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TDRPHDWHRLSPRMLLVHPVHEMLRQLPVLIGSVVLGSATGNPVWPLAALGVTVVFGVLRWFFTTYRIDD ENVSLRTGILSRRAVSVPRNRIRSVQTEARLLHRLLGLTVLRVGTGQEARGEAAFELDAVDSARVPRLRA LLLAESLAPVEPTGRVLARWQSSWLRYAPLSFSGLVMIGAVIGLGYQTGLAVRLPESGFARSAVDAAQRA GVVLVVAVTVLLVVGVSALLAVLFSWLTYGNLLLRRGGSGQEGVLHLRHGLLRVREHTYDMRRLRGATLR EPLLVRLLRGARLDAVMTGVHGEGQSSMLLPPCPFETATAVLTDLIDNTDAAAGPLRRHGPAAARRRWTR ALLVPTLAGVALIAAAPILGVPGWAWTLWAVLTAGCAGLAVDRVRSLGHRVADGWLVARAGSLQRRRDCI ACTGIIGWTVRQTLFQRRAGVATLVAATVAGRKGYQVLDVPAELAWSVAGAASPWVADSVWLRHGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1226c | - | - | 100% (487) | PROBABLE TRANSMEMBRANE PROTEIN |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1258c | - | 0.0 | 99.79% (487) | hypothetical protein Mb1258c |
| M. gilvum PYR-GCK | Mflv_0149 | - | 1e-165 | 62.16% (481) | membrane-flanked domain-containing protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1270 | - | 1e-26 | 28.57% (448) | hypothetical protein MAB_1270 |
| M. marinum M | MMAR_1258 | - | 8e-05 | 26.04% (96) | hypothetical protein MMAR_1258 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_0865 | - | 1e-179 | 63.96% (480) | membrane flanked domain-containing protein |
| M. thermoresistible (build 8) | TH_0887 | - | 4e-06 | 31.37% (102) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_2630 | - | 5e-05 | 26.04% (96) | hypothetical protein MUL_2630 |
| M. vanbaalenii PYR-1 | Mvan_0755 | - | 1e-174 | 64.86% (481) | membrane-flanked domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1226c|M.tuberculosis_H37Rv MTDRP------HDWHRLSPRMLLVHPVHEMLRQLPVLIGSVVLGSATGNP
Mb1258c|M.bovis_AF2122/97 MTDRP------HDWHRLSPRMLLVHPVHEMLRQLPVLIGSVVLGSATGNP
Mflv_0149|M.gilvum_PYR-GCK MTPQA-------DWLRLSPRMLVVHPVHEVVRQIPVLIGSLVVGSATGNP
Mvan_0755|M.vanbaalenii_PYR-1 MTP---------EWSRLSPRMLLVHPVHEVVRQIPVLVGSLVLGSATGNP
MSMEG_0865|M.smegmatis_MC2_155 MTAPPQPPGAGPQWQRLSPRMLLVHPVHEVLQQIPLLVGSVVLGSATGNP
MMAR_1258|M.marinum_M --------------------------------------------------
MUL_2630|M.ulcerans_Agy99 --------------------------------------------------
TH_0887|M.thermoresistible__bu --------------------------------------------------
MAB_1270|M.abscessus_ATCC_1997 ------------MTLRRSARWILREFIETLKIGWAGLALVLVN---ESFL
Rv1226c|M.tuberculosis_H37Rv VWPLAALGVTVVFGVLRWFFTTYRIDDENVSLRTGILSRRAVSVPRNRIR
Mb1258c|M.bovis_AF2122/97 VWPLAALGVTVVFGVLRWFFTTYRIDDENVSLRTGILSRRAVSVPRNRIR
Mflv_0149|M.gilvum_PYR-GCK LWAVVGVVLIVGYGLARWFTTTYRIGADEVQLRTGVLQRTVLSVPRNRIR
Mvan_0755|M.vanbaalenii_PYR-1 LWAVAGVALVIAYGLARWFTTTYRIGADDVQLRTGVLQRNVLSVPRNRIR
MSMEG_0865|M.smegmatis_MC2_155 LWTVAAIVLTILFGLARWFTTTYRIEPNEVQLRTGVLQRKVLAVPRNRIR
MMAR_1258|M.marinum_M -----------------------------------------MGYPDN--A
MUL_2630|M.ulcerans_Agy99 -----------------------------------------MGYPDN--A
TH_0887|M.thermoresistible__bu -----------------------------------------VGYPDN--V
MAB_1270|M.abscessus_ATCC_1997 LLFLAYLVLVVLLKTWAWRRTTIQVGGDAVVLEVRGVTTRRESVARSAVE
. . .
Rv1226c|M.tuberculosis_H37Rv SVQTEARLLHRLLGLTVLRVGTGQEARGEAAFELDAVDSARVPRLRALLL
Mb1258c|M.bovis_AF2122/97 SVQTEARLLHRLLGLTVLRVGTGQEARGEAAFELDAVDSARVPRLRALLL
Mflv_0149|M.gilvum_PYR-GCK SVSTDARLLHRLLGLTVLKVSTGQEATGDGVFELDAVPAAEVGRLRAVLL
Mvan_0755|M.vanbaalenii_PYR-1 SVSTDARLLHRLLGLTVVRVSTGQEATGDTSFELDAVPVAEVARLRAILL
MSMEG_0865|M.smegmatis_MC2_155 SVSTDARLLHRVMGLTVLRISTGQEAKGDAEFALDAVEAGQVPRLRAILL
MMAR_1258|M.marinum_M MAAGEQVVLHR---------------------------------------
MUL_2630|M.ulcerans_Agy99 MAAGEQVVLHR---------------------------------------
TH_0887|M.thermoresistible__bu LASDEQVVLHR---------------------------------------
MAB_1270|M.abscessus_ATCC_1997 TLVVSAEMLDRLCGLQTLQLTTNDDSNNLVLDGLSPQSVRDIGASLETEV
. :*.*
Rv1226c|M.tuberculosis_H37Rv AESLAP----VEPTGRVLARWQSSWLRYAPLSFSGLVMIGAVIGLGYQTG
Mb1258c|M.bovis_AF2122/97 AESLAP----VEPTGRVLARWQSSWLRYAPLSFSGLVMIGAVIGLGYQTG
Mflv_0149|M.gilvum_PYR-GCK AESLAA-PDVARAGGRELARWQPSWLRYSPLTFTGLITIVAALGVISQTG
Mvan_0755|M.vanbaalenii_PYR-1 AESLVP-AGSAEP-TRVLARWQPSWLRYSPLTFTGLLMIAAALGLLSHPG
MSMEG_0865|M.smegmatis_MC2_155 ADLADASPEEHVPAGRELARWQPAWLRYSPLSFTGLAMILAAFGIVYQAG
MMAR_1258|M.marinum_M ---------------------HPHWTR----------LVWPVVVLILITG
MUL_2630|M.ulcerans_Agy99 ---------------------HPHWAR----------LVWPVVVLILITG
TH_0887|M.thermoresistible__bu ---------------------HPHWKA----------LVAPVLTLLVASA
MAB_1270|M.abscessus_ATCC_1997 SEKASD--------VRVIAAFRPGWFGYSLLTPIGWAGVVGVAFLANRIG
:. * : . : .
Rv1226c|M.tuberculosis_H37Rv LAVRLPESGFARSAVDAAQRAGVVLVVAVTVLLVVGVSALLAVLFSWLTY
Mb1258c|M.bovis_AF2122/97 LAVRLPESGFARSAVDAAQRAGVVLVVAVTVLLVVGVSALLAVLFSWLTY
Mflv_0149|M.gilvum_PYR-GCK VLGALQDSQIVRAGEQATDRVGVAVAVALGAGAVLVASVVLSVTQSLISY
Mvan_0755|M.vanbaalenii_PYR-1 VFGALRDSGLVRKGERAAESLGVLGAVTVVVAVVLTASVALSVLQSLLSY
MSMEG_0865|M.smegmatis_MC2_155 AGALMRDSAFAQSGLDAAERLGVAVSIAIVVGAVLVASVVLSVLRSLLTY
MMAR_1258|M.marinum_M LAALG--SGFVNSTQWQQLAKNIIHGVIWGIWLVIVGWLTLWPFLSWLTT
MUL_2630|M.ulcerans_Agy99 LAALG--SGFVNSTQWQQLAKNIIHGVIWGIWLVIVGWLTLWPFLSWLTT
TH_0887|M.thermoresistible__bu VAAFA--AGWVNTTDWDGTAKNVLYIVIGAIWLVVIGWLTLWPFLNWLTT
MAB_1270|M.abscessus_ATCC_1997 DRFVSQFDGLSAQAR--AALAHIATPLLIVLGVASGVAIVLFSYAARYGG
: : . *
Rv1226c|M.tuberculosis_H37Rv GNLLLRR-GGSGQEGVLHLRHGLLRVREHTYDMRRLRGATLREPLLVRLL
Mb1258c|M.bovis_AF2122/97 GNLLLRR-GGSGQEGVLHLRHGLLRVREHTYDMRRLRGATLREPLLVRLL
Mflv_0149|M.gilvum_PYR-GCK GNLVLRR-----DAEVLHLSHGLLRVRERTFDMRRLRGGTLREPLLVRLF
Mvan_0755|M.vanbaalenii_PYR-1 GNLVLRR-----DAEVLHLSHGLLRVREHTFDMRRLRGGTLREPLLVRLF
MSMEG_0865|M.smegmatis_MC2_155 GNLVLTRRDGPGGDGVLHLQHGLLRVREHTYDMRRLRGGTLREPLLVRVF
MMAR_1258|M.marinum_M HFVVTNR--------RVMYRQGVLTRSGIDIPLARINSVEFRDRIFERML
MUL_2630|M.ulcerans_Agy99 HFVVTNR--------RVMYRQGVLTRSGIDIPLARINSVEFRDRIFERML
TH_0887|M.thermoresistible__bu HFVITDR--------RVMFRYGVLTRAGIDIPLARINSVEFRHNLMDRIL
MAB_1270|M.abscessus_ATCC_1997 FRLEESPGTGSGEDPLLIYRRGLLETKAITFARSRIRGIRLTEPIPLRWA
: : *:* *:.. : . : *
Rv1226c|M.tuberculosis_H37Rv RGARLDAVMTGVHGEGQSSMLLPPCPFETATAVLTDL-IDNTDAAAG--P
Mb1258c|M.bovis_AF2122/97 RGARLDAVMTGVHGEGQSSMLLPPCPFETATAVLTDL-IDNTDAAAG--P
Mflv_0149|M.gilvum_PYR-GCK GGARLDAVMTGVTGAGEASQLLPPCPRATAESVLIDL-IEQPAAVTG--P
Mvan_0755|M.vanbaalenii_PYR-1 GGARLDAVMTGVAGAGEASQLLPPCPRGTAEAVLADL-IDRPDAVTG--P
MSMEG_0865|M.smegmatis_MC2_155 GGARLDAVMTGIGGEGEASLLLPPCPAATARGVLTAL-IGRPDAVSG--P
MMAR_1258|M.marinum_M RTG---TLIIESASQDPLEFYNIPRLREVHALLYHEV-FDTLGSEEA--P
MUL_2630|M.ulcerans_Agy99 RTG---TLIIESASQDPLEFYNIPRLREVHALLYHEV-FDTLGSEEA--P
TH_0887|M.thermoresistible__bu RTG---TLIIESAAQDPLSFEDIPRVEQVHALLYHEV-FDTLGSEES--P
MAB_1270|M.abscessus_ATCC_1997 KGARLHAEIVGHKDIELLPPTARTFALHIARDVLSHHGLDAVAAVSAGGR
. : : . : : : .
Rv1226c|M.tuberculosis_H37Rv LRRHGPAAARRRWTRALLVPTLAGVALIAAAPILGVPGWAWTLWAVLTAG
Mb1258c|M.bovis_AF2122/97 LRRHGPAAARRRWTRALLVPTLAGVALIAAAPILGVPGWAWTLWAVLTAG
Mflv_0149|M.gilvum_PYR-GCK LTGHGRAAMRRRWTRAMTVPVLLAAALLVWAVFDAVPPWAWAAPAATAVA
Mvan_0755|M.vanbaalenii_PYR-1 LTAHGPVATRRRWTRAMLAPAAVVVGLAVVSVVTDVPGSAWLVPAVLTVG
MSMEG_0865|M.smegmatis_MC2_155 LRPHGPAATRRRWTRALVLPVIALPVLAVVG----VPVWAWVLWALVTVA
MMAR_1258|M.marinum_M S-------------------------------------------------
MUL_2630|M.ulcerans_Agy99 S-------------------------------------------------
TH_0887|M.thermoresistible__bu S-------------------------------------------------
MAB_1270|M.abscessus_ATCC_1997 LAAHGRAARRVSLQESATVPLVLIVAAAGAAVINAESSFLVILALVLLIV
Rv1226c|M.tuberculosis_H37Rv ----CAGLAVDRVRSLGHRVADGWLVARAG-SLQRRRDCIACTGIIGWTV
Mb1258c|M.bovis_AF2122/97 ----CAGLAVDRVRSLGHRVADGWLVARAG-SLQRRRDCIACTGIIGWTV
Mflv_0149|M.gilvum_PYR-GCK ----GALLAADRVRALGHRIGDGWLVARAG-SLQRRRDCIAAAGIVGWTV
Mvan_0755|M.vanbaalenii_PYR-1 ----CGFLAFDRARSLGHRVGGGWLVARAG-SLQRRRDCVAAAGIVGWTV
MSMEG_0865|M.smegmatis_MC2_155 ----AALLAADRSRALGHRVDGDWLVAQAG-SVERRRDCLHTDGIIGWTV
MMAR_1258|M.marinum_M --------------------------------------------------
MUL_2630|M.ulcerans_Agy99 --------------------------------------------------
TH_0887|M.thermoresistible__bu --------------------------------------------------
MAB_1270|M.abscessus_ATCC_1997 RLCYTWIVSGRRASAWGRRSNQPLVLAQSHPRLARNLSITTCDSALGVRT
Rv1226c|M.tuberculosis_H37Rv RQTLFQRRAGVATLVAATVAGRKGYQVLDVPAELAWSVAGAASPWVADSV
Mb1258c|M.bovis_AF2122/97 RQTLFQRRAGVATLVAATAAGRKGYQVLDVPAELAWSVAGAASPWVADSV
Mflv_0149|M.gilvum_PYR-GCK RQTLFQRRAGVATLIAATAAGVKRYELIDVPADAAWAIAGATSPWLAATG
Mvan_0755|M.vanbaalenii_PYR-1 RQSLPQRRAGVATLVAATAAGVKRYEVIDVPADLAWSIAAATSPWVGATA
MSMEG_0865|M.smegmatis_MC2_155 RQTLLQRRAGVATLIAATAAGQKRYEVIDVPAGQAWAIAAAGTPWIADSV
MMAR_1258|M.marinum_M --------------------------------------------------
MUL_2630|M.ulcerans_Agy99 --------------------------------------------------
TH_0887|M.thermoresistible__bu --------------------------------------------------
MAB_1270|M.abscessus_ATCC_1997 RQSWRQRRAGVADLRIRSNAGDGALAVDCLPVIAATNLAVCLCPVAATFA
Rv1226c|M.tuberculosis_H37Rv WLRHGS------------------------
Mb1258c|M.bovis_AF2122/97 WLRHGS------------------------
Mflv_0149|M.gilvum_PYR-GCK WARR--------------------------
Mvan_0755|M.vanbaalenii_PYR-1 WARR--------------------------
MSMEG_0865|M.smegmatis_MC2_155 WAHTPVGSDLR-------------------
MMAR_1258|M.marinum_M ------------------------------
MUL_2630|M.ulcerans_Agy99 ------------------------------
TH_0887|M.thermoresistible__bu ------------------------------
MAB_1270|M.abscessus_ATCC_1997 RPVSPPADPEHAVARFERFGTLHHGMGMTT