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VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVL LVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLA VLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGA ALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2208 | cobS | - | 100% (249) | cobalamin synthase |
| M. tuberculosis H37Rv | Rv2395 | - | 4e-05 | 23.89% (226) | integral membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2231 | cobS | 1e-136 | 99.60% (249) | cobalamin synthase |
| M. gilvum PYR-GCK | Mflv_2941 | cobS | 2e-79 | 59.43% (244) | cobalamin synthase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1952c | cobS | 3e-66 | 50.81% (246) | cobalamin synthase |
| M. marinum M | MMAR_3253 | cobS | 4e-99 | 72.62% (252) | cobalamin 5'-phosphate synthase CobS |
| M. avium 104 | MAV_2282 | cobS | 5e-95 | 68.92% (251) | cobalamin synthase |
| M. smegmatis MC2 155 | MSMEG_4277 | cobS | 6e-84 | 64.34% (244) | cobalamin synthase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3566 | cobS | 3e-99 | 72.62% (252) | cobalamin synthase |
| M. vanbaalenii PYR-1 | Mvan_3572 | cobS | 1e-81 | 61.07% (244) | cobalamin synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2208|M.tuberculosis_H37Rv ------MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALA
Mb2231|M.bovis_AF2122/97 ------MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALA
MMAR_3253|M.marinum_M ------MIRSLATALSFGTVIPVPASVAAPMGRGAMTALPVVGVVLGGLA
MUL_3566|M.ulcerans_Agy99 ------MIRSLATALSFGTVIPVPASVAAPMGRGAMTALPVVGVVLGGLA
MAV_2282|M.avium_104 ------MMRSLATAFAFGTVLPMPAGGRGPMGRGAMTALPVVGLALGALA
Mflv_2941|M.gilvum_PYR-GCK ------MTRSLAGAFAFATVMPVPSRRAAIAGRGVLTALPVVGLVLGSAA
Mvan_3572|M.vanbaalenii_PYR-1 ------MISSLTGAFAFATVLPTPTRATAMVGRGVLTALPVAGAALGVLA
MSMEG_4277|M.smegmatis_MC2_155 ------MIRSLAGAFAFGTVLPV--RASAGVGRGALTALPFVGLALGALA
MAB_1952c|M.abscessus_ATCC_199 MNALLRILRPVGGAFEFATVAPVPARLAGTLSGPVLGALPVVGAALGVLA
: .: *: *.** * . : ***..* .** *
Rv2208|M.tuberculosis_H37Rv AAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGP
Mb2231|M.bovis_AF2122/97 AAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGP
MMAR_3253|M.marinum_M AGVTWSASLVFGPVSPLPGLLAVAVLLLATRGLHIDAVADTADGLGCYGP
MUL_3566|M.ulcerans_Agy99 AGVTWSASLVFGPVSPLPGLLAVAVLLLATRGLHIDAVADTADGLGCYGP
MAV_2282|M.avium_104 AAVAWGGTVVFGRSSPLGGLLAVAALLLITRGLHIDGVADTADGLGCYGP
Mflv_2941|M.gilvum_PYR-GCK AAVCWLGTRAFGSGSVLAGALTVAVLLLATRGLHIDGLSDTTDALGCYGP
Mvan_3572|M.vanbaalenii_PYR-1 AGVLWAGSWAFGDGSALAGVLTVAVLLLATRGLHIDGLSDTVDALGCYGP
MSMEG_4277|M.smegmatis_MC2_155 AAVVWAGGWAFAAGSPLPGVLAVAVLLLATRGLHIDGFCDTVDGLGCYGP
MAB_1952c|M.abscessus_ATCC_199 AFVAWVMHFAY--MAPIAGLAAVAATILATRGLHIDGLSDTADGLGCYGP
* : * .: : : * :**. :: *******...**.*.******
Rv2208|M.tuberculosis_H37Rv PQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVG---IAGITLAV
Mb2231|M.bovis_AF2122/97 PQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVG---IAGITLAV
MMAR_3253|M.marinum_M PQRALAVMRDGSTGPFGVAAVVLVIAVQGSAFSTLSAAGSRGIAGIAVAV
MUL_3566|M.ulcerans_Agy99 PQRALAVMRDGSTGPFGVAAVVLVIAVQGSAFSTLSAAGSRGIAGIAVAV
MAV_2282|M.avium_104 PDRARAVMRDGSTGPFGVAAVVVVVMAQALAFSAL-AAGRPVPVGVAVAV
Mflv_2941|M.gilvum_PYR-GCK AERALAVMRDGRAGPFGVAAVAVTVVIQSVAFSQAGWAA------VLVAV
Mvan_3572|M.vanbaalenii_PYR-1 PERALAVMRDGTAGPFGVAAVAATLLVQSLAFAQSGWAA------VFIAV
MSMEG_4277|M.smegmatis_MC2_155 PERALAVMRDGSAGPFGVAAVVVVIAVQALTFAELSVLA------VVTAV
MAB_1952c|M.abscessus_ATCC_199 PERALTVMRDGSAGPFGVVVLIICLLAQALSFGVLASRQE--WLAVALAI
.:** :***** :*****..: : *. :*. : *:
Rv2208|M.tuberculosis_H37Rv LSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPA
Mb2231|M.bovis_AF2122/97 LSGRVTAVLVCRRSVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPA
MMAR_3253|M.marinum_M FAGRVTAVLGCRRSVPAAAGSSLGSRVAGTQPISVLVAWLAVLLFASLAA
MUL_3566|M.ulcerans_Agy99 FAGRVTAVLGCRRSVPAAAGSSLGSRVAGTQPISVLVAWLAVLLFASLAA
MAV_2282|M.avium_104 FAGRVAAVLACRRTVPAAAGSSLGAAVAGSQPATVAAAWVAVLLGMSLVA
Mflv_2941|M.gilvum_PYR-GCK AAGRVAVVVACRRGVPAAEGSTLGALVAGTQPLWVAAAWLVAIAGLATLA
Mvan_3572|M.vanbaalenii_PYR-1 VAGRVAVVAACRRGVPAAAGSTLGALVSGTQPRWVAAGWTVAVAAAAVPV
MSMEG_4277|M.smegmatis_MC2_155 VAGRVAVVAACRRSVPAAAGSTLGAAVAGSQPRWVVAGWIVALAALAVFA
MAB_1952c|M.abscessus_ATCC_199 TVGRISAVVACRRGVPGAAASGFGTRVAGSQPLWLAGMWVAAAMAVGLLA
**::.* *** **.* .* :*: *:*:** : * .. . .
Rv2208|M.tuberculosis_H37Rv GP-RPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA
Mb2231|M.bovis_AF2122/97 GP-RPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA
MMAR_3253|M.marinum_M AP-RPWQGPAAVVAAVCAGTLLIRHCVRRFGGITGDVLGCAIELATTVTA
MUL_3566|M.ulcerans_Agy99 AP-RPWQGPAAVVAAVCAGTLLIRHCVRRFGGITGDVLGCAIELATTVTA
MAV_2282|M.avium_104 GP-RPWHGPVAVLLGLGCGAVLVRHCVRRFGGISGDVLGAAIELTATVSA
Mflv_2941|M.gilvum_PYR-GCK GE-RAWQGPLAVVVAVACSVVMVAHCVRRFGGITGDVLGAAVEVTTTVTA
Mvan_3572|M.vanbaalenii_PYR-1 CA-RPWQGPLVVALALACSAGLVAHCVRRFGGITGDVLGAALEVTTTIAA
MSMEG_4277|M.smegmatis_MC2_155 CP-RPWQGPLAVLVAIGCSLALVAHCVRRFGGITGDVLGAAVEVTTTLAA
MAB_1952c|M.abscessus_ATCC_199 QTWRPWQGPVVVAVALIAGALLVRHCVRRFGGITGDVLGASIEITTTVAA
*.*:** .* .: .. : ***:****::*****.::*:::*::*
Rv2208|M.tuberculosis_H37Rv VTLAGLARL
Mb2231|M.bovis_AF2122/97 VTLAGLARL
MMAR_3253|M.marinum_M VVLAALVRL
MUL_3566|M.ulcerans_Agy99 VVLAALVRL
MAV_2282|M.avium_104 VALAALVRV
Mflv_2941|M.gilvum_PYR-GCK LGLAIA---
Mvan_3572|M.vanbaalenii_PYR-1 VGLAVR---
MSMEG_4277|M.smegmatis_MC2_155 LGLAIG---
MAB_1952c|M.abscessus_ATCC_199 LGFAAH---
: :*