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ADRLIVKGAREHNLRGVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSAYARQFLGQMDK PDVDFIEGLSPAVSIDQKSTNRNPRSTVGTITEVYDYLRLLYARAGTPHCPVCGERIARQTPQQIVDQVL AMPEGTRFLVLAPVVRTRKGEFADLFEKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHDIEVVVDRLTVK ASAKQRLTDSVETALNLADGIVVLEFVDHEHDAHNREQRFSEKLACPNGHALAVDDLEPRSFSFNSPYGA CPECSGLGIRKEVDPDLVVPDPERTLAEGAVAPWSTGHTAEYFTRMMAGLGDELGFDVDTPWRKLPAKAR KAILEGSDHQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMAQTESEQMKERYEGFMRDVPCPVCEGTRLK PEILAVTLAAGRHGKKSIAEVCELSISDCAEFLNTLTLGPREQAIAGQVLKEIQSRLGFLLDVGLEYLSL SRAAATLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLRDLGNTLIVVEHDEDT IAHADWIVDIGPRAGEHGGQIVHSGTYAELLANQDSITGAYLSGKESIEMPAIRRPVDRRRQLTVVGARE HNLRGIDVSFPLGVLTSVTGVSGSGKSTLVNDILATVLANRLNGARLVPGRHTRVTGLDHLDKLVRVDQS PIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVKGGRCEACTGDGTIKIEMNFLPDVYV PCEVCHGARYNRETLEVHYKGKTISEVLDMSIEEAAEFFEPITGIHRYLRTLVDVGLGYVRLGQPAPTLS GGEAQRVKLAAELQKRSTGRTIYILDEPTTGLHFDDIRKLLKVINGLVDKGNTVIVIEHNLDVIKTSDWI VDMGPEGGAEGGTVVAQGTPEDVAAVPESYTGKFLAEVIGRGGAAAGAPRRSSRRRKATA*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_3135 | uvrA | - | 100% (971) | excinuclease ABC subunit A |
M. avium 104 | MAV_4326 | - | 5e-10 | 32.19% (146) | ABC transporter, ATP-binding protein |
M. avium 104 | MAV_3010 | - | 2e-08 | 32.77% (119) | ABC transporter, ATP-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1664 | uvrA | 0.0 | 93.12% (974) | excinuclease ABC subunit A |
M. gilvum PYR-GCK | Mflv_3548 | uvrA | 0.0 | 88.58% (972) | excinuclease ABC subunit A |
M. tuberculosis H37Rv | Rv1638 | uvrA | 0.0 | 93.12% (974) | excinuclease ABC subunit A |
M. leprae Br4923 | MLBr_01392 | uvrA | 0.0 | 91.15% (972) | excinuclease ABC subunit A |
M. abscessus ATCC 19977 | MAB_2315 | uvrA | 0.0 | 86.87% (975) | excinuclease ABC subunit A |
M. marinum M | MMAR_2443 | uvrA | 0.0 | 92.59% (972) | excinuclease ABC (subunit A-DNA-binding ATPase) UvrA |
M. smegmatis MC2 155 | MSMEG_3808 | uvrA | 0.0 | 90.01% (971) | excinuclease ABC subunit A |
M. thermoresistible (build 8) | TH_1581 | uvrA | 0.0 | 88.26% (971) | excinuclease ABC, A subunit |
M. ulcerans Agy99 | MUL_1622 | uvrA | 0.0 | 92.28% (972) | excinuclease ABC subunit A |
M. vanbaalenii PYR-1 | Mvan_3339 | uvrA | 0.0 | 89.76% (967) | excinuclease ABC subunit A |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3548|M.gilvum_PYR-GCK MADRLVVKGAREHNLRGVDLDLPRDAMIVFTGLSGSGKSSLAFDTIFAEG Mvan_3339|M.vanbaalenii_PYR-1 MADRLVVKGAREHNLRGVDLDLPRDAMIVFTGLSGSGKSSLAFDTIFAEG MSMEG_3808|M.smegmatis_MC2_155 MADRLVVKGAREHNLRGVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG TH_1581|M.thermoresistible__bu LADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG Mb1664|M.bovis_AF2122/97 MADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG Rv1638|M.tuberculosis_H37Rv MADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG MMAR_2443|M.marinum_M MADRLIVKGAREHNLRGVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG MUL_1622|M.ulcerans_Agy99 MADRLIVKGAREHNLRGVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG MLBr_01392|M.leprae_Br4923 MADRLIVKGAREHNLRSVDLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEG MAV_3135|M.avium_104 MADRLIVKGAREHNLRGVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEG MAB_2315|M.abscessus_ATCC_1997 MADRLIVRGAREHNLRGIDLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEG :****:*:********.:*******::*********************** Mflv_3548|M.gilvum_PYR-GCK QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG Mvan_3339|M.vanbaalenii_PYR-1 QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG MSMEG_3808|M.smegmatis_MC2_155 QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG TH_1581|M.thermoresistible__bu QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG Mb1664|M.bovis_AF2122/97 QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG Rv1638|M.tuberculosis_H37Rv QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG MMAR_2443|M.marinum_M QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG MUL_1622|M.ulcerans_Agy99 QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG MLBr_01392|M.leprae_Br4923 QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG MAV_3135|M.avium_104 QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG MAB_2315|M.abscessus_ATCC_1997 QRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVG ************************************************** Mflv_3548|M.gilvum_PYR-GCK TITEVYDYLRLLYARAGTPHCPVCGERIAKQTPQQIVDQVLAMDEGLRFQ Mvan_3339|M.vanbaalenii_PYR-1 TITEVYDYLRLLYARAGTPHCPVCGERIARQTPQQIVDQVLAMDEGLRFQ MSMEG_3808|M.smegmatis_MC2_155 TITEVYDYLRLLYARAGTPHCPVCGERIARQTPQQIVDQVLAMDEGLRFQ TH_1581|M.thermoresistible__bu TITEVYDYLRLLYARAGTPHCPVCGERIARQTPQQIVDQVLAMDEGLRFQ Mb1664|M.bovis_AF2122/97 TITEVYDYLRLLYARAGTPHCPTCGERVARQTPQQIVDQVLAMPEGTRFL Rv1638|M.tuberculosis_H37Rv TITEVYDYLRLLYARAGTPHCPTCGERVARQTPQQIVDQVLAMPEGTRFL MMAR_2443|M.marinum_M TITEVYDYLRLLYARAGTPHCPTCGERIARQTPQQIVDQVLAMAEGTRFL MUL_1622|M.ulcerans_Agy99 TITEVYDYLRLLYARAGTPHCPTCGERIARQTPQQIVDQVLAMAEGTRFL MLBr_01392|M.leprae_Br4923 TITEVYDYLRLLYARAGTPHCPICGEQISRQTPQQIVDQVLVLPEGTRFL MAV_3135|M.avium_104 TITEVYDYLRLLYARAGTPHCPVCGERIARQTPQQIVDQVLAMPEGTRFL MAB_2315|M.abscessus_ATCC_1997 TITEVYDYLRLLYARAGTPHCPVCGEKIAKQTPQQIVDQVLDMEEGLRFQ ********************** ***::::*********** : ** ** Mflv_3548|M.gilvum_PYR-GCK VLAPVVRTRKGEFVDLFDKLNTQGYSRVRVDGVVYPLTDPPKLKKQEKHD Mvan_3339|M.vanbaalenii_PYR-1 VLAPVVRTRKGEFVDLFDKLNSQGYSRVRVDGVVHPLTDPPKLKKQEKHD MSMEG_3808|M.smegmatis_MC2_155 VLAPVVRTRKGEFVDLFEKLNSQGYSRVRVDGVVYPLTDPPKLKKQEKHD TH_1581|M.thermoresistible__bu VLAPVVRTRKGEFVDLFDKLNSQGYSRVRVDGVVYPLTDPPKLKKQEKHD Mb1664|M.bovis_AF2122/97 VLAPVVRTRKGEFADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHD Rv1638|M.tuberculosis_H37Rv VLAPVVRTRKGEFADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHD MMAR_2443|M.marinum_M VLAPVVRTRKGEFADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHD MUL_1622|M.ulcerans_Agy99 VLAPVVRTRKGEFADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHD MLBr_01392|M.leprae_Br4923 VLAPVVRTRKGEFADLFDKLNAQGYSRVRVDDVVYPLSDPPKLKKQEKHD MAV_3135|M.avium_104 VLAPVVRTRKGEFADLFEKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHD MAB_2315|M.abscessus_ATCC_1997 VLAPVVRTRKGEFVDLFEQLNSQGYSRIRVDGVVHSLTDPPKLKKQEKHD *************.***::**:*****:***.**:.*:************ Mflv_3548|M.gilvum_PYR-GCK IEVVVDRLTVKASSKQRLTDSIETALNLADGIVVLEFVD-REDDHPHREQ Mvan_3339|M.vanbaalenii_PYR-1 IEVVVDRLTVKATAKQRLTDSVETALNLADGIVVLEFVD-REDDHPHREQ MSMEG_3808|M.smegmatis_MC2_155 IEVVVDRLTVKASAKQRLTDSIETALNLADGIVVLEFVD-REDDHPHREQ TH_1581|M.thermoresistible__bu IEVVVDRLTVKPSAKQRLTDSIETALNLADGIVVLDFVD-RDEDDPHREQ Mb1664|M.bovis_AF2122/97 IEVVVDRLTVKAAAKRRLTDSVETALNLADGIVVLEFVD-HELGAPHREQ Rv1638|M.tuberculosis_H37Rv IEVVVDRLTVKAAAKRRLTDSVETALNLADGIVVLEFVD-HELGAPHREQ MMAR_2443|M.marinum_M IEVVVDRLTVKAAAKQRLTDSVETALNLADGIVVLEFPDDHDEHDHPREQ MUL_1622|M.ulcerans_Agy99 IEVVVDRLTVKAAAKQRLTDSVETALNLADGIVVLEFPDDHDEHDHPREQ MLBr_01392|M.leprae_Br4923 IEVVVDRLTVKIAAKQRLTDSVETALNLADGIVVLEFPDDHDERGHPREQ MAV_3135|M.avium_104 IEVVVDRLTVKASAKQRLTDSVETALNLADGIVVLEFVD-HEHDAHNREQ MAB_2315|M.abscessus_ATCC_1997 IEVVIDRLSVKASSKQRLTDSVETALHLADGIVVLEFVD-ADEDSPQRER ****:***:** ::*:*****:****:********:* * : **: Mflv_3548|M.gilvum_PYR-GCK RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECLGLGIRKEVDPDLV Mvan_3339|M.vanbaalenii_PYR-1 RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECTGLGIRKEVDPDLV MSMEG_3808|M.smegmatis_MC2_155 RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECTGLGIRKEVDPDLV TH_1581|M.thermoresistible__bu RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECAGLGIRKEVDVDLV Mb1664|M.bovis_AF2122/97 RFSEKLACPNGHALAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPELV Rv1638|M.tuberculosis_H37Rv RFSEKLACPNGHALAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPELV MMAR_2443|M.marinum_M RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPDLV MUL_1622|M.ulcerans_Agy99 RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPDLV MLBr_01392|M.leprae_Br4923 CFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECVGLGIRKEIDSDLV MAV_3135|M.avium_104 RFSEKLACPNGHALAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPDLV MAB_2315|M.abscessus_ATCC_1997 RFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECAGLGIKKEVDPDLV ***********.*********************** ****:**:* :** Mflv_3548|M.gilvum_PYR-GCK VPDPDLTLAEGAIAPWSMGNTADYFTRMLSGLGDQLGFDVNTPWKKLPAK Mvan_3339|M.vanbaalenii_PYR-1 VPDPDLTLAEGAIAPWSMGHTAEYFTRMLSGLGDQLGFDVNTPWKKLPAK MSMEG_3808|M.smegmatis_MC2_155 VPDPELTLAEGAVAPWSVGQSAEYFTRMLAGLGEEMGFDVNTPWKKLPAK TH_1581|M.thermoresistible__bu VPDPDLTLAEGAIAPWSMGQTAEYFTRMLAGLGEAMGFDVDTPWRKLPAK Mb1664|M.bovis_AF2122/97 VPDPDRTLAQGAVAPWSNGHTAEYFTRMMAGLGEALGFDVDTPWRKLPAK Rv1638|M.tuberculosis_H37Rv VPDPDRTLAQGAVAPWSNGHTAEYFTRMMAGLGEALGFDVDTPWRKLPAK MMAR_2443|M.marinum_M VPDPDRTLAEGAVAPWSTGHTAEYFTRMLAGLGDALGFDVDTPWRKLPAK MUL_1622|M.ulcerans_Agy99 VPDPDRTLAEGAVAPWSTGHTAEYFTRMLAGLGDALGFDVDTPWRKLPAK MLBr_01392|M.leprae_Br4923 VPDPDRTLAEGAVAPWSAGRTAEYFTRMMAGLGEKLGFDVDTPWRKLPAK MAV_3135|M.avium_104 VPDPERTLAEGAVAPWSTGHTAEYFTRMMAGLGDELGFDVDTPWRKLPAK MAB_2315|M.abscessus_ATCC_1997 VPDPDMTLAEGAIAPWSMGQNADYFVRLMAGLGDALGFDVDTPWKKLPAA ****: ***:**:**** *..*:**.*:::***: :****:***:**** Mflv_3548|M.gilvum_PYR-GCK ARKAILEGCDEQVHVRYKNRYGRTRSYYADFEGVMAFLQRRMEQTDSEQT Mvan_3339|M.vanbaalenii_PYR-1 ARRAILEGCDEQVHVRYKNRYGRTRSYYADFEGVMAFLQRRMEQTDSEQM MSMEG_3808|M.smegmatis_MC2_155 ARRAILEGCDHQVHVRYKNRYGRTRSYYADFEGVMAFLQRRMEQTDSEQM TH_1581|M.thermoresistible__bu VRKAILEGCDEQVHVRYKNRYGRVRSYYADFEGVMAYLHRRMEQTDSEQM Mb1664|M.bovis_AF2122/97 ARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMSQTESEQM Rv1638|M.tuberculosis_H37Rv ARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMSQTESEQM MMAR_2443|M.marinum_M ARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMAQTESEQM MUL_1622|M.ulcerans_Agy99 ARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMAQTESEQM MLBr_01392|M.leprae_Br4923 ARKAILEGSDHQVHVQYHNRYGRPRSYYVDFEGVLTFLQRKMEQTESEQM MAV_3135|M.avium_104 ARKAILEGSDHQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMAQTESEQM MAB_2315|M.abscessus_ATCC_1997 AKKAILDGSSEQVHVRYKNRYGRTRSYYAEFEGVLAFLQRRMEQTESEWA .::***:*...****:*:***** ****.:****:::*:*:* **:** Mflv_3548|M.gilvum_PYR-GCK KERLEGFMRDVPCPECDGTRLKPEILAVTMTA---GTFGAKSIAEVSELS Mvan_3339|M.vanbaalenii_PYR-1 KERLEGFMRDVPCPECDGTRLKPEILAVTMTA---GNFGAKSIAEVAELS MSMEG_3808|M.smegmatis_MC2_155 KERYEGFMRDIPCPECNGTRLKPEILAVTLSA---GDFGAKSIAQVAELS TH_1581|M.thermoresistible__bu KERLEGFMRDVPCPECGGTRLKPEILAVTLSA---GEFGEKSIAEVADLS Mb1664|M.bovis_AF2122/97 KERYEGFMRDVPCPVCAGTRLKPEILAVTLAGESKGEHGAKSIAEVCELS Rv1638|M.tuberculosis_H37Rv KERYEGFMRDVPCPVCAGTRLKPEILAVTLAGESKGEHGAKSIAEVCELS MMAR_2443|M.marinum_M KERYEGFMRDVPCPVCDGARLKPEILSVTLAA---GEQDAKSIAEVCELS MUL_1622|M.ulcerans_Agy99 KERYEGFMRDVPCPVCDGARLKPEILSVTLAA---GEQDAKSIAEVCELS MLBr_01392|M.leprae_Br4923 KERYEGFMRNIPCPVCQGTRLKPEILAVTLAA---GERGAKSIAEVCELS MAV_3135|M.avium_104 KERYEGFMRDVPCPVCEGTRLKPEILAVTLAA---GRHGKKSIAEVCELS MAB_2315|M.abscessus_ATCC_1997 KERYEGFMRDIPCPVCEGTRLKPEILSVTLTA---GEHGTKSIAEVCDLS *** *****::*** * *:*******:**::. * . ****:*.:** Mflv_3548|M.gilvum_PYR-GCK IADCAAFLNALTLGTREAAIAGQVLKEIQSRLGFLLDVGLDYLSLSRAAG Mvan_3339|M.vanbaalenii_PYR-1 IADCAEFLNALTLGTREAAIAGQVLKEIQSRLGFLLDVGLDYLSLSRAAG MSMEG_3808|M.smegmatis_MC2_155 IADCADFLNSLTLGPREQAIAGQVLKEIQSRLGFLLDVGLDYLSLSRAAA TH_1581|M.thermoresistible__bu IADCAEFLNALTLGPREQAIAGQVLKEIQSRLGFLLDVGLDYLSLSRAAA Mb1664|M.bovis_AF2122/97 IADCADFLNALTLGPREQAIAGQVLKEIRSRLGFLLDVGLEYLSLSRAAA Rv1638|M.tuberculosis_H37Rv IADCADFLNALTLGPREQAIAGQVLKEIRSRLGFLLDVGLEYLSLSRAAA MMAR_2443|M.marinum_M ISDCADFLNALTLGAREQAIAGQVLKEIQSRLGFLLDVGLEYLSLSRAAA MUL_1622|M.ulcerans_Agy99 ISDCADFLNALTLGAREQAIAGQVLKEIQSRLGFLLDVGLEYLSLSRAAA MLBr_01392|M.leprae_Br4923 IADCSAFLNALILGVREQAIAGQVLKEIQSRLGFLLDVGLEYLSLSRAAA MAV_3135|M.avium_104 ISDCAEFLNTLTLGPREQAIAGQVLKEIQSRLGFLLDVGLEYLSLSRAAA MAB_2315|M.abscessus_ATCC_1997 IADCAQFLGALTLGHREQAIAGQVLKEVQFRLGFLLDVGLQYLSLSRAAG *:**: **.:* ** ** *********:: **********:********. Mflv_3548|M.gilvum_PYR-GCK TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIDTLVRLR Mvan_3339|M.vanbaalenii_PYR-1 TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIDTLVRLR MSMEG_3808|M.smegmatis_MC2_155 TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIDTLVRLR TH_1581|M.thermoresistible__bu TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIDTLVRLR Mb1664|M.bovis_AF2122/97 TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR Rv1638|M.tuberculosis_H37Rv TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR MMAR_2443|M.marinum_M TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR MUL_1622|M.ulcerans_Agy99 TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR MLBr_01392|M.leprae_Br4923 TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR MAV_3135|M.avium_104 TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR MAB_2315|M.abscessus_ATCC_1997 TLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLR *******************************************:**.*** Mflv_3548|M.gilvum_PYR-GCK DLGNTLIVVEHDLDTIAHADWVVDIGPAAGEHGGQIVHSGTYADLLTNPE Mvan_3339|M.vanbaalenii_PYR-1 DLGNTLIVVEHDLDTIAHADWVVDIGPAAGEHGGQIVHSGTYEDLLRNPN MSMEG_3808|M.smegmatis_MC2_155 DLGNTLIVVEHDLDTIAHADWVVDIGPAAGEHGGQIVHSGTYDDLLRNPE TH_1581|M.thermoresistible__bu DLGNTLIVVEHDLDTIAHADWVVDIGPAAGEHGGRIVHSGPYADLLANPD Mb1664|M.bovis_AF2122/97 DLGNTLIVVEHDEDTIEHADWIVDIGPGAGEHGGRIVHSGPYDELLRNKD Rv1638|M.tuberculosis_H37Rv DLGNTLIVVEHDEDTIEHADWIVDIGPGAGEHGGRIVHSGPYDELLRNKD MMAR_2443|M.marinum_M DLGNTLIVVEHDEDTIEHADWVVDIGPGAGEHGGSIVHSGPYQELLRNQS MUL_1622|M.ulcerans_Agy99 DLGNTLIVVEHDEDTIEHADWVVDIGPGAGEHGGSIVHSGPYQELLRNQS MLBr_01392|M.leprae_Br4923 ALGNTLIVVEHDEDTIAHADWVVDIGPGAGEHGGQIVHNGTYRELLANKD MAV_3135|M.avium_104 DLGNTLIVVEHDEDTIAHADWIVDIGPRAGEHGGQIVHSGTYAELLANQD MAB_2315|M.abscessus_ATCC_1997 DLGNTLIVVEHDEDTIKHADWVVDIGPAAGEHGGQVVHSGTYAELLKNKN *********** *** ****:***** ****** :**.*.* :** * . Mflv_3548|M.gilvum_PYR-GCK SITGAYLSGKEEIEVPTMRRVVDKKRQLTVVGAREHNLREIDVSFPLGVL Mvan_3339|M.vanbaalenii_PYR-1 SITGAYLSGKEEIEVPDMRRVVDRKRQLTVVGAREHNLREIDVAFPLGVL MSMEG_3808|M.smegmatis_MC2_155 SLTGAYLSGKESIEVPAIRRPVDKKRQITVVGARENNLKEIDVAFPLGVL TH_1581|M.thermoresistible__bu SLTGEYLSGKKSIEVPAMRRPVDRKRQLTVVGARENNLRDIDVSFPLGVL Mb1664|M.bovis_AF2122/97 SITGAYLSGRESIEIPAIRRSVDPRRQLTVVGAREHNLRGIDVSFPLGVL Rv1638|M.tuberculosis_H37Rv SITGAYLSGRESIEIPAIRRSVDPRRQLTVVGAREHNLRGIDVSFPLGVL MMAR_2443|M.marinum_M SITGAFLSGREGIEIPTSRRSVDSRRQLTVVGAREHNLRGIDVAFPLGVL MUL_1622|M.ulcerans_Agy99 SITGAFLSGREGIEIPTSRRSIDSRRQLTVVGAREHNLRGLDVAFPLGVL MLBr_01392|M.leprae_Br4923 SITGAYLSGRESIATPTRRRSVDRKRELTVVGAREHNLRGIDVSFPLGVL MAV_3135|M.avium_104 SITGAYLSGKESIEMPAIRRPVDRRRQLTVVGAREHNLRGIDVSFPLGVL MAB_2315|M.abscessus_ATCC_1997 SVTGSYLSGAESIPLPLIRRVIDPKRQVTVVGAREHNLKDIDVSFPLGVL *:** :*** : * * ** :* :*::*******:**: :**:****** Mflv_3548|M.gilvum_PYR-GCK TSVTGVSGSGKSTLVNDILASVLANKLNGARLVPGRHTRINGLDHLDKLV Mvan_3339|M.vanbaalenii_PYR-1 TSVTGVSGSGKSTLVNDILASVLANKLNGARLVPGRHTRVNGLDHLDKLV MSMEG_3808|M.smegmatis_MC2_155 TSVTGVSGSGKSTMVNDILATVLANKLNGARLVPGRHTRVNGLDQLDKLV TH_1581|M.thermoresistible__bu TAVTGVSGSGKSTLVNDILAAALANKLNGARLVPGRHTRVNGLGEVDKLV Mb1664|M.bovis_AF2122/97 TSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLDYLDKLV Rv1638|M.tuberculosis_H37Rv TSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLDYLDKLV MMAR_2443|M.marinum_M TSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRITGLDHLDKLV MUL_1622|M.ulcerans_Agy99 TSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRITGLDHLDKLV MLBr_01392|M.leprae_Br4923 TSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLEHLDKLV MAV_3135|M.avium_104 TSVTGVSGSGKSTLVNDILATVLANRLNGARLVPGRHTRVTGLDHLDKLV MAB_2315|M.abscessus_ATCC_1997 TSVTGVSGSGKSTLVNDILATVLANKLNGARQVPGRHTRVTGLDKVDKLV *:***********:******:.***:***** *******:.** :**** Mflv_3548|M.gilvum_PYR-GCK RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK Mvan_3339|M.vanbaalenii_PYR-1 RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK MSMEG_3808|M.smegmatis_MC2_155 RVDQSPIGRTPRSNPATYTGVFDKIRSLFAATTEAKVRGYQPGRFSFNVK TH_1581|M.thermoresistible__bu RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK Mb1664|M.bovis_AF2122/97 RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK Rv1638|M.tuberculosis_H37Rv RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK MMAR_2443|M.marinum_M RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK MUL_1622|M.ulcerans_Agy99 RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK MLBr_01392|M.leprae_Br4923 RVDQSPIGRTPRSNPATYTGVFDKIRILFAATTEAKVRGYQPGRFSFNVK MAV_3135|M.avium_104 RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK MAB_2315|M.abscessus_ATCC_1997 RVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVK ************************** *********************** Mflv_3548|M.gilvum_PYR-GCK GGRCEACSGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTIA Mvan_3339|M.vanbaalenii_PYR-1 GGRCEACSGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTIA MSMEG_3808|M.smegmatis_MC2_155 GGRCEACSGDGTIKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKTIS TH_1581|M.thermoresistible__bu GGRCEACSGDGTLKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKTIA Mb1664|M.bovis_AF2122/97 GGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTVS Rv1638|M.tuberculosis_H37Rv GGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTVS MMAR_2443|M.marinum_M GGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTIS MUL_1622|M.ulcerans_Agy99 GGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYNGKTIS MLBr_01392|M.leprae_Br4923 GGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKAIS MAV_3135|M.avium_104 GGRCEACTGDGTIKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKTIS MAB_2315|M.abscessus_ATCC_1997 GGRCEACTGDGTIKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKTIA *******:****:*****************:*************:**::: Mflv_3548|M.gilvum_PYR-GCK EVLDMSIEEAAEFFAPISSIHRYLKTLVDVGLGYVRLGQPAPTLSGGEAQ Mvan_3339|M.vanbaalenii_PYR-1 EVLDMSIEEAAEFFAPISSIHRYLKTLVDVGLGYVRLGQPAPTLSGGEAQ MSMEG_3808|M.smegmatis_MC2_155 EVLDMSIEEATEFFEPISSIHRYLKTLVDVGLGYVRLGQPAPTLSGGEAQ TH_1581|M.thermoresistible__bu EVLDMSIEEAAEFFAPISSIHRYLQTLVDVGLGYVRLGQPAPTLSGGEAQ Mb1664|M.bovis_AF2122/97 EVLDMSIEEAAEFFEPIAGVHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ Rv1638|M.tuberculosis_H37Rv EVLDMSIEEAAEFFEPIAGVHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ MMAR_2443|M.marinum_M EVLDMSIEEAADFFEPISGIHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ MUL_1622|M.ulcerans_Agy99 EVLDMSIEEAADFFEPISGIHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ MLBr_01392|M.leprae_Br4923 EVLDMSIEEAAEFFEPIIGINRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ MAV_3135|M.avium_104 EVLDMSIEEAAEFFEPITGIHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQ MAB_2315|M.abscessus_ATCC_1997 QVLDMPIEEAAEFFEPITSIHRYLKTLVEVGLGYVRLGQPAPTLSGGEAQ :****.****::** ** .::***:***:********************* Mflv_3548|M.gilvum_PYR-GCK RVKLASELQKRSTGRTIYILDEPTTGLHFEDIRKLLTVINGLVDKGNTVI Mvan_3339|M.vanbaalenii_PYR-1 RVKLASELQKRSTGRTIYILDEPTTGLHFEDIRKLLTVINGLVDKGNTVI MSMEG_3808|M.smegmatis_MC2_155 RVKLAAELQKRSTGRTIYILDEPTTGLHFEDIRKLLKVINGLVDKGNTVI TH_1581|M.thermoresistible__bu RVKLASELQKRSTGRTVYILDEPTTGLHFEDIRKLLGVINGLVDKGNTVI Mb1664|M.bovis_AF2122/97 RVKLASELQKRSTGRTVYILDEPTTGLHFDDIRKLLNVINGLVDKGNTVI Rv1638|M.tuberculosis_H37Rv RVKLASELQKRSTGRTVYILDEPTTGLHFDDIRKLLNVINGLVDKGNTVI MMAR_2443|M.marinum_M RVKLASELQKRSTGRTIYILDEPTTGLHFDDIRKLLNVISGLVDKGNTVV MUL_1622|M.ulcerans_Agy99 RVKLASELQKRSTGRTIYILDEPTTGLHFDDIRKLLNVISGLVDKGNTVV MLBr_01392|M.leprae_Br4923 RVKLASELQKRSTGRTIYILDEPTTGLHFDDIRKLLNVINGLVDKDNTVI MAV_3135|M.avium_104 RVKLAAELQKRSTGRTIYILDEPTTGLHFDDIRKLLKVINGLVDKGNTVI MAB_2315|M.abscessus_ATCC_1997 RVKLAAELQKRSTGKTIYILDEPTTGLHFEDIRKLLTVINGLVDKGNTVI *****:********:*:************:****** **.*****.***: Mflv_3548|M.gilvum_PYR-GCK VIEHNLDVIKTSDWIIDMGPEGGSGGGTVVATGAPEDVAMNPDSYTGHFL Mvan_3339|M.vanbaalenii_PYR-1 VIEHNLDVIKTSDWVVDMGPEGGSGGGTVVATGTPEDVAANPDSYTGHFL MSMEG_3808|M.smegmatis_MC2_155 VIEHNLDVIKTSDWIIDMGPEGGAGGGTVVAQGTPEDVAANPDSYTGKFL TH_1581|M.thermoresistible__bu VIEHNLDVIKTADWIIDMGPEGGNGGGTVVAQGTPEDVAANPDSYTGQFL Mb1664|M.bovis_AF2122/97 VIEHNLDVIKTSDWIIDLGPEGGAGGGTVVAQGTPEDVAAVPASYTGKFL Rv1638|M.tuberculosis_H37Rv VIEHNLDVIKTSDWIIDLGPEGGAGGGTVVAQGTPEDVAAVPASYTGKFL MMAR_2443|M.marinum_M VIEHNLDVIKTSDWIIDMGPEGGAGGGTVVAQGAPEDIAAVPESYTGKFL MUL_1622|M.ulcerans_Agy99 VIEHNLDVIKTSDWIIDMGPEGGAGGGTVVAQGAPEDIAAVPESYTGKFL MLBr_01392|M.leprae_Br4923 VIEHNLDVIKTSDWIVDMGPEGGAQGGTVVAEGTPEDVAAVPESYTGKFL MAV_3135|M.avium_104 VIEHNLDVIKTSDWIVDMGPEGGAEGGTVVAQGTPEDVAAVPESYTGKFL MAB_2315|M.abscessus_ATCC_1997 VIEHNLDVIKTSDWIIDMGPEGGSGGGTVVAEGTPESVAQTAGSYTGEFL ***********:**::*:***** ****** *:**.:* . ****.** Mflv_3548|M.gilvum_PYR-GCK AETLGMN----------RPKPK------ARARRKVSA-- Mvan_3339|M.vanbaalenii_PYR-1 AETLGVA----------RPKPK------SRRRSKVSA-- MSMEG_3808|M.smegmatis_MC2_155 AELLDVP----------TPK---------RKRRKVSA-- TH_1581|M.thermoresistible__bu AEILDVP----------APT---------RKRRKVQVSA Mb1664|M.bovis_AF2122/97 AEVVGGGA------SAATSR--------SNRRRNVSA-- Rv1638|M.tuberculosis_H37Rv AEVVGGGA------SAATSR--------SNRRRNVSA-- MMAR_2443|M.marinum_M AEVLAARR------PSTTARR-------TNRRRKVSA-- MUL_1622|M.ulcerans_Agy99 AEVLAARR------PSTTARR-------TNRRRKVSA-- MLBr_01392|M.leprae_Br4923 AEVVGAG--------CAPART-------PRRRRTVTA-- MAV_3135|M.avium_104 AEVIGRGG------AAAGAPRR------SSRRRKATA-- MAB_2315|M.abscessus_ATCC_1997 VDLLPRPVRNGKAPAKAPAKSTGKTLAKARTRKVVTPV- .: : . * .