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M. abscessus ATCC 19977 MAB_2195 (-)

annotation: precorrin-6Y C5,15-methyltransferase CobL
coordinates: 2209762 - 2211036
length: 424

MAQDAAMSPSGEEHGAPMSPSGHEPEAPTGRITVVGIGADGVDGLSARSRRELHRASVIFGSLRQLELLA
EESLVAECRVWPSPLLPALPTMFDGLGDVHVLASGDPMLHGIGTTLTRLFGAQRVDVHPHISSVSLACSR
MGWAVNDIEIISLVNAPARSARRFGGRAVVLSRNAGTPRELAQTLSESGLGDSRLTVWEQLGGAGEHSFG
GVARSWDHPLGDALNVIAVEYVPAEEVAILPLVAGLPESVFEHDGQITKHEIRAVTLAALGPRPGQRLWD
VGAGSGSIAVEWSRSGTGCSASAFEIEPSRRASIAANATKFGVDIDVFGAAPDDFEQAVAPDVIFVGGGV
TQPGLLEACWERLPIGGRMVVNAVTAESEALLLRWYCRYGGELRRYRVEDAAPLGGFTSWRSRLPVVQWS
TEKS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. abscessus ATCC 19977MAB_2195--100% (424)precorrin-6Y C5,15-methyltransferase CobL

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2098ccobLb3e-9359.06% (298) precorrin-6y methyltransferase
M. gilvum PYR-GCKMflv_3101-1e-12058.66% (387) precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT
M. tuberculosis H37RvRv2072ccobL1e-12258.48% (395) precorrin-6y methyltransferase CobL
M. leprae Br4923MLBr_02273ubiE3e-0528.57% (133) ubiquinone/menaquinone biosynthesis methyltransferase
M. marinum MMMAR_3054cobL1e-11955.70% (395) precorrin-6y methyltransferase, CobL
M. avium 104MAV_2424cobL1e-12156.71% (395) precorrin-6Y C5,15-methyltransferase (decarboxylating)
M. smegmatis MC2 155MSMEG_3878cobL1e-13160.96% (397) precorrin-6Y C5,15-methyltransferase (decarboxylating)
M. thermoresistible (build 8)TH_0444cobL1e-12460.51% (395) Probable precorrin-6y methyltransferase CobL
M. ulcerans Agy99MUL_2298cobL1e-11855.44% (395) precorrin-6y methyltransferase, CobL
M. vanbaalenii PYR-1Mvan_3434-1e-11956.82% (396) precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_3878|M.smegmatis_MC2_155      ----------------------------MKLIIVVGIGADGMPGLSAASR
TH_0444|M.thermoresistible__bu      ------------------------------MITVVGIGADGMAGLSAESR
Mflv_3101|M.gilvum_PYR-GCK          -----------------------------------------MSGLPEVSR
Mvan_3434|M.vanbaalenii_PYR-1       ------------------------------MIIVVGIGADGMAGLAPASR
Mb2098c|M.bovis_AF2122/97           --------------------------------------------------
Rv2072c|M.tuberculosis_H37Rv        ------------------------------MIIVVGIGADGMTGLSEHSR
MMAR_3054|M.marinum_M               ------------------------------MIVVVGIGADGMPGLSDASR
MUL_2298|M.ulcerans_Agy99           ------------------------------MIVVVGIGADGIPGLSDASR
MAV_2424|M.avium_104                ------------------------------MIVVVGIGADGMAGLAEASR
MAB_2195|M.abscessus_ATCC_1997      MAQDAAMSPSGEEHGAPMSPSGHEPEAPTGRITVVGIGADGVDGLSARSR
MLBr_02273|M.leprae_Br4923          --------------------------------------------MPPGSV
                                                                                      

MSMEG_3878|M.smegmatis_MC2_155      DELARATVVFGAPRQLALLDDT-VIADRREWPSPMLPALPTLFDDFGGDV
TH_0444|M.thermoresistible__bu      AELARATVIYGSERQLGLLDDT-VTAERRAWPSPLLPALRSLDPDT--DP
Mflv_3101|M.gilvum_PYR-GCK          SELSRATVIYGSQRQLDLLDGT-VTAARRTWPSPLLPALPSLMDDSGGDI
Mvan_3434|M.vanbaalenii_PYR-1       AELARATVVYGSRRQLELLDGT-VTAPRRAWPTPLLPALGTLLDGGDADV
Mb2098c|M.bovis_AF2122/97           --------------------------------------------------
Rv2072c|M.tuberculosis_H37Rv        SELRRATVIYGSKRQLALLDDT-VTAERWEWPTPMLPAVQGLSPDGA-DL
MMAR_3054|M.marinum_M               CELQRATIIYGSKRQLDLLDET-VTTSRREWPSPMLPALRQLPADGP-DI
MUL_2298|M.ulcerans_Agy99           CELQRATIIYGSKRQLDLLDET-VTASRPEWPSPMLPALQQLPADGP-DI
MAV_2424|M.avium_104                AELRSAAVIYGSKRQLDLLDDT-VPAPRRHWPSPMLPALQSLLDDHTGDV
MAB_2195|M.abscessus_ATCC_1997      RELHRASVIFGSLRQLELLAEESLVAECRVWPSPLLPALPTMFDGLG-DV
MLBr_02273|M.leprae_Br4923          DVVSRAALDKDPRDVVAMFDDV----------------------------
                                                                                      

MSMEG_3878|M.smegmatis_MC2_155      HVVASGDPLCHGIGATLIRLFGADRVRVLPHVSSVTLACARMGWTVPDTE
TH_0444|M.thermoresistible__bu      HVLASGDPLLHGIGATLIRHFGTDRVRILPHVSSVTLACARMGWPVQDTE
Mflv_3101|M.gilvum_PYR-GCK          HVIASGDPLLHGIGGTLITLLGAQRVAVLPHVSSVTLACARVGWPVQDTE
Mvan_3434|M.vanbaalenii_PYR-1       HVVASGDPMLHGIGSTLIRLHGPDKVAVLPHVSSVTLACARVGWSVQDTE
Mb2098c|M.bovis_AF2122/97           ----------------------------MPHVSAVTLACARMGWNVYDTE
Rv2072c|M.tuberculosis_H37Rv        HVVASGDPLLHGIGSTLIRLFGHDNVTVLPHVSAVTLACARMGWNVYDTE
MMAR_3054|M.marinum_M               HVVASGDPLMHGIGGTLIRLFGPEHVRVVPHVSAVTLACARMGWNVHDTE
MUL_2298|M.ulcerans_Agy99           HVVASGDPLMHGIGGTLIRLFGPEHVRVVPHVSAVTLACARMGWNVHDTE
MAV_2424|M.avium_104                HIVASGDPLLHGIGGTLIRLYGAGRVRVLPHVSSVTLACARMGWNVHDTE
MAB_2195|M.abscessus_ATCC_1997      HVLASGDPMLHGIGTTLTRLFGAQRVDVHPHISSVSLACSRMGWAVNDIE
MLBr_02273|M.leprae_Br4923          -----------------------------AHRYDLTNTVLSLGQDR----
                                                                 .*   :: :   :*       

MSMEG_3878|M.smegmatis_MC2_155      VISLVTAPPHTAVRRGGRAVVLSRDASTPTDLARLLTESGRGDSGFTVLE
TH_0444|M.thermoresistible__bu      VISVVTAEVHTAVRRGGRAVVLSRDGGTPAALARLLARTGRGESRLAVLE
Mflv_3101|M.gilvum_PYR-GCK          IISLVNADPHTAVRRGGQAVVLSRDGSTPAALARLLTDAGRGDSELTILE
Mvan_3434|M.vanbaalenii_PYR-1       IISLVWHEPHTAVRRGGQAVVLSRDGSTPAELARLLTDAGRGDSELTVLE
Mb2098c|M.bovis_AF2122/97           VISLVTAQPHTAVRRGGRAIVLSGDRSTPQALAVLLTEHGRGDSKFSVLE
Rv2072c|M.tuberculosis_H37Rv        VISLVTAQPHTAVRRGGRAIVLSGDRSTPQALAVLLTEHGRGDSKFSVLE
MMAR_3054|M.marinum_M               VISLVTAPPHTALRRGGQAIILSNSKATPSQLAALLHAHGRGDSEFSVLE
MUL_2298|M.ulcerans_Agy99           VISLVTAPPHTALRRGGQAIILSNSKATPSQLAALLHAHGSGDSEFSVLE
MAV_2424|M.avium_104                VISLVTGQPHTAVRRGGQAIVLSQGAATPTELAALLTAHGRGDSQFTVLE
MAB_2195|M.abscessus_ATCC_1997      IISLVNAPARSARRFGGRAVVLSRNAGTPRELAQTLSESGLGDSRLTVWE
MLBr_02273|M.leprae_Br4923          ---YWRRATRSALRIGPGQKVLDLAAGTAVSTAELSK-------------
                                             ::* * *    :*.   .*.   *                 

MSMEG_3878|M.smegmatis_MC2_155      QLGGPGERRRDGTAADWSAAPAPDVDDLNVVAVTYRPEDRR-----AHAL
TH_0444|M.thermoresistible__bu      QLGGPRERRRDGTAERWAADPPTDVDDLNVIAVHYLPDARQ-----GQVL
Mflv_3101|M.gilvum_PYR-GCK          QLGGPGELRCSATAREWAARPPGDVDALNVIAVRYLPDARR-----HGAL
Mvan_3434|M.vanbaalenii_PYR-1       QLGGPKELRRTSTAREWAARPPADVDDLNVMAVRYLPDVRV-----LGTL
Mb2098c|M.bovis_AF2122/97           QLGGPAERRRDGTARAWACDPPLDVDELNVIAVRYLPDER------TSWA
Rv2072c|M.tuberculosis_H37Rv        QLGGPAERRRDGTARAWACDPPLDVDELNVIAVRYLLDER------TSWA
MMAR_3054|M.marinum_M               QLGGRAERHRHGTARKWAAEAPVDVDDLNVIAIRYLPEAR------VLAP
MUL_2298|M.ulcerans_Agy99           QLGGPLERHRHGTARKWAAEAPVDVDDLNVIAIRYLPEAR------VLAP
MAV_2424|M.avium_104                RLGALDEHRRDGTARDWA-DGAADIDPLNVIAVRYLPDER------VWPL
MAB_2195|M.abscessus_ATCC_1997      QLGGAGEHSFGGVARSWDHPLG---DALNVIAVEYVPAEEVAILPLVAGL
MLBr_02273|M.leprae_Br4923          -------------SGAWCVAADFSVRMLATGGARKVPKVAAD----ATQL
                                                 :  *          * . .                  

MSMEG_3878|M.smegmatis_MC2_155      PDEQFSHDGQITKQSIRAVTLAALGPRPGELLWDVGSGSGSIAIEWCRSA
TH_0444|M.thermoresistible__bu      PDDQFDHDGQLTKQSIRAVTLAALAPRPGELLWDVGAGSGSIAIEWCRSA
Mflv_3101|M.gilvum_PYR-GCK          PDDAFAHDGQITKQAIRAATLAALAPRPGQLLWDVGAGSGSVSVEWCLAG
Mvan_3434|M.vanbaalenii_PYR-1       PDDAFAHDGQLTKQMIRAATLAALAPRPGELLWDVGAGSGSISIEWCRSG
Mb2098c|M.bovis_AF2122/97           PDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWCRSW
Rv2072c|M.tuberculosis_H37Rv        PDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWCRSW
MMAR_3054|M.marinum_M               PDDAFAHDGQITKHGIRALTVAALAPRPGERLWDVGSGSGSIAVQWCRSW
MUL_2298|M.ulcerans_Agy99           PDDAFAHDGQITKHGIRALTVAALAPRPGERLWDVGSGSGSIAVQWCRSW
MAV_2424|M.avium_104                PDDAFTHDGQITKQRIRAVTLAALAPRPGERLWDVGAGSGSISVEWCLSG
MAB_2195|M.abscessus_ATCC_1997      PESVFEHDGQITKHEIRAVTLAALGPRPGQRLWDVGAGSGSIAVEWSRSG
MLBr_02273|M.leprae_Br4923          PFSDGVFDAVTISFGLRNIADYQAALR--EMARVTRPGGQLVVCEFSTPT
                                    * .   .*.   .  :*  :    . *  :    . .*.  :  ::. . 

MSMEG_3878|M.smegmatis_MC2_155      PGCTAVAFERDEQRRDRIRANVEAFGVRVDLRGAAPECFDGAPAPAAIFI
TH_0444|M.thermoresistible__bu      TGCRAVAFEQDEQRRERITANAAAFGAPVQVFGAAPAAFGGAPDPAAIFV
Mflv_3101|M.gilvum_PYR-GCK          TGCRAVAFERDEARRARITVNANTFGVRIEVGSDAPDSFGMAPPPDAVFV
Mvan_3434|M.vanbaalenii_PYR-1       PGCRAIAFERDEARRARITENAVAHGAGVEVRFDAPESFDSSPPPAAVFV
Mb2098c|M.bovis_AF2122/97           PGCTAVAFERDERRRRNIGFNAAAFGVSVDVRGDAPDAFDDAARPSVIFL
Rv2072c|M.tuberculosis_H37Rv        PGCTAVAFERDERRRRNIGFNAAAFGVSVDVRGDAPDAFDDAARPSVIFL
MMAR_3054|M.marinum_M               PGCTAVAFERDERRRANIESNAVSFGVSIDARGEAPLAFEGTAEPSAIFL
MUL_2298|M.ulcerans_Agy99           PGCTAVAFERDERRRANIESNAVSFGVSVDARGEAPLAFEGTAEPSAIFL
MAV_2424|M.avium_104                TGCRATAFERDAQRRHNLAANAAAFGAAIDVRGDAPHAFVGAEPPSAIFI
MAB_2195|M.abscessus_ATCC_1997      TGCSASAFEIEPSRRASIAANATKFGVDIDVFGAAPDDFEQAVAPDVIFV
MLBr_02273|M.leprae_Br4923          NALVANVYTEYLMR---------ALPQVARLVSSNPDAY--------IYL
                                     .  * .:     *                     *  :        :::

MSMEG_3878|M.smegmatis_MC2_155      GGGVTGPGVLEACFDRLSTGGRLVVNAVTVESEAVVAQWYSEKGGDLRRY
TH_0444|M.thermoresistible__bu      GGGVTGDGLLEACLQRLPAGGRLVANAVTAESEAVLAQWYSERGGELRRY
Mflv_3101|M.gilvum_PYR-GCK          GGGVSSPGLLQACWDALRDGGRMVVNAVTVESEAVLAHWYSQHGGELRRF
Mvan_3434|M.vanbaalenii_PYR-1       GGGVSRPGMIDACWERLGPGGRLVANAVTVESEAVLAQWYSRVGGELRRY
Mb2098c|M.bovis_AF2122/97           GGGVTQPGLLEACLDSLPAGGNLVANAVTVESEAALAHAYSRLGGELRRF
Rv2072c|M.tuberculosis_H37Rv        GGGVTQPGLLEACLDSLPAGGNLVANAVTVESEAALAHAYSRLGGELRRF
MMAR_3054|M.marinum_M               GGGLTQPGLLDSCLGHLPTGGRLVANVVTAESEAALVHAHSRLGGQLRRF
MUL_2298|M.ulcerans_Agy99           GGGLTQPGLLDSCLGHLPTGGRLVANVVTAESEAALVHAHSRLGGQLRRF
MAV_2424|M.avium_104                GGGLTRPGLLDACFDHLPSGGRLVANVVTTESEAVVIQAYTRFGGQLRRF
MAB_2195|M.abscessus_ATCC_1997      GGGVTQPGLLEACWERLPIGGRMVVNAVTAESEALLLRWYCRYGGELRRY
MLBr_02273|M.leprae_Br4923          AESIR-----------------------AWPDQVTLACQLSRTGWASPRW
                                    . .:                        :  .:. :     . *    *:

MSMEG_3878|M.smegmatis_MC2_155      QHYQGGAVGGFTAWRPALPVTQWSVVKA-------
TH_0444|M.thermoresistible__bu      QHYRGEPIGRFTGWRPAYPVTQWSVTKR-------
Mflv_3101|M.gilvum_PYR-GCK          QHYRGEAVGTFTGWRPAMPVTQWSVTKAVSMPDTT
Mvan_3434|M.vanbaalenii_PYR-1       QHYRGEAVGSFTGWRPAMPVTQWSVTK----PDTT
Mb2098c|M.bovis_AF2122/97           QHYLGEPLGGFTGWRPQLPVTQWSVTKR-------
Rv2072c|M.tuberculosis_H37Rv        QHYLGEPLGGFTGWRPQLPVTQWSVTKR-------
MMAR_3054|M.marinum_M               QHYQGEPLGGFTGWRPQMPVTQWAVTKR-------
MUL_2298|M.ulcerans_Agy99           QHYQGEPLGGFTGWRPQMPVTQWAVTKR-------
MAV_2424|M.avium_104                QHYHGKALGAFTGWHPQFPVTQWAVTR--------
MAB_2195|M.abscessus_ATCC_1997      RVEDAAPLGGFTSWRSRLPVVQWSTEKS-------
MLBr_02273|M.leprae_Br4923          RNLTGGIVALHAADKPVR-----------------
                                    :   .  :. .:. :.