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M. tuberculosis H37Rv Rv1638 (uvrA)

annotation: excinuclease ABC subunit A
coordinates: 1843741 - 1846659
length: 972

VADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSAYARQFLGQMD
KPDVDFIEGLSPAVSIDQKSTNRNPRSTVGTITEVYDYLRLLYARAGTPHCPTCGERVARQTPQQIVDQV
LAMPEGTRFLVLAPVVRTRKGEFADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHDIEVVVDRLTV
KAAAKRRLTDSVETALNLADGIVVLEFVDHELGAPHREQRFSEKLACPNGHALAVDDLEPRSFSFNSPYG
ACPECSGLGIRKEVDPELVVPDPDRTLAQGAVAPWSNGHTAEYFTRMMAGLGEALGFDVDTPWRKLPAKA
RKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMSQTESEQMKERYEGFMRDVPCPVCAGTRL
KPEILAVTLAGESKGEHGAKSIAEVCELSIADCADFLNALTLGPREQAIAGQVLKEIRSRLGFLLDVGLE
YLSLSRAAATLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLRDLGNTLIVVEH
DEDTIEHADWIVDIGPGAGEHGGRIVHSGPYDELLRNKDSITGAYLSGRESIEIPAIRRSVDPRRQLTVV
GAREHNLRGIDVSFPLGVLTSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLDYLDKLVR
VDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVKGGRCEACTGDGTIKIEMNFLP
DVYVPCEVCQGARYNRETLEVHYKGKTVSEVLDMSIEEAAEFFEPIAGVHRYLRTLVDVGLGYVRLGQPA
PTLSGGEAQRVKLASELQKRSTGRTVYILDEPTTGLHFDDIRKLLNVINGLVDKGNTVIVIEHNLDVIKT
SDWIIDLGPEGGAGGGTVVAQGTPEDVAAVPASYTGKFLAEVVGGGASAATSRSNRRRNVSA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1638uvrA-100% (972)excinuclease ABC subunit A
M. tuberculosis H37RvRv1747-5e-0931.40% (121) transmembrane ATP-binding protein ABC transporter
M. tuberculosis H37RvRv1859modC2e-0533.93% (112) molybdenum ABC transporter ATP-binding protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1664uvrA0.0100.00% (972) excinuclease ABC subunit A
M. gilvum PYR-GCKMflv_3548uvrA0.087.55% (972) excinuclease ABC subunit A
M. leprae Br4923MLBr_01392uvrA0.090.54% (973) excinuclease ABC subunit A
M. abscessus ATCC 19977MAB_2315uvrA0.086.57% (953) excinuclease ABC subunit A
M. marinum MMMAR_2443uvrA0.093.12% (974) excinuclease ABC (subunit A-DNA-binding ATPase) UvrA
M. avium 104MAV_3135uvrA0.093.12% (974) excinuclease ABC subunit A
M. smegmatis MC2 155MSMEG_3808uvrA0.088.17% (972) excinuclease ABC subunit A
M. thermoresistible (build 8)TH_1581uvrA0.088.07% (972) excinuclease ABC, A subunit
M. ulcerans Agy99MUL_1622uvrA0.092.81% (974) excinuclease ABC subunit A
M. vanbaalenii PYR-1Mvan_3339uvrA0.088.27% (972) excinuclease ABC subunit A

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3548|M.gilvum_PYR-GCK          MADRLVVKGAREHNLRGVDLDLPRDAMIVFTGLSGSGKSSLAFDTIFAEG
Mvan_3339|M.vanbaalenii_PYR-1       MADRLVVKGAREHNLRGVDLDLPRDAMIVFTGLSGSGKSSLAFDTIFAEG
MSMEG_3808|M.smegmatis_MC2_155      MADRLVVKGAREHNLRGVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG
TH_1581|M.thermoresistible__bu      LADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG
Rv1638|M.tuberculosis_H37Rv         MADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG
Mb1664|M.bovis_AF2122/97            MADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG
MMAR_2443|M.marinum_M               MADRLIVKGAREHNLRGVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG
MUL_1622|M.ulcerans_Agy99           MADRLIVKGAREHNLRGVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG
MLBr_01392|M.leprae_Br4923          MADRLIVKGAREHNLRSVDLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEG
MAV_3135|M.avium_104                MADRLIVKGAREHNLRGVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG
MAB_2315|M.abscessus_ATCC_1997      MADRLIVRGAREHNLRGIDLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEG
                                    :****:*:********.:*******::***********************

Mflv_3548|M.gilvum_PYR-GCK          QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG
Mvan_3339|M.vanbaalenii_PYR-1       QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG
MSMEG_3808|M.smegmatis_MC2_155      QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG
TH_1581|M.thermoresistible__bu      QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG
Rv1638|M.tuberculosis_H37Rv         QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG
Mb1664|M.bovis_AF2122/97            QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG
MMAR_2443|M.marinum_M               QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG
MUL_1622|M.ulcerans_Agy99           QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG
MLBr_01392|M.leprae_Br4923          QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG
MAV_3135|M.avium_104                QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG
MAB_2315|M.abscessus_ATCC_1997      QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG
                                    **************************************************

Mflv_3548|M.gilvum_PYR-GCK          TITEVYDYLRLLYARAGTPHCPVCGERIAKQTPQQIVDQVLAMDEGLRFQ
Mvan_3339|M.vanbaalenii_PYR-1       TITEVYDYLRLLYARAGTPHCPVCGERIARQTPQQIVDQVLAMDEGLRFQ
MSMEG_3808|M.smegmatis_MC2_155      TITEVYDYLRLLYARAGTPHCPVCGERIARQTPQQIVDQVLAMDEGLRFQ
TH_1581|M.thermoresistible__bu      TITEVYDYLRLLYARAGTPHCPVCGERIARQTPQQIVDQVLAMDEGLRFQ
Rv1638|M.tuberculosis_H37Rv         TITEVYDYLRLLYARAGTPHCPTCGERVARQTPQQIVDQVLAMPEGTRFL
Mb1664|M.bovis_AF2122/97            TITEVYDYLRLLYARAGTPHCPTCGERVARQTPQQIVDQVLAMPEGTRFL
MMAR_2443|M.marinum_M               TITEVYDYLRLLYARAGTPHCPTCGERIARQTPQQIVDQVLAMAEGTRFL
MUL_1622|M.ulcerans_Agy99           TITEVYDYLRLLYARAGTPHCPTCGERIARQTPQQIVDQVLAMAEGTRFL
MLBr_01392|M.leprae_Br4923          TITEVYDYLRLLYARAGTPHCPICGEQISRQTPQQIVDQVLVLPEGTRFL
MAV_3135|M.avium_104                TITEVYDYLRLLYARAGTPHCPVCGERIARQTPQQIVDQVLAMPEGTRFL
MAB_2315|M.abscessus_ATCC_1997      TITEVYDYLRLLYARAGTPHCPVCGEKIAKQTPQQIVDQVLDMEEGLRFQ
                                    ********************** ***::::*********** : ** ** 

Mflv_3548|M.gilvum_PYR-GCK          VLAPVVRTRKGEFVDLFDKLNTQGYSRVRVDGVVYPLTDPPKLKKQEKHD
Mvan_3339|M.vanbaalenii_PYR-1       VLAPVVRTRKGEFVDLFDKLNSQGYSRVRVDGVVHPLTDPPKLKKQEKHD
MSMEG_3808|M.smegmatis_MC2_155      VLAPVVRTRKGEFVDLFEKLNSQGYSRVRVDGVVYPLTDPPKLKKQEKHD
TH_1581|M.thermoresistible__bu      VLAPVVRTRKGEFVDLFDKLNSQGYSRVRVDGVVYPLTDPPKLKKQEKHD
Rv1638|M.tuberculosis_H37Rv         VLAPVVRTRKGEFADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHD
Mb1664|M.bovis_AF2122/97            VLAPVVRTRKGEFADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHD
MMAR_2443|M.marinum_M               VLAPVVRTRKGEFADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHD
MUL_1622|M.ulcerans_Agy99           VLAPVVRTRKGEFADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHD
MLBr_01392|M.leprae_Br4923          VLAPVVRTRKGEFADLFDKLNAQGYSRVRVDDVVYPLSDPPKLKKQEKHD
MAV_3135|M.avium_104                VLAPVVRTRKGEFADLFEKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHD
MAB_2315|M.abscessus_ATCC_1997      VLAPVVRTRKGEFVDLFEQLNSQGYSRIRVDGVVHSLTDPPKLKKQEKHD
                                    *************.***::**:*****:***.**:.*:************

Mflv_3548|M.gilvum_PYR-GCK          IEVVVDRLTVKASSKQRLTDSIETALNLADGIVVLEFVD-REDDHPHREQ
Mvan_3339|M.vanbaalenii_PYR-1       IEVVVDRLTVKATAKQRLTDSVETALNLADGIVVLEFVD-REDDHPHREQ
MSMEG_3808|M.smegmatis_MC2_155      IEVVVDRLTVKASAKQRLTDSIETALNLADGIVVLEFVD-REDDHPHREQ
TH_1581|M.thermoresistible__bu      IEVVVDRLTVKPSAKQRLTDSIETALNLADGIVVLDFVD-RDEDDPHREQ
Rv1638|M.tuberculosis_H37Rv         IEVVVDRLTVKAAAKRRLTDSVETALNLADGIVVLEFVD-HELGAPHREQ
Mb1664|M.bovis_AF2122/97            IEVVVDRLTVKAAAKRRLTDSVETALNLADGIVVLEFVD-HELGAPHREQ
MMAR_2443|M.marinum_M               IEVVVDRLTVKAAAKQRLTDSVETALNLADGIVVLEFPDDHDEHDHPREQ
MUL_1622|M.ulcerans_Agy99           IEVVVDRLTVKAAAKQRLTDSVETALNLADGIVVLEFPDDHDEHDHPREQ
MLBr_01392|M.leprae_Br4923          IEVVVDRLTVKIAAKQRLTDSVETALNLADGIVVLEFPDDHDERGHPREQ
MAV_3135|M.avium_104                IEVVVDRLTVKASAKQRLTDSVETALNLADGIVVLEFVD-HEHDAHNREQ
MAB_2315|M.abscessus_ATCC_1997      IEVVIDRLSVKASSKQRLTDSVETALHLADGIVVLEFVD-ADEDSPQRER
                                    ****:***:** ::*:*****:****:********:* *  :     **:

Mflv_3548|M.gilvum_PYR-GCK          RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECLGLGIRKEVDPDLV
Mvan_3339|M.vanbaalenii_PYR-1       RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECTGLGIRKEVDPDLV
MSMEG_3808|M.smegmatis_MC2_155      RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECTGLGIRKEVDPDLV
TH_1581|M.thermoresistible__bu      RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECAGLGIRKEVDVDLV
Rv1638|M.tuberculosis_H37Rv         RFSEKLACPNGHALAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPELV
Mb1664|M.bovis_AF2122/97            RFSEKLACPNGHALAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPELV
MMAR_2443|M.marinum_M               RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPDLV
MUL_1622|M.ulcerans_Agy99           RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPDLV
MLBr_01392|M.leprae_Br4923          CFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECVGLGIRKEIDSDLV
MAV_3135|M.avium_104                RFSEKLACPNGHALAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPDLV
MAB_2315|M.abscessus_ATCC_1997      RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECAGLGIKKEVDPDLV
                                     ***********.*********************** ****:**:* :**

Mflv_3548|M.gilvum_PYR-GCK          VPDPDLTLAEGAIAPWSMGNTADYFTRMLSGLGDQLGFDVNTPWKKLPAK
Mvan_3339|M.vanbaalenii_PYR-1       VPDPDLTLAEGAIAPWSMGHTAEYFTRMLSGLGDQLGFDVNTPWKKLPAK
MSMEG_3808|M.smegmatis_MC2_155      VPDPELTLAEGAVAPWSVGQSAEYFTRMLAGLGEEMGFDVNTPWKKLPAK
TH_1581|M.thermoresistible__bu      VPDPDLTLAEGAIAPWSMGQTAEYFTRMLAGLGEAMGFDVDTPWRKLPAK
Rv1638|M.tuberculosis_H37Rv         VPDPDRTLAQGAVAPWSNGHTAEYFTRMMAGLGEALGFDVDTPWRKLPAK
Mb1664|M.bovis_AF2122/97            VPDPDRTLAQGAVAPWSNGHTAEYFTRMMAGLGEALGFDVDTPWRKLPAK
MMAR_2443|M.marinum_M               VPDPDRTLAEGAVAPWSTGHTAEYFTRMLAGLGDALGFDVDTPWRKLPAK
MUL_1622|M.ulcerans_Agy99           VPDPDRTLAEGAVAPWSTGHTAEYFTRMLAGLGDALGFDVDTPWRKLPAK
MLBr_01392|M.leprae_Br4923          VPDPDRTLAEGAVAPWSAGRTAEYFTRMMAGLGEKLGFDVDTPWRKLPAK
MAV_3135|M.avium_104                VPDPERTLAEGAVAPWSTGHTAEYFTRMMAGLGDELGFDVDTPWRKLPAK
MAB_2315|M.abscessus_ATCC_1997      VPDPDMTLAEGAIAPWSMGQNADYFVRLMAGLGDALGFDVDTPWKKLPAA
                                    ****: ***:**:**** *..*:**.*:::***: :****:***:**** 

Mflv_3548|M.gilvum_PYR-GCK          ARKAILEGCDEQVHVRYKNRYGRTRSYYADFEGVMAFLQRRMEQTDSEQT
Mvan_3339|M.vanbaalenii_PYR-1       ARRAILEGCDEQVHVRYKNRYGRTRSYYADFEGVMAFLQRRMEQTDSEQM
MSMEG_3808|M.smegmatis_MC2_155      ARRAILEGCDHQVHVRYKNRYGRTRSYYADFEGVMAFLQRRMEQTDSEQM
TH_1581|M.thermoresistible__bu      VRKAILEGCDEQVHVRYKNRYGRVRSYYADFEGVMAYLHRRMEQTDSEQM
Rv1638|M.tuberculosis_H37Rv         ARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMSQTESEQM
Mb1664|M.bovis_AF2122/97            ARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMSQTESEQM
MMAR_2443|M.marinum_M               ARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMAQTESEQM
MUL_1622|M.ulcerans_Agy99           ARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMAQTESEQM
MLBr_01392|M.leprae_Br4923          ARKAILEGSDHQVHVQYHNRYGRPRSYYVDFEGVLTFLQRKMEQTESEQM
MAV_3135|M.avium_104                ARKAILEGSDHQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMAQTESEQM
MAB_2315|M.abscessus_ATCC_1997      AKKAILDGSSEQVHVRYKNRYGRTRSYYAEFEGVLAFLQRRMEQTESEWA
                                    .::***:*...****:*:***** ****.:****:::*:*:* **:**  

Mflv_3548|M.gilvum_PYR-GCK          KERLEGFMRDVPCPECDGTRLKPEILAVTMTA---GTFGAKSIAEVSELS
Mvan_3339|M.vanbaalenii_PYR-1       KERLEGFMRDVPCPECDGTRLKPEILAVTMTA---GNFGAKSIAEVAELS
MSMEG_3808|M.smegmatis_MC2_155      KERYEGFMRDIPCPECNGTRLKPEILAVTLSA---GDFGAKSIAQVAELS
TH_1581|M.thermoresistible__bu      KERLEGFMRDVPCPECGGTRLKPEILAVTLSA---GEFGEKSIAEVADLS
Rv1638|M.tuberculosis_H37Rv         KERYEGFMRDVPCPVCAGTRLKPEILAVTLAGESKGEHGAKSIAEVCELS
Mb1664|M.bovis_AF2122/97            KERYEGFMRDVPCPVCAGTRLKPEILAVTLAGESKGEHGAKSIAEVCELS
MMAR_2443|M.marinum_M               KERYEGFMRDVPCPVCDGARLKPEILSVTLAA---GEQDAKSIAEVCELS
MUL_1622|M.ulcerans_Agy99           KERYEGFMRDVPCPVCDGARLKPEILSVTLAA---GEQDAKSIAEVCELS
MLBr_01392|M.leprae_Br4923          KERYEGFMRNIPCPVCQGTRLKPEILAVTLAA---GERGAKSIAEVCELS
MAV_3135|M.avium_104                KERYEGFMRDVPCPVCEGTRLKPEILAVTLAA---GRHGKKSIAEVCELS
MAB_2315|M.abscessus_ATCC_1997      KERYEGFMRDIPCPVCEGTRLKPEILSVTLTA---GEHGTKSIAEVCDLS
                                    *** *****::*** * *:*******:**::.   *  . ****:*.:**

Mflv_3548|M.gilvum_PYR-GCK          IADCAAFLNALTLGTREAAIAGQVLKEIQSRLGFLLDVGLDYLSLSRAAG
Mvan_3339|M.vanbaalenii_PYR-1       IADCAEFLNALTLGTREAAIAGQVLKEIQSRLGFLLDVGLDYLSLSRAAG
MSMEG_3808|M.smegmatis_MC2_155      IADCADFLNSLTLGPREQAIAGQVLKEIQSRLGFLLDVGLDYLSLSRAAA
TH_1581|M.thermoresistible__bu      IADCAEFLNALTLGPREQAIAGQVLKEIQSRLGFLLDVGLDYLSLSRAAA
Rv1638|M.tuberculosis_H37Rv         IADCADFLNALTLGPREQAIAGQVLKEIRSRLGFLLDVGLEYLSLSRAAA
Mb1664|M.bovis_AF2122/97            IADCADFLNALTLGPREQAIAGQVLKEIRSRLGFLLDVGLEYLSLSRAAA
MMAR_2443|M.marinum_M               ISDCADFLNALTLGAREQAIAGQVLKEIQSRLGFLLDVGLEYLSLSRAAA
MUL_1622|M.ulcerans_Agy99           ISDCADFLNALTLGAREQAIAGQVLKEIQSRLGFLLDVGLEYLSLSRAAA
MLBr_01392|M.leprae_Br4923          IADCSAFLNALILGVREQAIAGQVLKEIQSRLGFLLDVGLEYLSLSRAAA
MAV_3135|M.avium_104                ISDCAEFLNTLTLGPREQAIAGQVLKEIQSRLGFLLDVGLEYLSLSRAAA
MAB_2315|M.abscessus_ATCC_1997      IADCAQFLGALTLGHREQAIAGQVLKEVQFRLGFLLDVGLQYLSLSRAAG
                                    *:**: **.:* ** ** *********:: **********:********.

Mflv_3548|M.gilvum_PYR-GCK          TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIDTLVRLR
Mvan_3339|M.vanbaalenii_PYR-1       TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIDTLVRLR
MSMEG_3808|M.smegmatis_MC2_155      TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIDTLVRLR
TH_1581|M.thermoresistible__bu      TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIDTLVRLR
Rv1638|M.tuberculosis_H37Rv         TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR
Mb1664|M.bovis_AF2122/97            TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR
MMAR_2443|M.marinum_M               TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR
MUL_1622|M.ulcerans_Agy99           TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR
MLBr_01392|M.leprae_Br4923          TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR
MAV_3135|M.avium_104                TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR
MAB_2315|M.abscessus_ATCC_1997      TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR
                                    *******************************************:**.***

Mflv_3548|M.gilvum_PYR-GCK          DLGNTLIVVEHDLDTIAHADWVVDIGPAAGEHGGQIVHSGTYADLLTNPE
Mvan_3339|M.vanbaalenii_PYR-1       DLGNTLIVVEHDLDTIAHADWVVDIGPAAGEHGGQIVHSGTYEDLLRNPN
MSMEG_3808|M.smegmatis_MC2_155      DLGNTLIVVEHDLDTIAHADWVVDIGPAAGEHGGQIVHSGTYDDLLRNPE
TH_1581|M.thermoresistible__bu      DLGNTLIVVEHDLDTIAHADWVVDIGPAAGEHGGRIVHSGPYADLLANPD
Rv1638|M.tuberculosis_H37Rv         DLGNTLIVVEHDEDTIEHADWIVDIGPGAGEHGGRIVHSGPYDELLRNKD
Mb1664|M.bovis_AF2122/97            DLGNTLIVVEHDEDTIEHADWIVDIGPGAGEHGGRIVHSGPYDELLRNKD
MMAR_2443|M.marinum_M               DLGNTLIVVEHDEDTIEHADWVVDIGPGAGEHGGSIVHSGPYQELLRNQS
MUL_1622|M.ulcerans_Agy99           DLGNTLIVVEHDEDTIEHADWVVDIGPGAGEHGGSIVHSGPYQELLRNQS
MLBr_01392|M.leprae_Br4923          ALGNTLIVVEHDEDTIAHADWVVDIGPGAGEHGGQIVHNGTYRELLANKD
MAV_3135|M.avium_104                DLGNTLIVVEHDEDTIAHADWIVDIGPRAGEHGGQIVHSGTYAELLANQD
MAB_2315|M.abscessus_ATCC_1997      DLGNTLIVVEHDEDTIKHADWVVDIGPAAGEHGGQVVHSGTYAELLKNKN
                                     *********** *** ****:***** ****** :**.*.* :** * .

Mflv_3548|M.gilvum_PYR-GCK          SITGAYLSGKEEIEVPTMRRVVDKKRQLTVVGAREHNLREIDVSFPLGVL
Mvan_3339|M.vanbaalenii_PYR-1       SITGAYLSGKEEIEVPDMRRVVDRKRQLTVVGAREHNLREIDVAFPLGVL
MSMEG_3808|M.smegmatis_MC2_155      SLTGAYLSGKESIEVPAIRRPVDKKRQITVVGARENNLKEIDVAFPLGVL
TH_1581|M.thermoresistible__bu      SLTGEYLSGKKSIEVPAMRRPVDRKRQLTVVGARENNLRDIDVSFPLGVL
Rv1638|M.tuberculosis_H37Rv         SITGAYLSGRESIEIPAIRRSVDPRRQLTVVGAREHNLRGIDVSFPLGVL
Mb1664|M.bovis_AF2122/97            SITGAYLSGRESIEIPAIRRSVDPRRQLTVVGAREHNLRGIDVSFPLGVL
MMAR_2443|M.marinum_M               SITGAFLSGREGIEIPTSRRSVDSRRQLTVVGAREHNLRGIDVAFPLGVL
MUL_1622|M.ulcerans_Agy99           SITGAFLSGREGIEIPTSRRSIDSRRQLTVVGAREHNLRGLDVAFPLGVL
MLBr_01392|M.leprae_Br4923          SITGAYLSGRESIATPTRRRSVDRKRELTVVGAREHNLRGIDVSFPLGVL
MAV_3135|M.avium_104                SITGAYLSGKESIEMPAIRRPVDRRRQLTVVGAREHNLRGIDVSFPLGVL
MAB_2315|M.abscessus_ATCC_1997      SVTGSYLSGAESIPLPLIRRVIDPKRQVTVVGAREHNLKDIDVSFPLGVL
                                    *:** :*** : *  *  ** :* :*::*******:**: :**:******

Mflv_3548|M.gilvum_PYR-GCK          TSVTGVSGSGKSTLVNDILASVLANKLNGARLVPGRHTRINGLDHLDKLV
Mvan_3339|M.vanbaalenii_PYR-1       TSVTGVSGSGKSTLVNDILASVLANKLNGARLVPGRHTRVNGLDHLDKLV
MSMEG_3808|M.smegmatis_MC2_155      TSVTGVSGSGKSTMVNDILATVLANKLNGARLVPGRHTRVNGLDQLDKLV
TH_1581|M.thermoresistible__bu      TAVTGVSGSGKSTLVNDILAAALANKLNGARLVPGRHTRVNGLGEVDKLV
Rv1638|M.tuberculosis_H37Rv         TSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLDYLDKLV
Mb1664|M.bovis_AF2122/97            TSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLDYLDKLV
MMAR_2443|M.marinum_M               TSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRITGLDHLDKLV
MUL_1622|M.ulcerans_Agy99           TSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRITGLDHLDKLV
MLBr_01392|M.leprae_Br4923          TSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLEHLDKLV
MAV_3135|M.avium_104                TSVTGVSGSGKSTLVNDILATVLANRLNGARLVPGRHTRVTGLDHLDKLV
MAB_2315|M.abscessus_ATCC_1997      TSVTGVSGSGKSTLVNDILATVLANKLNGARQVPGRHTRVTGLDKVDKLV
                                    *:***********:******:.***:***** *******:.**  :****

Mflv_3548|M.gilvum_PYR-GCK          RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK
Mvan_3339|M.vanbaalenii_PYR-1       RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK
MSMEG_3808|M.smegmatis_MC2_155      RVDQSPIGRTPRSNPATYTGVFDKIRSLFAATTEAKVRGYQPGRFSFNVK
TH_1581|M.thermoresistible__bu      RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK
Rv1638|M.tuberculosis_H37Rv         RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK
Mb1664|M.bovis_AF2122/97            RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK
MMAR_2443|M.marinum_M               RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK
MUL_1622|M.ulcerans_Agy99           RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK
MLBr_01392|M.leprae_Br4923          RVDQSPIGRTPRSNPATYTGVFDKIRILFAATTEAKVRGYQPGRFSFNVK
MAV_3135|M.avium_104                RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK
MAB_2315|M.abscessus_ATCC_1997      RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK
                                    ************************** ***********************

Mflv_3548|M.gilvum_PYR-GCK          GGRCEACSGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTIA
Mvan_3339|M.vanbaalenii_PYR-1       GGRCEACSGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTIA
MSMEG_3808|M.smegmatis_MC2_155      GGRCEACSGDGTIKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKTIS
TH_1581|M.thermoresistible__bu      GGRCEACSGDGTLKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKTIA
Rv1638|M.tuberculosis_H37Rv         GGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTVS
Mb1664|M.bovis_AF2122/97            GGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTVS
MMAR_2443|M.marinum_M               GGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTIS
MUL_1622|M.ulcerans_Agy99           GGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYNGKTIS
MLBr_01392|M.leprae_Br4923          GGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKAIS
MAV_3135|M.avium_104                GGRCEACTGDGTIKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKTIS
MAB_2315|M.abscessus_ATCC_1997      GGRCEACTGDGTIKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKTIA
                                    *******:****:*****************:*************:**:::

Mflv_3548|M.gilvum_PYR-GCK          EVLDMSIEEAAEFFAPISSIHRYLKTLVDVGLGYVRLGQPAPTLSGGEAQ
Mvan_3339|M.vanbaalenii_PYR-1       EVLDMSIEEAAEFFAPISSIHRYLKTLVDVGLGYVRLGQPAPTLSGGEAQ
MSMEG_3808|M.smegmatis_MC2_155      EVLDMSIEEATEFFEPISSIHRYLKTLVDVGLGYVRLGQPAPTLSGGEAQ
TH_1581|M.thermoresistible__bu      EVLDMSIEEAAEFFAPISSIHRYLQTLVDVGLGYVRLGQPAPTLSGGEAQ
Rv1638|M.tuberculosis_H37Rv         EVLDMSIEEAAEFFEPIAGVHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ
Mb1664|M.bovis_AF2122/97            EVLDMSIEEAAEFFEPIAGVHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ
MMAR_2443|M.marinum_M               EVLDMSIEEAADFFEPISGIHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ
MUL_1622|M.ulcerans_Agy99           EVLDMSIEEAADFFEPISGIHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ
MLBr_01392|M.leprae_Br4923          EVLDMSIEEAAEFFEPIIGINRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ
MAV_3135|M.avium_104                EVLDMSIEEAAEFFEPITGIHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ
MAB_2315|M.abscessus_ATCC_1997      QVLDMPIEEAAEFFEPITSIHRYLKTLVEVGLGYVRLGQPAPTLSGGEAQ
                                    :****.****::** ** .::***:***:*********************

Mflv_3548|M.gilvum_PYR-GCK          RVKLASELQKRSTGRTIYILDEPTTGLHFEDIRKLLTVINGLVDKGNTVI
Mvan_3339|M.vanbaalenii_PYR-1       RVKLASELQKRSTGRTIYILDEPTTGLHFEDIRKLLTVINGLVDKGNTVI
MSMEG_3808|M.smegmatis_MC2_155      RVKLAAELQKRSTGRTIYILDEPTTGLHFEDIRKLLKVINGLVDKGNTVI
TH_1581|M.thermoresistible__bu      RVKLASELQKRSTGRTVYILDEPTTGLHFEDIRKLLGVINGLVDKGNTVI
Rv1638|M.tuberculosis_H37Rv         RVKLASELQKRSTGRTVYILDEPTTGLHFDDIRKLLNVINGLVDKGNTVI
Mb1664|M.bovis_AF2122/97            RVKLASELQKRSTGRTVYILDEPTTGLHFDDIRKLLNVINGLVDKGNTVI
MMAR_2443|M.marinum_M               RVKLASELQKRSTGRTIYILDEPTTGLHFDDIRKLLNVISGLVDKGNTVV
MUL_1622|M.ulcerans_Agy99           RVKLASELQKRSTGRTIYILDEPTTGLHFDDIRKLLNVISGLVDKGNTVV
MLBr_01392|M.leprae_Br4923          RVKLASELQKRSTGRTIYILDEPTTGLHFDDIRKLLNVINGLVDKDNTVI
MAV_3135|M.avium_104                RVKLAAELQKRSTGRTIYILDEPTTGLHFDDIRKLLKVINGLVDKGNTVI
MAB_2315|M.abscessus_ATCC_1997      RVKLAAELQKRSTGKTIYILDEPTTGLHFEDIRKLLTVINGLVDKGNTVI
                                    *****:********:*:************:****** **.*****.***:

Mflv_3548|M.gilvum_PYR-GCK          VIEHNLDVIKTSDWIIDMGPEGGSGGGTVVATGAPEDVAMNPDSYTGHFL
Mvan_3339|M.vanbaalenii_PYR-1       VIEHNLDVIKTSDWVVDMGPEGGSGGGTVVATGTPEDVAANPDSYTGHFL
MSMEG_3808|M.smegmatis_MC2_155      VIEHNLDVIKTSDWIIDMGPEGGAGGGTVVAQGTPEDVAANPDSYTGKFL
TH_1581|M.thermoresistible__bu      VIEHNLDVIKTADWIIDMGPEGGNGGGTVVAQGTPEDVAANPDSYTGQFL
Rv1638|M.tuberculosis_H37Rv         VIEHNLDVIKTSDWIIDLGPEGGAGGGTVVAQGTPEDVAAVPASYTGKFL
Mb1664|M.bovis_AF2122/97            VIEHNLDVIKTSDWIIDLGPEGGAGGGTVVAQGTPEDVAAVPASYTGKFL
MMAR_2443|M.marinum_M               VIEHNLDVIKTSDWIIDMGPEGGAGGGTVVAQGAPEDIAAVPESYTGKFL
MUL_1622|M.ulcerans_Agy99           VIEHNLDVIKTSDWIIDMGPEGGAGGGTVVAQGAPEDIAAVPESYTGKFL
MLBr_01392|M.leprae_Br4923          VIEHNLDVIKTSDWIVDMGPEGGAQGGTVVAEGTPEDVAAVPESYTGKFL
MAV_3135|M.avium_104                VIEHNLDVIKTSDWIVDMGPEGGAEGGTVVAQGTPEDVAAVPESYTGKFL
MAB_2315|M.abscessus_ATCC_1997      VIEHNLDVIKTSDWIIDMGPEGGSGGGTVVAEGTPESVAQTAGSYTGEFL
                                    ***********:**::*:*****  ****** *:**.:*  . ****.**

Mflv_3548|M.gilvum_PYR-GCK          AETLGMN----------RPKPK------ARARRKVSA--
Mvan_3339|M.vanbaalenii_PYR-1       AETLGVA----------RPKPK------SRRRSKVSA--
MSMEG_3808|M.smegmatis_MC2_155      AELLDVP----------TPK---------RKRRKVSA--
TH_1581|M.thermoresistible__bu      AEILDVP----------APT---------RKRRKVQVSA
Rv1638|M.tuberculosis_H37Rv         AEVVGGGA------SAATSR--------SNRRRNVSA--
Mb1664|M.bovis_AF2122/97            AEVVGGGA------SAATSR--------SNRRRNVSA--
MMAR_2443|M.marinum_M               AEVLAARR------PSTTARR-------TNRRRKVSA--
MUL_1622|M.ulcerans_Agy99           AEVLAARR------PSTTARR-------TNRRRKVSA--
MLBr_01392|M.leprae_Br4923          AEVVGAG--------CAPART-------PRRRRTVTA--
MAV_3135|M.avium_104                AEVIGRGG------AAAGAPRR------SSRRRKATA--
MAB_2315|M.abscessus_ATCC_1997      VDLLPRPVRNGKAPAKAPAKSTGKTLAKARTRKVVTPV-
                                    .: :              .            *  .