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VIVPAREPEPQPRRVLNGLSDVRAFFHNNTVPLYFISPTPFNLLGIYRWIRNFFYLTYYDSFEGEHSRVF VPRRRDRRDFDGMGDVCNHLLRDPETLEFIKNRGPGGKACFVMLDEETQALARQAGLEVMHPPAELRHRL ESKIVMTRLADEAGVPSVPHVIGRVSSYDELSALAHGAGLGDDLVVEAAYGNAGSATFFVRGLRDWDQCA GGIVGQPEIKVMKRIRNVEVCIEATVTRHGTVIGPAMTSLVGYPELTPYRGAWCGNDVWRGALPPAQTRA AREMVAKLGDVLSREGYRGYFEVDLLHDLDADELYLGEVNPRLSGASPMTNLTTEAYADMPLFLFHLLEY MDVDYELDIEAINSRWERGYGEDEVWGQLIMSETSPDLELFTATPRTGMWRLNHDGRVSFARQGNDWATM LDESEAFYMRVAAPGDLRCEGAQLGVLVTRGHLQTDDYQLTERGRRWIDGLKAQFASTPLTPAAPIVSRL VARA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1722 | - | - | 100% (494) | biotin carboxylase-like protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1751 | - | 0.0 | 99.80% (494) | biotin carboxylase-like protein |
| M. gilvum PYR-GCK | Mflv_0222 | - | 6e-07 | 25.93% (216) | ATP-dependent carboxylate-amine ligase domain-containing |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4539c | - | 5e-05 | 25.11% (235) | putative acyl-CoA carboxylase alpha subunit AccA |
| M. marinum M | MMAR_3388 | - | 0.0 | 89.84% (492) | carboxylase |
| M. avium 104 | MAV_2716 | - | 0.0 | 83.96% (480) | biotin carboxylase-like protein |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1722|M.tuberculosis_H37Rv --------------MIVPAREPEPQPRRVLNGLSDVRAFFHNNTVPLYFI
Mb1751|M.bovis_AF2122/97 --------------MIVPAREPEPQPRRVLNGLSDVRAFFHNNTMPLYFI
MMAR_3388|M.marinum_M ----------------MTAGNPEPKPPRVLNGLSDVRAFFHNNKLPLYFI
MAV_2716|M.avium_104 ----------------------------MLNGLSDIRAFFHTNSVPLYFI
Mflv_0222|M.gilvum_PYR-GCK --------------------------------MTEMETAHEG--------
MAB_4539c|M.abscessus_ATCC_199 MTLQSVLIANRGEIAVRIASTLRAMGIRSIAVYTDGDTDHLGSCDTAVRL
:: : .
Rv1722|M.tuberculosis_H37Rv SPTPFNLLGIYRWIRNFFYLTYYDSFEGEHSRVFVPRRRDRRDFDGMGDV
Mb1751|M.bovis_AF2122/97 SPTPFNLLGIYRWIRNFFYLTYYDSFEGEHSRVFVPRRRDRRDFDGMGDV
MMAR_3388|M.marinum_M SPTPFNLLGIDRWVRNFFYLTYFDSFEGAHSRVFVPRRRDRRDFDGMGDV
MAV_2716|M.avium_104 SPTPFNLLGIDRWIRNFFYLTYFDSFEGIHSRVFVPRRRDRIDFDSMGDV
Mflv_0222|M.gilvum_PYR-GCK -RTVVLLLGAGERTR-----ELAPAFEHLGAQVVTAD-------AAADAQ
MAB_4539c|M.abscessus_ATCC_199 GADSSCYLDIDAIISAAKQTGAQAIHPGYGFVSENADFVRACQAAGIVFV
*. . . .
Rv1722|M.tuberculosis_H37Rv CNHLLRDPETLEFIKNRGPGGKACFVMLDEETQALARQA---GLEVMHPP
Mb1751|M.bovis_AF2122/97 CNHLLRDPETLEFIKNRGPGGKACFVMLDEETQALARQA---GLEVMHPP
MMAR_3388|M.marinum_M CNHLLRDPETLEFIARRGPGGKACFVMLDGETQALARQA---GLEVIHPP
MAV_2716|M.avium_104 CNHLLRDPETLEFIAGRGPGGKACFVMMDEETQALARQA---GLQVMHPP
Mflv_0222|M.gilvum_PYR-GCK TLTALIEQHAARYVVADLDTAEATNVATTGALHAIADRD---DVEVFPTL
MAB_4539c|M.abscessus_ATCC_199 GPPAEAMDAMGDKIRAKGTVAAAGEPVVPGSVGALSDAELVFTAEKIGAP
: . * *:: : : .
Rv1722|M.tuberculosis_H37Rv AELRHRLESKIVMTRLADEAG----VPSVPHVIGRVSSYDELSALAHGAG
Mb1751|M.bovis_AF2122/97 AELRHRLESKIVMTRLADEAG----VPSVPHVIGRVSSYDELSALAHGAG
MMAR_3388|M.marinum_M AELRHRLGSKIVMTRLANEAG----VPSVPHLIGRAGSYEELSTLAHDAG
MAV_2716|M.avium_104 VELRNRLGSKTVMTRLADEAG----IPSVPHVMGRAGSYQELLTLAQDAG
Mflv_0222|M.gilvum_PYR-GCK RSIRFALDGEALRRLAADELG----LPTAPFWF--AGTVEELTAIGQHAG
MAB_4539c|M.abscessus_ATCC_199 LIIKPSAGGGGKGMRVVHDLGGISDALVASRREAAALFGDDTLLVERYLA
:: . ..: * .. . :: : : .
Rv1722|M.tuberculosis_H37Rv LGDDLVVEAAYGNAGSATFFVRGLRDWDQCAGGIVGQP-----EIKVMKR
Mb1751|M.bovis_AF2122/97 LGDDLVVEAAYGNAGSATFFVRGLRDWDQCAGGIVGQP-----EIKVMKR
MMAR_3388|M.marinum_M LGDDLVIEAAYGNAGSATFFVRGERDWDQCAADLVEQP-----EIKVMKR
MAV_2716|M.avium_104 LGDDLVVSIPYGAAGSGTFFVRGQRDWDEHAGDLTAQQ-----EFKVMKR
Mflv_0222|M.gilvum_PYR-GCK FP--LVVKPVSGAPGEGESVLLRPEDVEPAWQRAVAAG-----APTRRRV
MAB_4539c|M.abscessus_ATCC_199 RPRHIEVQVFGDTHGNVVHLGERECSLQRRHQKVIEEAPSALLTPQLRAA
: :. . *. . . :
Rv1722|M.tuberculosis_H37Rv IRNVEVCIEATVTRHGT-----VIGPAMTSLVGYPELTPYRGAWC-----
Mb1751|M.bovis_AF2122/97 IRNVEVCIEATVTRHGT-----VIGPAMTSLVGYPELTPYRGAWC-----
MMAR_3388|M.marinum_M IRNVEVCIEGTVTRHGT-----VIGPAMTSLVGYPELTPSKGAWC-----
MAV_2716|M.avium_104 IRNVEVCLEGAVTRHGT-----VIGPAMTSLVGYPELTPHRGAWC-----
Mflv_0222|M.gilvum_PYR-GCK IAESVVEVDVEVTLLTVR----TAGPAGPTVSFCEPIGHHQSPEG-----
MAB_4539c|M.abscessus_ATCC_199 MGQTACQIARSVGYFGAGTVEFILDSDAPESYYFMEMNTRLQVEHPVTEM
: : : * . .. . :
Rv1722|M.tuberculosis_H37Rv --GNDVWR-GALPPA-----------------------------------
Mb1751|M.bovis_AF2122/97 --GNDVWR-GALPPA-----------------------------------
MMAR_3388|M.marinum_M --GNDVWR-EVLPPA-----------------------------------
MAV_2716|M.avium_104 --GNDIWR-EVLPPG-----------------------------------
Mflv_0222|M.gilvum_PYR-GCK --SLESWQPQQLSPV-----------------------------------
MAB_4539c|M.abscessus_ATCC_199 VTGIDLVQWQILVAAGERLPLSQEQIVLTGHAVEARVYAEDPAREFLPTG
. : : * .
Rv1722|M.tuberculosis_H37Rv -------QTRAAREMVAKLGDVLSREGYRGYFEVDLLHDLDADELYLGEV
Mb1751|M.bovis_AF2122/97 -------QTRAAREMVAKLGDVLSREGYRGYFEVDLLHDLDADELYLGEV
MMAR_3388|M.marinum_M -------QTRAAREMVRKLGDVLSREGYRGYFEVDLLHDLDANELYLGEV
MAV_2716|M.avium_104 -------QTHAARQMVGKLGDILSREGYRGYFEVDLLHDLDSDELYLGEV
Mflv_0222|M.gilvum_PYR-GCK -------ALDSAKSIAARIVNSLGG---RGVFAVELLVRGD--EVYFSDV
MAB_4539c|M.abscessus_ATCC_199 GTVALARFSGTARTDTALATGSVVGSRFDPMLAKVIVHAADR-DTALAEV
:*: . . : : :: * : :.:*
Rv1722|M.tuberculosis_H37Rv NPRLSGA-------------------SPMTNLTTEAYADMPLFLFHLLEY
Mb1751|M.bovis_AF2122/97 NPRLSGA-------------------SPMTNLTTEAYADMPLFLFHLLEY
MMAR_3388|M.marinum_M NPRLSGA-------------------SPMTNLTTEAYADMPLFLFHLLEY
MAV_2716|M.avium_104 NPRLSGA-------------------SPMTNLTTEAYADMPLFLFHLLEY
Mflv_0222|M.gilvum_PYR-GCK RPRLQDS-------------------GLVT------LRSQRLSQFELHAR
MAB_4539c|M.abscessus_ATCC_199 DRALAETRILGVGTNIDFLRALVTNPVVMSGDIDTALLDKIAAEYHPPAA
* : :: . :.
Rv1722|M.tuberculosis_H37Rv MDVDYELDIEAINSRWERGYGEDEVWGQLIMSETSPDLELFTATP-----
Mb1751|M.bovis_AF2122/97 MDVDYELDIEAINSRWERGYGEDEVWGQLIMSETSPDLELFTATP-----
MMAR_3388|M.marinum_M MDVEYELDIEEINTRWERGYGEDEVWGQLIMSETSPELELFTSTP-----
MAV_2716|M.avium_104 MDVDYELDIEGINARWERGYGEDEVWGQVILAETSPDVELFTATP-----
Mflv_0222|M.gilvum_PYR-GCK AVLGLPVDTIMISPGAAEVTCSADADARLVLGEA-----LAVAES-----
MAB_4539c|M.abscessus_ATCC_199 PPWVWVAASALLDGQSGAGTLWDGKSGWRVGAHAPRAHRLRIGDSTELVR
:. . : ..: * . .
Rv1722|M.tuberculosis_H37Rv -----------------RTGMWRLNHDGRVSFARQGNDWATMLDESEAFY
Mb1751|M.bovis_AF2122/97 -----------------RTGMWRLNHDGRVSFARQGNDWATMLDESEAFY
MMAR_3388|M.marinum_M -----------------RTGVWRLHHDGSVSFARQGNDWATLLDESEAFY
MAV_2716|M.avium_104 -----------------RTGVWRIDDDGRVSFSRTANDWATLLDGSEAFY
Mflv_0222|M.gilvum_PYR-GCK -----------------DVRVLRSEPPVRVSLATAP--------------
MAB_4539c|M.abscessus_ATCC_199 LWGDPVTEVSIGEGGRTPSRVHCATAEVSVEFAGQLHRADAVRSDAAAWV
: *.::
Rv1722|M.tuberculosis_H37Rv MR-----------------VAAPGDLRCEGAQLGVLVTRGHLQTDDYQLT
Mb1751|M.bovis_AF2122/97 MR-----------------VAAPGDLRCEGAQLGVLVTRGHLQTDDYQLT
MMAR_3388|M.marinum_M MR-----------------VAAPGDLRCEGAQLGVLVTRGHLQTDDYQLT
MAV_2716|M.avium_104 MR-----------------VAAPGDLRSEGAQLGVLVTRGHLQTDDYRLT
Mflv_0222|M.gilvum_PYR-GCK --------------------------------------------DPIVAR
MAB_4539c|M.abscessus_ATCC_199 ATGDGTWHADIAPEPRLRHLDGDDEDGEIRSSMPGVVRVVSVSTGAAVER
.
Rv1722|M.tuberculosis_H37Rv ERGRRWIDGLKAQFASTPLTPAAPIVSRLVARA-----------------
Mb1751|M.bovis_AF2122/97 ERGRRWIDGLKAQFASTPLTPAAPIVSRLVARA-----------------
MMAR_3388|M.marinum_M ERCQRWVKGLKAHFASTPLTPAAPIVSRLVARA-----------------
MAV_2716|M.avium_104 ERCQRWVKGMKAKFASTPLAPATPIVSRLVARA-----------------
Mflv_0222|M.gilvum_PYR-GCK DRARRVASALRRSV------------------------------------
MAB_4539c|M.abscessus_ATCC_199 EAAVVVVEAMKMEHTLRAPIAGTATVSVAVGDQVAVDQLLATIHPNTNPE
: ..::
Rv1722|M.tuberculosis_H37Rv ----
Mb1751|M.bovis_AF2122/97 ----
MMAR_3388|M.marinum_M ----
MAV_2716|M.avium_104 ----
Mflv_0222|M.gilvum_PYR-GCK ----
MAB_4539c|M.abscessus_ATCC_199 EGKP