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TRSNVLPVARTYSRTFSGARLRRLRQERGLTQVALAKALDLSTSYVNQLENDQRPITVPVLLLLTERFDL SAQYFSSDSDARLVADLSDVFTDIGVEHAVSGAQIEEFVARMPEVGHSLVAVHRRLRAATEELEGYRSRA TAETELPPARPMPFEEVRDFFYDRNNYIHDLDMAAERMFTESGMRTGGLDIQLAELMRDRFGISVVIDDN LPDTAKRRYHPDTKVLRVAHWLMPGQRAFQIATQLALVGQSDLISSIVATDDQLSTEARGVARIGLANYF AGAFLLPYREFHRAAEQLRYDIDLLGRRFGVGFETVCHRLSTLQRPRQRGIPFIFVRTDKAGNISKRQSA TAFHFSRVGGSCPLWVVHDAFAQPERIVRQVAQMPDGRSYFWVAKTTAADGLGYLGPHKNFAVGLGCDLA HAHKLVYSTGVVLDDPSTEVPIGAGCKICNRTSCAQRAFPYLGGRVAVDENAGSSLPYSSTEQSV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1129c | - | - | 100% (486) | PROBABLE TRANSCRIPTIONAL REGULATOR PROTEIN |
| M. tuberculosis H37Rv | Rv0465c | - | e-124 | 47.44% (468) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1160c | - | 0.0 | 100.00% (486) | transcriptional regulator protein |
| M. gilvum PYR-GCK | Mflv_0109 | - | 1e-123 | 47.27% (476) | hypothetical protein Mflv_0109 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4616c | - | 0.0 | 66.60% (473) | transcriptional regulator protein |
| M. marinum M | MMAR_1378 | - | 1e-177 | 67.24% (467) | transcriptional regulatory protein |
| M. avium 104 | MAV_0348 | - | 1e-176 | 65.18% (471) | transcriptional regulator, XRE family protein |
| M. smegmatis MC2 155 | MSMEG_6643 | - | 0.0 | 68.16% (468) | DNA-binding protein |
| M. thermoresistible (build 8) | TH_4348 | - | 1e-119 | 45.28% (477) | PUTATIVE protein of unknown function DUF955 |
| M. ulcerans Agy99 | MUL_2497 | - | 1e-177 | 67.02% (467) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0799 | - | 1e-121 | 46.76% (479) | hypothetical protein Mvan_0799 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1129c|M.tuberculosis_H37Rv MTRSNVLPVARTYSRTFSGARLRRLRQERGLTQVALAKALDLSTSYVNQL
Mb1160c|M.bovis_AF2122/97 MTRSNVLPVARTYSRTFSGARLRRLRQERGLTQVALAKALDLSTSYVNQL
MAB_4616c|M.abscessus_ATCC_199 ------------MSRPFAGARLRRLREERGLTQAALARVLDLSTSYVNQL
MMAR_1378|M.marinum_M ------------MPKTFAGARLRRLREDHGLTQVALARALGLSTSYVNQL
MUL_2497|M.ulcerans_Agy99 --MKGGARRVSHVPKTFAGARLRRLREDHGLTQVALARALGLSTSYVNQL
MAV_0348|M.avium_104 ------------MAKTFAGARLRRLREEQGLTQVALARVLGLSTSYVNQL
MSMEG_6643|M.smegmatis_MC2_155 ------------MAKTFIGPRLRRLREEHGLTQVALARALGLSTSYINQL
Mflv_0109|M.gilvum_PYR-GCK ------------MAKTFVGARVRQLRSERGFSQAALAQMLEISPSYLNQI
Mvan_0799|M.vanbaalenii_PYR-1 ------------MAKTFVGARIRQLRSERGFSQAALAQMLEISPSYLNQI
TH_4348|M.thermoresistible__bu ------------VAKTYVGSRVRQLRNERGYSQAALAEMLGISPSYLNQI
.:.: *.*:*:**.::* :*.***. * :*.**:**:
Rv1129c|M.tuberculosis_H37Rv ENDQRPITVPVLLLLTERFDLSAQYFSSDSDARLVADLSDVFTDIGVEHA
Mb1160c|M.bovis_AF2122/97 ENDQRPITVPVLLLLTERFDLSAQYFSSDSDARLVADLSDVFTDIGVEHA
MAB_4616c|M.abscessus_ATCC_199 ENDTRPVTVAVLLRLTERFDLSPHYFSPDSDARLVADLGEIFTEAAVG-E
MMAR_1378|M.marinum_M ENDQRPITVSVLLALAERFDLPTHYFAPDSDARLVSDLREVFAEGPAT--
MUL_2497|M.ulcerans_Agy99 ENDQRPITVSVLLALAERFDLPTHYFAPDSDARLVSDLREVFAEGPAT--
MAV_0348|M.avium_104 ENDQRPITVPVLLTLTERFDLPTQYFAPDSDARLIADLREVLAETPAT--
MSMEG_6643|M.smegmatis_MC2_155 ENDQRPVTVPVLLSLSERFDLPTHYFTPDSDARLVSDLRDILVDSAAT--
Mflv_0109|M.gilvum_PYR-GCK EHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLIAELREVTMDRDLDVE
Mvan_0799|M.vanbaalenii_PYR-1 EHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLIAELREVLMDRDLDVD
TH_4348|M.thermoresistible__bu EHDVRPLTVPVLLRITDLFGVDATFFAPEDNTRLIAELREVTLDRDLDIN
*:* **:**.*** ::: *.: . :*:.:.::**:::* :: :
Rv1129c|M.tuberculosis_H37Rv VSGAQIEEFVARMPEVGHSLVAVHRRLRAATEELEGYRSRATAE----TE
Mb1160c|M.bovis_AF2122/97 VSGAQIEEFVARMPEVGHSLVAVHRRLRAATEELEGYRSRATAE----TE
MAB_4616c|M.abscessus_ATCC_199 VSDLQLEELVARMPSVGQTLVGMHRRLRDVTAELESYRATENAE----TI
MMAR_1378|M.marinum_M --PAQIEELVARMPAVGQTLVNLHRRLYDATAELEALHSRATAD----VS
MUL_2497|M.ulcerans_Agy99 --PAQIEELVARMPAVGQTLVNLHRRLYDATAELEALHSRATAD----VS
MAV_0348|M.avium_104 --PGQVEELVARMPAIGQTLVNLHRRLHDTTADLEALYSRANLD----IS
MSMEG_6643|M.smegmatis_MC2_155 --QAQIEELVARMPAVGQTLVTLHRRLFDATTELEAMHTRASAD----AP
Mflv_0109|M.gilvum_PYR-GCK VDPAEIAEVVASHPSLARAMVNLHRRYQLTTTQLAAATEDRFNTAGLSSA
Mvan_0799|M.vanbaalenii_PYR-1 VDPAEVADMVGSHPALARAMVNLHRRYQLTTTQLAAATEDRFN------V
TH_4348|M.thermoresistible__bu VDMTEIADMVSAHPELARAMVNLHQRYRRTTTQLAAATEDRYHD----SS
:: :.*. * :.:::* :*:* .* :* .
Rv1129c|M.tuberculosis_H37Rv LP----PARPMPFEEVRDFFYDRNNYIHDLDMAAERMFTESGMRTGGLDI
Mb1160c|M.bovis_AF2122/97 LP----PARPMPFEEVRDFFYDRNNYIHDLDMAAERMFTESGMRTGGLDI
MAB_4616c|M.abscessus_ATCC_199 GDSVREPLRPMPFEEVRDFFYDHKNYLGELDTAAEDLFEHYGLHVGGLDI
MMAR_1378|M.marinum_M AVSG----QPMPFEEVRDFFYDRKNYIGELDIAAEEMFGRHGLRLGGLDA
MUL_2497|M.ulcerans_Agy99 AVSG----QPMPFEEVRDFFYDRKNYIGELDIAAEQMFGRHGLHLGGLDA
MAV_0348|M.avium_104 DTPGL-PHQPMPFEEVRDFFYDRKNYIGELDVAAEEMFDHNRLRIGGLDG
MSMEG_6643|M.smegmatis_MC2_155 VPLQ----QPMPFEEVRDFFYDRKNHVAELDQAAEGVFDRRGLRIGGLDA
Mflv_0109|M.gilvum_PYR-GCK GGGSGSGAISMPHEEVRDYFYQRQNYLHELDLAAENLTADMRVHRGELAG
Mvan_0799|M.vanbaalenii_PYR-1 GSGGGSGAITMPHEEVRDYFYQRQNYLHDLDTAAEALTADMRVHRGDLAG
TH_4348|M.thermoresistible__bu GFGSGSGSITMPHEEVRDYFYQRQNYLHELDTAAEDLTIRMGMTRTELAR
.**.*****:**:::*:: :** *** : : *
Rv1129c|M.tuberculosis_H37Rv QLAELMRDRFGISVVIDDN--LPDTAKRRYHPDTKVLRVAHWLMPGQRAF
Mb1160c|M.bovis_AF2122/97 QLAELMRDRFGISVVIDDN--LPDTAKRRYHPDTKVLRVAHWLMPGQRAF
MAB_4616c|M.abscessus_ATCC_199 QLATVLKQDLGIAVAVNKAGEPSDSSKRRFDATAGVLRIAHWLTPGQRAF
MMAR_1378|M.marinum_M QLARLLGDNLGTTVVLDDGQSLNPNSKRMFQPESKTLYLARWLNRGQRAF
MUL_2497|M.ulcerans_Agy99 QLARLLGDNLGITVVLDDGQSLNPNSKRMFQPESKTLYLARWLNRGQRAF
MAV_0348|M.avium_104 QLAQLLGEQLGVAVVIDDGQLLAPNSKRLFDPESKTVYLARWLHPGQRAF
MSMEG_6643|M.smegmatis_MC2_155 QLAELLSDELGINVVIDDGQVLSANGKRIYRPDHATLYVARWLHPGQRAF
Mflv_0109|M.gilvum_PYR-GCK DLADRLRFVHGVTIIRRID--LGEVVMHRYDPDTRRLEMSAQLSAGQRVF
Mvan_0799|M.vanbaalenii_PYR-1 DLSDRLRFVHGVTVIRSVD--LGEGVLHRYDPATRRLEVGAHLSSGQTVF
TH_4348|M.thermoresistible__bu QLADRLTMVHGVHIVRRVD--MPETVLHRYDPETRTLELNNQLSSGQQVF
:*: : * : : : . : : * ** .*
Rv1129c|M.tuberculosis_H37Rv QIATQLALVGQSDLISSIVATDDQLSTEARGVARIGLANYFAGAFLLPYR
Mb1160c|M.bovis_AF2122/97 QIATQLALVGQSDLISSIVATDDQLSTEARGVARIGLANYFAGAFLLPYR
MAB_4616c|M.abscessus_ATCC_199 QMATQLALVTQTETMAAILAGADQLSPEAIGVARIGLANYFAGAFLLPYK
MMAR_1378|M.marinum_M QLATQIALLTQADLITGIIAGDDQLSDEARGVARIGLANYFAGALLLPYR
MUL_2497|M.ulcerans_Agy99 QLATQIALLTQADLITGIIAGDDQLSDEARGVARIGLANYFAGALLLPYR
MAV_0348|M.avium_104 QLATQIALLTQPELITAIIAGDDQLSDDARGVARIGLANYFAGALLLPYR
MSMEG_6643|M.smegmatis_MC2_155 QIATQYALLTQAELIAELVADADDLSTEAREVARIGLANYYAGALLLPYR
Mflv_0109|M.gilvum_PYR-GCK RMAAELAYLECGDLIEKLVAEGHFTSEESRKLARMGLANYFAAATVLPYG
Mvan_0799|M.vanbaalenii_PYR-1 RMAAELAYLECGELIDKLVDEGKFTSEESRKLARMGLANYFAAAAVLPYG
TH_4348|M.thermoresistible__bu KMAAELGYLEFGDLIDKLVDEGHFTSDESRKLARLGLANYFAAATVLPYR
::*:: . : : : :: . * :: :**:*****:*.* :***
Rv1129c|M.tuberculosis_H37Rv EFHRAAEQLRYDIDLLGRRFGVGFETVCHRLSTLQRPRQRGIPFIFVRTD
Mb1160c|M.bovis_AF2122/97 EFHRAAEQLRYDIDLLGRRFGVGFETVCHRLSTLQRPRQRGIPFIFVRTD
MAB_4616c|M.abscessus_ATCC_199 QFHHAAESSRYDVDILARQFEVGHETVCHRLSTLQRPSMRGVPFILVRTD
MMAR_1378|M.marinum_M PFLDAAASTRYDIDQLARRFEVGFETICHRLSTLQRPNARGVPFIFVRTD
MUL_2497|M.ulcerans_Agy99 PFLDAAASTRYDIDQLARRFEVGFETICHRLSTLQRPNARGVPFIFVRTD
MAV_0348|M.avium_104 RFLDAAERVRYDIDQLSRRFEVGFETVCHRLSTLQRPNARGVPFIFVRTD
MSMEG_6643|M.smegmatis_MC2_155 MFLAAAEELRYDIDRLARRFEVGFETVCHRLSTLQRPDARGVPFIFVRTD
Mflv_0109|M.gilvum_PYR-GCK QFHEVAEKFRYDVERLSAYYSVSYETICHRLSTLQRPSMRGVPFSFVRVD
Mvan_0799|M.vanbaalenii_PYR-1 QFHEVAEKFRYDIERLSAYYSVSYETTCHRLSTLQRPSMRGVPFSFVRVD
TH_4348|M.thermoresistible__bu QFHGVTENFRYDIERLSAFYRVSYETICHRLSTLQRPSMRGVPFSFVRVD
* .: ***:: *. : *..** ********** **:** :**.*
Rv1129c|M.tuberculosis_H37Rv KAGNISKRQSATAFHFSRVGGSCPLWVVHDAFAQPERIVRQVAQMPDGRS
Mb1160c|M.bovis_AF2122/97 KAGNISKRQSATAFHFSRVGGSCPLWVVHDAFAQPERIVRQVAQMPDGRS
MAB_4616c|M.abscessus_ATCC_199 RAGNISKRQSATAFHFSRVGGNCPLWVVHEAFSNPGQFVTQVAEMPDGRT
MMAR_1378|M.marinum_M SAGNISKRQSATAFHFSRVGGNCPLWVIHQAFARPGRFLTQVAQMPDERT
MUL_2497|M.ulcerans_Agy99 SAGNISKRQSATAFHFSRVGGNCPLWVIHQAFARPGQFLTQVAQMPDERT
MAV_0348|M.avium_104 SAGNISKRQSATAFHFSRVGGNCPLWVVHHAFSRPGQFLTQVAQMPDDRT
MSMEG_6643|M.smegmatis_MC2_155 NAGNISKRQSATAFHFSRVGGNCPLWVVHQAFAQPGQFVTQVAQMPDGRS
Mflv_0109|M.gilvum_PYR-GCK RAGNMSKRQSATGFHFSSSGGTCPLWNVYETFANPGKIGVQIAEMPDGRA
Mvan_0799|M.vanbaalenii_PYR-1 RAGNMSKRQSATGFHFSSSGGTCPLWNVYETFANPGKISVQIAEMPDGRA
TH_4348|M.thermoresistible__bu RAGNMSKRQSASGFHFSSSGGTCPLWNVYETFAYPGKIMVQIAEMPDGRK
***:******:.**** **.**** ::.:*: * :: *:*:*** *
Rv1129c|M.tuberculosis_H37Rv YFWVAKTTAADGLGYLGPHKNFAVGLGCDLAHAHKLVYSTGVVLDDPS--
Mb1160c|M.bovis_AF2122/97 YFWVAKTTAADGLGYLGPHKNFAVGLGCDLAHAHKLVYSTGVVLDDPS--
MAB_4616c|M.abscessus_ATCC_199 YFWVARTSSTSTGGFLSTPKSFAIGLGCDIAHAHRLVYSTGIAIDDPS--
MMAR_1378|M.marinum_M YFWIARTTTAEPSRYLGPGKSFAIGLGCDLAHADKLIYSVGVDLTDTE--
MUL_2497|M.ulcerans_Agy99 YFWIARTTTAEPSRYLGPGKSFAIGLGCDLAHADKLIYSVGVDLTDTE--
MAV_0348|M.avium_104 YFWIARTTSGGPSRYLGPHKSFAIGLGCDVDHADKLIYSVGIDLRDTE--
MSMEG_6643|M.smegmatis_MC2_155 YFWIARTTAPSQSSYLGPTKSFAIGLGCDLAHAHRLIYSAGIDLADEA--
Mflv_0109|M.gilvum_PYR-GCK YMWVARTVERRAARYGQPGKTFAIGLGCELRHAQRLVYSEGLDLSGDPSV
Mvan_0799|M.vanbaalenii_PYR-1 YMWVARTVERRASRYGQPGKTFAIGLGCELRHAQRLVYSEGL-VTGDPNV
TH_4348|M.thermoresistible__bu YLWVARTVERRASRYGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGE---
*:*:*:* : . *.**:****:: **.:*:** *: : .
Rv1129c|M.tuberculosis_H37Rv TEVPIGAGCKICNRTSCAQRAFPYLGGRVAVDENAGSSLPYSSTEQSV-
Mb1160c|M.bovis_AF2122/97 TEVPIGAGCKICNRTSCAQRAFPYLGGRVAVDENAGSSLPYSSTEQSV-
MAB_4616c|M.abscessus_ATCC_199 TAVPIGPGCKVCVRESCAQRAFPYIGRSVHVDEDASSGLPYT-------
MMAR_1378|M.marinum_M AIAAIGAGCKICDRPSCPQRAFPYLGRPVRVDPHTSTDLPYPPAISTER
MUL_2497|M.ulcerans_Agy99 AIAAIGAGCKICDRPSCPQRAFPYLGRPVRVDPHTSTDLPYPPAISTER
MAV_0348|M.avium_104 SIVPIGAGCKICDRPACPQRAFPYLGRPVSVDPHRSTDLPYPPAITP--
MSMEG_6643|M.smegmatis_MC2_155 AAVPIGAGCKVCERPACPQRAFPYIGRPVKVDPHASSDLPYPTVNDPR-
Mflv_0109|M.gilvum_PYR-GCK RATPIGAGCRVCERDNCPQRAFPALGRALDIDEHRSTVSPYLVRQP---
Mvan_0799|M.vanbaalenii_PYR-1 PATPIGAGCRVCERDNCPQRAFPALGRALDIDEHRSTVSPYLVRQQ---
TH_4348|M.thermoresistible__bu NASPIGVGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVRRP---
.** **::* * *.***** :* : :* . .: **