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TDDVRDVNTETTDATEVAEIDSAAGEAGDSATEAFDTDSATESTAQKGQRHRDLWRMQVTLKPVPVILIL LMLISGGATGWLYLEQYRPDQQTDSGAARAAVAAASDGTIALLSYSPDTLDQDFATARSHLAGDFLSYYD QFTQQIVAPAAKQKSLKTTAKVVRAAVSELHPDSAVVLVFVDQSTTSKDSPNPSMAASSVMVTLAKVDGN WLITKFTPV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1362c | - | - | 100% (220) | POSSIBLE MEMBRANE PROTEIN |
| M. tuberculosis H37Rv | Rv1973 | - | 2e-26 | 50.00% (128) | MCE associated membrane protein |
| M. tuberculosis H37Rv | Rv0178 | - | 2e-14 | 29.78% (225) | mce associated membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1397c | - | 1e-120 | 99.55% (220) | hypothetical protein Mb1397c |
| M. gilvum PYR-GCK | Mflv_2527 | - | 1e-51 | 50.95% (210) | hypothetical protein Mflv_2527 |
| M. leprae Br4923 | MLBr_02598 | - | 2e-11 | 24.84% (157) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1004c | - | 2e-16 | 28.25% (223) | hypothetical protein MAB_1004c |
| M. marinum M | MMAR_3995 | - | 4e-73 | 61.61% (224) | hypothetical protein MMAR_3995 |
| M. avium 104 | MAV_0937 | - | 4e-63 | 65.03% (183) | hypothetical protein MAV_0937 |
| M. smegmatis MC2 155 | MSMEG_4770 | - | 3e-49 | 56.52% (161) | hypothetical protein MSMEG_4770 |
| M. thermoresistible (build 8) | TH_3191 | - | 4e-49 | 49.77% (221) | PUTATIVE twin-arginine translocation pathway signal |
| M. ulcerans Agy99 | MUL_3859 | - | 3e-73 | 61.61% (224) | hypothetical protein MUL_3859 |
| M. vanbaalenii PYR-1 | Mvan_4131 | - | 1e-54 | 49.57% (230) | twin-arginine translocation pathway signal |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2527|M.gilvum_PYR-GCK ---MSDREQTPDE-DVDATVVAEDPTPE----------DEVVTGTEP---
Mvan_4131|M.vanbaalenii_PYR-1 ---MTDENRTEDAAETDAALVEGDVIADVDSTDEADDVDEAAAGREPGDD
MSMEG_4770|M.smegmatis_MC2_155 ---MSAQDQTSDAVEAPETV------------------DQAVTATEP---
TH_3191|M.thermoresistible__bu --VTDEVKHTADTTEKAGGVAVG-------------VADEAVAAAPD---
Rv1362c|M.tuberculosis_H37Rv ---MTDDVRDVNTETTDATEVAEIDSAAGEAGDSATEAFDTDSATES---
Mb1397c|M.bovis_AF2122/97 ---MTDDVRDVNTETTDATEVAEIDSAAGEAGDSATEAFDTDSATES---
MAV_0937|M.avium_104 ---MSEDNR------------------SSDAAD--------DSADRP---
MMAR_3995|M.marinum_M ---MTDDVRNLDSAETTQFSAADETAAIDPDALELEDPDDTGEASDA---
MUL_3859|M.ulcerans_Agy99 ---MTDDARNLDSAETTQFSAADETAAIDPDALELEDPDDTGEASDA---
MAB_1004c|M.abscessus_ATCC_199 MVTMTKEDVDSTNDADTDTADDKETVDSAAETDSEIAEDAASTDTDAASS
MLBr_02598|M.leprae_Br4923 --------------------------------------------------
Mflv_2527|M.gilvum_PYR-GCK -----EPAPATPRATSRRSGRVLIGAIVAAVLMLAGSAGLAGWLYYNEYR
Mvan_4131|M.vanbaalenii_PYR-1 DKAEADSGAATTKPPTRRPVRGLVTAILLAVALLA-SAGMAGWLYLNDYR
MSMEG_4770|M.smegmatis_MC2_155 -----APAHAPSRG-VLKAIRAKTVPIMLGIALVA-SAALATFVYLTQYR
TH_3191|M.thermoresistible__bu -----TPGDNGRDRTAWRAVLKEPSGLILLIVALVAAAAVTASLWKFQYR
Rv1362c|M.tuberculosis_H37Rv -----TAQKGQRHRDLWRMQVTLKPVPVILILLMLISGGATGWLYLEQYR
Mb1397c|M.bovis_AF2122/97 -----TAQKGQRHRDLWRMQVTLKPVPVILILLMLISGGATGWLYLEQYR
MAV_0937|M.avium_104 -----EPGRPRARRN-------VKVVPIVLISLLLISGAGTAWLYFKEYL
MMAR_3995|M.marinum_M -----DSPEASGKRDLWRIKVNLRPVSIILVVLVMISGGIAAWLYVKTYR
MUL_3859|M.ulcerans_Agy99 -----DSPEASGKRDLWRIKVNLRPVSIILVVLVMISGGIAAWLYVKTYR
MAB_1004c|M.abscessus_ATCC_199 ADSDSETASSDEDGDAAKGASWVRYAALGAVAAIMVGALVFSGIFGWKVW
MLBr_02598|M.leprae_Br4923 -----MAAAEGGGSWRNRRAGQRTAIAVVVAAVLFVGSAAFAGAAVQPYL
. : : ..
Mflv_2527|M.gilvum_PYR-GCK PDRETDPAAAQVALEAAKTGTIALLSYSPESLDQDFANAKSKLTGDFLDY
Mvan_4131|M.vanbaalenii_PYR-1 PDQQTDPAAAQVALDAARTGTVALLSYSPESLDQDFANAKAKLTGEFLSY
MSMEG_4770|M.smegmatis_MC2_155 VDKETDPAAAEVALKAATDGTVALLSYAPESLDQDFATAKTHLTGDFLSY
TH_3191|M.thermoresistible__bu LDVQTNTDAAQVAVDAATEGTIALLSYAPETLQEDFAAAKEHLTGEFLDY
Rv1362c|M.tuberculosis_H37Rv PDQQTDSGAARAAVAAASDGTIALLSYSPDTLDQDFATARSHLAGDFLSY
Mb1397c|M.bovis_AF2122/97 PDQQTDSGAARAAGAAASDGTIALLSYSPDTLDQDFATARSHLAGDFLSY
MAV_0937|M.avium_104 PDKRTDARVASAVVNAASDGTVALLSYSPDTLDKDFAAAKSHLSGDFLSY
MMAR_3995|M.marinum_M PDQQVDPAVARQAVSAASDGTVALLSYSPDTLDDDFAAAKSHLSGDFLAY
MUL_3859|M.ulcerans_Agy99 PDQQVDPAVARQAVSAASDGTVALLSYSPDTLDDDFAAAKSHLSGDFLAY
MAB_1004c|M.abscessus_ATCC_199 QQHQID-AAGEQALAVAIPYTETLTSIDSNDIDESFRKILNGATGDLKKD
MLBr_02598|M.leprae_Br4923 ADRATVAVKLEVARTAAN-AITVLWTYTPENMDTLADRAATYVSGDFGAQ
: . .* .* : .: :: :*::
Mflv_2527|M.gilvum_PYR-GCK YTQFTEQIVTPAAKEKSVKTAASVVRAGVSQIAADSAEVLVFINQTTTS-
Mvan_4131|M.vanbaalenii_PYR-1 YTQFTEQIVTPAAKEKSVKTAASVVRAAVADIQPESAEVLVFINQTTTS-
MSMEG_4770|M.smegmatis_MC2_155 YTDFTTKVVAPAAQQKKVKTKATVVNGAVSEIKPESAVVLLFINQTTTS-
TH_3191|M.thermoresistible__bu YTEFTDTVVTPAAMEKQVSTSANVVKAAISEIHPDSAVVLVFLNQMTTS-
Rv1362c|M.tuberculosis_H37Rv YDQFTQQIVAPAAKQKSLKTTAKVVRAAVSELHPDSAVVLVFVDQSTTS-
Mb1397c|M.bovis_AF2122/97 YDQFTQQIVAPAAKQKSLKTTAKVVRAAVSELHPDSAVVLVFVDQSTTS-
MAV_0937|M.avium_104 YNQFTEQIVAPAAKQKSLKTNARVLGAAVSDLRPDSAVVLVLVDQSTTS-
MMAR_3995|M.marinum_M YEQFTEQFVAPAAKQKALKTSAQVVRAAVSELHPGSAEVLLFVDQSTSS-
MUL_3859|M.ulcerans_Agy99 YEQFTEQFVAPAAKQKALKTSAQVVRAAVSELHPGSAEVLLFVDQSTTS-
MAB_1004c|M.abscessus_ATCC_199 FTPASVQLRQLLLDNKAAS-HGKVVNSAIQYKSTNKVVLLMMVDQSITN-
MLBr_02598|M.leprae_Br4923 YRKFVDAIVGPNK-QAKITNSTEVTGVAVESLDASNAIAIVYTNTTSTSP
: . : . * .: . .. :: : :.
Mflv_2527|M.gilvum_PYR-GCK KENPDGAFAASSVKVGMKKIDGNWLIASFDPV---------
Mvan_4131|M.vanbaalenii_PYR-1 KENPDGAFAASSVKVGLKKIDGNWLIESFDPV---------
MSMEG_4770|M.smegmatis_MC2_155 QEIPDGSFATSSVKVGLTKIDGNWLISTFDPV---------
TH_3191|M.thermoresistible__bu KENPDGAFAASSVKVGLKKVDGRWLIEAFDPV---------
Rv1362c|M.tuberculosis_H37Rv KDSPNPSMAASSVMVTLAKVDGNWLITKFTPV---------
Mb1397c|M.bovis_AF2122/97 KDSPNPSMAASSVMVTLAKVDGNWLITKFTPV---------
MAV_0937|M.avium_104 KDNPDPAMASSSVLVSLTKVNGKWLITKFDPV---------
MMAR_3995|M.marinum_M KDHPDPTMMPISVLVSMAQIDGKWLITKFTPV---------
MUL_3859|M.ulcerans_Agy99 KDHPDPTMMPISVLVSMAQIDGKWLITKFTPV---------
MAB_1004c|M.abscessus_ATCC_199 TQRPDPRVDKSRMKITMEKIDGRWLASKLEYL---------
MLBr_02598|M.leprae_Br4923 LTKNIPALKYLSYRLFMKRSAVRWLVTRMTTITSLDLTPQL
. : : : .** : :