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VIRSLATALSFGTVIPVPASVAAPMGRGAMTALPVVGVVLGGLAAGVTWSASLVFGPVSPLPGLLAVAVL LLATRGLHIDAVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAVQGSAFSTLSAAGSRGIAGI AVAVFAGRVTAVLGCRRSVPAAAGSSLGSRVAGTQPISVLVAWLAVLLFASLAAAPRPWQGPAAVVAAVC AGTLLIRHCVRRFGGITGDVLGCAIELATTVTAVVLAALVRL
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3253 | cobS | - | 100% (252) | cobalamin 5'-phosphate synthase CobS |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2231 | cobS | 1e-100 | 73.02% (252) | cobalamin synthase |
M. gilvum PYR-GCK | Mflv_2941 | cobS | 1e-76 | 59.51% (247) | cobalamin synthase |
M. tuberculosis H37Rv | Rv2208 | cobS | 3e-99 | 72.62% (252) | cobalamin synthase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_1952c | cobS | 2e-68 | 52.21% (249) | cobalamin synthase |
M. avium 104 | MAV_2282 | cobS | 3e-96 | 71.03% (252) | cobalamin synthase |
M. smegmatis MC2 155 | MSMEG_4277 | cobS | 2e-81 | 62.75% (247) | cobalamin synthase |
M. thermoresistible (build 8) | TH_1633 | - | 2e-05 | 32.00% (200) | transport protein |
M. ulcerans Agy99 | MUL_3566 | cobS | 1e-137 | 100.00% (252) | cobalamin synthase |
M. vanbaalenii PYR-1 | Mvan_3572 | cobS | 2e-74 | 57.09% (247) | cobalamin synthase |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_3253|M.marinum_M ------MIRSLATALSFGTVIPVPASVAAPMGRGAMTALPVVGVVLGGLA MUL_3566|M.ulcerans_Agy99 ------MIRSLATALSFGTVIPVPASVAAPMGRGAMTALPVVGVVLGGLA Mb2231|M.bovis_AF2122/97 ------MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALA Rv2208|M.tuberculosis_H37Rv ------MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALA MAV_2282|M.avium_104 ------MMRSLATAFAFGTVLPMPAGGRGPMGRGAMTALPVVGLALGALA MSMEG_4277|M.smegmatis_MC2_155 ------MIRSLAGAFAFGTVLP--VRASAGVGRGALTALPFVGLALGALA Mvan_3572|M.vanbaalenii_PYR-1 ------MISSLTGAFAFATVLPTPTRATAMVGRGVLTALPVAGAALGVLA Mflv_2941|M.gilvum_PYR-GCK ------MTRSLAGAFAFATVMPVPSRRAAIAGRGVLTALPVVGLVLGSAA MAB_1952c|M.abscessus_ATCC_199 MNALLRILRPVGGAFEFATVAPVPARLAGTLSGPVLGALPVVGAALGVLA TH_1633|M.thermoresistible__bu -------LRDLSRTGRHIRVTDVVLLLAAGIVGGLTGSIAGLASVATYPA : : . * ::. . . * MMAR_3253|M.marinum_M AGVTWSASLVFGPVSPLPGLLAVAVLLLATRGLHIDAVADTADGLG--CY MUL_3566|M.ulcerans_Agy99 AGVTWSASLVFGPVSPLPGLLAVAVLLLATRGLHIDAVADTADGLG--CY Mb2231|M.bovis_AF2122/97 AAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLG--CY Rv2208|M.tuberculosis_H37Rv AAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLG--CY MAV_2282|M.avium_104 AAVAWGGTVVFGRSSPLGGLLAVAALLLITRGLHIDGVADTADGLG--CY MSMEG_4277|M.smegmatis_MC2_155 AAVVWAGGWAFAAGSPLPGVLAVAVLLLATRGLHIDGFCDTVDGLG--CY Mvan_3572|M.vanbaalenii_PYR-1 AGVLWAGSWAFGDGSALAGVLTVAVLLLATRGLHIDGLSDTVDALG--CY Mflv_2941|M.gilvum_PYR-GCK AAVCWLGTRAFGSGSVLAGALTVAVLLLATRGLHIDGLSDTTDALG--CY MAB_1952c|M.abscessus_ATCC_199 AFVAWVMHFAYMA--PIAGLAAVAATILATRGLHIDGLSDTADGLG--CY TH_1633|M.thermoresistible__bu LLVVGLPPVTANVTNTVALVFNGVGSVWGSRPELAGRRAWIMRLVPGAAL : . : . : :* . . : . MMAR_3253|M.marinum_M GPPQRALAVMRDGSTGPFGVAAVVLVIAVQGSAFSTLSAAGSR-GIAGIA MUL_3566|M.ulcerans_Agy99 GPPQRALAVMRDGSTGPFGVAAVVLVIAVQGSAFSTLSAAGSR-GIAGIA Mb2231|M.bovis_AF2122/97 GPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVG----IAGIT Rv2208|M.tuberculosis_H37Rv GPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVG----IAGIT MAV_2282|M.avium_104 GPPDRARAVMRDGSTGPFGVAAVVVVVMAQALAFSAL-AAGRP-VPVGVA MSMEG_4277|M.smegmatis_MC2_155 GPPERALAVMRDGSAGPFGVAAVVVVIAVQALTFAELS-------VLAVV Mvan_3572|M.vanbaalenii_PYR-1 GPPERALAVMRDGTAGPFGVAAVAATLLVQSLAFAQSG-------WAAVF Mflv_2941|M.gilvum_PYR-GCK GPAERALAVMRDGRAGPFGVAAVAVTVVIQSVAFSQAG-------WAAVL MAB_1952c|M.abscessus_ATCC_199 GPPERALTVMRDGSAGPFGVVVLIICLLAQALSFGVLASRQE---WLAVA TH_1633|M.thermoresistible__bu GGLAGAVLLLSIPPEGFENSVPPLLALAALAIAVPRRADRDQTGAGHSRL * * :: * . . : . :. . MMAR_3253|M.marinum_M VAVFAGRVTAVLGCRRSVPAAAGSSLGSRVAGTQPISVLVAWLAVLLFAS MUL_3566|M.ulcerans_Agy99 VAVFAGRVTAVLGCRRSVPAAAGSSLGSRVAGTQPISVLVAWLAVLLFAS Mb2231|M.bovis_AF2122/97 LAVLSGRVTAVLVCRRSVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVS Rv2208|M.tuberculosis_H37Rv LAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVS MAV_2282|M.avium_104 VAVFAGRVAAVLACRRTVPAAAGSSLGAAVAGSQPATVAAAWVAVLLGMS MSMEG_4277|M.smegmatis_MC2_155 TAVVAGRVAVVAACRRSVPAAAGSTLGAAVAGSQPRWVVAGWIVALAALA Mvan_3572|M.vanbaalenii_PYR-1 IAVVAGRVAVVAACRRGVPAAAGSTLGALVSGTQPRWVAAGWTVAVAAAA Mflv_2941|M.gilvum_PYR-GCK VAVAAGRVAVVVACRRGVPAAEGSTLGALVAGTQPLWVAAAWLVAIAGLA MAB_1952c|M.abscessus_ATCC_199 LAITVGRISAVVACRRGVPGAAASGFGTRVAGSQPLWLAGMWVAAAMAVG TH_1633|M.thermoresistible__bu LMLQAAAVFVVSIYSGYFGAAAGVLLLAVLLNLSDATLATANAGKNLTLG : . : .* . .* . : : : . . : . MMAR_3253|M.marinum_M LAAAP-RPWQGPAAVVAAVCAGTLLIRHCVR--RFG-GITGDVLGCAIEL MUL_3566|M.ulcerans_Agy99 LAAAP-RPWQGPAAVVAAVCAGTLLIRHCVR--RFG-GITGDVLGCAIEL Mb2231|M.bovis_AF2122/97 VPAGP-RPWQGPIAVLVAVTAGAALAAHCVH--RFG-GVTGDVLGSAIEL Rv2208|M.tuberculosis_H37Rv VPAGP-RPWQGPIAVLVAVTAGAALAAHCVH--RFG-GVTGDVLGSAIEL MAV_2282|M.avium_104 LVAGP-RPWHGPVAVLLGLGCGAVLVRHCVR--RFG-GISGDVLGAAIEL MSMEG_4277|M.smegmatis_MC2_155 VFACP-RPWQGPLAVLVAIGCSLALVAHCVR--RFG-GITGDVLGAAVEV Mvan_3572|M.vanbaalenii_PYR-1 VPVCA-RPWQGPLVVALALACSAGLVAHCVR--RFG-GITGDVLGAALEV Mflv_2941|M.gilvum_PYR-GCK TLAGE-RAWQGPLAVVVAVACSVVMVAHCVR--RFG-GITGDVLGAAVEV MAB_1952c|M.abscessus_ATCC_199 LLAQTWRPWQGPVVVAVALIAGALLVRHCVR--RFG-GITGDVLGASIEI TH_1633|M.thermoresistible__bu VANTV-AAAVFAVVAPVQWAAVAPLGAGCLIGSRLGPVVVRHAPATPLRL . . .. . : *: *:* : .. . .:.: MMAR_3253|M.marinum_M ATTVTAVVLAALVRL---- MUL_3566|M.ulcerans_Agy99 ATTVTAVVLAALVRL---- Mb2231|M.bovis_AF2122/97 STTVSAVTLAGLARL---- Rv2208|M.tuberculosis_H37Rv STTVSAVTLAGLARL---- MAV_2282|M.avium_104 TATVSAVALAALVRV---- MSMEG_4277|M.smegmatis_MC2_155 TTTLAALGLAIG------- Mvan_3572|M.vanbaalenii_PYR-1 TTTIAAVGLAVR------- Mflv_2941|M.gilvum_PYR-GCK TTTVTALGLAIA------- MAB_1952c|M.abscessus_ATCC_199 TTTVAALGFAAH------- TH_1633|M.thermoresistible__bu LIAASGLALAVKLGLDTYL : :.: :*