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SVQAPSVPDLRQQVHDAARRARGAARALASLSTETKNRALCTAADHVLMNTRTILDANTADLDAARAAGT PEAMLDRLALNPARVEGIADGLRQVAGLPDPIGEVIRGRTLPNGLQLRQQRVPLGVVGIVYEGRPNVTVD AFGLTLKSGNAVLLRGSSSAARSNAALVNALRAALATEGLDTDAVQLLPSEDRASVTHLIQARGLVDVVI PRGGAGLIDAVVRDAQVPTIETGVGNCHVFVHESADLDMAEEIVLNAKTRRPSVCNAAESLLIDAAIADV AVPRLTGALTAAGVTVHADPSEDELRAEFLSMDIALAIVDGVDGAISHINEYGTGHTEAIVTTDLAAAQR FSERVDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGDGHTRPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3934 | proA | - | 100% (415) | gamma-glutamyl phosphate reductase |
| M. vanbaalenii PYR-1 | Mvan_0443 | - | 4e-13 | 26.82% (302) | bifunctional acetaldehyde-CoA/alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5566 | - | 3e-09 | 28.90% (173) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2451c | proA | 0.0 | 78.80% (415) | gamma-glutamyl phosphate reductase |
| M. gilvum PYR-GCK | Mflv_2644 | proA | 0.0 | 93.01% (415) | gamma-glutamyl phosphate reductase |
| M. tuberculosis H37Rv | Rv2427c | proA | 0.0 | 78.80% (415) | gamma-glutamyl phosphate reductase |
| M. leprae Br4923 | MLBr_01458 | proA | 1e-168 | 74.57% (409) | gamma-glutamyl phosphate reductase |
| M. abscessus ATCC 19977 | MAB_1618 | proA | 1e-171 | 73.81% (420) | gamma-glutamyl phosphate reductase |
| M. marinum M | MMAR_3753 | proA | 0.0 | 81.57% (407) | gamma-glutamyl phosphate reductase protein ProA |
| M. avium 104 | MAV_1747 | proA | 1e-180 | 77.35% (415) | gamma-glutamyl phosphate reductase |
| M. smegmatis MC2 155 | MSMEG_4584 | proA | 0.0 | 83.09% (414) | gamma-glutamyl phosphate reductase |
| M. thermoresistible (build 8) | TH_0792 | proA | 0.0 | 83.86% (415) | PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA |
| M. ulcerans Agy99 | MUL_3696 | proA | 0.0 | 81.08% (407) | gamma-glutamyl phosphate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3934|M.vanbaalenii_PYR-1 MSVQAPSVP-------------------DLRQQVHDAARRARGAARALAS
Mflv_2644|M.gilvum_PYR-GCK MSVQAPSVP-------------------DLRQQVHDAARRARSAARGLAT
MSMEG_4584|M.smegmatis_MC2_155 MSVEAQSRSGAVD----------TQEPADLREQVHSAARRARVAARTLAT
TH_0792|M.thermoresistible__bu MSVEAPSVP-------------------GLRQQVHDAARRARGASRGLAT
MMAR_3753|M.marinum_M MTLQAAPRSAAA-----------QQREPDLRQEVHDAARRARVAARLLAV
MUL_3696|M.ulcerans_Agy99 MTLQAAPRSAAA-----------QQREPDLRQEVHDAARRARVAARLLAV
Mb2451c|M.bovis_AF2122/97 MTVPAPS-------------------QLDLRQEVHDAARRARVAARRLAS
Rv2427c|M.tuberculosis_H37Rv MTVPAPS-------------------QLDLRQEVHDAARRARVAARRLAS
MLBr_01458|M.leprae_Br4923 -----------------------------MRQEVHDAARRARVAARALAV
MAV_1747|M.avium_104 MGLQAPFRSGGGT---SRPQGRAAPRAVDLRREVHDAARRARVASRVLAL
MAB_1618|M.abscessus_ATCC_1997 MSVSTNELAPGAAGSAASAPVTEAPATADLRAGVHDAARRARVAARDLAR
:* **.****** *:* **
Mvan_3934|M.vanbaalenii_PYR-1 LSTETKNRALCTAADHVLMNTRTILDANTADLDAARAAGTPEAMLDRLAL
Mflv_2644|M.gilvum_PYR-GCK LSTDTKDRALRTAADHVLMNTRAILEANEADLDTARSSGTPEAMLDRLAL
MSMEG_4584|M.smegmatis_MC2_155 LSAEAKNRALHAAADSVLANVDAVLAANAADVDAARQGGTPEAMIDRLAL
TH_0792|M.thermoresistible__bu LGTTVKNQALHAAADAILAGADAILAANAEDLETARAAGTPEAMLDRLAL
MMAR_3753|M.marinum_M VPTGVKDRALHAAADAILAHVDRILSANAEDLDAARAADTPAAMLDRLAL
MUL_3696|M.ulcerans_Agy99 VPTGVKDRALHAAADAILAHVDRILSANAEDLDAARAADTPAAMLDRLAL
Mb2451c|M.bovis_AF2122/97 LPTTVKDRALHAAADELLAHRDQILAANAEDLNAAREADTPAAMLDRLSL
Rv2427c|M.tuberculosis_H37Rv LPTTVKDRALHAAADELLAHRDQILAANAEDLNAAREADTPAAMLDRLSL
MLBr_01458|M.leprae_Br4923 MPTVAKDHALRAAATAVTAHTEEILAANAEDLQAARATDTLAATLDRLAL
MAV_1747|M.avium_104 LPTVAKDQALRSAADAIAGHAELILSANAEDLETARAAGTPSAMLDRLAL
MAB_1618|M.abscessus_ATCC_1997 LTADAKNSALLAAADAIVASTDSIIAANADDLRRARDAGIGEAMLDRLAL
: : .*: ** :** : :: ** *: ** . * :***:*
Mvan_3934|M.vanbaalenii_PYR-1 NPARVEGIADGLRQVAGLPDPIGEVIRGRTLPNGLQLRQQRVPLGVVGIV
Mflv_2644|M.gilvum_PYR-GCK TPARVEGIADGLRQVAGLPDPVGEVLRGRTLPNGLQLRQQRVPLGVVGIV
MSMEG_4584|M.smegmatis_MC2_155 NPQRVDGIAAGLRQVAALPDPVGEVLRGKTLPNGLQLRQQRVPLGVVGMV
TH_0792|M.thermoresistible__bu NPQRIDGIAAGLRQVAGLPDPVGEVLRGRTLPNGLQLRQQRVPLGVVGIV
MMAR_3753|M.marinum_M NPQRVDGIAAGLRQVAGLPDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMI
MUL_3696|M.ulcerans_Agy99 NPQRVDGIAAGLRQVAGLPGPVGEVLRGYTLPNGLQLRQQRVPLGVVGMI
Mb2451c|M.bovis_AF2122/97 NPQRVDGIAAGLRQVAGLRDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMI
Rv2427c|M.tuberculosis_H37Rv NPQRVDGIAAGLRQVAGLRDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMI
MLBr_01458|M.leprae_Br4923 DRQRIDQIAGGLRQVAALPDPIGEVLRGYTLPNGLQLRQQRVPLGVVGMI
MAV_1747|M.avium_104 DTKRVEGIAAGLRQVAGLPDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMI
MAB_1618|M.abscessus_ATCC_1997 DTARVAGIADGLRQVAGLPDPVGEILRGSTRPNGLRLRQIRVPLGVVGMV
*: ** ******.* .*:**::** * ****:*** ********::
Mvan_3934|M.vanbaalenii_PYR-1 YEGRPNVTVDAFGLTLKSGNAVLLRGSSSAARSNAALVNALRAALATEGL
Mflv_2644|M.gilvum_PYR-GCK YEGRPNVTVDAFGLTLKSGNAVLLRGSSSAARSNAALVDALRAALATELL
MSMEG_4584|M.smegmatis_MC2_155 YEGRPNVTVDAFGLTLKSGNAALLRGSSSAARSNQALVDALRSALAEEGL
TH_0792|M.thermoresistible__bu YEGRPNVTVDAFGLTLKSGNAVLLRGSSSAARSNAALVEVLRASLTEQQL
MMAR_3753|M.marinum_M YEGRPNVTVDAFGLTLKSGNAALLRGSSSAARSNEALVNVLRSALDSEQL
MUL_3696|M.ulcerans_Agy99 YEGRPNVTVDAFGLTLKSGNAALLRGSSSAARSNEALVNVLRSALDSEQL
Mb2451c|M.bovis_AF2122/97 YEGRPNVTVDAFGLTLKSGNAALLRGSSSAAKSNEALVAVLRTALVGLEL
Rv2427c|M.tuberculosis_H37Rv YEGRPNVTVDAFGLTLKSGNAALLRGSSSAAKSNEALVAVLRTALVGLEL
MLBr_01458|M.leprae_Br4923 YEGRPNITVDAFGLAFKSGNAALLRGSSSAAKSNQALVEVLHAALVSEDL
MAV_1747|M.avium_104 YEGRPNVTVDAFGLALKSGNAVLLRGSSSATRSNQALVQVLRASLVSEDL
MAB_1618|M.abscessus_ATCC_1997 YEGRPNVTVDAFGLTLKSGNAVLLRGSSSAATSNTELVRVLRSSLVASGL
******:*******::*****.********: ** ** .*:::* *
Mvan_3934|M.vanbaalenii_PYR-1 DTDAVQLLPSEDRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTI
Mflv_2644|M.gilvum_PYR-GCK DVDAVQLLPSADRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTI
MSMEG_4584|M.smegmatis_MC2_155 PLDAVQLLPSQDRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTI
TH_0792|M.thermoresistible__bu DPDAVQLLPSDDRASVTHLIQARGLVDVVIPRGGAGLIEAVVRDAQVPTI
MMAR_3753|M.marinum_M PADAVQLLSSADRSTVTHLIQARGLVDVAIPRGGAGLIDAVVRDAQVPTI
MUL_3696|M.ulcerans_Agy99 PADAVQLLSSADRSTVTHLIQARGLVDVAIPRGGAGLIDAVVRDAQVPTI
Mb2451c|M.bovis_AF2122/97 PADAVQLLSAADRATVTHLIQARGLVDVVIPRGGAGLIEAVVRDAQVPTI
Rv2427c|M.tuberculosis_H37Rv PADAVQLLSAADRATVTHLIQARGLVDVVIPRGGAGLIEAVVRDAQVPTI
MLBr_01458|M.leprae_Br4923 PADAVQLLSAADRSTVTHLIQARGLVDVVIPRGGANLIDAVVRDAQVPII
MAV_1747|M.avium_104 PADAVQLLSADDRATVTHLIQARGLVDVVIPRGGANLINAVVRDAQVPTI
MAB_1618|M.abscessus_ATCC_1997 PADTVQLLDSRDRVTVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTI
*:**** : ** :*************.******.**:********* *
Mvan_3934|M.vanbaalenii_PYR-1 ETGVGNCHVFVHESADLDMAEEIVLNAKTRRPSVCNAAESLLIDAAIADV
Mflv_2644|M.gilvum_PYR-GCK ETGVGNCHVYVHSSADLDTAESIVLNAKTRRPSVCNAAESLLIDAAVADV
MSMEG_4584|M.smegmatis_MC2_155 ETGVGNCHVYVHSSADIDMAEKILLNAKTRRPSVCNAAETLLVDRALTDT
TH_0792|M.thermoresistible__bu ETGTGNCHVYVHSAADLDIAERIVLNSKTRRPSVCNSAESLLIDAGIADE
MMAR_3753|M.marinum_M ETGVGNCHVYVHEAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAEH
MUL_3696|M.ulcerans_Agy99 ETGVGNCHVYVHEAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAEH
Mb2451c|M.bovis_AF2122/97 ETGVGNCHVYVHQAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAET
Rv2427c|M.tuberculosis_H37Rv ETGVGNCHVYVHQAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAET
MLBr_01458|M.leprae_Br4923 ETGVGNCHVYVHQAADLEVAERILLNSKTRRPSVCNAAETLLIDAAIADH
MAV_1747|M.avium_104 ETGVGNCHVYVHEGADLEVAERVLLNSKTRRPSVCNAAETLLVDAAIAEE
MAB_1618|M.abscessus_ATCC_1997 ETGVGNCHVYVHADADLALAERILLNSKTRRPSVCNAAETLLIDRAIAEV
***.*****:** **: ** ::**:*********:**:**:* .:::
Mvan_3934|M.vanbaalenii_PYR-1 AVPRLTGALTAAGVTVH--------ADPSEDELRAEFLSMDIALAIVDGV
Mflv_2644|M.gilvum_PYR-GCK AVPRLTDALQAAGVTVH--------IDPTEDELRAEFLSMDIALAIVDGV
MSMEG_4584|M.smegmatis_MC2_155 ALPRLVKALQDAGVTVH--------ADPTEDELRAEFLSMDIALAVVDGL
TH_0792|M.thermoresistible__bu ALPRLVGALEQAGVVVR--------RDPSEEDLRAEFLSMDIALVVVDGL
MMAR_3753|M.marinum_M AMPRLIGALQDAGVTVH--------LDADEQDLRREYLAMEIAVAVVDGV
MUL_3696|M.ulcerans_Agy99 AMPRLIGALQDAGVTVH--------LDADEQDLRREYLAMEIAVAVVDGV
Mb2451c|M.bovis_AF2122/97 ALPRLLAALQHAGVTVH--------LDPDEADLRREYLSLDIAVAVVDGV
Rv2427c|M.tuberculosis_H37Rv ALPRLLAALQHAGVTVH--------LDPDEADLRREYLSLDIAVAVVDGV
MLBr_01458|M.leprae_Br4923 TMPRLVAALQGAGVTVHGGL----SGDPDKADLCREYLSMDIAVAVVDGV
MAV_1747|M.avium_104 ALPRLVTALQDAGVTVHGGF----ARDATEDDLRREYLSMDIAVAVVDGV
MAB_1618|M.abscessus_ATCC_1997 AVPQLVGALQAAGVTVHADLPVPGVVPVTEDDFGTEYLSLDIAVALVDGL
::*:* ** ***.*: : :: *:*:::**:.:***:
Mvan_3934|M.vanbaalenii_PYR-1 DGAISHINEYGTGHTEAIVTTDLAAAQRFSERVDAAAVMVNASTAFTDGE
Mflv_2644|M.gilvum_PYR-GCK DGAISHINEYGTGHTEAIVTTDLAAAQRFTERVDAAAVMVNASTAFTDGE
MSMEG_4584|M.smegmatis_MC2_155 DAAIDHINTYGTGHTEAIVTTDLAAAQRFTERVDAAAVMVNASTSFTDGE
TH_0792|M.thermoresistible__bu DAAIEHINEYGTGHTEAIVTTDLAAAQKFSDEVDAAAVMVNASTAFTDGE
MMAR_3753|M.marinum_M DGAIAHINEYGTGHTEAIVTTNLAAAQRFTERIDAAAVMVNASTAFTDGE
MUL_3696|M.ulcerans_Agy99 DGAIAHINEYGTGHTEAIVTTNLAAAQRFTERIDAAAVMVNASTAFTDGE
Mb2451c|M.bovis_AF2122/97 DAAIAHINEYGTGHTEAIVTTNLDAAQRFTEQIDAAAVMVNASTAFTDGE
Rv2427c|M.tuberculosis_H37Rv DAAIAHINEYGTGHTEAIVTTNLDAAQRFTEQIDAAAVMVNASTAFTDGE
MLBr_01458|M.leprae_Br4923 DAAIAHINEYGTGHTEAIVTTNMAAAQRFADGVDSATVMVNASTAFTDGG
MAV_1747|M.avium_104 DAAIAHINEYGTGHTEAIVTTNMAAAQRFTDGVDAAAVMVNASTAFTDGE
MAB_1618|M.abscessus_ATCC_1997 DAAIEHIDRYSSGHTDAIVTTNLSAAQEFTDRVDSAAVMVNASTAFTDGE
*.** **: *.:***:*****:: ***.*:: :*:*:*******:****
Mvan_3934|M.vanbaalenii_PYR-1 QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGDGHTRPA
Mflv_2644|M.gilvum_PYR-GCK QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGDGHTRPA
MSMEG_4584|M.smegmatis_MC2_155 QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGDGQIRPA
TH_0792|M.thermoresistible__bu QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGHGHTRPA
MMAR_3753|M.marinum_M QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGEGHTRPA
MUL_3696|M.ulcerans_Agy99 QFGFGAEIGISTQKLHARGPMGLPELTSTKWIVRGEGHTRPA
Mb2451c|M.bovis_AF2122/97 QFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGAGHTRPA
Rv2427c|M.tuberculosis_H37Rv QFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGAGHTRPA
MLBr_01458|M.leprae_Br4923 QFGFGAEIGISTQKLHARGPMGLSEMTSTKWIVWGDGQIRPA
MAV_1747|M.avium_104 QFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGDGQTRPA
MAB_1618|M.abscessus_ATCC_1997 QFGFGAEIGISTQKLHARGPMGLPELTTTKWIVLGDGQIRPA
***********************.*:*:****. * *: ***