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MAQDAAMSPSGEEHGAPMSPSGHEPEAPTGRITVVGIGADGVDGLSARSRRELHRASVIFGSLRQLELLA EESLVAECRVWPSPLLPALPTMFDGLGDVHVLASGDPMLHGIGTTLTRLFGAQRVDVHPHISSVSLACSR MGWAVNDIEIISLVNAPARSARRFGGRAVVLSRNAGTPRELAQTLSESGLGDSRLTVWEQLGGAGEHSFG GVARSWDHPLGDALNVIAVEYVPAEEVAILPLVAGLPESVFEHDGQITKHEIRAVTLAALGPRPGQRLWD VGAGSGSIAVEWSRSGTGCSASAFEIEPSRRASIAANATKFGVDIDVFGAAPDDFEQAVAPDVIFVGGGV TQPGLLEACWERLPIGGRMVVNAVTAESEALLLRWYCRYGGELRRYRVEDAAPLGGFTSWRSRLPVVQWS TEKS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_2195 | - | - | 100% (424) | precorrin-6Y C5,15-methyltransferase CobL |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2098c | cobLb | 3e-93 | 59.06% (298) | precorrin-6y methyltransferase |
M. gilvum PYR-GCK | Mflv_3101 | - | 1e-120 | 58.66% (387) | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT |
M. tuberculosis H37Rv | Rv2072c | cobL | 1e-122 | 58.48% (395) | precorrin-6y methyltransferase CobL |
M. leprae Br4923 | MLBr_02273 | ubiE | 3e-05 | 28.57% (133) | ubiquinone/menaquinone biosynthesis methyltransferase |
M. marinum M | MMAR_3054 | cobL | 1e-119 | 55.70% (395) | precorrin-6y methyltransferase, CobL |
M. avium 104 | MAV_2424 | cobL | 1e-121 | 56.71% (395) | precorrin-6Y C5,15-methyltransferase (decarboxylating) |
M. smegmatis MC2 155 | MSMEG_3878 | cobL | 1e-131 | 60.96% (397) | precorrin-6Y C5,15-methyltransferase (decarboxylating) |
M. thermoresistible (build 8) | TH_0444 | cobL | 1e-124 | 60.51% (395) | Probable precorrin-6y methyltransferase CobL |
M. ulcerans Agy99 | MUL_2298 | cobL | 1e-118 | 55.44% (395) | precorrin-6y methyltransferase, CobL |
M. vanbaalenii PYR-1 | Mvan_3434 | - | 1e-119 | 56.82% (396) | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_3878|M.smegmatis_MC2_155 ----------------------------MKLIIVVGIGADGMPGLSAASR TH_0444|M.thermoresistible__bu ------------------------------MITVVGIGADGMAGLSAESR Mflv_3101|M.gilvum_PYR-GCK -----------------------------------------MSGLPEVSR Mvan_3434|M.vanbaalenii_PYR-1 ------------------------------MIIVVGIGADGMAGLAPASR Mb2098c|M.bovis_AF2122/97 -------------------------------------------------- Rv2072c|M.tuberculosis_H37Rv ------------------------------MIIVVGIGADGMTGLSEHSR MMAR_3054|M.marinum_M ------------------------------MIVVVGIGADGMPGLSDASR MUL_2298|M.ulcerans_Agy99 ------------------------------MIVVVGIGADGIPGLSDASR MAV_2424|M.avium_104 ------------------------------MIVVVGIGADGMAGLAEASR MAB_2195|M.abscessus_ATCC_1997 MAQDAAMSPSGEEHGAPMSPSGHEPEAPTGRITVVGIGADGVDGLSARSR MLBr_02273|M.leprae_Br4923 --------------------------------------------MPPGSV MSMEG_3878|M.smegmatis_MC2_155 DELARATVVFGAPRQLALLDDT-VIADRREWPSPMLPALPTLFDDFGGDV TH_0444|M.thermoresistible__bu AELARATVIYGSERQLGLLDDT-VTAERRAWPSPLLPALRSLDPDT--DP Mflv_3101|M.gilvum_PYR-GCK SELSRATVIYGSQRQLDLLDGT-VTAARRTWPSPLLPALPSLMDDSGGDI Mvan_3434|M.vanbaalenii_PYR-1 AELARATVVYGSRRQLELLDGT-VTAPRRAWPTPLLPALGTLLDGGDADV Mb2098c|M.bovis_AF2122/97 -------------------------------------------------- Rv2072c|M.tuberculosis_H37Rv SELRRATVIYGSKRQLALLDDT-VTAERWEWPTPMLPAVQGLSPDGA-DL MMAR_3054|M.marinum_M CELQRATIIYGSKRQLDLLDET-VTTSRREWPSPMLPALRQLPADGP-DI MUL_2298|M.ulcerans_Agy99 CELQRATIIYGSKRQLDLLDET-VTASRPEWPSPMLPALQQLPADGP-DI MAV_2424|M.avium_104 AELRSAAVIYGSKRQLDLLDDT-VPAPRRHWPSPMLPALQSLLDDHTGDV MAB_2195|M.abscessus_ATCC_1997 RELHRASVIFGSLRQLELLAEESLVAECRVWPSPLLPALPTMFDGLG-DV MLBr_02273|M.leprae_Br4923 DVVSRAALDKDPRDVVAMFDDV---------------------------- MSMEG_3878|M.smegmatis_MC2_155 HVVASGDPLCHGIGATLIRLFGADRVRVLPHVSSVTLACARMGWTVPDTE TH_0444|M.thermoresistible__bu HVLASGDPLLHGIGATLIRHFGTDRVRILPHVSSVTLACARMGWPVQDTE Mflv_3101|M.gilvum_PYR-GCK HVIASGDPLLHGIGGTLITLLGAQRVAVLPHVSSVTLACARVGWPVQDTE Mvan_3434|M.vanbaalenii_PYR-1 HVVASGDPMLHGIGSTLIRLHGPDKVAVLPHVSSVTLACARVGWSVQDTE Mb2098c|M.bovis_AF2122/97 ----------------------------MPHVSAVTLACARMGWNVYDTE Rv2072c|M.tuberculosis_H37Rv HVVASGDPLLHGIGSTLIRLFGHDNVTVLPHVSAVTLACARMGWNVYDTE MMAR_3054|M.marinum_M HVVASGDPLMHGIGGTLIRLFGPEHVRVVPHVSAVTLACARMGWNVHDTE MUL_2298|M.ulcerans_Agy99 HVVASGDPLMHGIGGTLIRLFGPEHVRVVPHVSAVTLACARMGWNVHDTE MAV_2424|M.avium_104 HIVASGDPLLHGIGGTLIRLYGAGRVRVLPHVSSVTLACARMGWNVHDTE MAB_2195|M.abscessus_ATCC_1997 HVLASGDPMLHGIGTTLTRLFGAQRVDVHPHISSVSLACSRMGWAVNDIE MLBr_02273|M.leprae_Br4923 -----------------------------AHRYDLTNTVLSLGQDR---- .* :: : :* MSMEG_3878|M.smegmatis_MC2_155 VISLVTAPPHTAVRRGGRAVVLSRDASTPTDLARLLTESGRGDSGFTVLE TH_0444|M.thermoresistible__bu VISVVTAEVHTAVRRGGRAVVLSRDGGTPAALARLLARTGRGESRLAVLE Mflv_3101|M.gilvum_PYR-GCK IISLVNADPHTAVRRGGQAVVLSRDGSTPAALARLLTDAGRGDSELTILE Mvan_3434|M.vanbaalenii_PYR-1 IISLVWHEPHTAVRRGGQAVVLSRDGSTPAELARLLTDAGRGDSELTVLE Mb2098c|M.bovis_AF2122/97 VISLVTAQPHTAVRRGGRAIVLSGDRSTPQALAVLLTEHGRGDSKFSVLE Rv2072c|M.tuberculosis_H37Rv VISLVTAQPHTAVRRGGRAIVLSGDRSTPQALAVLLTEHGRGDSKFSVLE MMAR_3054|M.marinum_M VISLVTAPPHTALRRGGQAIILSNSKATPSQLAALLHAHGRGDSEFSVLE MUL_2298|M.ulcerans_Agy99 VISLVTAPPHTALRRGGQAIILSNSKATPSQLAALLHAHGSGDSEFSVLE MAV_2424|M.avium_104 VISLVTGQPHTAVRRGGQAIVLSQGAATPTELAALLTAHGRGDSQFTVLE MAB_2195|M.abscessus_ATCC_1997 IISLVNAPARSARRFGGRAVVLSRNAGTPRELAQTLSESGLGDSRLTVWE MLBr_02273|M.leprae_Br4923 ---YWRRATRSALRIGPGQKVLDLAAGTAVSTAELSK------------- ::* * * :*. .*. * MSMEG_3878|M.smegmatis_MC2_155 QLGGPGERRRDGTAADWSAAPAPDVDDLNVVAVTYRPEDRR-----AHAL TH_0444|M.thermoresistible__bu QLGGPRERRRDGTAERWAADPPTDVDDLNVIAVHYLPDARQ-----GQVL Mflv_3101|M.gilvum_PYR-GCK QLGGPGELRCSATAREWAARPPGDVDALNVIAVRYLPDARR-----HGAL Mvan_3434|M.vanbaalenii_PYR-1 QLGGPKELRRTSTAREWAARPPADVDDLNVMAVRYLPDVRV-----LGTL Mb2098c|M.bovis_AF2122/97 QLGGPAERRRDGTARAWACDPPLDVDELNVIAVRYLPDER------TSWA Rv2072c|M.tuberculosis_H37Rv QLGGPAERRRDGTARAWACDPPLDVDELNVIAVRYLLDER------TSWA MMAR_3054|M.marinum_M QLGGRAERHRHGTARKWAAEAPVDVDDLNVIAIRYLPEAR------VLAP MUL_2298|M.ulcerans_Agy99 QLGGPLERHRHGTARKWAAEAPVDVDDLNVIAIRYLPEAR------VLAP MAV_2424|M.avium_104 RLGALDEHRRDGTARDWA-DGAADIDPLNVIAVRYLPDER------VWPL MAB_2195|M.abscessus_ATCC_1997 QLGGAGEHSFGGVARSWDHPLG---DALNVIAVEYVPAEEVAILPLVAGL MLBr_02273|M.leprae_Br4923 -------------SGAWCVAADFSVRMLATGGARKVPKVAAD----ATQL : * * . . MSMEG_3878|M.smegmatis_MC2_155 PDEQFSHDGQITKQSIRAVTLAALGPRPGELLWDVGSGSGSIAIEWCRSA TH_0444|M.thermoresistible__bu PDDQFDHDGQLTKQSIRAVTLAALAPRPGELLWDVGAGSGSIAIEWCRSA Mflv_3101|M.gilvum_PYR-GCK PDDAFAHDGQITKQAIRAATLAALAPRPGQLLWDVGAGSGSVSVEWCLAG Mvan_3434|M.vanbaalenii_PYR-1 PDDAFAHDGQLTKQMIRAATLAALAPRPGELLWDVGAGSGSISIEWCRSG Mb2098c|M.bovis_AF2122/97 PDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWCRSW Rv2072c|M.tuberculosis_H37Rv PDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWCRSW MMAR_3054|M.marinum_M PDDAFAHDGQITKHGIRALTVAALAPRPGERLWDVGSGSGSIAVQWCRSW MUL_2298|M.ulcerans_Agy99 PDDAFAHDGQITKHGIRALTVAALAPRPGERLWDVGSGSGSIAVQWCRSW MAV_2424|M.avium_104 PDDAFTHDGQITKQRIRAVTLAALAPRPGERLWDVGAGSGSISVEWCLSG MAB_2195|M.abscessus_ATCC_1997 PESVFEHDGQITKHEIRAVTLAALGPRPGQRLWDVGAGSGSIAVEWSRSG MLBr_02273|M.leprae_Br4923 PFSDGVFDAVTISFGLRNIADYQAALR--EMARVTRPGGQLVVCEFSTPT * . .*. . :* : . * : . .*. : ::. . MSMEG_3878|M.smegmatis_MC2_155 PGCTAVAFERDEQRRDRIRANVEAFGVRVDLRGAAPECFDGAPAPAAIFI TH_0444|M.thermoresistible__bu TGCRAVAFEQDEQRRERITANAAAFGAPVQVFGAAPAAFGGAPDPAAIFV Mflv_3101|M.gilvum_PYR-GCK TGCRAVAFERDEARRARITVNANTFGVRIEVGSDAPDSFGMAPPPDAVFV Mvan_3434|M.vanbaalenii_PYR-1 PGCRAIAFERDEARRARITENAVAHGAGVEVRFDAPESFDSSPPPAAVFV Mb2098c|M.bovis_AF2122/97 PGCTAVAFERDERRRRNIGFNAAAFGVSVDVRGDAPDAFDDAARPSVIFL Rv2072c|M.tuberculosis_H37Rv PGCTAVAFERDERRRRNIGFNAAAFGVSVDVRGDAPDAFDDAARPSVIFL MMAR_3054|M.marinum_M PGCTAVAFERDERRRANIESNAVSFGVSIDARGEAPLAFEGTAEPSAIFL MUL_2298|M.ulcerans_Agy99 PGCTAVAFERDERRRANIESNAVSFGVSVDARGEAPLAFEGTAEPSAIFL MAV_2424|M.avium_104 TGCRATAFERDAQRRHNLAANAAAFGAAIDVRGDAPHAFVGAEPPSAIFI MAB_2195|M.abscessus_ATCC_1997 TGCSASAFEIEPSRRASIAANATKFGVDIDVFGAAPDDFEQAVAPDVIFV MLBr_02273|M.leprae_Br4923 NALVANVYTEYLMR---------ALPQVARLVSSNPDAY--------IYL . * .: * * : ::: MSMEG_3878|M.smegmatis_MC2_155 GGGVTGPGVLEACFDRLSTGGRLVVNAVTVESEAVVAQWYSEKGGDLRRY TH_0444|M.thermoresistible__bu GGGVTGDGLLEACLQRLPAGGRLVANAVTAESEAVLAQWYSERGGELRRY Mflv_3101|M.gilvum_PYR-GCK GGGVSSPGLLQACWDALRDGGRMVVNAVTVESEAVLAHWYSQHGGELRRF Mvan_3434|M.vanbaalenii_PYR-1 GGGVSRPGMIDACWERLGPGGRLVANAVTVESEAVLAQWYSRVGGELRRY Mb2098c|M.bovis_AF2122/97 GGGVTQPGLLEACLDSLPAGGNLVANAVTVESEAALAHAYSRLGGELRRF Rv2072c|M.tuberculosis_H37Rv GGGVTQPGLLEACLDSLPAGGNLVANAVTVESEAALAHAYSRLGGELRRF MMAR_3054|M.marinum_M GGGLTQPGLLDSCLGHLPTGGRLVANVVTAESEAALVHAHSRLGGQLRRF MUL_2298|M.ulcerans_Agy99 GGGLTQPGLLDSCLGHLPTGGRLVANVVTAESEAALVHAHSRLGGQLRRF MAV_2424|M.avium_104 GGGLTRPGLLDACFDHLPSGGRLVANVVTTESEAVVIQAYTRFGGQLRRF MAB_2195|M.abscessus_ATCC_1997 GGGVTQPGLLEACWERLPIGGRMVVNAVTAESEALLLRWYCRYGGELRRY MLBr_02273|M.leprae_Br4923 AESIR-----------------------AWPDQVTLACQLSRTGWASPRW . .: : .:. : . * *: MSMEG_3878|M.smegmatis_MC2_155 QHYQGGAVGGFTAWRPALPVTQWSVVKA------- TH_0444|M.thermoresistible__bu QHYRGEPIGRFTGWRPAYPVTQWSVTKR------- Mflv_3101|M.gilvum_PYR-GCK QHYRGEAVGTFTGWRPAMPVTQWSVTKAVSMPDTT Mvan_3434|M.vanbaalenii_PYR-1 QHYRGEAVGSFTGWRPAMPVTQWSVTK----PDTT Mb2098c|M.bovis_AF2122/97 QHYLGEPLGGFTGWRPQLPVTQWSVTKR------- Rv2072c|M.tuberculosis_H37Rv QHYLGEPLGGFTGWRPQLPVTQWSVTKR------- MMAR_3054|M.marinum_M QHYQGEPLGGFTGWRPQMPVTQWAVTKR------- MUL_2298|M.ulcerans_Agy99 QHYQGEPLGGFTGWRPQMPVTQWAVTKR------- MAV_2424|M.avium_104 QHYHGKALGAFTGWHPQFPVTQWAVTR-------- MAB_2195|M.abscessus_ATCC_1997 RVEDAAPLGGFTSWRSRLPVVQWSTEKS------- MLBr_02273|M.leprae_Br4923 RNLTGGIVALHAADKPVR----------------- : . :. .:. :.