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M. marinum M MMAR_3253 (cobS)

annotation: cobalamin 5'-phosphate synthase CobS
coordinates: 3961318 - 3962076
length: 252

VIRSLATALSFGTVIPVPASVAAPMGRGAMTALPVVGVVLGGLAAGVTWSASLVFGPVSPLPGLLAVAVL
LLATRGLHIDAVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAVQGSAFSTLSAAGSRGIAGI
AVAVFAGRVTAVLGCRRSVPAAAGSSLGSRVAGTQPISVLVAWLAVLLFASLAAAPRPWQGPAAVVAAVC
AGTLLIRHCVRRFGGITGDVLGCAIELATTVTAVVLAALVRL
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_3253cobS-100% (252)cobalamin 5'-phosphate synthase CobS

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2231cobS1e-10073.02% (252) cobalamin synthase
M. gilvum PYR-GCKMflv_2941cobS1e-7659.51% (247) cobalamin synthase
M. tuberculosis H37RvRv2208cobS3e-9972.62% (252) cobalamin synthase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_1952ccobS2e-6852.21% (249) cobalamin synthase
M. avium 104MAV_2282cobS3e-9671.03% (252) cobalamin synthase
M. smegmatis MC2 155MSMEG_4277cobS2e-8162.75% (247) cobalamin synthase
M. thermoresistible (build 8)TH_1633-2e-0532.00% (200) transport protein
M. ulcerans Agy99MUL_3566cobS1e-137100.00% (252) cobalamin synthase
M. vanbaalenii PYR-1Mvan_3572cobS2e-7457.09% (247) cobalamin synthase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3253|M.marinum_M               ------MIRSLATALSFGTVIPVPASVAAPMGRGAMTALPVVGVVLGGLA
MUL_3566|M.ulcerans_Agy99           ------MIRSLATALSFGTVIPVPASVAAPMGRGAMTALPVVGVVLGGLA
Mb2231|M.bovis_AF2122/97            ------MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALA
Rv2208|M.tuberculosis_H37Rv         ------MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALA
MAV_2282|M.avium_104                ------MMRSLATAFAFGTVLPMPAGGRGPMGRGAMTALPVVGLALGALA
MSMEG_4277|M.smegmatis_MC2_155      ------MIRSLAGAFAFGTVLP--VRASAGVGRGALTALPFVGLALGALA
Mvan_3572|M.vanbaalenii_PYR-1       ------MISSLTGAFAFATVLPTPTRATAMVGRGVLTALPVAGAALGVLA
Mflv_2941|M.gilvum_PYR-GCK          ------MTRSLAGAFAFATVMPVPSRRAAIAGRGVLTALPVVGLVLGSAA
MAB_1952c|M.abscessus_ATCC_199      MNALLRILRPVGGAFEFATVAPVPARLAGTLSGPVLGALPVVGAALGVLA
TH_1633|M.thermoresistible__bu      -------LRDLSRTGRHIRVTDVVLLLAAGIVGGLTGSIAGLASVATYPA
                                              :  :  .  *                 ::.  . .    *

MMAR_3253|M.marinum_M               AGVTWSASLVFGPVSPLPGLLAVAVLLLATRGLHIDAVADTADGLG--CY
MUL_3566|M.ulcerans_Agy99           AGVTWSASLVFGPVSPLPGLLAVAVLLLATRGLHIDAVADTADGLG--CY
Mb2231|M.bovis_AF2122/97            AAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLG--CY
Rv2208|M.tuberculosis_H37Rv         AAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLG--CY
MAV_2282|M.avium_104                AAVAWGGTVVFGRSSPLGGLLAVAALLLITRGLHIDGVADTADGLG--CY
MSMEG_4277|M.smegmatis_MC2_155      AAVVWAGGWAFAAGSPLPGVLAVAVLLLATRGLHIDGFCDTVDGLG--CY
Mvan_3572|M.vanbaalenii_PYR-1       AGVLWAGSWAFGDGSALAGVLTVAVLLLATRGLHIDGLSDTVDALG--CY
Mflv_2941|M.gilvum_PYR-GCK          AAVCWLGTRAFGSGSVLAGALTVAVLLLATRGLHIDGLSDTTDALG--CY
MAB_1952c|M.abscessus_ATCC_199      AFVAWVMHFAYMA--PIAGLAAVAATILATRGLHIDGLSDTADGLG--CY
TH_1633|M.thermoresistible__bu      LLVVGLPPVTANVTNTVALVFNGVGSVWGSRPELAGRRAWIMRLVPGAAL
                                      :      .      :      .  :  :*    .  .     :   . 

MMAR_3253|M.marinum_M               GPPQRALAVMRDGSTGPFGVAAVVLVIAVQGSAFSTLSAAGSR-GIAGIA
MUL_3566|M.ulcerans_Agy99           GPPQRALAVMRDGSTGPFGVAAVVLVIAVQGSAFSTLSAAGSR-GIAGIA
Mb2231|M.bovis_AF2122/97            GPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVG----IAGIT
Rv2208|M.tuberculosis_H37Rv         GPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVG----IAGIT
MAV_2282|M.avium_104                GPPDRARAVMRDGSTGPFGVAAVVVVVMAQALAFSAL-AAGRP-VPVGVA
MSMEG_4277|M.smegmatis_MC2_155      GPPERALAVMRDGSAGPFGVAAVVVVIAVQALTFAELS-------VLAVV
Mvan_3572|M.vanbaalenii_PYR-1       GPPERALAVMRDGTAGPFGVAAVAATLLVQSLAFAQSG-------WAAVF
Mflv_2941|M.gilvum_PYR-GCK          GPAERALAVMRDGRAGPFGVAAVAVTVVIQSVAFSQAG-------WAAVL
MAB_1952c|M.abscessus_ATCC_199      GPPERALTVMRDGSAGPFGVVVLIICLLAQALSFGVLASRQE---WLAVA
TH_1633|M.thermoresistible__bu      GGLAGAVLLLSIPPEGFENSVPPLLALAALAIAVPRRADRDQTGAGHSRL
                                    *    *  ::     *  . .     :   . :.             .  

MMAR_3253|M.marinum_M               VAVFAGRVTAVLGCRRSVPAAAGSSLGSRVAGTQPISVLVAWLAVLLFAS
MUL_3566|M.ulcerans_Agy99           VAVFAGRVTAVLGCRRSVPAAAGSSLGSRVAGTQPISVLVAWLAVLLFAS
Mb2231|M.bovis_AF2122/97            LAVLSGRVTAVLVCRRSVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVS
Rv2208|M.tuberculosis_H37Rv         LAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVS
MAV_2282|M.avium_104                VAVFAGRVAAVLACRRTVPAAAGSSLGAAVAGSQPATVAAAWVAVLLGMS
MSMEG_4277|M.smegmatis_MC2_155      TAVVAGRVAVVAACRRSVPAAAGSTLGAAVAGSQPRWVVAGWIVALAALA
Mvan_3572|M.vanbaalenii_PYR-1       IAVVAGRVAVVAACRRGVPAAAGSTLGALVSGTQPRWVAAGWTVAVAAAA
Mflv_2941|M.gilvum_PYR-GCK          VAVAAGRVAVVVACRRGVPAAEGSTLGALVAGTQPLWVAAAWLVAIAGLA
MAB_1952c|M.abscessus_ATCC_199      LAITVGRISAVVACRRGVPGAAASGFGTRVAGSQPLWLAGMWVAAAMAVG
TH_1633|M.thermoresistible__bu      LMLQAAAVFVVSIYSGYFGAAAGVLLLAVLLNLSDATLATANAGKNLTLG
                                      :  . : .*      . .* .  : : : . .   :           .

MMAR_3253|M.marinum_M               LAAAP-RPWQGPAAVVAAVCAGTLLIRHCVR--RFG-GITGDVLGCAIEL
MUL_3566|M.ulcerans_Agy99           LAAAP-RPWQGPAAVVAAVCAGTLLIRHCVR--RFG-GITGDVLGCAIEL
Mb2231|M.bovis_AF2122/97            VPAGP-RPWQGPIAVLVAVTAGAALAAHCVH--RFG-GVTGDVLGSAIEL
Rv2208|M.tuberculosis_H37Rv         VPAGP-RPWQGPIAVLVAVTAGAALAAHCVH--RFG-GVTGDVLGSAIEL
MAV_2282|M.avium_104                LVAGP-RPWHGPVAVLLGLGCGAVLVRHCVR--RFG-GISGDVLGAAIEL
MSMEG_4277|M.smegmatis_MC2_155      VFACP-RPWQGPLAVLVAIGCSLALVAHCVR--RFG-GITGDVLGAAVEV
Mvan_3572|M.vanbaalenii_PYR-1       VPVCA-RPWQGPLVVALALACSAGLVAHCVR--RFG-GITGDVLGAALEV
Mflv_2941|M.gilvum_PYR-GCK          TLAGE-RAWQGPLAVVVAVACSVVMVAHCVR--RFG-GITGDVLGAAVEV
MAB_1952c|M.abscessus_ATCC_199      LLAQTWRPWQGPVVVAVALIAGALLVRHCVR--RFG-GITGDVLGASIEI
TH_1633|M.thermoresistible__bu      VANTV-AAAVFAVVAPVQWAAVAPLGAGCLIGSRLGPVVVRHAPATPLRL
                                           .   . ..     .   :   *:   *:*  :  .. . .:.:

MMAR_3253|M.marinum_M               ATTVTAVVLAALVRL----
MUL_3566|M.ulcerans_Agy99           ATTVTAVVLAALVRL----
Mb2231|M.bovis_AF2122/97            STTVSAVTLAGLARL----
Rv2208|M.tuberculosis_H37Rv         STTVSAVTLAGLARL----
MAV_2282|M.avium_104                TATVSAVALAALVRV----
MSMEG_4277|M.smegmatis_MC2_155      TTTLAALGLAIG-------
Mvan_3572|M.vanbaalenii_PYR-1       TTTIAAVGLAVR-------
Mflv_2941|M.gilvum_PYR-GCK          TTTVTALGLAIA-------
MAB_1952c|M.abscessus_ATCC_199      TTTVAALGFAAH-------
TH_1633|M.thermoresistible__bu      LIAASGLALAVKLGLDTYL
                                      : :.: :*