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VTATLPPLVPAPGRPFGIYVHVPFCATRCGYCDFNTYTADELGEGTSPAGWLEALRAELELAARTLAGNP PVETVFVGGGTPSLLGGSGLAEVLDAIGAHFVLAPGAEVTTEANPESTSPAFFDTIRAAGYTRVSLGMQS AAPHVLATLDRVHAPGRAVAAAREARAAGLGHVNLDLIYGTPGETDDDLRRSIAAVLEAGVDHVSAYALV VEEGTALARRVRRGELPNPDEDALADRYQLLDAALTEAGLDWYEVSNWARPGGQCRHNLGYWAGGDWWGA GPGAHGHVNGVRWWNVKHPNTYARRLLGEGQLPVGGHEILSPVERHTEEVLLAVRLNTGIALTDLTIEER GRVPAVVDRGLGRLVDERLVLTDQGRLLADGVVRAILD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1663 | - | - | 100% (388) | coproporphyrinogen III oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2409c | hemN | 1e-147 | 69.95% (376) | coproporphyrinogen III oxidase |
| M. gilvum PYR-GCK | Mflv_2687 | - | 1e-150 | 67.45% (384) | coproporphyrinogen III oxidase |
| M. tuberculosis H37Rv | Rv2388c | hemN | 1e-147 | 69.95% (376) | coproporphyrinogen III oxidase |
| M. leprae Br4923 | MLBr_00989 | - | 5e-05 | 27.39% (230) | (dimethylallyl)adenosine tRNA methylthiotransferase |
| M. marinum M | MMAR_3709 | hemN | 1e-152 | 70.23% (383) | oxygen-independent coproporphyrinogen III oxidase HemN |
| M. avium 104 | MAV_1789 | - | 1e-147 | 67.88% (386) | coproporphyrinogen III oxidase |
| M. smegmatis MC2 155 | MSMEG_4525 | - | 1e-157 | 69.63% (382) | coproporphyrinogen III oxidase |
| M. thermoresistible (build 8) | TH_1442 | hemN | 1e-154 | 68.59% (382) | PROBABLE OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE |
| M. ulcerans Agy99 | MUL_3651 | hemN | 1e-153 | 70.50% (383) | coproporphyrinogen III oxidase |
| M. vanbaalenii PYR-1 | Mvan_3855 | - | 1e-153 | 68.81% (388) | coproporphyrinogen III oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4525|M.smegmatis_MC2_155 --MTTRTAPLGQPDLAPTP---GRPFGIYIHVPFCATRCGYCDFNTYTPS
TH_1442|M.thermoresistible__bu --MTVRPAP-ATPVLSATR---GRPFGVYIHVPFCATRCGYCDFNTYTPG
Mflv_2687|M.gilvum_PYR-GCK MSVGPSAAAARRPALPALTAPADRPFGVYIHVPFCATRCGYCDFNTYTPA
Mvan_3855|M.vanbaalenii_PYR-1 --MGVDAAVAELPELAAGRRRPSQPFGIYVHVPFCAVRCGYCDFNTYTPA
Mb2409c|M.bovis_AF2122/97 -----------------MP---GQPFGVYLHVPFCLTRCGYCDFNTYTPA
Rv2388c|M.tuberculosis_H37Rv -----------------MP---GQPFGVYLHVPFCLTRCGYCDFNTYTPA
MMAR_3709|M.marinum_M --MTVREAPVDLPALLPSP---GRPFGLYLHVPFCVTRCGYCDFNTYTPA
MUL_3651|M.ulcerans_Agy99 --MTVREAPVDLPALLPSP---GRPFGLYLHVPFCVTRCGYCDFNTYTPA
MAV_1789|M.avium_104 --MAIREQTVELPDVRVVD---GRPFGLYVHVPFCVTRCGYCDFNTYTPA
MAB_1663|M.abscessus_ATCC_1997 -------MTATLPPLVPAP---GRPFGIYVHVPFCATRCGYCDFNTYTAD
MLBr_00989|M.leprae_Br4923 -MVTRDAGMADDAATGSTRTYQVRTYGCQMNVHDSERLAGLLEAAGYQRA
:.:* ::* . .* : *
MSMEG_4525|M.smegmatis_MC2_155 ELG--GANPEGWLEALRVELRLAAERVG-----------ALAVQTVFVGG
TH_1442|M.thermoresistible__bu ELG--GADPHGWLAALRTELRLAARTLGD----------PPPVATVFVGG
Mflv_2687|M.gilvum_PYR-GCK ELGAGGATPDGWLTALRAELQMAAAHLGE----------PPPVSTVFVGG
Mvan_3855|M.vanbaalenii_PYR-1 ELG--GANPDGWLSALRTELRLAAAHLGE----------PPDVQTVFVGG
Mb2409c|M.bovis_AF2122/97 QLG--GVSPDRWLLALRAELELAAAKLD-----------APTVHTVYVGG
Rv2388c|M.tuberculosis_H37Rv QLG--GVSPDRWLLALRAELELAAAKLD-----------APTVHTVYVGG
MMAR_3709|M.marinum_M ELG--GVNPDAWLLALRSELELAAARLN-----------APTVNTVFVGG
MUL_3651|M.ulcerans_Agy99 ELG--GVNPDAWLLALRSELELAAARLN-----------APTVNTVFVGG
MAV_1789|M.avium_104 ELG--GVNPDAWLGALRTELELAAARLR-----------PPPVNTVFVGG
MAB_1663|M.abscessus_ATCC_1997 ELG-EGTSPAGWLEALRAELELAARTLAG----------NPPVETVFVGG
MLBr_00989|M.leprae_Br4923 ADEADVGDADVVVFNTCAVRENADNRLYGNLSHLAPRKRNNPDMQIAVGG
. : . * : : ***
MSMEG_4525|M.smegmatis_MC2_155 GTPS---------------LLGGDGLSAVLDAVR-DNFVLATGAEVTTEA
TH_1442|M.thermoresistible__bu GTPS---------------LLGADGLTAVLDAVR-EQFPIAPDAEITTEA
Mflv_2687|M.gilvum_PYR-GCK GTPS---------------LLGAAGLARVLDAVR-ADFTLTPDAEITTES
Mvan_3855|M.vanbaalenii_PYR-1 GTPS---------------LLGAAGLTAVLDAIR-EDFTLAPGAEVTTES
Mb2409c|M.bovis_AF2122/97 GTPS---------------LLGGERLATLLDMVR-DHFVLAPDAEVSTEA
Rv2388c|M.tuberculosis_H37Rv GTPS---------------LLGGERLATLLDMVR-DHFVLAPDAEVSTEA
MMAR_3709|M.marinum_M GTPS---------------LLGGQRLTTLLDMVR-DHFVLAPDVEITTEA
MUL_3651|M.ulcerans_Agy99 GTPS---------------LLGGQRLTTLLDMVR-DHFVLAPDVEITTEA
MAV_1789|M.avium_104 GTPS---------------LLGGARLALLLDMVR-EHFALAPDAEITTEA
MAB_1663|M.abscessus_ATCC_1997 GTPS---------------LLGGSGLAEVLDAIG-AHFVLAPGAEVTTEA
MLBr_00989|M.leprae_Br4923 CLAQKDKHTVLSKAPWVDIVFGTHNLGSLPTLLDRARHNKVAQVEIVEAL
.. ::* * : : . .. .*:
MSMEG_4525|M.smegmatis_MC2_155 NPESTSPELFAALRNAGYTRISLGMQSVAPHVLAVLNRTHSPGRA-----
TH_1442|M.thermoresistible__bu NPESTSPRFFAELRAAGYTRVSLGMQSVAPHVLAVLDRVHSPGRA-----
Mflv_2687|M.gilvum_PYR-GCK NPESTSPRFFAGLRAAGYTRVSLGMQSTAPHVLRALDRVHSPGRA-----
Mvan_3855|M.vanbaalenii_PYR-1 NPESTSPRFFDGLRRAGYTRVSLGMQSTAPHVLAALDRVHSPGRA-----
Mb2409c|M.bovis_AF2122/97 NPESTWPEFFATIRAAGYTRVSLGMQSVAPRVLATLDRVHSPGRA-----
Rv2388c|M.tuberculosis_H37Rv NPESTWPEFFATIRAAGYTRVSLGMQSVAPRVLATLDRVHSPGRA-----
MMAR_3709|M.marinum_M NPESTWPEFFDAIRSAGYTRVSLGMQSVAPRVLATLDRVHSPGRA-----
MUL_3651|M.ulcerans_Agy99 NPESTWPEFFDAIRSAGYTRVSLGMQSVAPRVLATLDRVHSPGRA-----
MAV_1789|M.avium_104 NPESTWPEFFDAIRAAGYTRVSLGMQSVAPRVLGVLDRIHTPNRS-----
MAB_1663|M.abscessus_ATCC_1997 NPESTSPAFFDTIRAAGYTRVSLGMQSAAPHVLATLDRVHAPGRA-----
MLBr_00989|M.leprae_Br4923 QHFPSSLPSARESDYAAWVSISVGCNNSCTFCIVPSLRGKEVDRSPADIL
: .: *.:. :*:* :. .. : * : .*:
MSMEG_4525|M.smegmatis_MC2_155 -------PAAVAEAKAAGFEHVNLDLIYGTPGESDDDLLRSVDAAVHAGV
TH_1442|M.thermoresistible__bu -------PAAAAEARAAGFDHVNIDLIYGTPGERDDDLLRSVDTAVAAGV
Mflv_2687|M.gilvum_PYR-GCK -------VDAAREARAEGFDHVNLDLIYGTPGETDDDLLRSADAAVEAGV
Mvan_3855|M.vanbaalenii_PYR-1 -------LDAAREAREAGFDHVNLDLIYGTPGETDDDLVRSASSAVEAGV
Mb2409c|M.bovis_AF2122/97 -------AAAATEAIAEGFTHVNLDLIYGTPGESDDDLVRSVDATVQAGV
Rv2388c|M.tuberculosis_H37Rv -------AAAATEAIAEGFTHVNLDLIYGTPGESDDDLVRSVDAAVQAGV
MMAR_3709|M.marinum_M -------SAAAREAFAAGFEHVNLDLIYGTPGETDDDLLRSVDAAIEAGV
MUL_3651|M.ulcerans_Agy99 -------SAAAREAFAAGFEHVNLDLIYGTPGETDDDLLRSIDAAIEAGV
MAV_1789|M.avium_104 -------ADAAREALAAGFEHVSLDLIYGTPGESDEDLLWSLDTAIETGV
MAB_1663|M.abscessus_ATCC_1997 -------VAAAREARAAGLGHVNLDLIYGTPGETDDDLRRSIAAVLEAGV
MLBr_00989|M.leprae_Br4923 AEVEALVADGVLEVTLLGQNVNAYGVSFADPALARNRGSFAELLRSCGSI
.. *. * .: :. *. : : .:
MSMEG_4525|M.smegmatis_MC2_155 DHVSGYALVVEDGTALARRVRRGEIAAPDDD-VLAHRYELLDAQLSAAGF
TH_1442|M.thermoresistible__bu DHISAYALIVEDGTALARRIRRGEIAAPDDD-VLADRYQLLDERLRAAGF
Mflv_2687|M.gilvum_PYR-GCK DHVSGYALIVEDGTALARRVRRGEIARPDDD-VHARRYELLDCRLTDAGF
Mvan_3855|M.vanbaalenii_PYR-1 DHVSAYALIVEDGTALARRVRRGEMPAPDDD-VLARRYELLDRRLADAGF
Mb2409c|M.bovis_AF2122/97 DHVSAYALVVEHGTALARRVRRGELAAPDDD-VLAHRYELVDARLSAAGF
Rv2388c|M.tuberculosis_H37Rv DHVSAYALVVEHGTALARRVRRGELAAPDDD-VLAHRYELVDARLSAAGF
MMAR_3709|M.marinum_M DHVSAYALVVEDGTAMARRVRQGELPPVDND-VLAHRYELADARLTAAGL
MUL_3651|M.ulcerans_Agy99 DHVSAYALVVEDGTAMARRVRQGELPPVDND-VLAHRYELADARLTAAGL
MAV_1789|M.avium_104 DHVSAYALVVEEGTALARRVRRGELAAPDDD-VLAHRYELVDARLSQAGL
MAB_1663|M.abscessus_ATCC_1997 DHVSAYALVVEEGTALARRVRRGELPNPDED-ALADRYQLLDAALTEAGL
MLBr_00989|M.leprae_Br4923 DGLERVRFTSPHPAEFTYDVIEAMAQTPNVCPSLHMPLQSGSDRVLRAMR
* :. : . : :: : .. : : . : *
MSMEG_4525|M.smegmatis_MC2_155 AWYEVSNWSRPGGECLHNLGYWDGGEWWGAGPG---------------AH
TH_1442|M.thermoresistible__bu GWYEVSNWSRPGGECRHNLGYWNGGEWWGAGPG---------------AH
Mflv_2687|M.gilvum_PYR-GCK TWYEVSNWSRPDGECRHNLGYWDGGQWWGAGPG---------------AH
Mvan_3855|M.vanbaalenii_PYR-1 DWYEVSNWSRPGGQCRHNIGYWDGGEWWGAGPG---------------AH
Mb2409c|M.bovis_AF2122/97 AWYEVSNWCRPGGECRHNLGYWDGGQWWGAGPG---------------AH
Rv2388c|M.tuberculosis_H37Rv AWYEVSNWCRPGGECRHNLGYWDGGQWWGAGPG---------------AH
MMAR_3709|M.marinum_M AWYEVSNWARPGGECRHNLGYWNGGQWWGAGPG---------------AH
MUL_3651|M.ulcerans_Agy99 AWYEVSNWARPGGECRHNLGYWNGGQWWGAGPG---------------AH
MAV_1789|M.avium_104 SWYEVSNWSRPGGQCRHNLGYWDGGQWWGAGPG---------------AH
MAB_1663|M.abscessus_ATCC_1997 DWYEVSNWARPGGQCRHNLGYWAGGDWWGAGPG---------------AH
MLBr_00989|M.leprae_Br4923 RSYRVERYLGIIGQVRAAMPHAAITTDLIVGFPGETEEDFAATLDVVRQV
*.*..: *: : : .*
MSMEG_4525|M.smegmatis_MC2_155 GFLNATRWWNAKHPNAYAQTLAE-GALPIADFEVLDAADRHTEDVMLRLR
TH_1442|M.thermoresistible__bu GHLGMTRWWNVKHPARYAEILAD-GRLPIADFEELDEDDRHTEEVMLRLR
Mflv_2687|M.gilvum_PYR-GCK GYVDATRWWNVKHPNAYAATLET-GALPVADLEAIDAETSHVEEVMLKTR
Mvan_3855|M.vanbaalenii_PYR-1 GYVDSVRWWNVKHPNAYAAASDK-GELPVADFEALDEPTAHIEDVMLRVR
Mb2409c|M.bovis_AF2122/97 GYIGVTRWWNVKHPNTYAEILAG-ATLPVAGFEQLGADALHTEDVLLKVR
Rv2388c|M.tuberculosis_H37Rv GYIGVTRWWNVKHPNTYAEILAG-ATLPVAGFEQLGADALHTEDVLLKVR
MMAR_3709|M.marinum_M GYVGATRWWNVKHPNTYAEILAG-SSLPVAGLERLEEDALHTEEVMLGLR
MUL_3651|M.ulcerans_Agy99 GYVGATRWWNVKHPNTYAEILAG-SSLPVAGLERLEEDALHTEEVMLGLR
MAV_1789|M.avium_104 GYVGTTRWWNVKHPNAYAERLNA-AALPVAGFEQLGSEALHTEDVLLKIR
MAB_1663|M.abscessus_ATCC_1997 GHVNGVRWWNVKHPNTYARRLLGEGQLPVGGHEILSPVERHTEEVLLAVR
MLBr_00989|M.leprae_Br4923 RFTAAFTFQYSKRPGTPAAELGGQLPKAVVQERYERLVELQEQICMEENR
. : *:* * .: . : : : *
MSMEG_4525|M.smegmatis_MC2_155 LRRGLALDDLAADERARVPEIVAEGLLDTAGERVVLTDRGR---------
TH_1442|M.thermoresistible__bu LRSGLPLGLLTAAERTRAGTAADAGLVSRHADRLVLTDRGR---------
Mflv_2687|M.gilvum_PYR-GCK LRTGLPAATLSARERERAAVAVADGLLRADGQSFVLTDRGR---------
Mvan_3855|M.vanbaalenii_PYR-1 LRTGLPAAALSAPERRRAERAVADGLLRTDGDALVLTDRGR---------
Mb2409c|M.bovis_AF2122/97 LRQGLPLARLGAAERERAEAVLADGLLDYHGDRLVLTGRGR---------
Rv2388c|M.tuberculosis_H37Rv LRQGLPLARLGAAERERAEAVLADGLLDYHGDRLVLTGRGR---------
MMAR_3709|M.marinum_M LRQGLPLAHLDAGERERAQAAVADGLLTAEGDSVVLTDRGR---------
MUL_3651|M.ulcerans_Agy99 LRQGLPLAHLDAGERERAQAAVADGLLTAEGDSVVLTDRGR---------
MAV_1789|M.avium_104 LRQGLPVDLLNPAERERVQGVVADGLLVRDGDRLVLTPRGR---------
MAB_1663|M.abscessus_ATCC_1997 LNTGIALTDLTIEERGRVPAVVDRGLGRLVDERLVLTDQGR---------
MLBr_00989|M.leprae_Br4923 VLIGRIVELLVTTGEGRKDARTARRTGRARDGRLVHFALDTPWEAQVRPG
: * * . * .* .
MSMEG_4525|M.smegmatis_MC2_155 -----LLADGVVRALLA---------------------------------
TH_1442|M.thermoresistible__bu -----LLADGIVRDLLG---------------------------------
Mflv_2687|M.gilvum_PYR-GCK -----LLADAVVRDLLT---------------------------------
Mvan_3855|M.vanbaalenii_PYR-1 -----LLADAVVRDLLG---------------------------------
Mb2409c|M.bovis_AF2122/97 -----LLADAVVRTLLG---------------------------------
Rv2388c|M.tuberculosis_H37Rv -----LLADAVVRTLLG---------------------------------
MMAR_3709|M.marinum_M -----LLADAVVRTLLG---------------------------------
MUL_3651|M.ulcerans_Agy99 -----LLADAVVRTLLG---------------------------------
MAV_1789|M.avium_104 -----LLADGVVRTLLG---------------------------------
MAB_1663|M.abscessus_ATCC_1997 -----LLADGVVRAILD---------------------------------
MLBr_00989|M.leprae_Br4923 DIITVMVTEAAPHHLIADAGILTHRRTRAGDAHAARQCPRSIGLGQIPLG
::::. : ::
MSMEG_4525|M.smegmatis_MC2_155 ------------------
TH_1442|M.thermoresistible__bu ------------------
Mflv_2687|M.gilvum_PYR-GCK ------------------
Mvan_3855|M.vanbaalenii_PYR-1 ------------------
Mb2409c|M.bovis_AF2122/97 ------------------
Rv2388c|M.tuberculosis_H37Rv ------------------
MMAR_3709|M.marinum_M ------------------
MUL_3651|M.ulcerans_Agy99 ------------------
MAV_1789|M.avium_104 ------------------
MAB_1663|M.abscessus_ATCC_1997 ------------------
MLBr_00989|M.leprae_Br4923 MPSVGQHSASIGSAGCAR