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VISSLTGAFAFATVLPTPTRATAMVGRGVLTALPVAGAALGVLAAGVLWAGSWAFGDGSALAGVLTVAVL LLATRGLHIDGLSDTVDALGCYGPPERALAVMRDGTAGPFGVAAVAATLLVQSLAFAQSGWAAVFIAVVA GRVAVVAACRRGVPAAAGSTLGALVSGTQPRWVAAGWTVAVAAAAVPVCARPWQGPLVVALALACSAGLV AHCVRRFGGITGDVLGAALEVTTTIAAVGLAVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3572 | cobS | - | 100% (243) | cobalamin synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2231 | cobS | 3e-82 | 61.07% (244) | cobalamin synthase |
| M. gilvum PYR-GCK | Mflv_2941 | cobS | 1e-100 | 73.97% (242) | cobalamin synthase |
| M. tuberculosis H37Rv | Rv2208 | cobS | 9e-82 | 61.07% (244) | cobalamin synthase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1952c | cobS | 6e-73 | 56.50% (246) | cobalamin synthase |
| M. marinum M | MMAR_3253 | cobS | 2e-74 | 57.09% (247) | cobalamin 5'-phosphate synthase CobS |
| M. avium 104 | MAV_2282 | cobS | 3e-77 | 58.94% (246) | cobalamin synthase |
| M. smegmatis MC2 155 | MSMEG_4277 | cobS | 3e-98 | 74.79% (242) | cobalamin synthase |
| M. thermoresistible (build 8) | TH_1460 | - | 5e-07 | 26.40% (250) | competence protein |
| M. ulcerans Agy99 | MUL_3566 | cobS | 1e-74 | 57.09% (247) | cobalamin synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2231|M.bovis_AF2122/97 -------------------MMRSLATAFAFATVIPTPGSATTPMGRGPMT
Rv2208|M.tuberculosis_H37Rv -------------------MMRSLATAFAFATVIPTPGSATTPMGRGPMT
MMAR_3253|M.marinum_M -------------------MIRSLATALSFGTVIPVPASVAAPMGRGAMT
MUL_3566|M.ulcerans_Agy99 -------------------MIRSLATALSFGTVIPVPASVAAPMGRGAMT
MAV_2282|M.avium_104 -------------------MMRSLATAFAFGTVLPMPAGGRGPMGRGAMT
Mvan_3572|M.vanbaalenii_PYR-1 -------------------MISSLTGAFAFATVLPTPTRATAMVGRGVLT
Mflv_2941|M.gilvum_PYR-GCK -------------------MTRSLAGAFAFATVMPVPSRRAAIAGRGVLT
MSMEG_4277|M.smegmatis_MC2_155 -------------------MIRSLAGAFAFGTVLPV--RASAGVGRGALT
MAB_1952c|M.abscessus_ATCC_199 -------------MNALLRILRPVGGAFEFATVAPVPARLAGTLSGPVLG
TH_1460|M.thermoresistible__bu MAVAITLRTDHLDRHPLTDRYGTVAGVVVTPTEIPRPLGGGRLMFRGTLR
.: .. * * :
Mb2231|M.bovis_AF2122/97 ALP-------VVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVT
Rv2208|M.tuberculosis_H37Rv ALP-------VVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVT
MMAR_3253|M.marinum_M ALP-------VVGVVLGGLAAGVTWSASLVFGPVSPLPGLLAVAVLLLAT
MUL_3566|M.ulcerans_Agy99 ALP-------VVGVVLGGLAAGVTWSASLVFGPVSPLPGLLAVAVLLLAT
MAV_2282|M.avium_104 ALP-------VVGLALGALAAAVAWGGTVVFGRSSPLGGLLAVAALLLIT
Mvan_3572|M.vanbaalenii_PYR-1 ALP-------VAGAALGVLAAGVLWAGSWAFGDGSALAGVLTVAVLLLAT
Mflv_2941|M.gilvum_PYR-GCK ALP-------VVGLVLGSAAAAVCWLGTRAFGSGSVLAGALTVAVLLLAT
MSMEG_4277|M.smegmatis_MC2_155 ALP-------FVGLALGALAAAVVWAGGWAFAAGSPLPGVLAVAVLLLAT
MAB_1952c|M.abscessus_ATCC_199 ALP-------VVGAALGVLAAFVAWVMHFAY--MAPIAGLAAVAATILAT
TH_1460|M.thermoresistible__bu SADGQRMSGRVVVFASAARYGELIAGQPAGFTARIGRPARRDLTVATLSA
: .. . . . : : . ::. : :
Mb2231|M.bovis_AF2122/97 RGLHID---------------GVADTADGLG---------------CYGP
Rv2208|M.tuberculosis_H37Rv RGLHID---------------GVADTADGLG---------------CYGP
MMAR_3253|M.marinum_M RGLHID---------------AVADTADGLG---------------CYGP
MUL_3566|M.ulcerans_Agy99 RGLHID---------------AVADTADGLG---------------CYGP
MAV_2282|M.avium_104 RGLHID---------------GVADTADGLG---------------CYGP
Mvan_3572|M.vanbaalenii_PYR-1 RGLHID---------------GLSDTVDALG---------------CYGP
Mflv_2941|M.gilvum_PYR-GCK RGLHID---------------GLSDTTDALG---------------CYGP
MSMEG_4277|M.smegmatis_MC2_155 RGLHID---------------GFCDTVDGLG---------------CYGP
MAB_1952c|M.abscessus_ATCC_199 RGLHID---------------GLSDTADGLG---------------CYGP
TH_1460|M.thermoresistible__bu TGSPVPGDAPALLRAAHRVRAGFAESARAVLPAEQAAMLPALVLGDTSAV
* : ...::. .: .
Mb2231|M.bovis_AF2122/97 PQRALAVMRDG----------------------STGPFGVAAVVLVIALQ
Rv2208|M.tuberculosis_H37Rv PQRALAVMRDG----------------------STGPFGVAAVVLVIALQ
MMAR_3253|M.marinum_M PQRALAVMRDG----------------------STGPFGVAAVVLVIAVQ
MUL_3566|M.ulcerans_Agy99 PQRALAVMRDG----------------------STGPFGVAAVVLVIAVQ
MAV_2282|M.avium_104 PDRARAVMRDG----------------------STGPFGVAAVVVVVMAQ
Mvan_3572|M.vanbaalenii_PYR-1 PERALAVMRDG----------------------TAGPFGVAAVAATLLVQ
Mflv_2941|M.gilvum_PYR-GCK AERALAVMRDG----------------------RAGPFGVAAVAVTVVIQ
MSMEG_4277|M.smegmatis_MC2_155 PERALAVMRDG----------------------SAGPFGVAAVVVVIAVQ
MAB_1952c|M.abscessus_ATCC_199 PERALTVMRDG----------------------SAGPFGVVVLIICLLAQ
TH_1460|M.thermoresistible__bu SGRVTAEFRAAGLTHLTAVSGANVTIVCGAVLLSAAVVGPRCAVAAAAVA
. *. : :* . :. .*
Mb2231|M.bovis_AF2122/97 GLAFATLTTVG---IAGITLAVLSGRVTAVLVCRRSVPAAHGSTLGSRVA
Rv2208|M.tuberculosis_H37Rv GLAFATLTTVG---IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVA
MMAR_3253|M.marinum_M GSAFSTLSAAGSRGIAGIAVAVFAGRVTAVLGCRRSVPAAAGSSLGSRVA
MUL_3566|M.ulcerans_Agy99 GSAFSTLSAAGSRGIAGIAVAVFAGRVTAVLGCRRSVPAAAGSSLGSRVA
MAV_2282|M.avium_104 ALAFSAL-AAGRPVPVGVAVAVFAGRVAAVLACRRTVPAAAGSSLGAAVA
Mvan_3572|M.vanbaalenii_PYR-1 SLAFAQSGWAA------VFIAVVAGRVAVVAACRRGVPAAAGSTLGALVS
Mflv_2941|M.gilvum_PYR-GCK SVAFSQAGWAA------VLVAVAAGRVAVVVACRRGVPAAEGSTLGALVA
MSMEG_4277|M.smegmatis_MC2_155 ALTFAELSVLA------VVTAVVAGRVAVVAACRRSVPAAAGSTLGAAVA
MAB_1952c|M.abscessus_ATCC_199 ALSFGVLASRQE--WLAVALAITVGRISAVVACRRGVPGAAASGFGTRVA
TH_1460|M.thermoresistible__bu LVAFVIVVLPSASVLRAAVMAAITLLAMVSHRRRQAIPALAASVLGLVVA
:* * . *: :*. .* :* *:
Mb2231|M.bovis_AF2122/97 GTQPAPVVAAWLAVLLAVSVPAGP---------RPWQGPIAVLVAVTAGA
Rv2208|M.tuberculosis_H37Rv GTQPAPVVAAWLAVLLAVSVPAGP---------RPWQGPIAVLVAVTAGA
MMAR_3253|M.marinum_M GTQPISVLVAWLAVLLFASLAAAP---------RPWQGPAAVVAAVCAGT
MUL_3566|M.ulcerans_Agy99 GTQPISVLVAWLAVLLFASLAAAP---------RPWQGPAAVVAAVCAGT
MAV_2282|M.avium_104 GSQPATVAAAWVAVLLGMSLVAGP---------RPWHGPVAVLLGLGCGA
Mvan_3572|M.vanbaalenii_PYR-1 GTQPRWVAAGWTVAVAAAAVPVCA---------RPWQGPLVVALALACSA
Mflv_2941|M.gilvum_PYR-GCK GTQPLWVAAAWLVAIAGLATLAGE---------RAWQGPLAVVVAVACSV
MSMEG_4277|M.smegmatis_MC2_155 GSQPRWVVAGWIVALAALAVFACP---------RPWQGPLAVLVAIGCSL
MAB_1952c|M.abscessus_ATCC_199 GSQPLWLAGMWVAAAMAVGLLAQTW--------RPWQGPVVVAVALIAGA
TH_1460|M.thermoresistible__bu APELAVDAGFALSVAATAALIVIAPAWSRRLTARGWPKPLADAVSIATAA
..: . . . * * * . .: .
Mb2231|M.bovis_AF2122/97 ALAAH---------------------------------------------
Rv2208|M.tuberculosis_H37Rv ALAAH---------------------------------------------
MMAR_3253|M.marinum_M LLIRH---------------------------------------------
MUL_3566|M.ulcerans_Agy99 LLIRH---------------------------------------------
MAV_2282|M.avium_104 VLVRH---------------------------------------------
Mvan_3572|M.vanbaalenii_PYR-1 GLVAH---------------------------------------------
Mflv_2941|M.gilvum_PYR-GCK VMVAH---------------------------------------------
MSMEG_4277|M.smegmatis_MC2_155 ALVAH---------------------------------------------
MAB_1952c|M.abscessus_ATCC_199 LLVRH---------------------------------------------
TH_1460|M.thermoresistible__bu QVVTAPLIAGISGRLSLVSIAANLAVAVVIPPITVLGTVAAALGACWPDG
:
Mb2231|M.bovis_AF2122/97 --CVHRFGG-----------VTGDVLGSAIELSTTVSAVTLAGLARL---
Rv2208|M.tuberculosis_H37Rv --CVHRFGG-----------VTGDVLGSAIELSTTVSAVTLAGLARL---
MMAR_3253|M.marinum_M --CVRRFGG-----------ITGDVLGCAIELATTVTAVVLAALVRL---
MUL_3566|M.ulcerans_Agy99 --CVRRFGG-----------ITGDVLGCAIELATTVTAVVLAALVRL---
MAV_2282|M.avium_104 --CVRRFGG-----------ISGDVLGAAIELTATVSAVALAALVRV---
Mvan_3572|M.vanbaalenii_PYR-1 --CVRRFGG-----------ITGDVLGAALEVTTTIAAVGLAVR------
Mflv_2941|M.gilvum_PYR-GCK --CVRRFGG-----------ITGDVLGAAVEVTTTVTALGLAIA------
MSMEG_4277|M.smegmatis_MC2_155 --CVRRFGG-----------ITGDVLGAAVEVTTTLAALGLAIG------
MAB_1952c|M.abscessus_ATCC_199 --CVRRFGG-----------ITGDVLGASIEITTTVAALGFAAH------
TH_1460|M.thermoresistible__bu AQLLIRFAGPEVWWLLEVARWSAAVPGSAVPVPSGVAGVTVVAGGAVAAV
: **.* :. * *.:: :.: ::.: ..
Mb2231|M.bovis_AF2122/97 -------------------------------
Rv2208|M.tuberculosis_H37Rv -------------------------------
MMAR_3253|M.marinum_M -------------------------------
MUL_3566|M.ulcerans_Agy99 -------------------------------
MAV_2282|M.avium_104 -------------------------------
Mvan_3572|M.vanbaalenii_PYR-1 -------------------------------
Mflv_2941|M.gilvum_PYR-GCK -------------------------------
MSMEG_4277|M.smegmatis_MC2_155 -------------------------------
MAB_1952c|M.abscessus_ATCC_199 -------------------------------
TH_1460|M.thermoresistible__bu LLWRRPWIRWATAGTVLSLVAWTVAGPGPSG