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TAGNPEPKPPRVLNGLSDVRAFFHNNKLPLYFISPTPFNLLGIDRWVRNFFYLTYFDSFEGAHSRVFVPR RRDRRDFDGMGDVCNHLLRDPETLEFIARRGPGGKACFVMLDGETQALARQAGLEVIHPPAELRHRLGSK IVMTRLANEAGVPSVPHLIGRAGSYEELSTLAHDAGLGDDLVIEAAYGNAGSATFFVRGERDWDQCAADL VEQPEIKVMKRIRNVEVCIEGTVTRHGTVIGPAMTSLVGYPELTPSKGAWCGNDVWREVLPPAQTRAARE MVRKLGDVLSREGYRGYFEVDLLHDLDANELYLGEVNPRLSGASPMTNLTTEAYADMPLFLFHLLEYMDV EYELDIEEINTRWERGYGEDEVWGQLIMSETSPELELFTSTPRTGVWRLHHDGSVSFARQGNDWATLLDE SEAFYMRVAAPGDLRCEGAQLGVLVTRGHLQTDDYQLTERCQRWVKGLKAHFASTPLTPAAPIVSRLVAR A*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3388 | - | - | 100% (492) | carboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1751 | - | 0.0 | 89.84% (492) | biotin carboxylase-like protein |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv1722 | - | 0.0 | 89.84% (492) | biotin carboxylase-like protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4539c | - | 2e-05 | 25.94% (239) | putative acyl-CoA carboxylase alpha subunit AccA |
| M. avium 104 | MAV_2716 | - | 0.0 | 85.00% (480) | biotin carboxylase-like protein |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0345 | - | 4e-07 | 27.07% (229) | carbamoyl-phosphate synthase L chain, ATP-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1751|M.bovis_AF2122/97 MIVPAREPEPQPRRVLNGLSDVRAFFHNNTMPLYFISPTPFNLLGIYRWI
Rv1722|M.tuberculosis_H37Rv MIVPAREPEPQPRRVLNGLSDVRAFFHNNTVPLYFISPTPFNLLGIYRWI
MMAR_3388|M.marinum_M --MTAGNPEPKPPRVLNGLSDVRAFFHNNKLPLYFISPTPFNLLGIDRWV
MAV_2716|M.avium_104 --------------MLNGLSDIRAFFHTNSVPLYFISPTPFNLLGIDRWI
MAB_4539c|M.abscessus_ATCC_199 ----------------------------MTLQSVLIANRGEIAVRIASTL
Mvan_0345|M.vanbaalenii_PYR-1 -------------------------MTNPTITKLLIANRGEIAARIIRTA
.: :*: *
Mb1751|M.bovis_AF2122/97 RNFFYLTYYDSFEGEHSRVFVPRRRDRRDFDGMGDVCNHLLRDPETLEFI
Rv1722|M.tuberculosis_H37Rv RNFFYLTYYDSFEGEHSRVFVPRRRDRRDFDGMGDVCNHLLRDPETLEFI
MMAR_3388|M.marinum_M RNFFYLTYFDSFEGAHSRVFVPRRRDRRDFDGMGDVCNHLLRDPETLEFI
MAV_2716|M.avium_104 RNFFYLTYFDSFEGIHSRVFVPRRRDRIDFDSMGDVCNHLLRDPETLEFI
MAB_4539c|M.abscessus_ATCC_199 RAMGIRSIAVYTDGDTDH--LGSCDTAVRLG--ADSSCYLDIDAIISAAK
Mvan_0345|M.vanbaalenii_PYR-1 RAMDVATVALYSDADRDAPYVTLADESVHLPGTAPADTYLRADLVLAAAA
* : : :. . : : . :* *
Mb1751|M.bovis_AF2122/97 KNRGPGGK--ACFVMLDEETQALARQAGLEVMHPPAELRHRLESKIVMTR
Rv1722|M.tuberculosis_H37Rv KNRGPGGK--ACFVMLDEETQALARQAGLEVMHPPAELRHRLESKIVMTR
MMAR_3388|M.marinum_M ARRGPGGK--ACFVMLDGETQALARQAGLEVIHPPAELRHRLGSKIVMTR
MAV_2716|M.avium_104 AGRGPGGK--ACFVMMDEETQALARQAGLQVMHPPVELRNRLGSKTVMTR
MAB_4539c|M.abscessus_ATCC_199 QTGAQAIHPGYGFVSENADFVRACQAAGIVFVGPPAEAMDAMGDKIRAKG
Mvan_0345|M.vanbaalenii_PYR-1 RTGADAVHPGYGFLSENADFARACAQAGVIFVGPSPEAIVAMGSKIAAKD
. . : *: : : . **: .: *. * : .* .
Mb1751|M.bovis_AF2122/97 LADEAGVPSVPHVIG-RVSSYDELSALAHGAGLGDDLVVEAAYGNAGSAT
Rv1722|M.tuberculosis_H37Rv LADEAGVPSVPHVIG-RVSSYDELSALAHGAGLGDDLVVEAAYGNAGSAT
MMAR_3388|M.marinum_M LANEAGVPSVPHLIG-RAGSYEELSTLAHDAGLGDDLVIEAAYGNAGSAT
MAV_2716|M.avium_104 LADEAGIPSVPHVMG-RAGSYQELLTLAQDAGLGDDLVVSIPYGAAGSGT
MAB_4539c|M.abscessus_ATCC_199 TVAAAGEPVVPG----SVGALSDAELVFTAEKIGAPLIIKPSAGGGGKGM
Mvan_0345|M.vanbaalenii_PYR-1 MMRAAGVPVLPGTTVESEEDQDPERLRTAAADIGFPILVKAAFGGGGRGM
** * :* . :* :::. . * .* .
Mb1751|M.bovis_AF2122/97 FFVRGLRDWDQCAGGIVGQPEIKVMKRIRNVEVCIEATVTRHGTVIGPAM
Rv1722|M.tuberculosis_H37Rv FFVRGLRDWDQCAGGIVGQPEIKVMKRIRNVEVCIEATVTRHGTVIGPAM
MMAR_3388|M.marinum_M FFVRGERDWDQCAADLVEQPEIKVMKRIRNVEVCIEGTVTRHGTVIGPAM
MAV_2716|M.avium_104 FFVRGQRDWDEHAGDLTAQQEFKVMKRIRNVEVCLEGAVTRHGTVIGPAM
MAB_4539c|M.abscessus_ATCC_199 RVVHDLGGISDALVASRREAAALFGDDTLLVERYLARPRHIEVQVFGDTH
Mvan_0345|M.vanbaalenii_PYR-1 RIVRGEHELVEAVASARREAASAFGDGTVFLEKFVESPRHIEVQIFGDSH
.*:. : : . . :* : . . ::* :
Mb1751|M.bovis_AF2122/97 TSLVGYPELTPYRGAWCGNDVWRGALPPAQTRAAREMVAKLGDVLSREGY
Rv1722|M.tuberculosis_H37Rv TSLVGYPELTPYRGAWCGNDVWRGALPPAQTRAAREMVAKLGDVLSREGY
MMAR_3388|M.marinum_M TSLVGYPELTPSKGAWCGNDVWREVLPPAQTRAAREMVRKLGDVLSREGY
MAV_2716|M.avium_104 TSLVGYPELTPHRGAWCGNDIWREVLPPGQTHAARQMVGKLGDILSREGY
MAB_4539c|M.abscessus_ATCC_199 GNVVHLGERECSLQRRHQKVIEEAPSALLTPQLRAAMGQTACQIARSVGY
Mvan_0345|M.vanbaalenii_PYR-1 GTVVHLGERECSIQRRYQKIIEEAPSTAVDERLRDELGRAAVAAGKALSY
.:* * : : . . : : .*
Mb1751|M.bovis_AF2122/97 RGYFEVDLLHDLDA-DELYLGEVNPRLSGASPMTNLTTEAYADMPLFLFH
Rv1722|M.tuberculosis_H37Rv RGYFEVDLLHDLDA-DELYLGEVNPRLSGASPMTNLTTEAYADMPLFLFH
MMAR_3388|M.marinum_M RGYFEVDLLHDLDA-NELYLGEVNPRLSGASPMTNLTTEAYADMPLFLFH
MAV_2716|M.avium_104 RGYFEVDLLHDLDS-DELYLGEVNPRLSGASPMTNLTTEAYADMPLFLFH
MAB_4539c|M.abscessus_ATCC_199 FGAGTVEFILDSDAPESYYFMEMNTRLQVEHPVTEMVTGIDLVQWQILVA
Mvan_0345|M.vanbaalenii_PYR-1 EGAGTVEFVMAPDG--SFYFLEVNTRLQVEHPVTELVTGIDLVRAQLLVA
* *::: *. . *: *:*.**. *:*::.* :*.
Mb1751|M.bovis_AF2122/97 LLEYMDVDYELDIEAINSRWERGYGEDEVWGQLIMS--------------
Rv1722|M.tuberculosis_H37Rv LLEYMDVDYELDIEAINSRWERGYGEDEVWGQLIMS--------------
MMAR_3388|M.marinum_M LLEYMDVEYELDIEEINTRWERGYGEDEVWGQLIMS--------------
MAV_2716|M.avium_104 LLEYMDVDYELDIEGINARWERGYGEDEVWGQVILA--------------
MAB_4539c|M.abscessus_ATCC_199 AGERLPLSQEQIVLTGHAVEARVYAEDPAREFLPTGGTVALARFS--GTA
Mvan_0345|M.vanbaalenii_PYR-1 AGHPIPSEMLHATPRGHAVEVRLYAEDVAAGFVPVSGTLTTLEFPTFDGI
. : . :: * *.** . : .
Mb1751|M.bovis_AF2122/97 -----------------------------------------------ETS
Rv1722|M.tuberculosis_H37Rv -----------------------------------------------ETS
MMAR_3388|M.marinum_M -----------------------------------------------ETS
MAV_2716|M.avium_104 -----------------------------------------------ETS
MAB_4539c|M.abscessus_ATCC_199 RTDTALATGSVVGSRFDPMLAKVIVHAADRDTALAEVDRALAETRILGVG
Mvan_0345|M.vanbaalenii_PYR-1 RIDAGFTSGSKVSTFYDPMLAKVIGFGATRADACALVARALTETRVHGVT
.
Mb1751|M.bovis_AF2122/97 PDLELFTATPRTG-------------------------------------
Rv1722|M.tuberculosis_H37Rv PDLELFTATPRTG-------------------------------------
MMAR_3388|M.marinum_M PELELFTSTPRTG-------------------------------------
MAV_2716|M.avium_104 PDVELFTATPRTG-------------------------------------
MAB_4539c|M.abscessus_ATCC_199 TNIDFLRALVTNPVVMSGDIDTALLDKIAAEYHPPAAP------PWVWVA
Mvan_0345|M.vanbaalenii_PYR-1 TNRDLLVGILREQEFLAGAIDTGYLERHDPAELTGASSSVSTLRTHALAA
.: ::: .
Mb1751|M.bovis_AF2122/97 --------------------MWRLNHDGRVSFARQGNDWATMLD------
Rv1722|M.tuberculosis_H37Rv --------------------MWRLNHDGRVSFARQGNDWATMLD------
MMAR_3388|M.marinum_M --------------------VWRLHHDGSVSFARQGNDWATLLD------
MAV_2716|M.avium_104 --------------------VWRIDDDGRVSFSRTANDWATLLD------
MAB_4539c|M.abscessus_ATCC_199 ASALLDGQSGAGTLWDGK-SGWRVGAHAPRAHRLRIGDSTELVR-LWGDP
Mvan_0345|M.vanbaalenii_PYR-1 ALAAQAGRRTDTSILPGLPSGWRTLRSQDQVVAFTAGDHTVEVRYRFGRA
** .* : :
Mb1751|M.bovis_AF2122/97 --------------------------------------------------
Rv1722|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3388|M.marinum_M --------------------------------------------------
MAV_2716|M.avium_104 --------------------------------------------------
MAB_4539c|M.abscessus_ATCC_199 VTEVSIGEGGRTPSRVHCATAEVSVEFAGQLHRADAVRSDAAAWVATGDG
Mvan_0345|M.vanbaalenii_PYR-1 TVSVRIGDWEPEVQIVAASASCLDAVIDGVRRQYHLTISGATHYVDSGLG
Mb1751|M.bovis_AF2122/97 -----------------ESEAFYMRVAAPGDLRCEGAQLGVLVTRG--HL
Rv1722|M.tuberculosis_H37Rv -----------------ESEAFYMRVAAPGDLRCEGAQLGVLVTRG--HL
MMAR_3388|M.marinum_M -----------------ESEAFYMRVAAPGDLRCEGAQLGVLVTRG--HL
MAV_2716|M.avium_104 -----------------GSEAFYMRVAAPGDLRSEGAQLGVLVTRG--HL
MAB_4539c|M.abscessus_ATCC_199 TWHADIAPEPRLRHLDGDDEDGEIRSSMPGVVRVVSVSTGAAVEREAAVV
Mvan_0345|M.vanbaalenii_PYR-1 --SSALTEVDRFPDPSANQEPGSLLAPMPGSVVRVEVDEGAEVAAGTTIV
.* : . ** : .. *. * :
Mb1751|M.bovis_AF2122/97 QTDDYQLTERGRRWIDGLKAQFASTPLTPAAPIVSRLVARA---------
Rv1722|M.tuberculosis_H37Rv QTDDYQLTERGRRWIDGLKAQFASTPLTPAAPIVSRLVARA---------
MMAR_3388|M.marinum_M QTDDYQLTERCQRWVKGLKAHFASTPLTPAAPIVSRLVARA---------
MAV_2716|M.avium_104 QTDDYRLTERCQRWVKGMKAKFASTPLAPATPIVSRLVARA---------
MAB_4539c|M.abscessus_ATCC_199 VVEAMKMEHTLRAPIAG-TATVSVAVGDQVAVDQLLATIHPNTNPEEGKP
Mvan_0345|M.vanbaalenii_PYR-1 VLEAMKMEHSVRAPAGGVVASLSVAVGTQVESGQVLAVVA------EAQP
: :: . : * * .: : . .