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VKGGARRVSHVPKTFAGARLRRLREDHGLTQVALARALGLSTSYVNQLENDQRPITVSVLLALAERFDLP THYFAPDSDARLVSDLREVFAEGPATPAQIEELVARMPAVGQTLVNLHRRLYDATAELEALHSRATADVS AVSGQPMPFEEVRDFFYDRKNYIGELDIAAEQMFGRHGLHLGGLDAQLARLLGDNLGITVVLDDGQSLNP NSKRMFQPESKTLYLARWLNRGQRAFQLATQIALLTQADLITGIIAGDDQLSDEARGVARIGLANYFAGA LLLPYRPFLDAAASTRYDIDQLARRFEVGFETICHRLSTLQRPNARGVPFIFVRTDSAGNISKRQSATAF HFSRVGGNCPLWVIHQAFARPGQFLTQVAQMPDERTYFWIARTTTAEPSRYLGPGKSFAIGLGCDLAHAD KLIYSVGVDLTDTEAIAAIGAGCKICDRPSCPQRAFPYLGRPVRVDPHTSTDLPYPPAISTER
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2497 | - | - | 100% (483) | transcriptional regulatory protein |
| M. ulcerans Agy99 | MUL_4534 | - | e-124 | 47.99% (473) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1160c | - | 1e-177 | 67.02% (467) | transcriptional regulator protein |
| M. gilvum PYR-GCK | Mflv_0109 | - | 1e-122 | 47.40% (481) | hypothetical protein Mflv_0109 |
| M. tuberculosis H37Rv | Rv1129c | - | 1e-177 | 67.02% (467) | transcriptional regulator protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4616c | - | 1e-175 | 64.68% (470) | transcriptional regulator protein |
| M. marinum M | MMAR_1378 | - | 0.0 | 99.15% (473) | transcriptional regulatory protein |
| M. avium 104 | MAV_0348 | - | 0.0 | 83.30% (473) | transcriptional regulator, XRE family protein |
| M. smegmatis MC2 155 | MSMEG_6643 | - | 0.0 | 76.82% (466) | DNA-binding protein |
| M. thermoresistible (build 8) | TH_4348 | - | 1e-117 | 46.72% (473) | PUTATIVE protein of unknown function DUF955 |
| M. vanbaalenii PYR-1 | Mvan_0799 | - | 1e-117 | 46.61% (472) | hypothetical protein Mvan_0799 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2497|M.ulcerans_Agy99 --MKGGARRVSHVPKTFAGARLRRLREDHGLTQVALARALGLSTSYVNQL
MMAR_1378|M.marinum_M ------------MPKTFAGARLRRLREDHGLTQVALARALGLSTSYVNQL
MAV_0348|M.avium_104 ------------MAKTFAGARLRRLREEQGLTQVALARVLGLSTSYVNQL
MSMEG_6643|M.smegmatis_MC2_155 ------------MAKTFIGPRLRRLREEHGLTQVALARALGLSTSYINQL
Mb1160c|M.bovis_AF2122/97 MTRSNVLPVARTYSRTFSGARLRRLRQERGLTQVALAKALDLSTSYVNQL
Rv1129c|M.tuberculosis_H37Rv MTRSNVLPVARTYSRTFSGARLRRLRQERGLTQVALAKALDLSTSYVNQL
MAB_4616c|M.abscessus_ATCC_199 ------------MSRPFAGARLRRLREERGLTQAALARVLDLSTSYVNQL
Mflv_0109|M.gilvum_PYR-GCK ------------MAKTFVGARVRQLRSERGFSQAALAQMLEISPSYLNQI
Mvan_0799|M.vanbaalenii_PYR-1 ------------MAKTFVGARIRQLRSERGFSQAALAQMLEISPSYLNQI
TH_4348|M.thermoresistible__bu ------------VAKTYVGSRVRQLRNERGYSQAALAEMLGISPSYLNQI
.:.: *.*:*:**.::* :*.***. * :*.**:**:
MUL_2497|M.ulcerans_Agy99 ENDQRPITVSVLLALAERFDLPTHYFAPDSDARLVSDLREVFAEGPAT--
MMAR_1378|M.marinum_M ENDQRPITVSVLLALAERFDLPTHYFAPDSDARLVSDLREVFAEGPAT--
MAV_0348|M.avium_104 ENDQRPITVPVLLTLTERFDLPTQYFAPDSDARLIADLREVLAETPAT--
MSMEG_6643|M.smegmatis_MC2_155 ENDQRPVTVPVLLSLSERFDLPTHYFTPDSDARLVSDLRDILVDSAAT--
Mb1160c|M.bovis_AF2122/97 ENDQRPITVPVLLLLTERFDLSAQYFSSDSDARLVADLSDVFTDIGVEHA
Rv1129c|M.tuberculosis_H37Rv ENDQRPITVPVLLLLTERFDLSAQYFSSDSDARLVADLSDVFTDIGVEHA
MAB_4616c|M.abscessus_ATCC_199 ENDTRPVTVAVLLRLTERFDLSPHYFSPDSDARLVADLGEIFTEAAVG-E
Mflv_0109|M.gilvum_PYR-GCK EHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLIAELREVTMDRDLDVE
Mvan_0799|M.vanbaalenii_PYR-1 EHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLIAELREVLMDRDLDVD
TH_4348|M.thermoresistible__bu EHDVRPLTVPVLLRITDLFGVDATFFAPEDNTRLIAELREVTLDRDLDIN
*:* **:**.*** ::: *.: . :*:.:.::**:::* :: :
MUL_2497|M.ulcerans_Agy99 --PAQIEELVARMPAVGQTLVNLHRRLYDATAELEALHSRATAD----VS
MMAR_1378|M.marinum_M --PAQIEELVARMPAVGQTLVNLHRRLYDATAELEALHSRATAD----VS
MAV_0348|M.avium_104 --PGQVEELVARMPAIGQTLVNLHRRLHDTTADLEALYSRANLD----IS
MSMEG_6643|M.smegmatis_MC2_155 --QAQIEELVARMPAVGQTLVTLHRRLFDATTELEAMHTRASAD----AP
Mb1160c|M.bovis_AF2122/97 VSGAQIEEFVARMPEVGHSLVAVHRRLRAATEELEGYRSRATAE----TE
Rv1129c|M.tuberculosis_H37Rv VSGAQIEEFVARMPEVGHSLVAVHRRLRAATEELEGYRSRATAE----TE
MAB_4616c|M.abscessus_ATCC_199 VSDLQLEELVARMPSVGQTLVGMHRRLRDVTAELESYRATENAE----TI
Mflv_0109|M.gilvum_PYR-GCK VDPAEIAEVVASHPSLARAMVNLHRRYQLTTTQLAAATEDRFNTAGLSSA
Mvan_0799|M.vanbaalenii_PYR-1 VDPAEVADMVGSHPALARAMVNLHRRYQLTTTQLAAATEDRFN------V
TH_4348|M.thermoresistible__bu VDMTEIADMVSAHPELARAMVNLHQRYRRTTTQLAAATEDRYHD----SS
:: :.*. * :.:::* :*:* .* :* .
MUL_2497|M.ulcerans_Agy99 AVSG----QPMPFEEVRDFFYDRKNYIGELDIAAEQMFGRHGLHLGGLDA
MMAR_1378|M.marinum_M AVSG----QPMPFEEVRDFFYDRKNYIGELDIAAEEMFGRHGLRLGGLDA
MAV_0348|M.avium_104 DTPGL-PHQPMPFEEVRDFFYDRKNYIGELDVAAEEMFDHNRLRIGGLDG
MSMEG_6643|M.smegmatis_MC2_155 VPLQ----QPMPFEEVRDFFYDRKNHVAELDQAAEGVFDRRGLRIGGLDA
Mb1160c|M.bovis_AF2122/97 LP----PARPMPFEEVRDFFYDRNNYIHDLDMAAERMFTESGMRTGGLDI
Rv1129c|M.tuberculosis_H37Rv LP----PARPMPFEEVRDFFYDRNNYIHDLDMAAERMFTESGMRTGGLDI
MAB_4616c|M.abscessus_ATCC_199 GDSVREPLRPMPFEEVRDFFYDHKNYLGELDTAAEDLFEHYGLHVGGLDI
Mflv_0109|M.gilvum_PYR-GCK GGGSGSGAISMPHEEVRDYFYQRQNYLHELDLAAENLTADMRVHRGELAG
Mvan_0799|M.vanbaalenii_PYR-1 GSGGGSGAITMPHEEVRDYFYQRQNYLHDLDTAAEALTADMRVHRGDLAG
TH_4348|M.thermoresistible__bu GFGSGSGSITMPHEEVRDYFYQRQNYLHELDTAAEDLTIRMGMTRTELAR
.**.*****:**:::*:: :** *** : : *
MUL_2497|M.ulcerans_Agy99 QLARLLGDNLGITVVLDDGQSLNPNSKRMFQPESKTLYLARWLNRGQRAF
MMAR_1378|M.marinum_M QLARLLGDNLGTTVVLDDGQSLNPNSKRMFQPESKTLYLARWLNRGQRAF
MAV_0348|M.avium_104 QLAQLLGEQLGVAVVIDDGQLLAPNSKRLFDPESKTVYLARWLHPGQRAF
MSMEG_6643|M.smegmatis_MC2_155 QLAELLSDELGINVVIDDGQVLSANGKRIYRPDHATLYVARWLHPGQRAF
Mb1160c|M.bovis_AF2122/97 QLAELMRDRFGISVVIDDN--LPDTAKRRYHPDTKVLRVAHWLMPGQRAF
Rv1129c|M.tuberculosis_H37Rv QLAELMRDRFGISVVIDDN--LPDTAKRRYHPDTKVLRVAHWLMPGQRAF
MAB_4616c|M.abscessus_ATCC_199 QLATVLKQDLGIAVAVNKAGEPSDSSKRRFDATAGVLRIAHWLTPGQRAF
Mflv_0109|M.gilvum_PYR-GCK DLADRLRFVHGVTIIRRID--LGEVVMHRYDPDTRRLEMSAQLSAGQRVF
Mvan_0799|M.vanbaalenii_PYR-1 DLSDRLRFVHGVTVIRSVD--LGEGVLHRYDPATRRLEVGAHLSSGQTVF
TH_4348|M.thermoresistible__bu QLADRLTMVHGVHIVRRVD--MPETVLHRYDPETRTLELNNQLSSGQQVF
:*: : * : : : . : : * ** .*
MUL_2497|M.ulcerans_Agy99 QLATQIALLTQADLITGIIAGDDQLSDEARGVARIGLANYFAGALLLPYR
MMAR_1378|M.marinum_M QLATQIALLTQADLITGIIAGDDQLSDEARGVARIGLANYFAGALLLPYR
MAV_0348|M.avium_104 QLATQIALLTQPELITAIIAGDDQLSDDARGVARIGLANYFAGALLLPYR
MSMEG_6643|M.smegmatis_MC2_155 QIATQYALLTQAELIAELVADADDLSTEAREVARIGLANYYAGALLLPYR
Mb1160c|M.bovis_AF2122/97 QIATQLALVGQSDLISSIVATDDQLSTEARGVARIGLANYFAGAFLLPYR
Rv1129c|M.tuberculosis_H37Rv QIATQLALVGQSDLISSIVATDDQLSTEARGVARIGLANYFAGAFLLPYR
MAB_4616c|M.abscessus_ATCC_199 QMATQLALVTQTETMAAILAGADQLSPEAIGVARIGLANYFAGAFLLPYK
Mflv_0109|M.gilvum_PYR-GCK RMAAELAYLECGDLIEKLVAEGHFTSEESRKLARMGLANYFAAATVLPYG
Mvan_0799|M.vanbaalenii_PYR-1 RMAAELAYLECGELIDKLVDEGKFTSEESRKLARMGLANYFAAAAVLPYG
TH_4348|M.thermoresistible__bu KMAAELGYLEFGDLIDKLVDEGHFTSDESRKLARLGLANYFAAATVLPYR
::*:: . : : : :: . * :: :**:*****:*.* :***
MUL_2497|M.ulcerans_Agy99 PFLDAAASTRYDIDQLARRFEVGFETICHRLSTLQRPNARGVPFIFVRTD
MMAR_1378|M.marinum_M PFLDAAASTRYDIDQLARRFEVGFETICHRLSTLQRPNARGVPFIFVRTD
MAV_0348|M.avium_104 RFLDAAERVRYDIDQLSRRFEVGFETVCHRLSTLQRPNARGVPFIFVRTD
MSMEG_6643|M.smegmatis_MC2_155 MFLAAAEELRYDIDRLARRFEVGFETVCHRLSTLQRPDARGVPFIFVRTD
Mb1160c|M.bovis_AF2122/97 EFHRAAEQLRYDIDLLGRRFGVGFETVCHRLSTLQRPRQRGIPFIFVRTD
Rv1129c|M.tuberculosis_H37Rv EFHRAAEQLRYDIDLLGRRFGVGFETVCHRLSTLQRPRQRGIPFIFVRTD
MAB_4616c|M.abscessus_ATCC_199 QFHHAAESSRYDVDILARQFEVGHETVCHRLSTLQRPSMRGVPFILVRTD
Mflv_0109|M.gilvum_PYR-GCK QFHEVAEKFRYDVERLSAYYSVSYETICHRLSTLQRPSMRGVPFSFVRVD
Mvan_0799|M.vanbaalenii_PYR-1 QFHEVAEKFRYDIERLSAYYSVSYETTCHRLSTLQRPSMRGVPFSFVRVD
TH_4348|M.thermoresistible__bu QFHGVTENFRYDIERLSAFYRVSYETICHRLSTLQRPSMRGVPFSFVRVD
* .: ***:: *. : *..** ********** **:** :**.*
MUL_2497|M.ulcerans_Agy99 SAGNISKRQSATAFHFSRVGGNCPLWVIHQAFARPGQFLTQVAQMPDERT
MMAR_1378|M.marinum_M SAGNISKRQSATAFHFSRVGGNCPLWVIHQAFARPGRFLTQVAQMPDERT
MAV_0348|M.avium_104 SAGNISKRQSATAFHFSRVGGNCPLWVVHHAFSRPGQFLTQVAQMPDDRT
MSMEG_6643|M.smegmatis_MC2_155 NAGNISKRQSATAFHFSRVGGNCPLWVVHQAFAQPGQFVTQVAQMPDGRS
Mb1160c|M.bovis_AF2122/97 KAGNISKRQSATAFHFSRVGGSCPLWVVHDAFAQPERIVRQVAQMPDGRS
Rv1129c|M.tuberculosis_H37Rv KAGNISKRQSATAFHFSRVGGSCPLWVVHDAFAQPERIVRQVAQMPDGRS
MAB_4616c|M.abscessus_ATCC_199 RAGNISKRQSATAFHFSRVGGNCPLWVVHEAFSNPGQFVTQVAEMPDGRT
Mflv_0109|M.gilvum_PYR-GCK RAGNMSKRQSATGFHFSSSGGTCPLWNVYETFANPGKIGVQIAEMPDGRA
Mvan_0799|M.vanbaalenii_PYR-1 RAGNMSKRQSATGFHFSSSGGTCPLWNVYETFANPGKISVQIAEMPDGRA
TH_4348|M.thermoresistible__bu RAGNMSKRQSASGFHFSSSGGTCPLWNVYETFAYPGKIMVQIAEMPDGRK
***:******:.**** **.**** ::.:*: * :: *:*:*** *
MUL_2497|M.ulcerans_Agy99 YFWIARTTTAEPSRYLGPGKSFAIGLGCDLAHADKLIYSVGVDLTDTE--
MMAR_1378|M.marinum_M YFWIARTTTAEPSRYLGPGKSFAIGLGCDLAHADKLIYSVGVDLTDTE--
MAV_0348|M.avium_104 YFWIARTTSGGPSRYLGPHKSFAIGLGCDVDHADKLIYSVGIDLRDTE--
MSMEG_6643|M.smegmatis_MC2_155 YFWIARTTAPSQSSYLGPTKSFAIGLGCDLAHAHRLIYSAGIDLADEA--
Mb1160c|M.bovis_AF2122/97 YFWVAKTTAADGLGYLGPHKNFAVGLGCDLAHAHKLVYSTGVVLDDPS--
Rv1129c|M.tuberculosis_H37Rv YFWVAKTTAADGLGYLGPHKNFAVGLGCDLAHAHKLVYSTGVVLDDPS--
MAB_4616c|M.abscessus_ATCC_199 YFWVARTSSTSTGGFLSTPKSFAIGLGCDIAHAHRLVYSTGIAIDDPS--
Mflv_0109|M.gilvum_PYR-GCK YMWVARTVERRAARYGQPGKTFAIGLGCELRHAQRLVYSEGLDLSGDPSV
Mvan_0799|M.vanbaalenii_PYR-1 YMWVARTVERRASRYGQPGKTFAIGLGCELRHAQRLVYSEGL-VTGDPNV
TH_4348|M.thermoresistible__bu YLWVARTVERRASRYGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGE---
*:*:*:* : . *.**:****:: **.:*:** *: : .
MUL_2497|M.ulcerans_Agy99 AIAAIGAGCKICDRPSCPQRAFPYLGRPVRVDPHTSTDLPYPPAISTER
MMAR_1378|M.marinum_M AIAAIGAGCKICDRPSCPQRAFPYLGRPVRVDPHTSTDLPYPPAISTER
MAV_0348|M.avium_104 SIVPIGAGCKICDRPACPQRAFPYLGRPVSVDPHRSTDLPYPPAITP--
MSMEG_6643|M.smegmatis_MC2_155 AAVPIGAGCKVCERPACPQRAFPYIGRPVKVDPHASSDLPYPTVNDPR-
Mb1160c|M.bovis_AF2122/97 TEVPIGAGCKICNRTSCAQRAFPYLGGRVAVDENAGSSLPYSSTEQSV-
Rv1129c|M.tuberculosis_H37Rv TEVPIGAGCKICNRTSCAQRAFPYLGGRVAVDENAGSSLPYSSTEQSV-
MAB_4616c|M.abscessus_ATCC_199 TAVPIGPGCKVCVRESCAQRAFPYIGRSVHVDEDASSGLPYT-------
Mflv_0109|M.gilvum_PYR-GCK RATPIGAGCRVCERDNCPQRAFPALGRALDIDEHRSTVSPYLVRQP---
Mvan_0799|M.vanbaalenii_PYR-1 PATPIGAGCRVCERDNCPQRAFPALGRALDIDEHRSTVSPYLVRQQ---
TH_4348|M.thermoresistible__bu NASPIGVGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVRRP---
.** **::* * *.***** :* : :* . .: **