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TVREAPVDLPALLPSPGRPFGLYLHVPFCVTRCGYCDFNTYTPAELGGVNPDAWLLALRSELELAAARLN APTVNTVFVGGGTPSLLGGQRLTTLLDMVRDHFVLAPDVEITTEANPESTWPEFFDAIRSAGYTRVSLGM QSVAPRVLATLDRVHSPGRASAAAREAFAAGFEHVNLDLIYGTPGETDDDLLRSIDAAIEAGVDHVSAYA LVVEDGTAMARRVRQGELPPVDNDVLAHRYELADARLTAAGLAWYEVSNWARPGGECRHNLGYWNGGQWW GAGPGAHGYVGATRWWNVKHPNTYAEILAGSSLPVAGLERLEEDALHTEEVMLGLRLRQGLPLAHLDAGE RERAQAAVADGLLTAEGDSVVLTDRGRLLADAVVRTLLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3651 | hemN | - | 100% (390) | coproporphyrinogen III oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2409c | hemN | 0.0 | 82.35% (374) | coproporphyrinogen III oxidase |
| M. gilvum PYR-GCK | Mflv_2687 | - | 1e-162 | 73.11% (383) | coproporphyrinogen III oxidase |
| M. tuberculosis H37Rv | Rv2388c | hemN | 0.0 | 82.62% (374) | coproporphyrinogen III oxidase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1663 | - | 1e-153 | 70.50% (383) | coproporphyrinogen III oxidase |
| M. marinum M | MMAR_3709 | hemN | 0.0 | 99.74% (390) | oxygen-independent coproporphyrinogen III oxidase HemN |
| M. avium 104 | MAV_1789 | - | 0.0 | 77.95% (390) | coproporphyrinogen III oxidase |
| M. smegmatis MC2 155 | MSMEG_4525 | - | 1e-167 | 71.98% (389) | coproporphyrinogen III oxidase |
| M. thermoresistible (build 8) | TH_1442 | hemN | 1e-164 | 71.36% (391) | PROBABLE OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE |
| M. vanbaalenii PYR-1 | Mvan_3855 | - | 1e-163 | 70.30% (394) | coproporphyrinogen III oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3651|M.ulcerans_Agy99 --MTVREAPVDLPALLPSP---GRPFGLYLHVPFCVTRCGYCDFNTYTPA
MMAR_3709|M.marinum_M --MTVREAPVDLPALLPSP---GRPFGLYLHVPFCVTRCGYCDFNTYTPA
Mb2409c|M.bovis_AF2122/97 -----------------MP---GQPFGVYLHVPFCLTRCGYCDFNTYTPA
Rv2388c|M.tuberculosis_H37Rv -----------------MP---GQPFGVYLHVPFCLTRCGYCDFNTYTPA
MAV_1789|M.avium_104 --MAIREQTVELPDVRVVD---GRPFGLYVHVPFCVTRCGYCDFNTYTPA
MSMEG_4525|M.smegmatis_MC2_155 --MTTRTAPLGQPDLAPTP---GRPFGIYIHVPFCATRCGYCDFNTYTPS
TH_1442|M.thermoresistible__bu --MTVRPAP-ATPVLSATR---GRPFGVYIHVPFCATRCGYCDFNTYTPG
Mflv_2687|M.gilvum_PYR-GCK MSVGPSAAAARRPALPALTAPADRPFGVYIHVPFCATRCGYCDFNTYTPA
Mvan_3855|M.vanbaalenii_PYR-1 --MGVDAAVAELPELAAGRRRPSQPFGIYVHVPFCAVRCGYCDFNTYTPA
MAB_1663|M.abscessus_ATCC_1997 -------MTATLPPLVPAP---GRPFGIYVHVPFCATRCGYCDFNTYTAD
.:***:*:***** .***********.
MUL_3651|M.ulcerans_Agy99 ELG--GVNPDAWLLALRSELELAAARLN-APTVNTVFVGGGTPSLLGGQR
MMAR_3709|M.marinum_M ELG--GVNPDAWLLALRSELELAAARLN-APTVNTVFVGGGTPSLLGGQR
Mb2409c|M.bovis_AF2122/97 QLG--GVSPDRWLLALRAELELAAAKLD-APTVHTVYVGGGTPSLLGGER
Rv2388c|M.tuberculosis_H37Rv QLG--GVSPDRWLLALRAELELAAAKLD-APTVHTVYVGGGTPSLLGGER
MAV_1789|M.avium_104 ELG--GVNPDAWLGALRTELELAAARLR-PPPVNTVFVGGGTPSLLGGAR
MSMEG_4525|M.smegmatis_MC2_155 ELG--GANPEGWLEALRVELRLAAERVG-ALAVQTVFVGGGTPSLLGGDG
TH_1442|M.thermoresistible__bu ELG--GADPHGWLAALRTELRLAARTLGDPPPVATVFVGGGTPSLLGADG
Mflv_2687|M.gilvum_PYR-GCK ELGAGGATPDGWLTALRAELQMAAAHLGEPPPVSTVFVGGGTPSLLGAAG
Mvan_3855|M.vanbaalenii_PYR-1 ELG--GANPDGWLSALRTELRLAAAHLGEPPDVQTVFVGGGTPSLLGAAG
MAB_1663|M.abscessus_ATCC_1997 ELG-EGTSPAGWLEALRAELELAARTLAGNPPVETVFVGGGTPSLLGGSG
:** *. * ** *** **.:** : * **:**********.
MUL_3651|M.ulcerans_Agy99 LTTLLDMVRDHFVLAPDVEITTEANPESTWPEFFDAIRSAGYTRVSLGMQ
MMAR_3709|M.marinum_M LTTLLDMVRDHFVLAPDVEITTEANPESTWPEFFDAIRSAGYTRVSLGMQ
Mb2409c|M.bovis_AF2122/97 LATLLDMVRDHFVLAPDAEVSTEANPESTWPEFFATIRAAGYTRVSLGMQ
Rv2388c|M.tuberculosis_H37Rv LATLLDMVRDHFVLAPDAEVSTEANPESTWPEFFATIRAAGYTRVSLGMQ
MAV_1789|M.avium_104 LALLLDMVREHFALAPDAEITTEANPESTWPEFFDAIRAAGYTRVSLGMQ
MSMEG_4525|M.smegmatis_MC2_155 LSAVLDAVRDNFVLATGAEVTTEANPESTSPELFAALRNAGYTRISLGMQ
TH_1442|M.thermoresistible__bu LTAVLDAVREQFPIAPDAEITTEANPESTSPRFFAELRAAGYTRVSLGMQ
Mflv_2687|M.gilvum_PYR-GCK LARVLDAVRADFTLTPDAEITTESNPESTSPRFFAGLRAAGYTRVSLGMQ
Mvan_3855|M.vanbaalenii_PYR-1 LTAVLDAIREDFTLAPGAEVTTESNPESTSPRFFDGLRRAGYTRVSLGMQ
MAB_1663|M.abscessus_ATCC_1997 LAEVLDAIGAHFVLAPGAEVTTEANPESTSPAFFDTIRAAGYTRVSLGMQ
*: :** : .* ::...*::**:***** * :* :* *****:*****
MUL_3651|M.ulcerans_Agy99 SVAPRVLATLDRVHSPGRASAAAREAFAAGFEHVNLDLIYGTPGETDDDL
MMAR_3709|M.marinum_M SVAPRVLATLDRVHSPGRASAAAREAFAAGFEHVNLDLIYGTPGETDDDL
Mb2409c|M.bovis_AF2122/97 SVAPRVLATLDRVHSPGRAAAAATEAIAEGFTHVNLDLIYGTPGESDDDL
Rv2388c|M.tuberculosis_H37Rv SVAPRVLATLDRVHSPGRAAAAATEAIAEGFTHVNLDLIYGTPGESDDDL
MAV_1789|M.avium_104 SVAPRVLGVLDRIHTPNRSADAAREALAAGFEHVSLDLIYGTPGESDEDL
MSMEG_4525|M.smegmatis_MC2_155 SVAPHVLAVLNRTHSPGRAPAAVAEAKAAGFEHVNLDLIYGTPGESDDDL
TH_1442|M.thermoresistible__bu SVAPHVLAVLDRVHSPGRAPAAAAEARAAGFDHVNIDLIYGTPGERDDDL
Mflv_2687|M.gilvum_PYR-GCK STAPHVLRALDRVHSPGRAVDAAREARAEGFDHVNLDLIYGTPGETDDDL
Mvan_3855|M.vanbaalenii_PYR-1 STAPHVLAALDRVHSPGRALDAAREAREAGFDHVNLDLIYGTPGETDDDL
MAB_1663|M.abscessus_ATCC_1997 SAAPHVLATLDRVHAPGRAVAAAREARAAGLGHVNLDLIYGTPGETDDDL
*.**:** .*:* *:*.*: *. ** *: **.:********* *:**
MUL_3651|M.ulcerans_Agy99 LRSIDAAIEAGVDHVSAYALVVEDGTAMARRVRQGELPPVDNDVLAHRYE
MMAR_3709|M.marinum_M LRSVDAAIEAGVDHVSAYALVVEDGTAMARRVRQGELPPVDNDVLAHRYE
Mb2409c|M.bovis_AF2122/97 VRSVDATVQAGVDHVSAYALVVEHGTALARRVRRGELAAPDDDVLAHRYE
Rv2388c|M.tuberculosis_H37Rv VRSVDAAVQAGVDHVSAYALVVEHGTALARRVRRGELAAPDDDVLAHRYE
MAV_1789|M.avium_104 LWSLDTAIETGVDHVSAYALVVEEGTALARRVRRGELAAPDDDVLAHRYE
MSMEG_4525|M.smegmatis_MC2_155 LRSVDAAVHAGVDHVSGYALVVEDGTALARRVRRGEIAAPDDDVLAHRYE
TH_1442|M.thermoresistible__bu LRSVDTAVAAGVDHISAYALIVEDGTALARRIRRGEIAAPDDDVLADRYQ
Mflv_2687|M.gilvum_PYR-GCK LRSADAAVEAGVDHVSGYALIVEDGTALARRVRRGEIARPDDDVHARRYE
Mvan_3855|M.vanbaalenii_PYR-1 VRSASSAVEAGVDHVSAYALIVEDGTALARRVRRGEMPAPDDDVLARRYE
MAB_1663|M.abscessus_ATCC_1997 RRSIAAVLEAGVDHVSAYALVVEEGTALARRVRRGELPNPDEDALADRYQ
* :.: :****:*.***:**.***:***:*:**:. *:*. * **:
MUL_3651|M.ulcerans_Agy99 LADARLTAAGLAWYEVSNWARPGGECRHNLGYWNGGQWWGAGPGAHGYVG
MMAR_3709|M.marinum_M LADARLTAAGLAWYEVSNWARPGGECRHNLGYWNGGQWWGAGPGAHGYVG
Mb2409c|M.bovis_AF2122/97 LVDARLSAAGFAWYEVSNWCRPGGECRHNLGYWDGGQWWGAGPGAHGYIG
Rv2388c|M.tuberculosis_H37Rv LVDARLSAAGFAWYEVSNWCRPGGECRHNLGYWDGGQWWGAGPGAHGYIG
MAV_1789|M.avium_104 LVDARLSQAGLSWYEVSNWSRPGGQCRHNLGYWDGGQWWGAGPGAHGYVG
MSMEG_4525|M.smegmatis_MC2_155 LLDAQLSAAGFAWYEVSNWSRPGGECLHNLGYWDGGEWWGAGPGAHGFLN
TH_1442|M.thermoresistible__bu LLDERLRAAGFGWYEVSNWSRPGGECRHNLGYWNGGEWWGAGPGAHGHLG
Mflv_2687|M.gilvum_PYR-GCK LLDCRLTDAGFTWYEVSNWSRPDGECRHNLGYWDGGQWWGAGPGAHGYVD
Mvan_3855|M.vanbaalenii_PYR-1 LLDRRLADAGFDWYEVSNWSRPGGQCRHNIGYWDGGEWWGAGPGAHGYVD
MAB_1663|M.abscessus_ATCC_1997 LLDAALTEAGLDWYEVSNWARPGGQCRHNLGYWAGGDWWGAGPGAHGHVN
* * * **: *******.**.*:* **:*** **:**********.:.
MUL_3651|M.ulcerans_Agy99 ATRWWNVKHPNTYAEILA-GSSLPVAGLERLEEDALHTEEVMLGLRLRQG
MMAR_3709|M.marinum_M ATRWWNVKHPNTYAEILA-GSSLPVAGLERLEEDALHTEEVMLGLRLRQG
Mb2409c|M.bovis_AF2122/97 VTRWWNVKHPNTYAEILA-GATLPVAGFEQLGADALHTEDVLLKVRLRQG
Rv2388c|M.tuberculosis_H37Rv VTRWWNVKHPNTYAEILA-GATLPVAGFEQLGADALHTEDVLLKVRLRQG
MAV_1789|M.avium_104 TTRWWNVKHPNAYAERLN-AAALPVAGFEQLGSEALHTEDVLLKIRLRQG
MSMEG_4525|M.smegmatis_MC2_155 ATRWWNAKHPNAYAQTLA-EGALPIADFEVLDAADRHTEDVMLRLRLRRG
TH_1442|M.thermoresistible__bu MTRWWNVKHPARYAEILA-DGRLPIADFEELDEDDRHTEEVMLRLRLRSG
Mflv_2687|M.gilvum_PYR-GCK ATRWWNVKHPNAYAATLE-TGALPVADLEAIDAETSHVEEVMLKTRLRTG
Mvan_3855|M.vanbaalenii_PYR-1 SVRWWNVKHPNAYAAASD-KGELPVADFEALDEPTAHIEDVMLRVRLRTG
MAB_1663|M.abscessus_ATCC_1997 GVRWWNVKHPNTYARRLLGEGQLPVGGHEILSPVERHTEEVLLAVRLNTG
.****.*** ** . **:.. * : * *:*:* **. *
MUL_3651|M.ulcerans_Agy99 LPLAHLDAGERERAQAAVADGLLTAEGDSVVLTDRGRLLADAVVRTLLG
MMAR_3709|M.marinum_M LPLAHLDAGERERAQAAVADGLLTAEGDSVVLTDRGRLLADAVVRTLLG
Mb2409c|M.bovis_AF2122/97 LPLARLGAAERERAEAVLADGLLDYHGDRLVLTGRGRLLADAVVRTLLG
Rv2388c|M.tuberculosis_H37Rv LPLARLGAAERERAEAVLADGLLDYHGDRLVLTGRGRLLADAVVRTLLG
MAV_1789|M.avium_104 LPVDLLNPAERERVQGVVADGLLVRDGDRLVLTPRGRLLADGVVRTLLG
MSMEG_4525|M.smegmatis_MC2_155 LALDDLAADERARVPEIVAEGLLDTAGERVVLTDRGRLLADGVVRALLA
TH_1442|M.thermoresistible__bu LPLGLLTAAERTRAGTAADAGLVSRHADRLVLTDRGRLLADGIVRDLLG
Mflv_2687|M.gilvum_PYR-GCK LPAATLSARERERAAVAVADGLLRADGQSFVLTDRGRLLADAVVRDLLT
Mvan_3855|M.vanbaalenii_PYR-1 LPAAALSAPERRRAERAVADGLLRTDGDALVLTDRGRLLADAVVRDLLG
MAB_1663|M.abscessus_ATCC_1997 IALTDLTIEERGRVPAVVDRGLGRLVDERLVLTDQGRLLADGVVRAILD
:. * ** *. ** : .*** :******.:** :*