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MSGLPEVSRSELSRATVIYGSQRQLDLLDGTVTAARRTWPSPLLPALPSLMDDSGGDIHVIASGDPLLHG IGGTLITLLGAQRVAVLPHVSSVTLACARVGWPVQDTEIISLVNADPHTAVRRGGQAVVLSRDGSTPAAL ARLLTDAGRGDSELTILEQLGGPGELRCSATAREWAARPPGDVDALNVIAVRYLPDARRHGALPDDAFAH DGQITKQAIRAATLAALAPRPGQLLWDVGAGSGSVSVEWCLAGTGCRAVAFERDEARRARITVNANTFGV RIEVGSDAPDSFGMAPPPDAVFVGGGVSSPGLLQACWDALRDGGRMVVNAVTVESEAVLAHWYSQHGGEL RRFQHYRGEAVGTFTGWRPAMPVTQWSVTKAVSMPDTT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3101 | - | - | 100% (388) | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit |
| M. gilvum PYR-GCK | Mflv_3104 | - | 3e-05 | 24.81% (262) | precorrin-3B C17-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2098c | cobLb | 1e-115 | 69.39% (294) | precorrin-6y methyltransferase |
| M. tuberculosis H37Rv | Rv2072c | cobL | 1e-146 | 68.68% (380) | precorrin-6y methyltransferase CobL |
| M. leprae Br4923 | MLBr_02273 | ubiE | 3e-05 | 27.78% (180) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. abscessus ATCC 19977 | MAB_2195 | - | 1e-121 | 58.66% (387) | precorrin-6Y C5,15-methyltransferase CobL |
| M. marinum M | MMAR_3054 | cobL | 1e-140 | 65.00% (380) | precorrin-6y methyltransferase, CobL |
| M. avium 104 | MAV_2424 | cobL | 1e-147 | 67.37% (380) | precorrin-6Y C5,15-methyltransferase (decarboxylating) |
| M. smegmatis MC2 155 | MSMEG_3878 | cobL | 1e-156 | 69.03% (381) | precorrin-6Y C5,15-methyltransferase (decarboxylating) |
| M. thermoresistible (build 8) | TH_0444 | cobL | 1e-156 | 71.58% (380) | Probable precorrin-6y methyltransferase CobL |
| M. ulcerans Agy99 | MUL_2298 | cobL | 1e-139 | 64.81% (378) | precorrin-6y methyltransferase, CobL |
| M. vanbaalenii PYR-1 | Mvan_3434 | - | 1e-176 | 77.58% (388) | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2098c|M.bovis_AF2122/97 --------------------------------------------------
Rv2072c|M.tuberculosis_H37Rv ------------------------------MIIVVGIGADGMTGLSEHSR
MMAR_3054|M.marinum_M ------------------------------MIVVVGIGADGMPGLSDASR
MUL_2298|M.ulcerans_Agy99 ------------------------------MIVVVGIGADGIPGLSDASR
MAV_2424|M.avium_104 ------------------------------MIVVVGIGADGMAGLAEASR
Mflv_3101|M.gilvum_PYR-GCK -----------------------------------------MSGLPEVSR
Mvan_3434|M.vanbaalenii_PYR-1 ------------------------------MIIVVGIGADGMAGLAPASR
MSMEG_3878|M.smegmatis_MC2_155 ----------------------------MKLIIVVGIGADGMPGLSAASR
TH_0444|M.thermoresistible__bu ------------------------------MITVVGIGADGMAGLSAESR
MAB_2195|M.abscessus_ATCC_1997 MAQDAAMSPSGEEHGAPMSPSGHEPEAPTGRITVVGIGADGVDGLSARSR
MLBr_02273|M.leprae_Br4923 --------------------------------------------MPPGSV
Mb2098c|M.bovis_AF2122/97 --------------------------------------------------
Rv2072c|M.tuberculosis_H37Rv SELRRATVIYGSKRQLALLDDT-VTAERWEWPTPMLPAVQGLSPDGA-DL
MMAR_3054|M.marinum_M CELQRATIIYGSKRQLDLLDET-VTTSRREWPSPMLPALRQLPADGP-DI
MUL_2298|M.ulcerans_Agy99 CELQRATIIYGSKRQLDLLDET-VTASRPEWPSPMLPALQQLPADGP-DI
MAV_2424|M.avium_104 AELRSAAVIYGSKRQLDLLDDT-VPAPRRHWPSPMLPALQSLLDDHTGDV
Mflv_3101|M.gilvum_PYR-GCK SELSRATVIYGSQRQLDLLDGT-VTAARRTWPSPLLPALPSLMDDSGGDI
Mvan_3434|M.vanbaalenii_PYR-1 AELARATVVYGSRRQLELLDGT-VTAPRRAWPTPLLPALGTLLDGGDADV
MSMEG_3878|M.smegmatis_MC2_155 DELARATVVFGAPRQLALLDDT-VIADRREWPSPMLPALPTLFDDFGGDV
TH_0444|M.thermoresistible__bu AELARATVIYGSERQLGLLDDT-VTAERRAWPSPLLPALRSLDPDT--DP
MAB_2195|M.abscessus_ATCC_1997 RELHRASVIFGSLRQLELLAEESLVAECRVWPSPLLPALPTMFDGLG-DV
MLBr_02273|M.leprae_Br4923 DVVSRAALDKDPRDVVAMFDDV----------------------------
Mb2098c|M.bovis_AF2122/97 ----------------------------MPHVSAVTLACARMGWNVYDTE
Rv2072c|M.tuberculosis_H37Rv HVVASGDPLLHGIGSTLIRLFGHDNVTVLPHVSAVTLACARMGWNVYDTE
MMAR_3054|M.marinum_M HVVASGDPLMHGIGGTLIRLFGPEHVRVVPHVSAVTLACARMGWNVHDTE
MUL_2298|M.ulcerans_Agy99 HVVASGDPLMHGIGGTLIRLFGPEHVRVVPHVSAVTLACARMGWNVHDTE
MAV_2424|M.avium_104 HIVASGDPLLHGIGGTLIRLYGAGRVRVLPHVSSVTLACARMGWNVHDTE
Mflv_3101|M.gilvum_PYR-GCK HVIASGDPLLHGIGGTLITLLGAQRVAVLPHVSSVTLACARVGWPVQDTE
Mvan_3434|M.vanbaalenii_PYR-1 HVVASGDPMLHGIGSTLIRLHGPDKVAVLPHVSSVTLACARVGWSVQDTE
MSMEG_3878|M.smegmatis_MC2_155 HVVASGDPLCHGIGATLIRLFGADRVRVLPHVSSVTLACARMGWTVPDTE
TH_0444|M.thermoresistible__bu HVLASGDPLLHGIGATLIRHFGTDRVRILPHVSSVTLACARMGWPVQDTE
MAB_2195|M.abscessus_ATCC_1997 HVLASGDPMLHGIGTTLTRLFGAQRVDVHPHISSVSLACSRMGWAVNDIE
MLBr_02273|M.leprae_Br4923 -----------------------------AHRYDLTNTVLSLGQDR----
.* :: : :*
Mb2098c|M.bovis_AF2122/97 VISLVTAQPHTAVRRGGRAIVLSGDRSTPQALAVLLTEHGRGDSKFSVLE
Rv2072c|M.tuberculosis_H37Rv VISLVTAQPHTAVRRGGRAIVLSGDRSTPQALAVLLTEHGRGDSKFSVLE
MMAR_3054|M.marinum_M VISLVTAPPHTALRRGGQAIILSNSKATPSQLAALLHAHGRGDSEFSVLE
MUL_2298|M.ulcerans_Agy99 VISLVTAPPHTALRRGGQAIILSNSKATPSQLAALLHAHGSGDSEFSVLE
MAV_2424|M.avium_104 VISLVTGQPHTAVRRGGQAIVLSQGAATPTELAALLTAHGRGDSQFTVLE
Mflv_3101|M.gilvum_PYR-GCK IISLVNADPHTAVRRGGQAVVLSRDGSTPAALARLLTDAGRGDSELTILE
Mvan_3434|M.vanbaalenii_PYR-1 IISLVWHEPHTAVRRGGQAVVLSRDGSTPAELARLLTDAGRGDSELTVLE
MSMEG_3878|M.smegmatis_MC2_155 VISLVTAPPHTAVRRGGRAVVLSRDASTPTDLARLLTESGRGDSGFTVLE
TH_0444|M.thermoresistible__bu VISVVTAEVHTAVRRGGRAVVLSRDGGTPAALARLLARTGRGESRLAVLE
MAB_2195|M.abscessus_ATCC_1997 IISLVNAPARSARRFGGRAVVLSRNAGTPRELAQTLSESGLGDSRLTVWE
MLBr_02273|M.leprae_Br4923 ---YWRRATRSALRIGPGQKVLDLAAGTAVSTAELSK-------------
::* * * :*. .*. *
Mb2098c|M.bovis_AF2122/97 QLGGPAERRRDGTARAWACDPPLDVDELNVIAVRYLPDER------TSWA
Rv2072c|M.tuberculosis_H37Rv QLGGPAERRRDGTARAWACDPPLDVDELNVIAVRYLLDER------TSWA
MMAR_3054|M.marinum_M QLGGRAERHRHGTARKWAAEAPVDVDDLNVIAIRYLPEAR------VLAP
MUL_2298|M.ulcerans_Agy99 QLGGPLERHRHGTARKWAAEAPVDVDDLNVIAIRYLPEAR------VLAP
MAV_2424|M.avium_104 RLGALDEHRRDGTARDWA-DGAADIDPLNVIAVRYLPDER------VWPL
Mflv_3101|M.gilvum_PYR-GCK QLGGPGELRCSATAREWAARPPGDVDALNVIAVRYLPDARR-----HGAL
Mvan_3434|M.vanbaalenii_PYR-1 QLGGPKELRRTSTAREWAARPPADVDDLNVMAVRYLPDVRV-----LGTL
MSMEG_3878|M.smegmatis_MC2_155 QLGGPGERRRDGTAADWSAAPAPDVDDLNVVAVTYRPEDRR-----AHAL
TH_0444|M.thermoresistible__bu QLGGPRERRRDGTAERWAADPPTDVDDLNVIAVHYLPDARQ-----GQVL
MAB_2195|M.abscessus_ATCC_1997 QLGGAGEHSFGGVARSWDHPLG---DALNVIAVEYVPAEEVAILPLVAGL
MLBr_02273|M.leprae_Br4923 -------------SGAWCVAADFSVRMLATGGARKVPKVAAD----ATQL
: * * . .
Mb2098c|M.bovis_AF2122/97 PDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWCRSW
Rv2072c|M.tuberculosis_H37Rv PDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWCRSW
MMAR_3054|M.marinum_M PDDAFAHDGQITKHGIRALTVAALAPRPGERLWDVGSGSGSIAVQWCRSW
MUL_2298|M.ulcerans_Agy99 PDDAFAHDGQITKHGIRALTVAALAPRPGERLWDVGSGSGSIAVQWCRSW
MAV_2424|M.avium_104 PDDAFTHDGQITKQRIRAVTLAALAPRPGERLWDVGAGSGSISVEWCLSG
Mflv_3101|M.gilvum_PYR-GCK PDDAFAHDGQITKQAIRAATLAALAPRPGQLLWDVGAGSGSVSVEWCLAG
Mvan_3434|M.vanbaalenii_PYR-1 PDDAFAHDGQLTKQMIRAATLAALAPRPGELLWDVGAGSGSISIEWCRSG
MSMEG_3878|M.smegmatis_MC2_155 PDEQFSHDGQITKQSIRAVTLAALGPRPGELLWDVGSGSGSIAIEWCRSA
TH_0444|M.thermoresistible__bu PDDQFDHDGQLTKQSIRAVTLAALAPRPGELLWDVGAGSGSIAIEWCRSA
MAB_2195|M.abscessus_ATCC_1997 PESVFEHDGQITKHEIRAVTLAALGPRPGQRLWDVGAGSGSIAVEWSRSG
MLBr_02273|M.leprae_Br4923 PFSDGVFDAVTISFGLRNIADYQAALR--EMARVTRPGGQLVVCEFSTPT
* . .*. . :* : . * : . .*. : ::. .
Mb2098c|M.bovis_AF2122/97 PGCTAVAFERDERRRRNIGFNAAAFGVSVDVRGDAPDAFDDAARPSVIFL
Rv2072c|M.tuberculosis_H37Rv PGCTAVAFERDERRRRNIGFNAAAFGVSVDVRGDAPDAFDDAARPSVIFL
MMAR_3054|M.marinum_M PGCTAVAFERDERRRANIESNAVSFGVSIDARGEAPLAFEGTAEPSAIFL
MUL_2298|M.ulcerans_Agy99 PGCTAVAFERDERRRANIESNAVSFGVSVDARGEAPLAFEGTAEPSAIFL
MAV_2424|M.avium_104 TGCRATAFERDAQRRHNLAANAAAFGAAIDVRGDAPHAFVGAEPPSAIFI
Mflv_3101|M.gilvum_PYR-GCK TGCRAVAFERDEARRARITVNANTFGVRIEVGSDAPDSFGMAPPPDAVFV
Mvan_3434|M.vanbaalenii_PYR-1 PGCRAIAFERDEARRARITENAVAHGAGVEVRFDAPESFDSSPPPAAVFV
MSMEG_3878|M.smegmatis_MC2_155 PGCTAVAFERDEQRRDRIRANVEAFGVRVDLRGAAPECFDGAPAPAAIFI
TH_0444|M.thermoresistible__bu TGCRAVAFEQDEQRRERITANAAAFGAPVQVFGAAPAAFGGAPDPAAIFV
MAB_2195|M.abscessus_ATCC_1997 TGCSASAFEIEPSRRASIAANATKFGVDIDVFGAAPDDFEQAVAPDVIFV
MLBr_02273|M.leprae_Br4923 NALVANVYTEYLMR---------ALPQVARLVSSNPDAY--------IYL
. * .: * * : :::
Mb2098c|M.bovis_AF2122/97 GGGVTQPGLLEACLDSLPAGGNLVANAVTVESEAALAHAYSRLGGELRRF
Rv2072c|M.tuberculosis_H37Rv GGGVTQPGLLEACLDSLPAGGNLVANAVTVESEAALAHAYSRLGGELRRF
MMAR_3054|M.marinum_M GGGLTQPGLLDSCLGHLPTGGRLVANVVTAESEAALVHAHSRLGGQLRRF
MUL_2298|M.ulcerans_Agy99 GGGLTQPGLLDSCLGHLPTGGRLVANVVTAESEAALVHAHSRLGGQLRRF
MAV_2424|M.avium_104 GGGLTRPGLLDACFDHLPSGGRLVANVVTTESEAVVIQAYTRFGGQLRRF
Mflv_3101|M.gilvum_PYR-GCK GGGVSSPGLLQACWDALRDGGRMVVNAVTVESEAVLAHWYSQHGGELRRF
Mvan_3434|M.vanbaalenii_PYR-1 GGGVSRPGMIDACWERLGPGGRLVANAVTVESEAVLAQWYSRVGGELRRY
MSMEG_3878|M.smegmatis_MC2_155 GGGVTGPGVLEACFDRLSTGGRLVVNAVTVESEAVVAQWYSEKGGDLRRY
TH_0444|M.thermoresistible__bu GGGVTGDGLLEACLQRLPAGGRLVANAVTAESEAVLAQWYSERGGELRRY
MAB_2195|M.abscessus_ATCC_1997 GGGVTQPGLLEACWERLPIGGRMVVNAVTAESEALLLRWYCRYGGELRRY
MLBr_02273|M.leprae_Br4923 AESIR-----------------------AWPDQVTLACQLSRTGWASPRW
. .: : .:. : . * *:
Mb2098c|M.bovis_AF2122/97 QHYLGEPLGGFTGWRPQLPVTQWSVTKR-------
Rv2072c|M.tuberculosis_H37Rv QHYLGEPLGGFTGWRPQLPVTQWSVTKR-------
MMAR_3054|M.marinum_M QHYQGEPLGGFTGWRPQMPVTQWAVTKR-------
MUL_2298|M.ulcerans_Agy99 QHYQGEPLGGFTGWRPQMPVTQWAVTKR-------
MAV_2424|M.avium_104 QHYHGKALGAFTGWHPQFPVTQWAVTR--------
Mflv_3101|M.gilvum_PYR-GCK QHYRGEAVGTFTGWRPAMPVTQWSVTKAVSMPDTT
Mvan_3434|M.vanbaalenii_PYR-1 QHYRGEAVGSFTGWRPAMPVTQWSVTK----PDTT
MSMEG_3878|M.smegmatis_MC2_155 QHYQGGAVGGFTAWRPALPVTQWSVVKA-------
TH_0444|M.thermoresistible__bu QHYRGEPIGRFTGWRPAYPVTQWSVTKR-------
MAB_2195|M.abscessus_ATCC_1997 RVEDAAPLGGFTSWRSRLPVVQWSTEKS-------
MLBr_02273|M.leprae_Br4923 RNLTGGIVALHAADKPVR-----------------
: . :. .:. :.