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KDTVSQPAGGRGATAPRPADAASPSCGSSPSADSVSVVLAGGGTAGHVEPAMAVADALVALDPRVRITAL GTLRGLETRLVPQRGYHLELITAVPMPRKPGGDLARLPSRVWRAVREARDVLDDVDADVVVGFGGYVALP AYLAARGLPLPPRRRRRIPVVIHEANARAGLANRVGAHTADRVLSAVPDSGLRRAEVVGVPVRASIAALD RAVLRAEARAHFGFPDDARVLLVFGGSQGAVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGD PPYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGLPAIYVPLPIGNGEQRLNALPVVNAGGGMVVA DAALTPELVARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALAVATGAGARTTT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2153c | murG | - | 100% (410) | N-acetylglucosaminyl transferase |
| M. tuberculosis H37Rv | Rv2958c | - | 4e-06 | 29.86% (144) | glycosyl transferase |
| M. tuberculosis H37Rv | Rv2739c | - | 4e-06 | 28.12% (313) | alanine rich transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2177c | murG | 0.0 | 99.51% (410) | undecaprenyldiphospho-muramoylpentapeptide beta-N- |
| M. gilvum PYR-GCK | Mflv_2988 | murG | 1e-154 | 73.96% (384) | N-acetylglucosaminyl transferase |
| M. leprae Br4923 | MLBr_00914 | murG | 1e-163 | 76.56% (401) | undecaprenyldiphospho-muramoylpentapeptide beta-N- |
| M. abscessus ATCC 19977 | MAB_2006 | murG | 1e-151 | 76.50% (366) | undecaprenyldiphospho-muramoylpentapeptide beta-N- |
| M. marinum M | MMAR_3193 | murG | 1e-173 | 79.27% (410) | UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide) |
| M. avium 104 | MAV_2336 | murG | 1e-169 | 78.10% (411) | N-acetylglucosaminyl transferase |
| M. smegmatis MC2 155 | MSMEG_4227 | murG | 1e-149 | 75.88% (369) | N-acetylglucosaminyl transferase |
| M. thermoresistible (build 8) | TH_1477 | - | 1e-151 | 77.05% (366) | Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) |
| M. ulcerans Agy99 | MUL_3501 | murG | 1e-173 | 79.27% (410) | undecaprenyldiphospho-muramoylpentapeptide beta-N- |
| M. vanbaalenii PYR-1 | Mvan_3523 | murG | 1e-151 | 71.00% (400) | N-acetylglucosaminyl transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2153c|M.tuberculosis_H37Rv ---------------MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADS
Mb2177c|M.bovis_AF2122/97 ---------------MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADS
MMAR_3193|M.marinum_M ---------------MNDTVREPTGGLGV-NHGPA---------------
MUL_3501|M.ulcerans_Agy99 ---------------MNDTVREPAGGLGV-NHGPA---------------
MAV_2336|M.avium_104 ---------------MNDTVKKPTGGRGD-DPLPAGAALSAVAPH---EP
MLBr_00914|M.leprae_Br4923 ---------------MNNSVREPTRGRRG-SPPVADAALSVN------PP
MAB_2006|M.abscessus_ATCC_1997 ---------------MSDELRP----------------------------
Mflv_2988|M.gilvum_PYR-GCK MT-------------GISVPAGQARRDRA---------------------
Mvan_3523|M.vanbaalenii_PYR-1 MTRISVPAGQERNDGGISVPAGQERSDRG---------------------
MSMEG_4227|M.smegmatis_MC2_155 ---------------MNKGSRDNNHSDRG---------------------
TH_1477|M.thermoresistible__bu ---------------MPD-PEDREMVDRE---------------------
.
Rv2153c|M.tuberculosis_H37Rv VSVVLAGGGTAGHVEPAMAVADALVALDPRVRITALGTLRGLETRLVPQR
Mb2177c|M.bovis_AF2122/97 LSVVLAGGGTAGHVEPAMAVADALVALDPRVRITALGTPRGLETRLVPQR
MMAR_3193|M.marinum_M LSVVLAGGGTAGHVEPAMAVADALSVLEPNVRITALGTARGLETRLVPAR
MUL_3501|M.ulcerans_Agy99 LSVVLAGGGTAGHVEPAMAVADALSVLEPNVRITALGTSRGLETRLVPAR
MAV_2336|M.avium_104 VSVVLAGGGTAGHVEPAMAVADALKALDPNVRITSLGTARGLETRLVPER
MLBr_00914|M.leprae_Br4923 LSVVLAGGGTAGHVEPAMAVADALRALDPQVRITALGTSRGLETRLVPER
MAB_2006|M.abscessus_ATCC_1997 LSVVLAGGGTAGHVEPAMAVADALREIDPTVRITALGTERGLETRLVPDR
Mflv_2988|M.gilvum_PYR-GCK ISVVLAGGGTAGHIEPAMAVADALTALEPNVRITALGTARGLETRLVPQR
Mvan_3523|M.vanbaalenii_PYR-1 ISVVLAGGGTAGHIEPAMAVADALTALDPDVRITALGTERGLETRLVPQR
MSMEG_4227|M.smegmatis_MC2_155 ISVVLAGGGTAGHVEPAMAVADALRALDPDVRITALGTQRGLETRLVPQR
TH_1477|M.thermoresistible__bu ISVVLAGGGTAGHVEPAMAVADALTALEPGVRITALGTHRGLETRLVPER
:************:********** ::* ****:*** ********* *
Rv2153c|M.tuberculosis_H37Rv GYHLELITAVPMPRKPGGDLARLPSRVWRAVREARDVLDDVDADVVVGFG
Mb2177c|M.bovis_AF2122/97 GYHLELITAVPMPRKPGGDLARLPSRVWRAVREARDVLDDVDADVVVGFG
MMAR_3193|M.marinum_M GYHLELITPVPLPRKPSGDLARLPPRVWRAVRETRAVLDLVDADVVIGFG
MUL_3501|M.ulcerans_Agy99 GYHLELITPVPLPRKPSGDLARLPPRVWRSVRETRAVLDLVDADVVIGFG
MAV_2336|M.avium_104 GYDLELITPVPLPRKPTGDLARLPSRVWRAVRETRAVLHAVDADVVIGFG
MLBr_00914|M.leprae_Br4923 GYHLELITPVPLPRKLTGDLARLPLRVWRAVRETRAVFEVVEAHVVVGFG
MAB_2006|M.abscessus_ATCC_1997 GYHLELIVPVPLPRRLTGDLVRLPLRVRRAVRQTRAVFDGVQADVVIGFG
Mflv_2988|M.gilvum_PYR-GCK GYDLELITPVPLPRKLSADLLRLPMRVRRAVRETRAVFEAVDADVVIGFG
Mvan_3523|M.vanbaalenii_PYR-1 GYHLELITLVPLPRKLSADLFRLPMRVLRAVRQTRRILDEVSADVVVGFG
MSMEG_4227|M.smegmatis_MC2_155 GYDLELITPVPLPRKPSKDLLRLPMRVRTAIRQTRDVLTGVNADVVVGFG
TH_1477|M.thermoresistible__bu GYRLELITPVPLPRKPTADLARLPLRVRRAVRETRAVLDAVRADVVIGFG
** ****. **:**: ** *** ** ::*::* :: * *.**:***
Rv2153c|M.tuberculosis_H37Rv GYVALPAYLAARGLPLPPRRRRRIPVVIHEANARAGLANRVGAHTADRVL
Mb2177c|M.bovis_AF2122/97 GYVALPAYLAARGLPLPPRRRRRIPVVIHEANARAGLANRVGAHTADRVL
MMAR_3193|M.marinum_M GYVALPAYLAARGIPG---LRRRIPVVIHEANARAGLANRVGLRTADRVL
MUL_3501|M.ulcerans_Agy99 GYVALPAYLAARGIPG---LRRRIPVVIHEANARAGLANRVGLRTADRVL
MAV_2336|M.avium_104 GYVALPAYLAARGVSP---RKPRVPVVIHEANASAGLANRVGARTAQRVL
MLBr_00914|M.leprae_Br4923 GYVALPAYLAARGIPR---VRRRIPVVVHEANARAGIANRVGVRTAERVL
MAB_2006|M.abscessus_ATCC_1997 GYVALPAYLAARRGPL---RRRRVPVVIHEANARAGLANRVGARGAQRVL
Mflv_2988|M.gilvum_PYR-GCK GYVALPAYLAAR---------RRVPVVVHEANASAGWANKVGARVATRVL
Mvan_3523|M.vanbaalenii_PYR-1 GYVAVPAYLAARS-LR---THRRVPVVVHEANASAGWANKVGARSAQRVL
MSMEG_4227|M.smegmatis_MC2_155 GYVALPAYLAARGGLT---GRRKVPVVVHEANARAGLANRVGARSARRVL
TH_1477|M.thermoresistible__bu GYVALPAYLAARGGLR---RRSAVPVVVHEANAHAGWANRVGARAAQRVL
****:******* :***:***** ** **:** : * ***
Rv2153c|M.tuberculosis_H37Rv SAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVF
Mb2177c|M.bovis_AF2122/97 SAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVF
MMAR_3193|M.marinum_M SAVPDSGLRGAEVVGVPVRAAITALDRMALRAEARAHFGFADDARVLLVF
MUL_3501|M.ulcerans_Agy99 SAVPDSGLRGAEVVGVPVRAAITALDRMALRAEARAHFGFADDARVLLVF
MAV_2336|M.avium_104 SAVADCGLPGAEVVGVPVREAITSLDRAAVRAEARRHFGFADDARVLLVF
MLBr_00914|M.leprae_Br4923 SAVPGSGLRGAEVVGVPIHATITTLNRPALRADARKHFGFTDDARVLLVF
MAB_2006|M.abscessus_ATCC_1997 SAVPDSGLRDAEVVGVPVRGSITALDRAALRHQARAHYGFDDDALVLLVF
Mflv_2988|M.gilvum_PYR-GCK SAVPDPGLGHVDVVGVPVREAITSLDRSALRAEARAHFGFADDARVLLVF
Mvan_3523|M.vanbaalenii_PYR-1 SAVPDPGLPHVEVVGVPVREAITSLDRMALRAEARAHFGFADDARVLLVF
MSMEG_4227|M.smegmatis_MC2_155 SAVPDSGLRNVEVVGVPVRESITSLDRAALRAQARAEFGFAEDARVLLVF
TH_1477|M.thermoresistible__bu SAVPDPGLGPVEVVGVPLRSSITSMDRHALRAEARACFGFDADARVLLVF
***.. ** .:*****:: :*::::* .:* :** :** ** *****
Rv2153c|M.tuberculosis_H37Rv GGSQGAVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQ---GDP
Mb2177c|M.bovis_AF2122/97 GGSQGAVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQ---GDP
MMAR_3193|M.marinum_M GGSQGAVSLNKAVSAAAAELAASGVSVLHAHGPKNVLELLAPRTPGQDDP
MUL_3501|M.ulcerans_Agy99 GGSQGAVSLNKAVSAAAAELAASGVSVLHAHGPKNVLELLAPRTPDQDDP
MAV_2336|M.avium_104 GGSQGAASLNRAVSGAAAQLAAAGVSVLHAHGPKNTLDLREPQP---GDP
MLBr_00914|M.leprae_Br4923 GGSQGAVSLNRAVAGAAEDLAASGVAVLHAYGLKNTLELRTPEY---GEP
MAB_2006|M.abscessus_ATCC_1997 GGSQGAVSLNNAVSAAANDLAAAGVSVLHAHGPKNTIKLPERPP---GAP
Mflv_2988|M.gilvum_PYR-GCK GGSQGAQSLNRAVSGAAEGLAAAGISVLHAHGPKNTLDLRAPRP---GDP
Mvan_3523|M.vanbaalenii_PYR-1 GGSQGAQSLNRAVAGAAEKLAEQGISVLHAHGPKNTLDLPAPRP---GDP
MSMEG_4227|M.smegmatis_MC2_155 GGSQGAQSINRAVSAAAKDLAAAGISVLHAHGPKNTLDLPPADP---QAP
TH_1477|M.thermoresistible__bu GGSQGAQSINRAVAAAARRLAAAGISVLHAHGPKNTLQLPAPAD---GAP
****** *:*.**:.** ** *:.****:* :*.:.* *
Rv2153c|M.tuberculosis_H37Rv PYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGLPAIYVPLPIGNG
Mb2177c|M.bovis_AF2122/97 PYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGLPAIYVPLPIGNG
MMAR_3193|M.marinum_M PYVAVPYLDRMDLAYAAADLVICRSGAMTVAEVSAVGLPAIYVPLPIGNG
MUL_3501|M.ulcerans_Agy99 PYVAVPYLDRMDLAYAAADLVICRSGAMTVAEVSAVGLPAIYVPLPIGNG
MAV_2336|M.avium_104 PYVAVPYLDRMDLAYAAADLVICRSGAMTVAEVSAVGLPAIYVPLPIGNG
MLBr_00914|M.leprae_Br4923 PYVAVPYLDRMDLAYAAADLVICRSGAMTVAEVSAVGLPAIYVPFPIGNG
MAB_2006|M.abscessus_ATCC_1997 RYVALPYLDRMDLAYAAADIAVCRSGAMTVAEVSAVGLPAIYVPLPIGNG
Mflv_2988|M.gilvum_PYR-GCK PYVAVPYLERMDLAYAAADLAVCRSGAMTVAEVSAVGLPAVYVPLPIGNG
Mvan_3523|M.vanbaalenii_PYR-1 PYVAVPYLERMDLAYAAADLAVCRSGAMTVAEVSAVGLPAVYVPLPIGNG
MSMEG_4227|M.smegmatis_MC2_155 PYVAVPYLDRMDLAYAAADLAICRSGAMTVAEVTAVGLPAIYVPLPIGNG
TH_1477|M.thermoresistible__bu PYVAVPYLDRMDLAYAAADLAICRSGAMTVAEVSAVGLPAIYVPLPIGNG
***:***:**:*******:.:**:********:******:***:*****
Rv2153c|M.tuberculosis_H37Rv EQRLNALPVVNAGGGMVVADAALTPELVARQVAGLLTDPARLAAMTAAAA
Mb2177c|M.bovis_AF2122/97 EQRLNALPVVNAGGGMVVADAALTPELVARQVAGLLTDPARLAAMTAAAA
MMAR_3193|M.marinum_M EQRLNALPVVNAGGGMVVADADLTPALVAREVTGLLTDPPRLAAMTAAAA
MUL_3501|M.ulcerans_Agy99 EQRLNALPVVNAGGGMVVADADLTPALVAREVTGLLTDPPRLAAMTAAAA
MAV_2336|M.avium_104 EQRLNALPVVNAGGGMVVADADLTPELVAREVAGLVGDPPRLAAMTTAAA
MLBr_00914|M.leprae_Br4923 EQRLNALPVVNAGGGLVVADADLTPGLVARQVVRLFSDPAQLAAMTAAAA
MAB_2006|M.abscessus_ATCC_1997 EQRLNALPIVDAGGGVIVADRDLTPESLAHMVIEMVSDPAKLAAMTSAAA
Mflv_2988|M.gilvum_PYR-GCK EQRLNALPVVEAGGGLVVDDASLTPQFVAGTVAGLLNDPDRLATMTAAAA
Mvan_3523|M.vanbaalenii_PYR-1 EQRLNALPVVEAGGGILVEDRSLTPEFVAETVPGLLNNADTLAAMTAAAA
MSMEG_4227|M.smegmatis_MC2_155 EQRLNALPVVDAGGGLLVDDADLSGDTVARTVIPLLTDDSKLAAMTAAAS
TH_1477|M.thermoresistible__bu EQRFNALPVVQAGGGLLIDDADLGPDLVADTVIGLLTDPARLAAMTTAAA
***:****:*:****::: * * :* * :. : **:**:**:
Rv2153c|M.tuberculosis_H37Rv RVGHRDAAGQVARAALAVATGAG---ARTTT-----------------
Mb2177c|M.bovis_AF2122/97 RVGHRDAAGQVARAALAVATGAG---ARTTT-----------------
MMAR_3193|M.marinum_M QVGHRDAAAQVAQAALDIARLAPS--RRRAVGGRR-------------
MUL_3501|M.ulcerans_Agy99 QVGHRDAAAQVAQAALDIARLAPS--RRRAVGGRR-------------
MAV_2336|M.avium_104 RVGHPDAARRVAQAALDIGRTARR--ARGATGGRP-------------
MLBr_00914|M.leprae_Br4923 RVGHRDAAHHVAKVALDLARAERDTASGRSAGGKP-------------
MAB_2006|M.abscessus_ATCC_1997 LSGHPEAARQVAQVALDVARERRS----RERGGRR-------------
Mflv_2988|M.gilvum_PYR-GCK LAGHPDAARRVAEVALDVARGTGS--RR--------------------
Mvan_3523|M.vanbaalenii_PYR-1 LAGHPDAARRVAEVALEVARRARD--LRTRR-----------------
MSMEG_4227|M.smegmatis_MC2_155 LSGHPDAARRVAQVALEIARAARK--KAS-------------------
TH_1477|M.thermoresistible__bu LAGHRDAAEQVAKVALEVARDGRR--ARDGSAGRVVRRTSRSRREGGR
** :** :**..** :.