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VTAPATMQSAAMLRSGAIEAPPATMQSAAMRWGHLPLAEESGTIAPQLVLTAHGSKDPRSAANARAIAGR LARMRPGLDVRVAFCELNSPNLVDVLNRCRGAAVVTPLLLADAYHARVDIPAQIASCRVGHRVRQASVLG EDIRLVSALHERLTELGVSPFDHTLGVVVLAIGSSHPAANARTSTVASRLAEGTQWAAVTTAFITRPEAS LADATDRLRRHGARRMVIAPWLLAPGILSDRVRGYAREAGIAMAQPLGAHPMVAATMWDRYRQAVAGRIA A
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2393 | - | - | 100% (281) | hypothetical protein Rv2393 |
| M. tuberculosis H37Rv | Rv0259c | - | 9e-22 | 32.77% (235) | hypothetical protein Rv0259c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2414 | - | 1e-157 | 100.00% (281) | hypothetical protein Mb2414 |
| M. gilvum PYR-GCK | Mflv_2684 | - | 4e-63 | 57.45% (235) | cobalamin (vitamin B12) biosynthesis CbiX protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1658c | - | 4e-52 | 47.01% (234) | hypothetical protein MAB_1658c |
| M. marinum M | MMAR_3712 | - | 2e-85 | 67.52% (234) | hypothetical protein MMAR_3712 |
| M. avium 104 | MAV_2152 | - | 1e-79 | 66.67% (237) | secreted protein |
| M. smegmatis MC2 155 | MSMEG_4529 | - | 2e-70 | 58.80% (233) | secreted protein |
| M. thermoresistible (build 8) | TH_1445 | - | 1e-70 | 59.32% (236) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3654 | - | 9e-78 | 65.92% (223) | hypothetical protein MUL_3654 |
| M. vanbaalenii PYR-1 | Mvan_3859 | - | 7e-63 | 57.45% (235) | cobalamin (vitamin B12) biosynthesis CbiX protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2393|M.tuberculosis_H37Rv MTAPATMQSAAMLRSGAIEAPPATMQSAAMRWGHLPLAEESGTIAPQLVL
Mb2414|M.bovis_AF2122/97 MTAPATMQSAAMLRSGAIEAPPATMQSAAMRWGHLPLAEESGTIAPQLVL
MMAR_3712|M.marinum_M MTA--------------------------------------------LVL
MUL_3654|M.ulcerans_Agy99 MTA--------------------------------------------LVL
MAV_2152|M.avium_104 MST--------------------------------------------LVL
MSMEG_4529|M.smegmatis_MC2_155 ---------------------------------------------MTLVL
TH_1445|M.thermoresistible__bu ------------------------------VTRALAPAPASVAGPPALIL
Mflv_2684|M.gilvum_PYR-GCK ---------------------------------------------MTLIL
Mvan_3859|M.vanbaalenii_PYR-1 ---------------------------------------------MTLIL
MAB_1658c|M.abscessus_ATCC_199 ------------------------------------------MRNPTLVA
*:
Rv2393|M.tuberculosis_H37Rv TAHGSKDPRSAANARAIAGRLARMRPGLDVRVAFCELNSPNLVDVLNRCR
Mb2414|M.bovis_AF2122/97 TAHGSKDPRSAANARAIAGRLARMRPGLDVRVAFCELNSPNLVDVLNRCR
MMAR_3712|M.marinum_M TAHGSRDPRSSANARAVAARVARMRPDLDVRLAFCELNSPGLVEVLNGCS
MUL_3654|M.ulcerans_Agy99 TAHGSRDPRSSANARAVAARVARMRPDLDVRLAFCELNSPGLVEVLNGCS
MAV_2152|M.avium_104 TAHGSRDPRSAANAEAVADRLRRMRPGLDVRLAFLELNAPNFVDVLAGLP
MSMEG_4529|M.smegmatis_MC2_155 TAHGSADPRSSANAHAIAGHVRRLLPDTEVRVAFCEQNEPNLADVLTAVE
TH_1445|M.thermoresistible__bu TAHGSADPRSAANAHAIAGHLRRLAPDVEVRVAFCEQNTPNLADVLAQMR
Mflv_2684|M.gilvum_PYR-GCK TAHGSADPRSAATARSIVECIRRLRPDLDARIAFCEQNSPNLRDVLADLP
Mvan_3859|M.vanbaalenii_PYR-1 TAHGSADPRSAQTARAIVDCIRCLRPTLDARIAFCEQSSPNLRDELAALR
MAB_1658c|M.abscessus_ATCC_199 VAHGSRDARFAQNARRVVRQVRSLRPDLDVRLAFLELSEPNLLDVLGDLS
.**** *.* : .*. :. : : * :.*:** * . *.: : *
Rv2393|M.tuberculosis_H37Rv G--AAVVTPLLLADAYHARVDIPAQIASCRVGHRVRQASVLGEDIRLVSA
Mb2414|M.bovis_AF2122/97 G--AAVVTPLLLADAYHARVDIPAQIASCRVGHRVRQASVLGEDIRLVSA
MMAR_3712|M.marinum_M G--DAVVTPLLLANGYHAGIDIPAQIASCRESLRVRQANVLGTDDRLVSV
MUL_3654|M.ulcerans_Agy99 G--DAVVTPLLLANGYHAGIDIPAQIASCRESLRVRQANVLGTDDRLVSV
MAV_2152|M.avium_104 DSRRAVVAPLLLASAYHARLDIPEQIARAG-AHGIRQADVLGEDDRLVAV
MSMEG_4529|M.smegmatis_MC2_155 A-G-SVVVPLLLASAYHARIDIPALIAQTG--ADVVQADVLGNDPRLLQV
TH_1445|M.thermoresistible__bu T-G-AVVVPLLLARAYHARVDIPELIAASG--ADVAQADVLGADPRLLHV
Mflv_2684|M.gilvum_PYR-GCK G-RHGVVVPLLLADAYHARVDIPQMIADSG--ADVRQAAVLGEDERLIHV
Mvan_3859|M.vanbaalenii_PYR-1 R-RQAVVVPLLLADAYHARVDIPEMIAASG--ADVRQAGVLGEDDRLIHV
MAB_1658c|M.abscessus_ATCC_199 G--DAVVVPLLLSDAYHARIDLPTVLSAAPARLRVMQACVLGADNRLLAL
.**.****: .*** :*:* :: : ** *** * **:
Rv2393|M.tuberculosis_H37Rv LHERLTELGVSPFDHTLGVVVLAIGSSHPAANARTSTVASRLAEGTQWAA
Mb2414|M.bovis_AF2122/97 LHERLTELGVSPFDHTLGVVVLAIGSSHPAANARTSTVASRLAEGTQWAA
MMAR_3712|M.marinum_M LRQRVTALGVSRFDDGLGVLVVAIGSSNAAVNSHTAQVGPKLAEGTRWAA
MUL_3654|M.ulcerans_Agy99 LRQRVTALGVSRFDDGLGVLVVAIGSSNAAVNSHTAQVGPKLAEGTRWAA
MAV_2152|M.avium_104 LRGRLAEIGVSPLDDDLGVMVVAIGSSNTAANARTAKVASRLAAGTRWAC
MSMEG_4529|M.smegmatis_MC2_155 MRERLTALGVSRFDSSLGVVLTGVGSSHAAANARTAELAADLAEGTRWVG
TH_1445|M.thermoresistible__bu MRGRLSALGVSRFDAGLGVVMVGVGSSHADANARTAAVAQALGEGTRWTG
Mflv_2684|M.gilvum_PYR-GCK LRQRLEHAGVSRLDPRVGILVTAVGSSRAAANANTEAVARELTLTTRWA-
Mvan_3859|M.vanbaalenii_PYR-1 LRQRLEHAGVSRLDPSVGVIVTAVGSSRPAANVRTATVARELTLTTRWT-
MAB_1658c|M.abscessus_ATCC_199 ARRRVTELGIAHP----GVILSAVGSSDSTANTRTRALA------AQWPI
: *: *:: *::: .:*** . .* .* :. ::*
Rv2393|M.tuberculosis_H37Rv VTTAFITRPEASLADATDRLRRHGARRMVIAPWLLAPGILSDRVRGYARE
Mb2414|M.bovis_AF2122/97 VTTAFITRPEASLADATDRLRRHGARRMVIAPWLLAPGILSDRVRGYARE
MMAR_3712|M.marinum_M VATAFATHPPAALAEAVSRLRRRGAHRVVVAPWFLAHGRLPDRVQRFAAD
MUL_3654|M.ulcerans_Agy99 VATAFATHPPAALAEAVSRLRRRGAHRVVVAPWFLAHGRLPDRVQRFAAD
MAV_2152|M.avium_104 ATTAFATRPEASVARAADQLRRRGARRLVIAPWFLAPGFITDGVSTFARD
MSMEG_4529|M.smegmatis_MC2_155 THVAFATGQDPSVSRAVERLRARGATRLVIAPWFLAHGRITDRVAEYARR
TH_1445|M.thermoresistible__bu VEVAFATGPAPSVPDAVARLRARGADRIAISPWFLAHGRITDRVAGFARG
Mflv_2684|M.gilvum_PYR-GCK ATTAFATGPQPSLTDAAAHLRALGASRLVIAPWFLAHGRITDRVAAFARA
Mvan_3859|M.vanbaalenii_PYR-1 ATTAFATGPHPSPAEAADELRRRGATRLVIAPWFLAHGRITDRVADFAAA
MAB_1658c|M.abscessus_ATCC_199 STTVFATGDPTSLAEAAESLRARGATDIVVAPWFLSPGLLLDRVRAEAAQ
..* * .: . *. ** ** :.::**:*: * : * * *
Rv2393|M.tuberculosis_H37Rv AGIAMAQPLGAHPMVAATMWDRYRQAVAGRIAA---
Mb2414|M.bovis_AF2122/97 AGIAMAQPLGAHPMVAATMWDRYRQAVAGRIAA---
MMAR_3712|M.marinum_M TGLAMAAPLGAHRLVAETVLDRFAQATAGRVAA---
MUL_3654|M.ulcerans_Agy99 TGLAMAA----HPWVRTVWWPRQY------------
MAV_2152|M.avium_104 NGIRMAAPLGAHRLVAETVLDRYDEALSADAAA---
MSMEG_4529|M.smegmatis_MC2_155 EGIPMAEPLGPHRLVAATVLDRYEEAIEARTAGFAA
TH_1445|M.thermoresistible__bu AGIPMAEPLGPHRLVAATVLDRYEETVAA--AALAA
Mflv_2684|M.gilvum_PYR-GCK HDIPMSAPLGAHRQVAETVLDRFDAALVHRAAA---
Mvan_3859|M.vanbaalenii_PYR-1 QRIPMSAPLGAHRQVAETVLDRFDAALAVHAAA---
MAB_1658c|M.abscessus_ATCC_199 LDMPVAAPLGADRLVADVVVQRYASAIAAPVPTPH-
: :: . * . *