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GVDAAVAELPELAAGRRRPSQPFGIYVHVPFCAVRCGYCDFNTYTPAELGGANPDGWLSALRTELRLAAA HLGEPPDVQTVFVGGGTPSLLGAAGLTAVLDAIREDFTLAPGAEVTTESNPESTSPRFFDGLRRAGYTRV SLGMQSTAPHVLAALDRVHSPGRALDAAREAREAGFDHVNLDLIYGTPGETDDDLVRSASSAVEAGVDHV SAYALIVEDGTALARRVRRGEMPAPDDDVLARRYELLDRRLADAGFDWYEVSNWSRPGGQCRHNIGYWDG GEWWGAGPGAHGYVDSVRWWNVKHPNAYAAASDKGELPVADFEALDEPTAHIEDVMLRVRLRTGLPAAAL SAPERRRAERAVADGLLRTDGDALVLTDRGRLLADAVVRDLLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3855 | - | - | 100% (394) | coproporphyrinogen III oxidase |
| M. vanbaalenii PYR-1 | Mvan_5047 | moaA | 2e-05 | 26.06% (165) | molybdenum cofactor biosynthesis protein A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2409c | hemN | 1e-158 | 71.73% (375) | coproporphyrinogen III oxidase |
| M. gilvum PYR-GCK | Mflv_2687 | - | 0.0 | 79.75% (395) | coproporphyrinogen III oxidase |
| M. tuberculosis H37Rv | Rv2388c | hemN | 1e-159 | 72.00% (375) | coproporphyrinogen III oxidase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1663 | - | 1e-153 | 68.81% (388) | coproporphyrinogen III oxidase |
| M. marinum M | MMAR_3709 | hemN | 1e-163 | 70.30% (394) | oxygen-independent coproporphyrinogen III oxidase HemN |
| M. avium 104 | MAV_1789 | - | 1e-163 | 69.54% (394) | coproporphyrinogen III oxidase |
| M. smegmatis MC2 155 | MSMEG_4525 | - | 1e-164 | 72.32% (383) | coproporphyrinogen III oxidase |
| M. thermoresistible (build 8) | TH_1442 | hemN | 1e-170 | 74.74% (384) | PROBABLE OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE |
| M. ulcerans Agy99 | MUL_3651 | hemN | 1e-163 | 70.30% (394) | coproporphyrinogen III oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2409c|M.bovis_AF2122/97 -----------------MP---GQPFGVYLHVPFCLTRCGYCDFNTYTPA
Rv2388c|M.tuberculosis_H37Rv -----------------MP---GQPFGVYLHVPFCLTRCGYCDFNTYTPA
MMAR_3709|M.marinum_M --MTVREAPVDLPALLPSP---GRPFGLYLHVPFCVTRCGYCDFNTYTPA
MUL_3651|M.ulcerans_Agy99 --MTVREAPVDLPALLPSP---GRPFGLYLHVPFCVTRCGYCDFNTYTPA
MAV_1789|M.avium_104 --MAIREQTVELPDVRVVD---GRPFGLYVHVPFCVTRCGYCDFNTYTPA
Mvan_3855|M.vanbaalenii_PYR-1 --MGVDAAVAELPELAAGRRRPSQPFGIYVHVPFCAVRCGYCDFNTYTPA
Mflv_2687|M.gilvum_PYR-GCK MSVGPSAAAARRPALPALTAPADRPFGVYIHVPFCATRCGYCDFNTYTPA
MSMEG_4525|M.smegmatis_MC2_155 --MTTRTAPLGQPDLAPTP---GRPFGIYIHVPFCATRCGYCDFNTYTPS
TH_1442|M.thermoresistible__bu --MTVRPAP-ATPVLSATR---GRPFGVYIHVPFCATRCGYCDFNTYTPG
MAB_1663|M.abscessus_ATCC_1997 -------MTATLPPLVPAP---GRPFGIYVHVPFCATRCGYCDFNTYTAD
.:***:*:***** .***********.
Mb2409c|M.bovis_AF2122/97 QLG--GVSPDRWLLALRAELELAAAKLD-APTVHTVYVGGGTPSLLGGER
Rv2388c|M.tuberculosis_H37Rv QLG--GVSPDRWLLALRAELELAAAKLD-APTVHTVYVGGGTPSLLGGER
MMAR_3709|M.marinum_M ELG--GVNPDAWLLALRSELELAAARLN-APTVNTVFVGGGTPSLLGGQR
MUL_3651|M.ulcerans_Agy99 ELG--GVNPDAWLLALRSELELAAARLN-APTVNTVFVGGGTPSLLGGQR
MAV_1789|M.avium_104 ELG--GVNPDAWLGALRTELELAAARLR-PPPVNTVFVGGGTPSLLGGAR
Mvan_3855|M.vanbaalenii_PYR-1 ELG--GANPDGWLSALRTELRLAAAHLGEPPDVQTVFVGGGTPSLLGAAG
Mflv_2687|M.gilvum_PYR-GCK ELGAGGATPDGWLTALRAELQMAAAHLGEPPPVSTVFVGGGTPSLLGAAG
MSMEG_4525|M.smegmatis_MC2_155 ELG--GANPEGWLEALRVELRLAAERVG-ALAVQTVFVGGGTPSLLGGDG
TH_1442|M.thermoresistible__bu ELG--GADPHGWLAALRTELRLAARTLGDPPPVATVFVGGGTPSLLGADG
MAB_1663|M.abscessus_ATCC_1997 ELG-EGTSPAGWLEALRAELELAARTLAGNPPVETVFVGGGTPSLLGGSG
:** *. * ** *** **.:** : * **:**********.
Mb2409c|M.bovis_AF2122/97 LATLLDMVRDHFVLAPDAEVSTEANPESTWPEFFATIRAAGYTRVSLGMQ
Rv2388c|M.tuberculosis_H37Rv LATLLDMVRDHFVLAPDAEVSTEANPESTWPEFFATIRAAGYTRVSLGMQ
MMAR_3709|M.marinum_M LTTLLDMVRDHFVLAPDVEITTEANPESTWPEFFDAIRSAGYTRVSLGMQ
MUL_3651|M.ulcerans_Agy99 LTTLLDMVRDHFVLAPDVEITTEANPESTWPEFFDAIRSAGYTRVSLGMQ
MAV_1789|M.avium_104 LALLLDMVREHFALAPDAEITTEANPESTWPEFFDAIRAAGYTRVSLGMQ
Mvan_3855|M.vanbaalenii_PYR-1 LTAVLDAIREDFTLAPGAEVTTESNPESTSPRFFDGLRRAGYTRVSLGMQ
Mflv_2687|M.gilvum_PYR-GCK LARVLDAVRADFTLTPDAEITTESNPESTSPRFFAGLRAAGYTRVSLGMQ
MSMEG_4525|M.smegmatis_MC2_155 LSAVLDAVRDNFVLATGAEVTTEANPESTSPELFAALRNAGYTRISLGMQ
TH_1442|M.thermoresistible__bu LTAVLDAVREQFPIAPDAEITTEANPESTSPRFFAELRAAGYTRVSLGMQ
MAB_1663|M.abscessus_ATCC_1997 LAEVLDAIGAHFVLAPGAEVTTEANPESTSPAFFDTIRAAGYTRVSLGMQ
*: :** : .* ::...*::**:***** * :* :* *****:*****
Mb2409c|M.bovis_AF2122/97 SVAPRVLATLDRVHSPGRAAAAATEAIAEGFTHVNLDLIYGTPGESDDDL
Rv2388c|M.tuberculosis_H37Rv SVAPRVLATLDRVHSPGRAAAAATEAIAEGFTHVNLDLIYGTPGESDDDL
MMAR_3709|M.marinum_M SVAPRVLATLDRVHSPGRASAAAREAFAAGFEHVNLDLIYGTPGETDDDL
MUL_3651|M.ulcerans_Agy99 SVAPRVLATLDRVHSPGRASAAAREAFAAGFEHVNLDLIYGTPGETDDDL
MAV_1789|M.avium_104 SVAPRVLGVLDRIHTPNRSADAAREALAAGFEHVSLDLIYGTPGESDEDL
Mvan_3855|M.vanbaalenii_PYR-1 STAPHVLAALDRVHSPGRALDAAREAREAGFDHVNLDLIYGTPGETDDDL
Mflv_2687|M.gilvum_PYR-GCK STAPHVLRALDRVHSPGRAVDAAREARAEGFDHVNLDLIYGTPGETDDDL
MSMEG_4525|M.smegmatis_MC2_155 SVAPHVLAVLNRTHSPGRAPAAVAEAKAAGFEHVNLDLIYGTPGESDDDL
TH_1442|M.thermoresistible__bu SVAPHVLAVLDRVHSPGRAPAAAAEARAAGFDHVNIDLIYGTPGERDDDL
MAB_1663|M.abscessus_ATCC_1997 SAAPHVLATLDRVHAPGRAVAAAREARAAGLGHVNLDLIYGTPGETDDDL
*.**:** .*:* *:*.*: *. ** *: **.:********* *:**
Mb2409c|M.bovis_AF2122/97 VRSVDATVQAGVDHVSAYALVVEHGTALARRVRRGELAAPDDDVLAHRYE
Rv2388c|M.tuberculosis_H37Rv VRSVDAAVQAGVDHVSAYALVVEHGTALARRVRRGELAAPDDDVLAHRYE
MMAR_3709|M.marinum_M LRSVDAAIEAGVDHVSAYALVVEDGTAMARRVRQGELPPVDNDVLAHRYE
MUL_3651|M.ulcerans_Agy99 LRSIDAAIEAGVDHVSAYALVVEDGTAMARRVRQGELPPVDNDVLAHRYE
MAV_1789|M.avium_104 LWSLDTAIETGVDHVSAYALVVEEGTALARRVRRGELAAPDDDVLAHRYE
Mvan_3855|M.vanbaalenii_PYR-1 VRSASSAVEAGVDHVSAYALIVEDGTALARRVRRGEMPAPDDDVLARRYE
Mflv_2687|M.gilvum_PYR-GCK LRSADAAVEAGVDHVSGYALIVEDGTALARRVRRGEIARPDDDVHARRYE
MSMEG_4525|M.smegmatis_MC2_155 LRSVDAAVHAGVDHVSGYALVVEDGTALARRVRRGEIAAPDDDVLAHRYE
TH_1442|M.thermoresistible__bu LRSVDTAVAAGVDHISAYALIVEDGTALARRIRRGEIAAPDDDVLADRYQ
MAB_1663|M.abscessus_ATCC_1997 RRSIAAVLEAGVDHVSAYALVVEEGTALARRVRRGELPNPDEDALADRYQ
* :.: :****:*.***:**.***:***:*:**:. *:*. * **:
Mb2409c|M.bovis_AF2122/97 LVDARLSAAGFAWYEVSNWCRPGGECRHNLGYWDGGQWWGAGPGAHGYIG
Rv2388c|M.tuberculosis_H37Rv LVDARLSAAGFAWYEVSNWCRPGGECRHNLGYWDGGQWWGAGPGAHGYIG
MMAR_3709|M.marinum_M LADARLTAAGLAWYEVSNWARPGGECRHNLGYWNGGQWWGAGPGAHGYVG
MUL_3651|M.ulcerans_Agy99 LADARLTAAGLAWYEVSNWARPGGECRHNLGYWNGGQWWGAGPGAHGYVG
MAV_1789|M.avium_104 LVDARLSQAGLSWYEVSNWSRPGGQCRHNLGYWDGGQWWGAGPGAHGYVG
Mvan_3855|M.vanbaalenii_PYR-1 LLDRRLADAGFDWYEVSNWSRPGGQCRHNIGYWDGGEWWGAGPGAHGYVD
Mflv_2687|M.gilvum_PYR-GCK LLDCRLTDAGFTWYEVSNWSRPDGECRHNLGYWDGGQWWGAGPGAHGYVD
MSMEG_4525|M.smegmatis_MC2_155 LLDAQLSAAGFAWYEVSNWSRPGGECLHNLGYWDGGEWWGAGPGAHGFLN
TH_1442|M.thermoresistible__bu LLDERLRAAGFGWYEVSNWSRPGGECRHNLGYWNGGEWWGAGPGAHGHLG
MAB_1663|M.abscessus_ATCC_1997 LLDAALTEAGLDWYEVSNWARPGGQCRHNLGYWAGGDWWGAGPGAHGHVN
* * * **: *******.**.*:* **:*** **:**********.:.
Mb2409c|M.bovis_AF2122/97 VTRWWNVKHPNTYAEILA-GATLPVAGFEQLGADALHTEDVLLKVRLRQG
Rv2388c|M.tuberculosis_H37Rv VTRWWNVKHPNTYAEILA-GATLPVAGFEQLGADALHTEDVLLKVRLRQG
MMAR_3709|M.marinum_M ATRWWNVKHPNTYAEILA-GSSLPVAGLERLEEDALHTEEVMLGLRLRQG
MUL_3651|M.ulcerans_Agy99 ATRWWNVKHPNTYAEILA-GSSLPVAGLERLEEDALHTEEVMLGLRLRQG
MAV_1789|M.avium_104 TTRWWNVKHPNAYAERLN-AAALPVAGFEQLGSEALHTEDVLLKIRLRQG
Mvan_3855|M.vanbaalenii_PYR-1 SVRWWNVKHPNAYAAASD-KGELPVADFEALDEPTAHIEDVMLRVRLRTG
Mflv_2687|M.gilvum_PYR-GCK ATRWWNVKHPNAYAATLE-TGALPVADLEAIDAETSHVEEVMLKTRLRTG
MSMEG_4525|M.smegmatis_MC2_155 ATRWWNAKHPNAYAQTLA-EGALPIADFEVLDAADRHTEDVMLRLRLRRG
TH_1442|M.thermoresistible__bu MTRWWNVKHPARYAEILA-DGRLPIADFEELDEDDRHTEEVMLRLRLRSG
MAB_1663|M.abscessus_ATCC_1997 GVRWWNVKHPNTYARRLLGEGQLPVGGHEILSPVERHTEEVLLAVRLNTG
.****.*** ** . **:.. * : * *:*:* **. *
Mb2409c|M.bovis_AF2122/97 LPLARLGAAERERAEAVLADGLLDYHGDRLVLTGRGRLLADAVVRTLLG
Rv2388c|M.tuberculosis_H37Rv LPLARLGAAERERAEAVLADGLLDYHGDRLVLTGRGRLLADAVVRTLLG
MMAR_3709|M.marinum_M LPLAHLDAGERERAQAAVADGLLTAEGDSVVLTDRGRLLADAVVRTLLG
MUL_3651|M.ulcerans_Agy99 LPLAHLDAGERERAQAAVADGLLTAEGDSVVLTDRGRLLADAVVRTLLG
MAV_1789|M.avium_104 LPVDLLNPAERERVQGVVADGLLVRDGDRLVLTPRGRLLADGVVRTLLG
Mvan_3855|M.vanbaalenii_PYR-1 LPAAALSAPERRRAERAVADGLLRTDGDALVLTDRGRLLADAVVRDLLG
Mflv_2687|M.gilvum_PYR-GCK LPAATLSARERERAAVAVADGLLRADGQSFVLTDRGRLLADAVVRDLLT
MSMEG_4525|M.smegmatis_MC2_155 LALDDLAADERARVPEIVAEGLLDTAGERVVLTDRGRLLADGVVRALLA
TH_1442|M.thermoresistible__bu LPLGLLTAAERTRAGTAADAGLVSRHADRLVLTDRGRLLADGIVRDLLG
MAB_1663|M.abscessus_ATCC_1997 IALTDLTIEERGRVPAVVDRGLGRLVDERLVLTDQGRLLADGVVRAILD
:. * ** *. ** : .*** :******.:** :*