscessus_ATCC_199 VTIELIARGIIGRAPRTAG------------------------