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TVPAPSQLDLRQEVHDAARRARVAARRLASLPTTVKDRALHAAADELLAHRDQILAANAEDLNAAREADT PAAMLDRLSLNPQRVDGIAAGLRQVAGLRDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVD AFGLTLKSGNAALLRGSSSAAKSNEALVAVLRTALVGLELPADAVQLLSAADRATVTHLIQARGLVDVVI PRGGAGLIEAVVRDAQVPTIETGVGNCHVYVHQAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAET ALPRLLAALQHAGVTVHLDPDEADLRREYLSLDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNLDAAQR FTEQIDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGAGHTRPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2427c | proA | - | 100% (415) | gamma-glutamyl phosphate reductase |
| M. tuberculosis H37Rv | Rv3293 | pcd | 5e-06 | 24.21% (442) | piperideine-6-carboxilic acid dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2451c | proA | 0.0 | 100.00% (415) | gamma-glutamyl phosphate reductase |
| M. gilvum PYR-GCK | Mflv_2644 | proA | 0.0 | 79.28% (415) | gamma-glutamyl phosphate reductase |
| M. leprae Br4923 | MLBr_01458 | proA | 0.0 | 82.15% (409) | gamma-glutamyl phosphate reductase |
| M. abscessus ATCC 19977 | MAB_1618 | proA | 1e-169 | 74.94% (419) | gamma-glutamyl phosphate reductase |
| M. marinum M | MMAR_3753 | proA | 0.0 | 90.15% (406) | gamma-glutamyl phosphate reductase protein ProA |
| M. avium 104 | MAV_1747 | proA | 0.0 | 83.37% (415) | gamma-glutamyl phosphate reductase |
| M. smegmatis MC2 155 | MSMEG_4584 | proA | 0.0 | 81.03% (406) | gamma-glutamyl phosphate reductase |
| M. thermoresistible (build 8) | TH_0792 | proA | 0.0 | 80.72% (415) | PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA |
| M. ulcerans Agy99 | MUL_3696 | proA | 0.0 | 89.66% (406) | gamma-glutamyl phosphate reductase |
| M. vanbaalenii PYR-1 | Mvan_3934 | proA | 0.0 | 78.80% (415) | gamma-glutamyl phosphate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2644|M.gilvum_PYR-GCK MSVQAPSVP-------------------DLRQQVHDAARRARSAARGLAT
Mvan_3934|M.vanbaalenii_PYR-1 MSVQAPSVP-------------------DLRQQVHDAARRARGAARALAS
MSMEG_4584|M.smegmatis_MC2_155 MSVEAQSRSGAVD----------TQEPADLREQVHSAARRARVAARTLAT
TH_0792|M.thermoresistible__bu MSVEAPSVP-------------------GLRQQVHDAARRARGASRGLAT
Rv2427c|M.tuberculosis_H37Rv MTVPAPS-------------------QLDLRQEVHDAARRARVAARRLAS
Mb2451c|M.bovis_AF2122/97 MTVPAPS-------------------QLDLRQEVHDAARRARVAARRLAS
MMAR_3753|M.marinum_M MTLQAAPRSAAA-----------QQREPDLRQEVHDAARRARVAARLLAV
MUL_3696|M.ulcerans_Agy99 MTLQAAPRSAAA-----------QQREPDLRQEVHDAARRARVAARLLAV
MLBr_01458|M.leprae_Br4923 -----------------------------MRQEVHDAARRARVAARALAV
MAV_1747|M.avium_104 MGLQAPFRSGGGT---SRPQGRAAPRAVDLRREVHDAARRARVASRVLAL
MAB_1618|M.abscessus_ATCC_1997 MSVSTNELAPGAAGSAASAPVTEAPATADLRAGVHDAARRARVAARDLAR
:* **.****** *:* **
Mflv_2644|M.gilvum_PYR-GCK LSTDTKDRALRTAADHVLMNTRAILEANEADLDTARSSGTPEAMLDRLAL
Mvan_3934|M.vanbaalenii_PYR-1 LSTETKNRALCTAADHVLMNTRTILDANTADLDAARAAGTPEAMLDRLAL
MSMEG_4584|M.smegmatis_MC2_155 LSAEAKNRALHAAADSVLANVDAVLAANAADVDAARQGGTPEAMIDRLAL
TH_0792|M.thermoresistible__bu LGTTVKNQALHAAADAILAGADAILAANAEDLETARAAGTPEAMLDRLAL
Rv2427c|M.tuberculosis_H37Rv LPTTVKDRALHAAADELLAHRDQILAANAEDLNAAREADTPAAMLDRLSL
Mb2451c|M.bovis_AF2122/97 LPTTVKDRALHAAADELLAHRDQILAANAEDLNAAREADTPAAMLDRLSL
MMAR_3753|M.marinum_M VPTGVKDRALHAAADAILAHVDRILSANAEDLDAARAADTPAAMLDRLAL
MUL_3696|M.ulcerans_Agy99 VPTGVKDRALHAAADAILAHVDRILSANAEDLDAARAADTPAAMLDRLAL
MLBr_01458|M.leprae_Br4923 MPTVAKDHALRAAATAVTAHTEEILAANAEDLQAARATDTLAATLDRLAL
MAV_1747|M.avium_104 LPTVAKDQALRSAADAIAGHAELILSANAEDLETARAAGTPSAMLDRLAL
MAB_1618|M.abscessus_ATCC_1997 LTADAKNSALLAAADAIVASTDSIIAANADDLRRARDAGIGEAMLDRLAL
: : .*: ** :** : :: ** *: ** . * :***:*
Mflv_2644|M.gilvum_PYR-GCK TPARVEGIADGLRQVAGLPDPVGEVLRGRTLPNGLQLRQQRVPLGVVGIV
Mvan_3934|M.vanbaalenii_PYR-1 NPARVEGIADGLRQVAGLPDPIGEVIRGRTLPNGLQLRQQRVPLGVVGIV
MSMEG_4584|M.smegmatis_MC2_155 NPQRVDGIAAGLRQVAALPDPVGEVLRGKTLPNGLQLRQQRVPLGVVGMV
TH_0792|M.thermoresistible__bu NPQRIDGIAAGLRQVAGLPDPVGEVLRGRTLPNGLQLRQQRVPLGVVGIV
Rv2427c|M.tuberculosis_H37Rv NPQRVDGIAAGLRQVAGLRDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMI
Mb2451c|M.bovis_AF2122/97 NPQRVDGIAAGLRQVAGLRDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMI
MMAR_3753|M.marinum_M NPQRVDGIAAGLRQVAGLPDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMI
MUL_3696|M.ulcerans_Agy99 NPQRVDGIAAGLRQVAGLPGPVGEVLRGYTLPNGLQLRQQRVPLGVVGMI
MLBr_01458|M.leprae_Br4923 DRQRIDQIAGGLRQVAALPDPIGEVLRGYTLPNGLQLRQQRVPLGVVGMI
MAV_1747|M.avium_104 DTKRVEGIAAGLRQVAGLPDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMI
MAB_1618|M.abscessus_ATCC_1997 DTARVAGIADGLRQVAGLPDPVGEILRGSTRPNGLRLRQIRVPLGVVGMV
*: ** ******.* .*:**::** * ****:*** ********::
Mflv_2644|M.gilvum_PYR-GCK YEGRPNVTVDAFGLTLKSGNAVLLRGSSSAARSNAALVDALRAALATELL
Mvan_3934|M.vanbaalenii_PYR-1 YEGRPNVTVDAFGLTLKSGNAVLLRGSSSAARSNAALVNALRAALATEGL
MSMEG_4584|M.smegmatis_MC2_155 YEGRPNVTVDAFGLTLKSGNAALLRGSSSAARSNQALVDALRSALAEEGL
TH_0792|M.thermoresistible__bu YEGRPNVTVDAFGLTLKSGNAVLLRGSSSAARSNAALVEVLRASLTEQQL
Rv2427c|M.tuberculosis_H37Rv YEGRPNVTVDAFGLTLKSGNAALLRGSSSAAKSNEALVAVLRTALVGLEL
Mb2451c|M.bovis_AF2122/97 YEGRPNVTVDAFGLTLKSGNAALLRGSSSAAKSNEALVAVLRTALVGLEL
MMAR_3753|M.marinum_M YEGRPNVTVDAFGLTLKSGNAALLRGSSSAARSNEALVNVLRSALDSEQL
MUL_3696|M.ulcerans_Agy99 YEGRPNVTVDAFGLTLKSGNAALLRGSSSAARSNEALVNVLRSALDSEQL
MLBr_01458|M.leprae_Br4923 YEGRPNITVDAFGLAFKSGNAALLRGSSSAAKSNQALVEVLHAALVSEDL
MAV_1747|M.avium_104 YEGRPNVTVDAFGLALKSGNAVLLRGSSSATRSNQALVQVLRASLVSEDL
MAB_1618|M.abscessus_ATCC_1997 YEGRPNVTVDAFGLTLKSGNAVLLRGSSSAATSNTELVRVLRSSLVASGL
******:*******::*****.********: ** ** .*:::* *
Mflv_2644|M.gilvum_PYR-GCK DVDAVQLLPSADRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTI
Mvan_3934|M.vanbaalenii_PYR-1 DTDAVQLLPSEDRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTI
MSMEG_4584|M.smegmatis_MC2_155 PLDAVQLLPSQDRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTI
TH_0792|M.thermoresistible__bu DPDAVQLLPSDDRASVTHLIQARGLVDVVIPRGGAGLIEAVVRDAQVPTI
Rv2427c|M.tuberculosis_H37Rv PADAVQLLSAADRATVTHLIQARGLVDVVIPRGGAGLIEAVVRDAQVPTI
Mb2451c|M.bovis_AF2122/97 PADAVQLLSAADRATVTHLIQARGLVDVVIPRGGAGLIEAVVRDAQVPTI
MMAR_3753|M.marinum_M PADAVQLLSSADRSTVTHLIQARGLVDVAIPRGGAGLIDAVVRDAQVPTI
MUL_3696|M.ulcerans_Agy99 PADAVQLLSSADRSTVTHLIQARGLVDVAIPRGGAGLIDAVVRDAQVPTI
MLBr_01458|M.leprae_Br4923 PADAVQLLSAADRSTVTHLIQARGLVDVVIPRGGANLIDAVVRDAQVPII
MAV_1747|M.avium_104 PADAVQLLSADDRATVTHLIQARGLVDVVIPRGGANLINAVVRDAQVPTI
MAB_1618|M.abscessus_ATCC_1997 PADTVQLLDSRDRVTVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTI
*:**** : ** :*************.******.**:********* *
Mflv_2644|M.gilvum_PYR-GCK ETGVGNCHVYVHSSADLDTAESIVLNAKTRRPSVCNAAESLLIDAAVADV
Mvan_3934|M.vanbaalenii_PYR-1 ETGVGNCHVFVHESADLDMAEEIVLNAKTRRPSVCNAAESLLIDAAIADV
MSMEG_4584|M.smegmatis_MC2_155 ETGVGNCHVYVHSSADIDMAEKILLNAKTRRPSVCNAAETLLVDRALTDT
TH_0792|M.thermoresistible__bu ETGTGNCHVYVHSAADLDIAERIVLNSKTRRPSVCNSAESLLIDAGIADE
Rv2427c|M.tuberculosis_H37Rv ETGVGNCHVYVHQAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAET
Mb2451c|M.bovis_AF2122/97 ETGVGNCHVYVHQAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAET
MMAR_3753|M.marinum_M ETGVGNCHVYVHEAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAEH
MUL_3696|M.ulcerans_Agy99 ETGVGNCHVYVHEAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAEH
MLBr_01458|M.leprae_Br4923 ETGVGNCHVYVHQAADLEVAERILLNSKTRRPSVCNAAETLLIDAAIADH
MAV_1747|M.avium_104 ETGVGNCHVYVHEGADLEVAERVLLNSKTRRPSVCNAAETLLVDAAIAEE
MAB_1618|M.abscessus_ATCC_1997 ETGVGNCHVYVHADADLALAERILLNSKTRRPSVCNAAETLLIDRAIAEV
***.*****:** **: ** ::**:*********:**:**:* .:::
Mflv_2644|M.gilvum_PYR-GCK AVPRLTDALQAAGVTVH--------IDPTEDELRAEFLSMDIALAIVDGV
Mvan_3934|M.vanbaalenii_PYR-1 AVPRLTGALTAAGVTVH--------ADPSEDELRAEFLSMDIALAIVDGV
MSMEG_4584|M.smegmatis_MC2_155 ALPRLVKALQDAGVTVH--------ADPTEDELRAEFLSMDIALAVVDGL
TH_0792|M.thermoresistible__bu ALPRLVGALEQAGVVVR--------RDPSEEDLRAEFLSMDIALVVVDGL
Rv2427c|M.tuberculosis_H37Rv ALPRLLAALQHAGVTVH--------LDPDEADLRREYLSLDIAVAVVDGV
Mb2451c|M.bovis_AF2122/97 ALPRLLAALQHAGVTVH--------LDPDEADLRREYLSLDIAVAVVDGV
MMAR_3753|M.marinum_M AMPRLIGALQDAGVTVH--------LDADEQDLRREYLAMEIAVAVVDGV
MUL_3696|M.ulcerans_Agy99 AMPRLIGALQDAGVTVH--------LDADEQDLRREYLAMEIAVAVVDGV
MLBr_01458|M.leprae_Br4923 TMPRLVAALQGAGVTVHGGL----SGDPDKADLCREYLSMDIAVAVVDGV
MAV_1747|M.avium_104 ALPRLVTALQDAGVTVHGGF----ARDATEDDLRREYLSMDIAVAVVDGV
MAB_1618|M.abscessus_ATCC_1997 AVPQLVGALQAAGVTVHADLPVPGVVPVTEDDFGTEYLSLDIAVALVDGL
::*:* ** ***.*: : :: *:*:::**:.:***:
Mflv_2644|M.gilvum_PYR-GCK DGAISHINEYGTGHTEAIVTTDLAAAQRFTERVDAAAVMVNASTAFTDGE
Mvan_3934|M.vanbaalenii_PYR-1 DGAISHINEYGTGHTEAIVTTDLAAAQRFSERVDAAAVMVNASTAFTDGE
MSMEG_4584|M.smegmatis_MC2_155 DAAIDHINTYGTGHTEAIVTTDLAAAQRFTERVDAAAVMVNASTSFTDGE
TH_0792|M.thermoresistible__bu DAAIEHINEYGTGHTEAIVTTDLAAAQKFSDEVDAAAVMVNASTAFTDGE
Rv2427c|M.tuberculosis_H37Rv DAAIAHINEYGTGHTEAIVTTNLDAAQRFTEQIDAAAVMVNASTAFTDGE
Mb2451c|M.bovis_AF2122/97 DAAIAHINEYGTGHTEAIVTTNLDAAQRFTEQIDAAAVMVNASTAFTDGE
MMAR_3753|M.marinum_M DGAIAHINEYGTGHTEAIVTTNLAAAQRFTERIDAAAVMVNASTAFTDGE
MUL_3696|M.ulcerans_Agy99 DGAIAHINEYGTGHTEAIVTTNLAAAQRFTERIDAAAVMVNASTAFTDGE
MLBr_01458|M.leprae_Br4923 DAAIAHINEYGTGHTEAIVTTNMAAAQRFADGVDSATVMVNASTAFTDGG
MAV_1747|M.avium_104 DAAIAHINEYGTGHTEAIVTTNMAAAQRFTDGVDAAAVMVNASTAFTDGE
MAB_1618|M.abscessus_ATCC_1997 DAAIEHIDRYSSGHTDAIVTTNLSAAQEFTDRVDSAAVMVNASTAFTDGE
*.** **: *.:***:*****:: ***.*:: :*:*:*******:****
Mflv_2644|M.gilvum_PYR-GCK QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGDGHTRPA
Mvan_3934|M.vanbaalenii_PYR-1 QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGDGHTRPA
MSMEG_4584|M.smegmatis_MC2_155 QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGDGQIRPA
TH_0792|M.thermoresistible__bu QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGHGHTRPA
Rv2427c|M.tuberculosis_H37Rv QFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGAGHTRPA
Mb2451c|M.bovis_AF2122/97 QFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGAGHTRPA
MMAR_3753|M.marinum_M QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGEGHTRPA
MUL_3696|M.ulcerans_Agy99 QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVRGEGHTRPA
MLBr_01458|M.leprae_Br4923 QFGFGAEIGISTQKLHARGPMGLSEMTSTKWIVWGDGQIRPA
MAV_1747|M.avium_104 QFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGDGQTRPA
MAB_1618|M.abscessus_ATCC_1997 QFGFGAEIGISTQKLHARGPMGLPELTTTKWIVLGDGQIRPA
***********************.*:*:****. * *: ***