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PGQPFGVYLHVPFCLTRCGYCDFNTYTPAQLGGVSPDRWLLALRAELELAAAKLDAPTVHTVYVGGGTPS LLGGERLATLLDMVRDHFVLAPDAEVSTEANPESTWPEFFATIRAAGYTRVSLGMQSVAPRVLATLDRVH SPGRAAAAATEAIAEGFTHVNLDLIYGTPGESDDDLVRSVDAAVQAGVDHVSAYALVVEHGTALARRVRR GELAAPDDDVLAHRYELVDARLSAAGFAWYEVSNWCRPGGECRHNLGYWDGGQWWGAGPGAHGYIGVTRW WNVKHPNTYAEILAGATLPVAGFEQLGADALHTEDVLLKVRLRQGLPLARLGAAERERAEAVLADGLLDY HGDRLVLTGRGRLLADAVVRTLLG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv2388c | hemN | - | 100% (375) | coproporphyrinogen III oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2409c | hemN | 0.0 | 99.73% (375) | coproporphyrinogen III oxidase |
M. gilvum PYR-GCK | Mflv_2687 | - | 1e-159 | 72.73% (374) | coproporphyrinogen III oxidase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_1663 | - | 1e-147 | 69.95% (376) | coproporphyrinogen III oxidase |
M. marinum M | MMAR_3709 | hemN | 0.0 | 82.89% (374) | oxygen-independent coproporphyrinogen III oxidase HemN |
M. avium 104 | MAV_1789 | - | 0.0 | 80.43% (373) | coproporphyrinogen III oxidase |
M. smegmatis MC2 155 | MSMEG_4525 | - | 1e-164 | 73.73% (373) | coproporphyrinogen III oxidase |
M. thermoresistible (build 8) | TH_1442 | hemN | 1e-164 | 73.26% (374) | PROBABLE OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE |
M. ulcerans Agy99 | MUL_3651 | hemN | 0.0 | 82.62% (374) | coproporphyrinogen III oxidase |
M. vanbaalenii PYR-1 | Mvan_3855 | - | 1e-158 | 72.00% (375) | coproporphyrinogen III oxidase |
CLUSTAL 2.0.9 multiple sequence alignment Rv2388c|M.tuberculosis_H37Rv -----------------MP---GQPFGVYLHVPFCLTRCGYCDFNTYTPA Mb2409c|M.bovis_AF2122/97 -----------------MP---GQPFGVYLHVPFCLTRCGYCDFNTYTPA MMAR_3709|M.marinum_M --MTVREAPVDLPALLPSP---GRPFGLYLHVPFCVTRCGYCDFNTYTPA MUL_3651|M.ulcerans_Agy99 --MTVREAPVDLPALLPSP---GRPFGLYLHVPFCVTRCGYCDFNTYTPA MAV_1789|M.avium_104 --MAIREQTVELPDVRVVD---GRPFGLYVHVPFCVTRCGYCDFNTYTPA MSMEG_4525|M.smegmatis_MC2_155 --MTTRTAPLGQPDLAPTP---GRPFGIYIHVPFCATRCGYCDFNTYTPS TH_1442|M.thermoresistible__bu --MTVRPAP-ATPVLSATR---GRPFGVYIHVPFCATRCGYCDFNTYTPG Mflv_2687|M.gilvum_PYR-GCK MSVGPSAAAARRPALPALTAPADRPFGVYIHVPFCATRCGYCDFNTYTPA Mvan_3855|M.vanbaalenii_PYR-1 --MGVDAAVAELPELAAGRRRPSQPFGIYVHVPFCAVRCGYCDFNTYTPA MAB_1663|M.abscessus_ATCC_1997 -------MTATLPPLVPAP---GRPFGIYVHVPFCATRCGYCDFNTYTAD .:***:*:***** .***********. Rv2388c|M.tuberculosis_H37Rv QLG--GVSPDRWLLALRAELELAAAKLD-APTVHTVYVGGGTPSLLGGER Mb2409c|M.bovis_AF2122/97 QLG--GVSPDRWLLALRAELELAAAKLD-APTVHTVYVGGGTPSLLGGER MMAR_3709|M.marinum_M ELG--GVNPDAWLLALRSELELAAARLN-APTVNTVFVGGGTPSLLGGQR MUL_3651|M.ulcerans_Agy99 ELG--GVNPDAWLLALRSELELAAARLN-APTVNTVFVGGGTPSLLGGQR MAV_1789|M.avium_104 ELG--GVNPDAWLGALRTELELAAARLR-PPPVNTVFVGGGTPSLLGGAR MSMEG_4525|M.smegmatis_MC2_155 ELG--GANPEGWLEALRVELRLAAERVG-ALAVQTVFVGGGTPSLLGGDG TH_1442|M.thermoresistible__bu ELG--GADPHGWLAALRTELRLAARTLGDPPPVATVFVGGGTPSLLGADG Mflv_2687|M.gilvum_PYR-GCK ELGAGGATPDGWLTALRAELQMAAAHLGEPPPVSTVFVGGGTPSLLGAAG Mvan_3855|M.vanbaalenii_PYR-1 ELG--GANPDGWLSALRTELRLAAAHLGEPPDVQTVFVGGGTPSLLGAAG MAB_1663|M.abscessus_ATCC_1997 ELG-EGTSPAGWLEALRAELELAARTLAGNPPVETVFVGGGTPSLLGGSG :** *. * ** *** **.:** : * **:**********. Rv2388c|M.tuberculosis_H37Rv LATLLDMVRDHFVLAPDAEVSTEANPESTWPEFFATIRAAGYTRVSLGMQ Mb2409c|M.bovis_AF2122/97 LATLLDMVRDHFVLAPDAEVSTEANPESTWPEFFATIRAAGYTRVSLGMQ MMAR_3709|M.marinum_M LTTLLDMVRDHFVLAPDVEITTEANPESTWPEFFDAIRSAGYTRVSLGMQ MUL_3651|M.ulcerans_Agy99 LTTLLDMVRDHFVLAPDVEITTEANPESTWPEFFDAIRSAGYTRVSLGMQ MAV_1789|M.avium_104 LALLLDMVREHFALAPDAEITTEANPESTWPEFFDAIRAAGYTRVSLGMQ MSMEG_4525|M.smegmatis_MC2_155 LSAVLDAVRDNFVLATGAEVTTEANPESTSPELFAALRNAGYTRISLGMQ TH_1442|M.thermoresistible__bu LTAVLDAVREQFPIAPDAEITTEANPESTSPRFFAELRAAGYTRVSLGMQ Mflv_2687|M.gilvum_PYR-GCK LARVLDAVRADFTLTPDAEITTESNPESTSPRFFAGLRAAGYTRVSLGMQ Mvan_3855|M.vanbaalenii_PYR-1 LTAVLDAIREDFTLAPGAEVTTESNPESTSPRFFDGLRRAGYTRVSLGMQ MAB_1663|M.abscessus_ATCC_1997 LAEVLDAIGAHFVLAPGAEVTTEANPESTSPAFFDTIRAAGYTRVSLGMQ *: :** : .* ::...*::**:***** * :* :* *****:***** Rv2388c|M.tuberculosis_H37Rv SVAPRVLATLDRVHSPGRAAAAATEAIAEGFTHVNLDLIYGTPGESDDDL Mb2409c|M.bovis_AF2122/97 SVAPRVLATLDRVHSPGRAAAAATEAIAEGFTHVNLDLIYGTPGESDDDL MMAR_3709|M.marinum_M SVAPRVLATLDRVHSPGRASAAAREAFAAGFEHVNLDLIYGTPGETDDDL MUL_3651|M.ulcerans_Agy99 SVAPRVLATLDRVHSPGRASAAAREAFAAGFEHVNLDLIYGTPGETDDDL MAV_1789|M.avium_104 SVAPRVLGVLDRIHTPNRSADAAREALAAGFEHVSLDLIYGTPGESDEDL MSMEG_4525|M.smegmatis_MC2_155 SVAPHVLAVLNRTHSPGRAPAAVAEAKAAGFEHVNLDLIYGTPGESDDDL TH_1442|M.thermoresistible__bu SVAPHVLAVLDRVHSPGRAPAAAAEARAAGFDHVNIDLIYGTPGERDDDL Mflv_2687|M.gilvum_PYR-GCK STAPHVLRALDRVHSPGRAVDAAREARAEGFDHVNLDLIYGTPGETDDDL Mvan_3855|M.vanbaalenii_PYR-1 STAPHVLAALDRVHSPGRALDAAREAREAGFDHVNLDLIYGTPGETDDDL MAB_1663|M.abscessus_ATCC_1997 SAAPHVLATLDRVHAPGRAVAAAREARAAGLGHVNLDLIYGTPGETDDDL *.**:** .*:* *:*.*: *. ** *: **.:********* *:** Rv2388c|M.tuberculosis_H37Rv VRSVDAAVQAGVDHVSAYALVVEHGTALARRVRRGELAAPDDDVLAHRYE Mb2409c|M.bovis_AF2122/97 VRSVDATVQAGVDHVSAYALVVEHGTALARRVRRGELAAPDDDVLAHRYE MMAR_3709|M.marinum_M LRSVDAAIEAGVDHVSAYALVVEDGTAMARRVRQGELPPVDNDVLAHRYE MUL_3651|M.ulcerans_Agy99 LRSIDAAIEAGVDHVSAYALVVEDGTAMARRVRQGELPPVDNDVLAHRYE MAV_1789|M.avium_104 LWSLDTAIETGVDHVSAYALVVEEGTALARRVRRGELAAPDDDVLAHRYE MSMEG_4525|M.smegmatis_MC2_155 LRSVDAAVHAGVDHVSGYALVVEDGTALARRVRRGEIAAPDDDVLAHRYE TH_1442|M.thermoresistible__bu LRSVDTAVAAGVDHISAYALIVEDGTALARRIRRGEIAAPDDDVLADRYQ Mflv_2687|M.gilvum_PYR-GCK LRSADAAVEAGVDHVSGYALIVEDGTALARRVRRGEIARPDDDVHARRYE Mvan_3855|M.vanbaalenii_PYR-1 VRSASSAVEAGVDHVSAYALIVEDGTALARRVRRGEMPAPDDDVLARRYE MAB_1663|M.abscessus_ATCC_1997 RRSIAAVLEAGVDHVSAYALVVEEGTALARRVRRGELPNPDEDALADRYQ * :.: :****:*.***:**.***:***:*:**:. *:*. * **: Rv2388c|M.tuberculosis_H37Rv LVDARLSAAGFAWYEVSNWCRPGGECRHNLGYWDGGQWWGAGPGAHGYIG Mb2409c|M.bovis_AF2122/97 LVDARLSAAGFAWYEVSNWCRPGGECRHNLGYWDGGQWWGAGPGAHGYIG MMAR_3709|M.marinum_M LADARLTAAGLAWYEVSNWARPGGECRHNLGYWNGGQWWGAGPGAHGYVG MUL_3651|M.ulcerans_Agy99 LADARLTAAGLAWYEVSNWARPGGECRHNLGYWNGGQWWGAGPGAHGYVG MAV_1789|M.avium_104 LVDARLSQAGLSWYEVSNWSRPGGQCRHNLGYWDGGQWWGAGPGAHGYVG MSMEG_4525|M.smegmatis_MC2_155 LLDAQLSAAGFAWYEVSNWSRPGGECLHNLGYWDGGEWWGAGPGAHGFLN TH_1442|M.thermoresistible__bu LLDERLRAAGFGWYEVSNWSRPGGECRHNLGYWNGGEWWGAGPGAHGHLG Mflv_2687|M.gilvum_PYR-GCK LLDCRLTDAGFTWYEVSNWSRPDGECRHNLGYWDGGQWWGAGPGAHGYVD Mvan_3855|M.vanbaalenii_PYR-1 LLDRRLADAGFDWYEVSNWSRPGGQCRHNIGYWDGGEWWGAGPGAHGYVD MAB_1663|M.abscessus_ATCC_1997 LLDAALTEAGLDWYEVSNWARPGGQCRHNLGYWAGGDWWGAGPGAHGHVN * * * **: *******.**.*:* **:*** **:**********.:. Rv2388c|M.tuberculosis_H37Rv VTRWWNVKHPNTYAEILA-GATLPVAGFEQLGADALHTEDVLLKVRLRQG Mb2409c|M.bovis_AF2122/97 VTRWWNVKHPNTYAEILA-GATLPVAGFEQLGADALHTEDVLLKVRLRQG MMAR_3709|M.marinum_M ATRWWNVKHPNTYAEILA-GSSLPVAGLERLEEDALHTEEVMLGLRLRQG MUL_3651|M.ulcerans_Agy99 ATRWWNVKHPNTYAEILA-GSSLPVAGLERLEEDALHTEEVMLGLRLRQG MAV_1789|M.avium_104 TTRWWNVKHPNAYAERLN-AAALPVAGFEQLGSEALHTEDVLLKIRLRQG MSMEG_4525|M.smegmatis_MC2_155 ATRWWNAKHPNAYAQTLA-EGALPIADFEVLDAADRHTEDVMLRLRLRRG TH_1442|M.thermoresistible__bu MTRWWNVKHPARYAEILA-DGRLPIADFEELDEDDRHTEEVMLRLRLRSG Mflv_2687|M.gilvum_PYR-GCK ATRWWNVKHPNAYAATLE-TGALPVADLEAIDAETSHVEEVMLKTRLRTG Mvan_3855|M.vanbaalenii_PYR-1 SVRWWNVKHPNAYAAASD-KGELPVADFEALDEPTAHIEDVMLRVRLRTG MAB_1663|M.abscessus_ATCC_1997 GVRWWNVKHPNTYARRLLGEGQLPVGGHEILSPVERHTEEVLLAVRLNTG .****.*** ** . **:.. * : * *:*:* **. * Rv2388c|M.tuberculosis_H37Rv LPLARLGAAERERAEAVLADGLLDYHGDRLVLTGRGRLLADAVVRTLLG Mb2409c|M.bovis_AF2122/97 LPLARLGAAERERAEAVLADGLLDYHGDRLVLTGRGRLLADAVVRTLLG MMAR_3709|M.marinum_M LPLAHLDAGERERAQAAVADGLLTAEGDSVVLTDRGRLLADAVVRTLLG MUL_3651|M.ulcerans_Agy99 LPLAHLDAGERERAQAAVADGLLTAEGDSVVLTDRGRLLADAVVRTLLG MAV_1789|M.avium_104 LPVDLLNPAERERVQGVVADGLLVRDGDRLVLTPRGRLLADGVVRTLLG MSMEG_4525|M.smegmatis_MC2_155 LALDDLAADERARVPEIVAEGLLDTAGERVVLTDRGRLLADGVVRALLA TH_1442|M.thermoresistible__bu LPLGLLTAAERTRAGTAADAGLVSRHADRLVLTDRGRLLADGIVRDLLG Mflv_2687|M.gilvum_PYR-GCK LPAATLSARERERAAVAVADGLLRADGQSFVLTDRGRLLADAVVRDLLT Mvan_3855|M.vanbaalenii_PYR-1 LPAAALSAPERRRAERAVADGLLRTDGDALVLTDRGRLLADAVVRDLLG MAB_1663|M.abscessus_ATCC_1997 IALTDLTIEERGRVPAVVDRGLGRLVDERLVLTDQGRLLADGVVRAILD :. * ** *. ** : .*** :******.:** :*