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DPAGNPATGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAVMALERVPADIRAQGGVSRMSDPDM IEGIIAAVTIPVMAKVRIGHFVEAQILQTLGVDYIDESEVLTPADYAHHIDKWNFTVPFVCGATNLGEAL RRISEGAAMIRSKGEAGTGDVSNATTHMRAIGGEIRRLTSMSEDELFVAAKELQAPYELVAEVARAGKLP VTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGAPEHRAAAIVKATTFFDDPDVLAKVSRGLGEAMV GINVDEIAVGHRLAQRGW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2606c | - | - | 100% (299) | pyridoxine biosynthesis protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2638c | - | 1e-168 | 100.00% (299) | pyridoxal biosynthesis lyase PdxS |
| M. gilvum PYR-GCK | Mflv_3832 | - | 1e-151 | 91.22% (296) | pyridoxine biosynthesis protein |
| M. leprae Br4923 | MLBr_00450 | - | 1e-146 | 89.69% (291) | pyridoxal biosynthesis lyase PdxS |
| M. abscessus ATCC 19977 | MAB_2892c | - | 1e-150 | 91.75% (291) | pyridoxal biosynthesis lyase PdxS |
| M. marinum M | MMAR_2094 | snzP | 1e-150 | 95.74% (282) | pyridoxine biosynthesis protein, SnzP |
| M. avium 104 | MAV_3484 | - | 1e-152 | 91.58% (297) | pyridoxine biosynthesis protein |
| M. smegmatis MC2 155 | MSMEG_2937 | - | 1e-152 | 93.47% (291) | pyridoxine biosynthesis protein |
| M. thermoresistible (build 8) | TH_2055 | - | 1e-148 | 89.53% (296) | Possible pyridoxine biosynthesis protein |
| M. ulcerans Agy99 | MUL_3250 | snzP | 1e-156 | 94.26% (296) | pyridoxal biosynthesis lyase PdxS |
| M. vanbaalenii PYR-1 | Mvan_2564 | - | 1e-153 | 92.54% (295) | pyridoxine biosynthesis protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2606c|M.tuberculosis_H37Rv -----------------------------------MDPAGNP--------
Mb2638c|M.bovis_AF2122/97 -----------------------------------MDPAGNP--------
MMAR_2094|M.marinum_M --------------------------------------------------
MUL_3250|M.ulcerans_Agy99 -----------------------------------MDSATQPRGDRPDPA
TH_2055|M.thermoresistible__bu --------------------------------VEEMTVETRDKAVGPNGS
MLBr_00450|M.leprae_Br4923 -----------------------------------MDSAAQSNQAQSVF-
MAV_3484|M.avium_104 -----------------------------------MNTAHSPDGS-----
Mflv_3832|M.gilvum_PYR-GCK -----MGSQARRSGSNGFAAASKLDQQRIK--EIAVESELTGAASGA---
Mvan_2564|M.vanbaalenii_PYR-1 -----------------------------------MESETSGAGLGA---
MAB_2892c|M.abscessus_ATCC_199 MRQSKSGEARHRTSRHKIAGAAALDWSQTPRFRSPQLTSTTNGTSPE---
MSMEG_2937|M.smegmatis_MC2_155 -----------------------------------METAAQNGSSNQ---
Rv2606c|M.tuberculosis_H37Rv ----------ATGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAV
Mb2638c|M.bovis_AF2122/97 ----------ATGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAV
MMAR_2094|M.marinum_M --------------------MAEMLKGGVIMDVVTPEQARIAEGAGAVAV
MUL_3250|M.ulcerans_Agy99 SSKQAQSGSSQTGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAV
TH_2055|M.thermoresistible__bu ADG------AQTGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAV
MLBr_00450|M.leprae_Br4923 ---------GQTGTARVKRGMAEMLKGGVIMDVVIPEQARIAEGSGAVAV
MAV_3484|M.avium_104 ---------GRTGTARVKRGMAEMLKGGVIMDVVTPEQAKIAEGAGAVAV
Mflv_3832|M.gilvum_PYR-GCK ---------PARGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAV
Mvan_2564|M.vanbaalenii_PYR-1 ---------PARGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAV
MAB_2892c|M.abscessus_ATCC_199 ---------TGTGTARVKRGMAEMLKGGVIMDVVTPEQAKIAEDAGAVAV
MSMEG_2937|M.smegmatis_MC2_155 ---------TGT--ARVKRGMAEMLKGGVIMDVVTPEQARIAEAAGAVAV
************** ****:*** :*****
Rv2606c|M.tuberculosis_H37Rv MALERVPADIRAQGGVSRMSDPDMIEGIIAAVTIPVMAKVRIGHFVEAQI
Mb2638c|M.bovis_AF2122/97 MALERVPADIRAQGGVSRMSDPDMIEGIIAAVTIPVMAKVRIGHFVEAQI
MMAR_2094|M.marinum_M MALERVPADIRAQGGVSRMSDPDMIEGIIEAVTIPVMAKARIGHFVEAQI
MUL_3250|M.ulcerans_Agy99 MALERVPADIRAQGGVSRMSDPDMIEGIIEAVTIPVMAKARIGHFVEAQI
TH_2055|M.thermoresistible__bu MALERVPADIRAQGGVARMSDPDLIEGIINAVTIPVMAKVRIGHFVEAQI
MLBr_00450|M.leprae_Br4923 MALERVPSDIRAQGGVSRMSDPDMIESIIAAVTIPVMAKARIGHFVEAQI
MAV_3484|M.avium_104 MALERVPADIRAQGGVSRMSDPDMIEGIISAVTIPVMAKARIGHFVEAQI
Mflv_3832|M.gilvum_PYR-GCK MALERVPADIRAQGGVSRMSDPDMIEGIIDAVTIPVMAKARIGHFVEAQI
Mvan_2564|M.vanbaalenii_PYR-1 MALERVPADIRAQGGVSRMSDPDMIEGIIDAVTIPVMAKARIGHFVEAQI
MAB_2892c|M.abscessus_ATCC_199 MALERVPADIRAQGGVSRMSDPDMIDGIISAVSIPVMAKARIGHFVEAQI
MSMEG_2937|M.smegmatis_MC2_155 MALERVPADIRAQGGVSRMSDPDMIEGIIDAVTIPVMAKARIGHFVEAQI
*******:********:******:*:.** **:******.**********
Rv2606c|M.tuberculosis_H37Rv LQTLGVDYIDESEVLTPADYAHHIDKWNFTVPFVCGATNLGEALRRISEG
Mb2638c|M.bovis_AF2122/97 LQTLGVDYIDESEVLTPADYAHHIDKWNFTVPFVCGATNLGEALRRISEG
MMAR_2094|M.marinum_M LQSLGVDYIDESEVLTPADYTHHIDKWKFTVPFVCGATNLGEALRRIGEG
MUL_3250|M.ulcerans_Agy99 LQSLGVDYIDESEVLTPADYTHHIDKWKFTVPFVCGATNLGEALRRIGEG
TH_2055|M.thermoresistible__bu LQSLGVDYIDESEVLTPADYTHHIDKWKFTVPFVCGATNLGEALRRIAEG
MLBr_00450|M.leprae_Br4923 LQSLGVDYIDESEVLTPADYTHHIDKWKFTVPFVCGATNLGEALRRINEG
MAV_3484|M.avium_104 LQSLGVDYIDESEVLTPADYTHHIDKWKFTVPFVCGATNLGEALRRINEG
Mflv_3832|M.gilvum_PYR-GCK LQSLGVDYVDESEVLTPADYTNHIDKWKFTVPFVCGATNLGEALRRITEG
Mvan_2564|M.vanbaalenii_PYR-1 LQSLGVDYIDESEVLTPADYANHIDKWRFTVPFVCGATNLGEALRRLTEG
MAB_2892c|M.abscessus_ATCC_199 LQSLGVDYIDESEVLTPADYTNHIDKWKFTVPFVCGATNLGEALRRITEG
MSMEG_2937|M.smegmatis_MC2_155 LQSLGVDYVDESEVLTPADYTNHIDKWKFTVPFVCGATNLGEALRRITEG
**:*****:***********::*****.******************: **
Rv2606c|M.tuberculosis_H37Rv AAMIRSKGEAGTGDVSNATTHMRAIGGEIRRLTSMSEDELFVAAKELQAP
Mb2638c|M.bovis_AF2122/97 AAMIRSKGEAGTGDVSNATTHMRAIGGEIRRLTSMSEDELFVAAKELQAP
MMAR_2094|M.marinum_M AAMIRSKGEAGTGDVSNATTHMRSIAGEIRRLTSMSEDELFVAAKELQAP
MUL_3250|M.ulcerans_Agy99 AAMIRSKGEAGTGDVSNATTHMRSIAGEIRRLTSMSEDELFVAAKELQAP
TH_2055|M.thermoresistible__bu AAMIRSKGEAGTGDVSNATTHMRQIRAEIRRLSALPEDELYVAAKELQAP
MLBr_00450|M.leprae_Br4923 AAMIRSKGEAGTGDVSNATTHMRAIAGDIRRLTSLSEDELYVAAKELHAP
MAV_3484|M.avium_104 AAMIRSKGEAGTGDVSNATTHMRAIGGEIRRLMSLSEDELYVAAKELQAP
Mflv_3832|M.gilvum_PYR-GCK AAMIRSKGEAGTGDVSNATTHMRKIGGEIRRLTSLSEDELYVAAKELQAP
Mvan_2564|M.vanbaalenii_PYR-1 AAMIRSKGEAGTGDVSNATTHMRKIGGEIRRLTSLSEDELYVAAKELQAP
MAB_2892c|M.abscessus_ATCC_199 AAMIRSKGEAGTGDVSNATTHMRKIGGEIRRLTSLAEDELYVAAKELQAP
MSMEG_2937|M.smegmatis_MC2_155 AAMIRSKGEAGTGDVSNATTHMRKIGGEIRRLTSMSEDELYVAAKELQAP
*********************** * .:**** ::.****:******:**
Rv2606c|M.tuberculosis_H37Rv YELVAEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSG
Mb2638c|M.bovis_AF2122/97 YELVAEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSG
MMAR_2094|M.marinum_M YELVAEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSG
MUL_3250|M.ulcerans_Agy99 YELVVEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSG
TH_2055|M.thermoresistible__bu YELVAEVARTGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSG
MLBr_00450|M.leprae_Br4923 YELVIEVARTNKLPVTLFTAGGIATPADAAMMMQLGAEGIFVGSGIFKSS
MAV_3484|M.avium_104 YELVVEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSG
Mflv_3832|M.gilvum_PYR-GCK YDLVVEVAQAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSG
Mvan_2564|M.vanbaalenii_PYR-1 YDLVVEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSG
MAB_2892c|M.abscessus_ATCC_199 YELVVEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSG
MSMEG_2937|M.smegmatis_MC2_155 YELVVEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSG
*:** ***::.****************************:*********.
Rv2606c|M.tuberculosis_H37Rv APEHRAAAIVKATTFFDDPDVLAKVSRGLGEAMVGINVDEIAVGHRLAQR
Mb2638c|M.bovis_AF2122/97 APEHRAAAIVKATTFFDDPDVLAKVSRGLGEAMVGINVDEIAVGHRLAQR
MMAR_2094|M.marinum_M APEHRAAAIVKATTFYDDPDVLAKVSRGLGEAMVGINVEEIAQPHRLAQR
MUL_3250|M.ulcerans_Agy99 APEHRAAAIVKATTFYDDPDVLAKVSRGLGEAMVGINVEEIAQPHRLAQR
TH_2055|M.thermoresistible__bu NPEQRAAAIVKATTFYDDPDVLAKVSRNLGEPMVGINVADVPVPHRLAER
MLBr_00450|M.leprae_Br4923 DPAQRAAAIVKATTFYDDPDVLAKVSRGLGEAMAGIDVEQIAQPDRLAQR
MAV_3484|M.avium_104 DPAQRAAAIVKATTFYDDPDVLAKVSRGLGEAMVGINVEQIAQPERLAER
Mflv_3832|M.gilvum_PYR-GCK NPAERAAAIVKATTFYDDPDVLAKVSRGLGEAMVGINVEDIAQPHRLAER
Mvan_2564|M.vanbaalenii_PYR-1 NPAERAAAIVKATTFYDDPDVLAKVSRGLGEAMVGINVDDIPVPHRLAER
MAB_2892c|M.abscessus_ATCC_199 NPEQRAAAIVKATTFYDDPDVLAKVSRGLGEAMVGINVEDIAQPHRLAER
MSMEG_2937|M.smegmatis_MC2_155 NPEQRAAAIVKATTFYDDPDVLAKVSRGLGEAMVGINVEEIAQPHRLAER
* .***********:***********.***.*.**:* ::. .***:*
Rv2606c|M.tuberculosis_H37Rv GW
Mb2638c|M.bovis_AF2122/97 GW
MMAR_2094|M.marinum_M GW
MUL_3250|M.ulcerans_Agy99 GW
TH_2055|M.thermoresistible__bu GW
MLBr_00450|M.leprae_Br4923 GW
MAV_3484|M.avium_104 GW
Mflv_3832|M.gilvum_PYR-GCK GW
Mvan_2564|M.vanbaalenii_PYR-1 GW
MAB_2892c|M.abscessus_ATCC_199 GW
MSMEG_2937|M.smegmatis_MC2_155 GW
**