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TLILTAHGSADPRSAATARSIVECIRRLRPDLDARIAFCEQNSPNLRDVLADLPGRHGVVVPLLLADAYH ARVDIPQMIADSGADVRQAAVLGEDERLIHVLRQRLEHAGVSRLDPRVGILVTAVGSSRAAANANTEAVA RELTLTTRWAATTAFATGPQPSLTDAAAHLRALGASRLVIAPWFLAHGRITDRVAAFARAHDIPMSAPLG AHRQVAETVLDRFDAALVHRAAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2684 | - | - | 100% (234) | cobalamin (vitamin B12) biosynthesis CbiX protein |
| M. gilvum PYR-GCK | Mflv_0381 | - | 3e-20 | 30.26% (228) | cobalamin (vitamin B12) biosynthesis CbiX protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2414 | - | 2e-63 | 57.45% (235) | hypothetical protein Mb2414 |
| M. tuberculosis H37Rv | Rv2393 | - | 2e-63 | 57.45% (235) | hypothetical protein Rv2393 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1658c | - | 6e-52 | 48.47% (229) | hypothetical protein MAB_1658c |
| M. marinum M | MMAR_3418 | - | 1e-71 | 61.86% (236) | hypothetical protein MMAR_3418 |
| M. avium 104 | MAV_2152 | - | 7e-72 | 62.71% (236) | secreted protein |
| M. smegmatis MC2 155 | MSMEG_4529 | - | 4e-74 | 61.54% (234) | secreted protein |
| M. thermoresistible (build 8) | TH_1445 | - | 6e-75 | 63.68% (234) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2697 | - | 3e-72 | 62.29% (236) | hypothetical protein MUL_2697 |
| M. vanbaalenii PYR-1 | Mvan_3859 | - | 1e-103 | 82.48% (234) | cobalamin (vitamin B12) biosynthesis CbiX protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2414|M.bovis_AF2122/97 MTAPATMQSAAMLRSGAIEAPPATMQSAAMRWGHLPLAEESGTIAPQLVL
Rv2393|M.tuberculosis_H37Rv MTAPATMQSAAMLRSGAIEAPPATMQSAAMRWGHLPLAEESGTIAPQLVL
MMAR_3418|M.marinum_M --------------------------------------------MSTLVL
MUL_2697|M.ulcerans_Agy99 --------------------------------------------MSTLVL
MAV_2152|M.avium_104 --------------------------------------------MSTLVL
Mflv_2684|M.gilvum_PYR-GCK ---------------------------------------------MTLIL
Mvan_3859|M.vanbaalenii_PYR-1 ---------------------------------------------MTLIL
MSMEG_4529|M.smegmatis_MC2_155 ---------------------------------------------MTLVL
TH_1445|M.thermoresistible__bu ------------------------------VTRALAPAPASVAGPPALIL
MAB_1658c|M.abscessus_ATCC_199 ------------------------------------------MRNPTLVA
*:
Mb2414|M.bovis_AF2122/97 TAHGSKDPRSAANARAIAGRLARMRPGLDVRVAFCELNSPNLVDVLNRCR
Rv2393|M.tuberculosis_H37Rv TAHGSKDPRSAANARAIAGRLARMRPGLDVRVAFCELNSPNLVDVLNRCR
MMAR_3418|M.marinum_M TAHGSRDPRSADNARAVAAALRRMRPNLDVRLAFLELCAPNFVEVLAELP
MUL_2697|M.ulcerans_Agy99 TAHGSRDPRSADNARAVAAALRRMRPNLDVRLAFLELCAPNFVDVLAELP
MAV_2152|M.avium_104 TAHGSRDPRSAANAEAVADRLRRMRPGLDVRLAFLELNAPNFVDVLAGLP
Mflv_2684|M.gilvum_PYR-GCK TAHGSADPRSAATARSIVECIRRLRPDLDARIAFCEQNSPNLRDVLADLP
Mvan_3859|M.vanbaalenii_PYR-1 TAHGSADPRSAQTARAIVDCIRCLRPTLDARIAFCEQSSPNLRDELAALR
MSMEG_4529|M.smegmatis_MC2_155 TAHGSADPRSSANAHAIAGHVRRLLPDTEVRVAFCEQNEPNLADVLTAVE
TH_1445|M.thermoresistible__bu TAHGSADPRSAANAHAIAGHLRRLAPDVEVRVAFCEQNTPNLADVLAQMR
MAB_1658c|M.abscessus_ATCC_199 VAHGSRDARFAQNARRVVRQVRSLRPDLDVRLAFLELSEPNLLDVLGDLS
.**** *.* : .*. :. : : * :.*:** * **: : *
Mb2414|M.bovis_AF2122/97 G--AAVVTPLLLADAYHARVDIPAQIASCRVGHRVRQASVLGEDIRLVSA
Rv2393|M.tuberculosis_H37Rv G--AAVVTPLLLADAYHARVDIPAQIASCRVGHRVRQASVLGEDIRLVSA
MMAR_3418|M.marinum_M DSQRAVVTPLLLASAYHARTDIPEQIARSGA-LGVREAAVLGEDDRLVSV
MUL_2697|M.ulcerans_Agy99 DSQRAVVTPLLLASAYHARTDIPEQIARSGA-LGVREAAVLGEDDRLVSV
MAV_2152|M.avium_104 DSRRAVVAPLLLASAYHARLDIPEQIARAGA-HGIRQADVLGEDDRLVAV
Mflv_2684|M.gilvum_PYR-GCK G-RHGVVVPLLLADAYHARVDIPQMIADSGA--DVRQAAVLGEDERLIHV
Mvan_3859|M.vanbaalenii_PYR-1 R-RQAVVVPLLLADAYHARVDIPEMIAASGA--DVRQAGVLGEDDRLIHV
MSMEG_4529|M.smegmatis_MC2_155 A-G-SVVVPLLLASAYHARIDIPALIAQTGA--DVVQADVLGNDPRLLQV
TH_1445|M.thermoresistible__bu T-G-AVVVPLLLARAYHARVDIPELIAASGA--DVAQADVLGADPRLLHV
MAB_1658c|M.abscessus_ATCC_199 G--DAVVVPLLLSDAYHARIDLPTVLSAAPARLRVMQACVLGADNRLLAL
.**.****: ***** *:* :: . : :* *** * **:
Mb2414|M.bovis_AF2122/97 LHERLTELGVSPFDHTLGVVVLAIGSSHPAANARTSTVASRLAEGTQWAA
Rv2393|M.tuberculosis_H37Rv LHERLTELGVSPFDHTLGVVVLAIGSSHPAANARTSTVASRLAEGTQWAA
MMAR_3418|M.marinum_M LRDRLAERGVSPRDRNIGVLVVAVGSSHAPVNARTARVAAKLGAGTRWAG
MUL_2697|M.ulcerans_Agy99 LRDRLAERGVSPRDRNIGVLVVAVGSSHAPVNARTARVAAKLGAGTRWAG
MAV_2152|M.avium_104 LRGRLAEIGVSPLDDDLGVMVVAIGSSNTAANARTAKVASRLAAGTRWAC
Mflv_2684|M.gilvum_PYR-GCK LRQRLEHAGVSRLDPRVGILVTAVGSSRAAANANTEAVARELTLTTRWA-
Mvan_3859|M.vanbaalenii_PYR-1 LRQRLEHAGVSRLDPSVGVIVTAVGSSRPAANVRTATVARELTLTTRWT-
MSMEG_4529|M.smegmatis_MC2_155 MRERLTALGVSRFDSSLGVVLTGVGSSHAAANARTAELAADLAEGTRWVG
TH_1445|M.thermoresistible__bu MRGRLSALGVSRFDAGLGVVMVGVGSSHADANARTAAVAQALGEGTRWTG
MAB_1658c|M.abscessus_ATCC_199 ARRRVTELGIAHP----GVILSAVGSSDSTANTRTRALAA------QWPI
: *: *:: *::: .:*** . .*..* :* :*
Mb2414|M.bovis_AF2122/97 VTTAFITRPEASLADATDRLRRHGARRMVIAPWLLAPGILSDRVRGYARE
Rv2393|M.tuberculosis_H37Rv VTTAFITRPEASLADATDRLRRHGARRMVIAPWLLAPGILSDRVRGYARE
MMAR_3418|M.marinum_M TTMAFATGPKPSVADAAAQLRASGARRLVIAPWFLAPGLITDRVWKYACD
MUL_2697|M.ulcerans_Agy99 TTMAFATGPKPSVADAAAQLRASGARRLVIAPWFLAPGLITDRVWKYACD
MAV_2152|M.avium_104 ATTAFATRPEASVARAADQLRRRGARRLVIAPWFLAPGFITDGVSTFARD
Mflv_2684|M.gilvum_PYR-GCK ATTAFATGPQPSLTDAAAHLRALGASRLVIAPWFLAHGRITDRVAAFARA
Mvan_3859|M.vanbaalenii_PYR-1 ATTAFATGPHPSPAEAADELRRRGATRLVIAPWFLAHGRITDRVADFAAA
MSMEG_4529|M.smegmatis_MC2_155 THVAFATGQDPSVSRAVERLRARGATRLVIAPWFLAHGRITDRVAEYARR
TH_1445|M.thermoresistible__bu VEVAFATGPAPSVPDAVARLRARGADRIAISPWFLAHGRITDRVAGFARG
MAB_1658c|M.abscessus_ATCC_199 STTVFATGDPTSLAEAAESLRARGATDIVVAPWFLSPGLLLDRVRAEAAQ
.* * .* . *. ** ** :.::**:*: * : * * *
Mb2414|M.bovis_AF2122/97 AGIAMAQPLGAHPMVAATMWDRYRQAVAGRIAA---
Rv2393|M.tuberculosis_H37Rv AGIAMAQPLGAHPMVAATMWDRYRQAVAGRIAA---
MMAR_3418|M.marinum_M NDIAMARPMGAHPLVAQTVLDRYDQALATGDAAA--
MUL_2697|M.ulcerans_Agy99 NDIAMARPMGAHPLVAQTVLDRYDQALAAGDAAA--
MAV_2152|M.avium_104 NGIRMAAPLGAHRLVAETVLDRYDEALSA-DAAA--
Mflv_2684|M.gilvum_PYR-GCK HDIPMSAPLGAHRQVAETVLDRFDAALVHRAAA---
Mvan_3859|M.vanbaalenii_PYR-1 QRIPMSAPLGAHRQVAETVLDRFDAALAVHAAA---
MSMEG_4529|M.smegmatis_MC2_155 EGIPMAEPLGPHRLVAATVLDRYEEAIEARTAGFAA
TH_1445|M.thermoresistible__bu AGIPMAEPLGPHRLVAATVLDRYEETVAA--AALAA
MAB_1658c|M.abscessus_ATCC_199 LDMPVAAPLGADRLVADVVVQRYASAIAAPVPTPH-
: :: *:*.. ** .: :*: :: .