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IIVVGIGADGMTGLSEHSRSELRRATVIYGSKRQLALLDDTVTAERWEWPTPMLPAVQGLSPDGADLHVV ASGDPLLHGIGSTLIRLFGHDNVTVLPHVSAVTLACARMGWNVYDTEVISLVTAQPHTAVRRGGRAIVLS GDRSTPQALAVLLTEHGRGDSKFSVLEQLGGPAERRRDGTARAWACDPPLDVDELNVIAVRYLLDERTSW APDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWCRSWPGCTAVAFERDERRRRNIG FNAAAFGVSVDVRGDAPDAFDDAARPSVIFLGGGVTQPGLLEACLDSLPAGGNLVANAVTVESEAALAHA YSRLGGELRRFQHYLGEPLGGFTGWRPQLPVTQWSVTKR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2072c | cobL | - | 100% (390) | Probable precorrin-6y methyltransferase CobL |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2098c | cobLb | 1e-172 | 99.66% (294) | precorrin-6y methyltransferase |
| M. gilvum PYR-GCK | Mflv_3101 | - | 1e-146 | 68.68% (380) | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2195 | - | 1e-122 | 58.48% (395) | precorrin-6Y C5,15-methyltransferase CobL |
| M. marinum M | MMAR_3054 | cobL | 1e-176 | 75.64% (390) | precorrin-6y methyltransferase, CobL |
| M. avium 104 | MAV_2424 | cobL | 1e-158 | 70.77% (390) | precorrin-6Y C5,15-methyltransferase (decarboxylating) |
| M. smegmatis MC2 155 | MSMEG_3878 | cobL | 1e-156 | 70.84% (391) | precorrin-6Y C5,15-methyltransferase (decarboxylating) |
| M. thermoresistible (build 8) | TH_0444 | cobL | 1e-157 | 71.61% (391) | Probable precorrin-6y methyltransferase CobL |
| M. ulcerans Agy99 | MUL_2298 | cobL | 1e-176 | 75.90% (390) | precorrin-6y methyltransferase, CobL |
| M. vanbaalenii PYR-1 | Mvan_3434 | - | 1e-153 | 68.54% (391) | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2072c|M.tuberculosis_H37Rv ------------------------------MIIVVGIGADGMTGLSEHSR
Mb2098c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3054|M.marinum_M ------------------------------MIVVVGIGADGMPGLSDASR
MUL_2298|M.ulcerans_Agy99 ------------------------------MIVVVGIGADGIPGLSDASR
MAV_2424|M.avium_104 ------------------------------MIVVVGIGADGMAGLAEASR
Mflv_3101|M.gilvum_PYR-GCK -----------------------------------------MSGLPEVSR
Mvan_3434|M.vanbaalenii_PYR-1 ------------------------------MIIVVGIGADGMAGLAPASR
TH_0444|M.thermoresistible__bu ------------------------------MITVVGIGADGMAGLSAESR
MSMEG_3878|M.smegmatis_MC2_155 ----------------------------MKLIIVVGIGADGMPGLSAASR
MAB_2195|M.abscessus_ATCC_1997 MAQDAAMSPSGEEHGAPMSPSGHEPEAPTGRITVVGIGADGVDGLSARSR
Rv2072c|M.tuberculosis_H37Rv SELRRATVIYGSKRQLALLDDT-VTAERWEWPTPMLPAVQGLSPDGA-DL
Mb2098c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3054|M.marinum_M CELQRATIIYGSKRQLDLLDET-VTTSRREWPSPMLPALRQLPADGP-DI
MUL_2298|M.ulcerans_Agy99 CELQRATIIYGSKRQLDLLDET-VTASRPEWPSPMLPALQQLPADGP-DI
MAV_2424|M.avium_104 AELRSAAVIYGSKRQLDLLDDT-VPAPRRHWPSPMLPALQSLLDDHTGDV
Mflv_3101|M.gilvum_PYR-GCK SELSRATVIYGSQRQLDLLDGT-VTAARRTWPSPLLPALPSLMDDSGGDI
Mvan_3434|M.vanbaalenii_PYR-1 AELARATVVYGSRRQLELLDGT-VTAPRRAWPTPLLPALGTLLDGGDADV
TH_0444|M.thermoresistible__bu AELARATVIYGSERQLGLLDDT-VTAERRAWPSPLLPALRSLDPDT--DP
MSMEG_3878|M.smegmatis_MC2_155 DELARATVVFGAPRQLALLDDT-VIADRREWPSPMLPALPTLFDDFGGDV
MAB_2195|M.abscessus_ATCC_1997 RELHRASVIFGSLRQLELLAEESLVAECRVWPSPLLPALPTMFDGLG-DV
Rv2072c|M.tuberculosis_H37Rv HVVASGDPLLHGIGSTLIRLFGHDNVTVLPHVSAVTLACARMGWNVYDTE
Mb2098c|M.bovis_AF2122/97 ----------------------------MPHVSAVTLACARMGWNVYDTE
MMAR_3054|M.marinum_M HVVASGDPLMHGIGGTLIRLFGPEHVRVVPHVSAVTLACARMGWNVHDTE
MUL_2298|M.ulcerans_Agy99 HVVASGDPLMHGIGGTLIRLFGPEHVRVVPHVSAVTLACARMGWNVHDTE
MAV_2424|M.avium_104 HIVASGDPLLHGIGGTLIRLYGAGRVRVLPHVSSVTLACARMGWNVHDTE
Mflv_3101|M.gilvum_PYR-GCK HVIASGDPLLHGIGGTLITLLGAQRVAVLPHVSSVTLACARVGWPVQDTE
Mvan_3434|M.vanbaalenii_PYR-1 HVVASGDPMLHGIGSTLIRLHGPDKVAVLPHVSSVTLACARVGWSVQDTE
TH_0444|M.thermoresistible__bu HVLASGDPLLHGIGATLIRHFGTDRVRILPHVSSVTLACARMGWPVQDTE
MSMEG_3878|M.smegmatis_MC2_155 HVVASGDPLCHGIGATLIRLFGADRVRVLPHVSSVTLACARMGWTVPDTE
MAB_2195|M.abscessus_ATCC_1997 HVLASGDPMLHGIGTTLTRLFGAQRVDVHPHISSVSLACSRMGWAVNDIE
**:*:*:***:*:** * * *
Rv2072c|M.tuberculosis_H37Rv VISLVTAQPHTAVRRGGRAIVLSGDRSTPQALAVLLTEHGRGDSKFSVLE
Mb2098c|M.bovis_AF2122/97 VISLVTAQPHTAVRRGGRAIVLSGDRSTPQALAVLLTEHGRGDSKFSVLE
MMAR_3054|M.marinum_M VISLVTAPPHTALRRGGQAIILSNSKATPSQLAALLHAHGRGDSEFSVLE
MUL_2298|M.ulcerans_Agy99 VISLVTAPPHTALRRGGQAIILSNSKATPSQLAALLHAHGSGDSEFSVLE
MAV_2424|M.avium_104 VISLVTGQPHTAVRRGGQAIVLSQGAATPTELAALLTAHGRGDSQFTVLE
Mflv_3101|M.gilvum_PYR-GCK IISLVNADPHTAVRRGGQAVVLSRDGSTPAALARLLTDAGRGDSELTILE
Mvan_3434|M.vanbaalenii_PYR-1 IISLVWHEPHTAVRRGGQAVVLSRDGSTPAELARLLTDAGRGDSELTVLE
TH_0444|M.thermoresistible__bu VISVVTAEVHTAVRRGGRAVVLSRDGGTPAALARLLARTGRGESRLAVLE
MSMEG_3878|M.smegmatis_MC2_155 VISLVTAPPHTAVRRGGRAVVLSRDASTPTDLARLLTESGRGDSGFTVLE
MAB_2195|M.abscessus_ATCC_1997 IISLVNAPARSARRFGGRAVVLSRNAGTPRELAQTLSESGLGDSRLTVWE
:**:* ::* * **:*::** . .** ** * * *:* ::: *
Rv2072c|M.tuberculosis_H37Rv QLGGPAERRRDGTARAWACDPPLDVDELNVIAVRYLLDER------TSWA
Mb2098c|M.bovis_AF2122/97 QLGGPAERRRDGTARAWACDPPLDVDELNVIAVRYLPDER------TSWA
MMAR_3054|M.marinum_M QLGGRAERHRHGTARKWAAEAPVDVDDLNVIAIRYLPEAR------VLAP
MUL_2298|M.ulcerans_Agy99 QLGGPLERHRHGTARKWAAEAPVDVDDLNVIAIRYLPEAR------VLAP
MAV_2424|M.avium_104 RLGALDEHRRDGTARDWA-DGAADIDPLNVIAVRYLPDER------VWPL
Mflv_3101|M.gilvum_PYR-GCK QLGGPGELRCSATAREWAARPPGDVDALNVIAVRYLPDARR-----HGAL
Mvan_3434|M.vanbaalenii_PYR-1 QLGGPKELRRTSTAREWAARPPADVDDLNVMAVRYLPDVRV-----LGTL
TH_0444|M.thermoresistible__bu QLGGPRERRRDGTAERWAADPPTDVDDLNVIAVHYLPDARQ-----GQVL
MSMEG_3878|M.smegmatis_MC2_155 QLGGPGERRRDGTAADWSAAPAPDVDDLNVVAVTYRPEDRR-----AHAL
MAB_2195|M.abscessus_ATCC_1997 QLGGAGEHSFGGVARSWDHPLG---DALNVIAVEYVPAEEVAILPLVAGL
:**. * ..* * * ***:*: * .
Rv2072c|M.tuberculosis_H37Rv PDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWCRSW
Mb2098c|M.bovis_AF2122/97 PDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWCRSW
MMAR_3054|M.marinum_M PDDAFAHDGQITKHGIRALTVAALAPRPGERLWDVGSGSGSIAVQWCRSW
MUL_2298|M.ulcerans_Agy99 PDDAFAHDGQITKHGIRALTVAALAPRPGERLWDVGSGSGSIAVQWCRSW
MAV_2424|M.avium_104 PDDAFTHDGQITKQRIRAVTLAALAPRPGERLWDVGAGSGSISVEWCLSG
Mflv_3101|M.gilvum_PYR-GCK PDDAFAHDGQITKQAIRAATLAALAPRPGQLLWDVGAGSGSVSVEWCLAG
Mvan_3434|M.vanbaalenii_PYR-1 PDDAFAHDGQLTKQMIRAATLAALAPRPGELLWDVGAGSGSISIEWCRSG
TH_0444|M.thermoresistible__bu PDDQFDHDGQLTKQSIRAVTLAALAPRPGELLWDVGAGSGSIAIEWCRSA
MSMEG_3878|M.smegmatis_MC2_155 PDEQFSHDGQITKQSIRAVTLAALGPRPGELLWDVGSGSGSIAIEWCRSA
MAB_2195|M.abscessus_ATCC_1997 PESVFEHDGQITKHEIRAVTLAALGPRPGQRLWDVGAGSGSIAVEWSRSG
*:. * ****:**: **. *:***.****: *****:***:::::*. :
Rv2072c|M.tuberculosis_H37Rv PGCTAVAFERDERRRRNIGFNAAAFGVSVDVRGDAPDAFDDAARPSVIFL
Mb2098c|M.bovis_AF2122/97 PGCTAVAFERDERRRRNIGFNAAAFGVSVDVRGDAPDAFDDAARPSVIFL
MMAR_3054|M.marinum_M PGCTAVAFERDERRRANIESNAVSFGVSIDARGEAPLAFEGTAEPSAIFL
MUL_2298|M.ulcerans_Agy99 PGCTAVAFERDERRRANIESNAVSFGVSVDARGEAPLAFEGTAEPSAIFL
MAV_2424|M.avium_104 TGCRATAFERDAQRRHNLAANAAAFGAAIDVRGDAPHAFVGAEPPSAIFI
Mflv_3101|M.gilvum_PYR-GCK TGCRAVAFERDEARRARITVNANTFGVRIEVGSDAPDSFGMAPPPDAVFV
Mvan_3434|M.vanbaalenii_PYR-1 PGCRAIAFERDEARRARITENAVAHGAGVEVRFDAPESFDSSPPPAAVFV
TH_0444|M.thermoresistible__bu TGCRAVAFEQDEQRRERITANAAAFGAPVQVFGAAPAAFGGAPDPAAIFV
MSMEG_3878|M.smegmatis_MC2_155 PGCTAVAFERDEQRRDRIRANVEAFGVRVDLRGAAPECFDGAPAPAAIFI
MAB_2195|M.abscessus_ATCC_1997 TGCSASAFEIEPSRRASIAANATKFGVDIDVFGAAPDDFEQAVAPDVIFV
.** * *** : ** : *. .*. :: ** * : * .:*:
Rv2072c|M.tuberculosis_H37Rv GGGVTQPGLLEACLDSLPAGGNLVANAVTVESEAALAHAYSRLGGELRRF
Mb2098c|M.bovis_AF2122/97 GGGVTQPGLLEACLDSLPAGGNLVANAVTVESEAALAHAYSRLGGELRRF
MMAR_3054|M.marinum_M GGGLTQPGLLDSCLGHLPTGGRLVANVVTAESEAALVHAHSRLGGQLRRF
MUL_2298|M.ulcerans_Agy99 GGGLTQPGLLDSCLGHLPTGGRLVANVVTAESEAALVHAHSRLGGQLRRF
MAV_2424|M.avium_104 GGGLTRPGLLDACFDHLPSGGRLVANVVTTESEAVVIQAYTRFGGQLRRF
Mflv_3101|M.gilvum_PYR-GCK GGGVSSPGLLQACWDALRDGGRMVVNAVTVESEAVLAHWYSQHGGELRRF
Mvan_3434|M.vanbaalenii_PYR-1 GGGVSRPGMIDACWERLGPGGRLVANAVTVESEAVLAQWYSRVGGELRRY
TH_0444|M.thermoresistible__bu GGGVTGDGLLEACLQRLPAGGRLVANAVTAESEAVLAQWYSERGGELRRY
MSMEG_3878|M.smegmatis_MC2_155 GGGVTGPGVLEACFDRLSTGGRLVVNAVTVESEAVVAQWYSEKGGDLRRY
MAB_2195|M.abscessus_ATCC_1997 GGGVTQPGLLEACWERLPIGGRMVVNAVTAESEALLLRWYCRYGGELRRY
***:: *::::* * **.:*.*.**.**** : : : . **:***:
Rv2072c|M.tuberculosis_H37Rv QHYLGEPLGGFTGWRPQLPVTQWSVTKR-------
Mb2098c|M.bovis_AF2122/97 QHYLGEPLGGFTGWRPQLPVTQWSVTKR-------
MMAR_3054|M.marinum_M QHYQGEPLGGFTGWRPQMPVTQWAVTKR-------
MUL_2298|M.ulcerans_Agy99 QHYQGEPLGGFTGWRPQMPVTQWAVTKR-------
MAV_2424|M.avium_104 QHYHGKALGAFTGWHPQFPVTQWAVTR--------
Mflv_3101|M.gilvum_PYR-GCK QHYRGEAVGTFTGWRPAMPVTQWSVTKAVSMPDTT
Mvan_3434|M.vanbaalenii_PYR-1 QHYRGEAVGSFTGWRPAMPVTQWSVTK----PDTT
TH_0444|M.thermoresistible__bu QHYRGEPIGRFTGWRPAYPVTQWSVTKR-------
MSMEG_3878|M.smegmatis_MC2_155 QHYQGGAVGGFTAWRPALPVTQWSVVKA-------
MAB_2195|M.abscessus_ATCC_1997 RVEDAAPLGGFTSWRSRLPVVQWSTEKS-------
: . .:* **.*:. **.**:. :