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MAGPLSGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSVDGISRDAMLRNRRIVTADLKSDQGLELA LKLIAKADVLIEGYRPGVTERLGLGPEECAKVNDRLIYARMTGWGQTGPRSQQAGHDINYISLNGILHAI GRGDERPVPPLNLVGDFGGGSMFLLVGILAALWERQSSGKGQVVDAAMVDGSSVLIQMMWAMRATGMWTD TRGANMLDGGAPYYDTYECADGRYVAVGAIEPQFYAAMLAGLGLDAAELPPQNDRARWPELRALLTEAFA SHDRDHWGAVFANSDACVTPVLAFGEVHNEPHIIERNTFYEANGGWQPMPAPRFSRTASSQPRPPAATID IEAVLTDWDG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1143 | mcr | - | 100% (360) | PROBABLE ALPHA-METHYLACYL-CoA RACEMASE MCR (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) |
| M. tuberculosis H37Rv | Rv0855 | far | e-113 | 57.64% (347) | fatty-acid-CoA racemase |
| M. tuberculosis H37Rv | Rv3272 | - | 2e-26 | 27.01% (385) | hypothetical protein Rv3272 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1175 | mcr | 0.0 | 100.00% (360) | alpha-methylacyl-CoA racemase |
| M. gilvum PYR-GCK | Mflv_2126 | - | 1e-155 | 71.90% (363) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0845 | - | 1e-111 | 54.37% (355) | fatty-acid-CoA racemase Far |
| M. marinum M | MMAR_4308 | mcr | 1e-180 | 84.89% (364) | alpha-methylacyl-CoA racemase Mcr |
| M. avium 104 | MAV_1284 | - | 1e-180 | 84.68% (359) | Mcr protein |
| M. smegmatis MC2 155 | MSMEG_5184 | - | 1e-158 | 74.31% (362) | alpha-methylacyl-CoA racemase, putative |
| M. thermoresistible (build 8) | TH_4477 | - | 1e-156 | 73.63% (364) | PUTATIVE L-carnitine dehydratase/bile acid-inducible protein F |
| M. ulcerans Agy99 | MUL_0986 | mcr | 1e-180 | 84.89% (364) | alpha-methylacyl-CoA racemase Mcr |
| M. vanbaalenii PYR-1 | Mvan_4578 | - | 1e-157 | 74.10% (363) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1143|M.tuberculosis_H37Rv ------MAGPLSGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPS----
Mb1175|M.bovis_AF2122/97 ------MAGPLSGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPS----
MMAR_4308|M.marinum_M ------MSGPLNGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSSAG
MUL_0986|M.ulcerans_Agy99 ------MSGPLNGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSSAG
MAV_1284|M.avium_104 ------MAGPLQGLRVVELSGIGPGPHAAMILGDLGADVVRIDRPS---G
Mflv_2126|M.gilvum_PYR-GCK ------MAGPLQGLRVVELAGIGPGPHAAMIFGDLGADVVRIERPGKGPG
Mvan_4578|M.vanbaalenii_PYR-1 ------MAGPLQGLRVVELAGIGPGPHAAMILGDLGADVVRIERPGKGPG
TH_4477|M.thermoresistible__bu ------MAGPLQGLRVVELAGIGPGPHAAMILGDLGADVVRIERPRNTPG
MSMEG_5184|M.smegmatis_MC2_155 ------MAGPLQGLRVVELAGIGPGPHAAMILGDLGADVVRIERPGKGGG
MAB_0845|M.abscessus_ATCC_1997 MADTGVKTGPLAGVKVIELGGIGPGPHAAMMLSDLGADVIRVRRPG---G
:*** *::*:**.**********::.******:*: **
Rv1143|M.tuberculosis_H37Rv -SVDGISRDAMLRNRRIVTADLKSDQGLELALKLIAKADVLIEGYRPGVT
Mb1175|M.bovis_AF2122/97 -SVDGISRDAMLRNRRIVTADLKSDQGLELALKLIAKADVLIEGYRPGVT
MMAR_4308|M.marinum_M -GRGGGVKDAMLRNRRIVTADLKSDQGRELVLKLVAKADVLIEGYRPGVT
MUL_0986|M.ulcerans_Agy99 -GRGGGVKDAMLRNRRIVTADLKSDQGRELVLKLVAKADVLIEGYRPGVT
MAV_1284|M.avium_104 -APGGVVKDAMSRNRRIVTADLKSDQGRELVLKLVAKADVLIEGYRPGVT
Mflv_2126|M.gilvum_PYR-GCK PATKPGG-DYLLRNRRSVAANLKSDEDREMVLRLIAKADVLIEGFRPGVT
Mvan_4578|M.vanbaalenii_PYR-1 PATKPGG-DYLLRNRRSVAANLKSEEDRDMVLRLIAKADVLIEGFRPGVT
TH_4477|M.thermoresistible__bu PGIPRGAKDHLLRNRRSVAADLKTEEGKELVRKLIAKADVLIEGYRPGVT
MSMEG_5184|M.smegmatis_MC2_155 --VPAGDRDAMLRNRRSVVADLKAPEGRDLVLQLVAKADVLIEGYRPGVT
MAB_0845|M.abscessus_ATCC_1997 LAIPAEETDLFHRGKRLVNLDVKKDP--EALLALVDKADVLLDPFRPGVC
* : *.:* * ::* : *: *****:: :****
Rv1143|M.tuberculosis_H37Rv ERLGLGPEECAKVNDRLIYARMTGWGQTGPRSQQAGHDINYISLNGILHA
Mb1175|M.bovis_AF2122/97 ERLGLGPEECAKVNDRLIYARMTGWGQTGPRSQQAGHDINYISLNGILHA
MMAR_4308|M.marinum_M ERLGLGPQDCAKVNDRLIYARMTGWGQAGPRSQQAGHDINYISLNGILHA
MUL_0986|M.ulcerans_Agy99 ERLGLGPQDCAKVNDRLIYARMTGWGQAGPRSQQAGHDINYISLNGILHA
MAV_1284|M.avium_104 ERLGLGPQDCAKVNDRLIYARMTGWGQTGPRSQQAGHDINYISLNGILHA
Mflv_2126|M.gilvum_PYR-GCK ERLGLGPEDCAKVNEKLVYARMTGWGQDGPRAQQAGHDINYISLNGVLHA
Mvan_4578|M.vanbaalenii_PYR-1 ERLGLGPHDCAKVNEKLIYARMTGWGQDGPRAQQAGHDINYISLNGALHA
TH_4477|M.thermoresistible__bu ERLGLGPEDCAKINPRLIYGRMTGWGQDGPRAQQAGHDINYISLNGTLHA
MSMEG_5184|M.smegmatis_MC2_155 ERLGLGPEDCAKVNERLIYARMTGWGQDGPRALQAGHDINYISLNGTLHA
MAB_0845|M.abscessus_ATCC_1997 ERIGIGPEECAKRNPRLIFARMTGWGQHGPMADRAGHDINYLSLTGALGS
**:*:**.:*** * :*::.******* ** : :*******:**.* * :
Rv1143|M.tuberculosis_H37Rv IGRGDERPVPPLNLVGDFGGGSMFLLVGILAALWERQSSGKGQVVDAAMV
Mb1175|M.bovis_AF2122/97 IGRGDERPVPPLNLVGDFGGGSMFLLVGILAALWERQSSGKGQVVDAAMV
MMAR_4308|M.marinum_M IGRVGERPVPPLNLVGDFGGGSMFLLVGILAALWERHNSGKGQVIDAAMV
MUL_0986|M.ulcerans_Agy99 IGRVGERPVPPLNLVGDFGGGSMFLLVGILAALWERHNSGKGQVIDAAMV
MAV_1284|M.avium_104 IGRANERPVPPLNLVGDFGGGSMFLLLGILSALWERQSSGKGQVVDAAMV
Mflv_2126|M.gilvum_PYR-GCK IGRHGERPVPPLNLAGDFGGGSMFLLVGVLAALWERERSGKGQVVDAAMV
Mvan_4578|M.vanbaalenii_PYR-1 IGRAGERPVPPLNLVGDFGGGSMFLLVGVLSALYERERSGKGQVVDAAMV
TH_4477|M.thermoresistible__bu VGRKGERPVPPLNLAGDFGGGSMFLLVGILAALFERQTSGKGQVVDAAMI
MSMEG_5184|M.smegmatis_MC2_155 VGRKGGRPVPPLNLAGDFGGGSMFLLVGILSALYERQASGKGQVIDAAMV
MAB_0845|M.abscessus_ATCC_1997 MGYKDRPPMPPMNLVADFGGGSMLLVQGILAALYEREKSGKGQVIDGAMV
:* . *:**:**..*******:*: *:*:**:**. ******:*.**:
Rv1143|M.tuberculosis_H37Rv DGSSVLIQMMWAMRATGMWTDTRGANMLDGGAPYYDTYECADGRYVAVGA
Mb1175|M.bovis_AF2122/97 DGSSVLIQMMWAMRATGMWTDTRGANMLDGGAPYYDTYECADGRYVAVGA
MMAR_4308|M.marinum_M DGSSVLVQMMWAMRGIGIWSDVRGTNMLDGGAPYYDTYECADGGYVAVGA
MUL_0986|M.ulcerans_Agy99 DGSSVLVQMMWAMRGIGIWSDVRGTNMLDGGAPYYDTYECADGGYVAVGA
MAV_1284|M.avium_104 DGSSVLVQMMWQMRASGMWTDARGTNLLDGGAPYYDTYECADGRYVAVGA
Mflv_2126|M.gilvum_PYR-GCK DGSSVLSMMMWSFRGMGMWSDERGVNMLDTGAPYYDTYECSDGRHIAVGC
Mvan_4578|M.vanbaalenii_PYR-1 DGSSVLSMMMWAFRGMGMWSDERGTNMLDTGAPYYDTYETADGKYVAVGA
TH_4477|M.thermoresistible__bu DGSAVLMQMMWAFRAMGMWSDERGVNMLDTGAPYYDTYETADGKYVAVGA
MSMEG_5184|M.smegmatis_MC2_155 DGSAVLMEMMWSFRANGMWSDERGTNMLDTGAPYYDTYETADGKYIAVGA
MAB_0845|M.abscessus_ATCC_1997 DGVSQLAQMQWTMYNNGLLFDEREAGLLDGGSPFYGTYETSDGKYMAVGS
** : * * * : *: * * ..:** *:*:*.*** :** ::***.
Rv1143|M.tuberculosis_H37Rv IEPQFYAAMLAGLGLDAAELPPQNDRARWPELRALLTEAFASHDRDHWGA
Mb1175|M.bovis_AF2122/97 IEPQFYAAMLAGLGLDAAELPPQNDRARWPELRALLTEAFASHDRDHWGA
MMAR_4308|M.marinum_M IEPQFYAAMLAGLGLDAVNLPPQNDVARWPELRAVLTEAFGRYDRDHWAK
MUL_0986|M.ulcerans_Agy99 IEPQFYAAMLAGLGLDAVNLPPQNDVARWPELRAVLTEAFGRYDRDHWAK
MAV_1284|M.avium_104 IEPQFYAAMLAGLGLDGADLPGQNDVSRWPELRAALTEKFASRDRDHWAK
Mflv_2126|M.gilvum_PYR-GCK IEPQFYAEFLKGVGLEGADLPGQNDMGRWPELREAFSKAIAAHDRDHWAG
Mvan_4578|M.vanbaalenii_PYR-1 IEPQFYAEMLKGIGLDGADLPDQNDMSRWPELREAFTKAFAAHDRDHWAK
TH_4477|M.thermoresistible__bu IEPQFYAEMLKGLGLEGEDLPDQNDMSRWDELRARFAEVFKSKDRDHWAQ
MSMEG_5184|M.smegmatis_MC2_155 IEPQFYAELLKGLGLDGADLPAQNDISRWPELREAFAKAFAAHDRAHWTK
MAB_0845|M.abscessus_ATCC_1997 IEPQFFAILVQGLGLDPESVPFQLDKARYPEMRKMFDDAFKTKTRDEWTE
*****:* :: *:**: .:* * * .*: *:* : . : * .*
Rv1143|M.tuberculosis_H37Rv VFANSDACVTPVLAFGEVHNEPHIIERNTFYEAN-GGWQPMPAPRFSRTA
Mb1175|M.bovis_AF2122/97 VFANSDACVTPVLAFGEVHNEPHIIERNTFYEAN-GGWQPMPAPRFSRTA
MMAR_4308|M.marinum_M VFADSDACVTPVLSFGEVHTEPHIAERNTFYEGDDGGPQPMPAPRFSRTV
MUL_0986|M.ulcerans_Agy99 VFADSDACVTPVLSFGEVHTEPHIAERNTFYEGDDGGPQPMPAPRFSRTV
MAV_1284|M.avium_104 VFADSDACVTPVLAFGEVQTEPHITERNTFYEVD-GGLQPLPAPRFSRTA
Mflv_2126|M.gilvum_PYR-GCK VFAGTDACVTPVLSFAEVESEPHNTERDTFYSEN-GSLYPAPAPRFSRSV
Mvan_4578|M.vanbaalenii_PYR-1 VFAGTDACVTPVLSFAEVESEPHNTERDTFYSEN-GSLYPAPAPRFSRSA
TH_4477|M.thermoresistible__bu VFAGTDACVTPVLSFAEVESEAHVVERNTFYREG-DHLLPAPAPRFSRSV
MSMEG_5184|M.smegmatis_MC2_155 VFEGTDACTTPVLSFAEVLDEPHVAERNTFYDDE-GNLQPMPAPRFSRTQ
MAB_0845|M.abscessus_ATCC_1997 IFIGTDACVSPVLTWGEAKQNEHLRDRGTIVDVD-GVTQAAPAPRFSRTP
:* .:***.:***::.*. : * :*.*: . . *******:
Rv1143|M.tuberculosis_H37Rv SSQPRPPAATI-DIEAVLTDWDG
Mb1175|M.bovis_AF2122/97 SSQPRPPAATI-DIEAVLTDWDG
MMAR_4308|M.marinum_M PSRPRPPAAPLTDVEAVLSDWV-
MUL_0986|M.ulcerans_Agy99 PSRPRPPAAPLTDVEAVLSDWA-
MAV_1284|M.avium_104 PETPR-PAAPVTDATAILDEWV-
Mflv_2126|M.gilvum_PYR-GCK PSAPKAPGVPGADTEAVLQEWV-
Mvan_4578|M.vanbaalenii_PYR-1 PSAPKPPGVPGADTEAVLREWV-
TH_4477|M.thermoresistible__bu PSAPTPPRDPGADTDAVLQDWQ-
MSMEG_5184|M.smegmatis_MC2_155 PGRPTPPPQRGADTEAVLRDWS-
MAB_0845|M.abscessus_ATCC_1997 SGPLGAPPKDTTELSDIG--W--
. * : : *