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M. tuberculosis H37Rv Rv1127c (ppdK)

annotation: pyruvate phosphate dikinase
coordinates: 1249932 - 1251404
length: 490

TRITRANGCPDGTLENAVVALDGGANYPREILGNKGHGIDMMRRHHLPVPPAFCITTEVGVRYLAAPGST
IAAIWDDVLDRMSWLETETSCTFGRGPNPLLVSVRSGATQSMPGMMDTILDVGMTDAVERVLARPGAADF
AHDTRRRFTSMYRRIVGSAGPITDDPYAQLRASIEAVFASWNSPRAVAYRDHHGLDDQGGTAVVVQAMVF
GNLTANSGAGVLSSRNPITGANEPFGEWLPGGQGDDVVSGLVAVAPITALRDQQPAVYDQLMAAARSLER
MAGDVQEIEFTVEDSQLWLLQTRGAERSAQAAVRLALQLHHEGLIDDTETLRRVTPTHIETLLRPSLQTE
TRLAAPLLAKGLPACPGVVSGTAYTEVDEALDAADRGEPVILVRDHTRPEDVMGMLAAQGIVTEVGGAAS
HAAVVSRELGRVAVVGCGPGVAAALAGKEITVDGYEGEVRQGVLALSAWSESDTPELRELADIAQRISS*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1127cppdK-100% (490)pyruvate phosphate dikinase
M. tuberculosis H37RvRv2047c-1e-0934.85% (132) hypothetical protein Rv2047c

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1158cppdK0.099.59% (490) pyruvate phosphate dikinase
M. gilvum PYR-GCKMflv_4990-1e-1926.44% (450) phosphoenolpyruvate synthase
M. leprae Br4923MLBr_00955ppdK0.071.76% (478) pyruvate phosphate dikinase
M. abscessus ATCC 19977-----
M. marinum MMMAR_4331ppdK0.076.84% (488) pyruvate, phosphate dikinase PpdK
M. avium 104MAV_1259-0.076.86% (471) pyruvate phosphate dikinase
M. smegmatis MC2 155MSMEG_3934-1e-2027.15% (453) phosphoenolpyruvate synthase
M. thermoresistible (build 8)TH_2849-8e-9743.61% (477) PUTATIVE pyruvate, phosphate dikinase
M. ulcerans Agy99MUL_0141ppdK0.076.84% (488) pyruvate phosphate dikinase
M. vanbaalenii PYR-1Mvan_4106-6e-0833.33% (102) phosphoenolpyruvate synthase

CLUSTAL 2.0.9 multiple sequence alignment


Rv1127c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1158c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_4331|M.marinum_M               -----MWKHSERSGSLPKTTRGCT--------------------------
MUL_0141|M.ulcerans_Agy99           ---------------MPKTTRGCT--------------------------
MLBr_00955|M.leprae_Br4923          MPGQSHKEPHRRATSTPRSLKQATSELRWALSLAAPESPAFMRHLLGNAH
MAV_1259|M.avium_104                --------------------------------------------------
TH_2849|M.thermoresistible__bu      --------------------------------------------------
Mflv_4990|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_3934|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_4106|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv1127c|M.tuberculosis_H37Rv        -MTRITRANGCPDGTLENAVVALDGGANYP-REILGNKGHGIDMMRR---
Mb1158c|M.bovis_AF2122/97           -MTRITRANGCPDGTLENAVVALDGGANYP-REILGNKGHGIDMMRR---
MMAR_4331|M.marinum_M               -TTRFSRAGGIP--FTGPAVVLLDGRAHQP-REVLGNKGHGIDSMRR---
MUL_0141|M.ulcerans_Agy99           -TTRFSRAGGIP--FTGPAVVLLDGRAHQP-REVLGNKGHGIDSMRR---
MLBr_00955|M.leprae_Br4923          DKVDITTSSEHVAAFTEHAIVLLNGNAHQT-RELLGGKGYNINAMRR---
MAV_1259|M.avium_104                -------------------MVLLDGTSSHP-RELLGNKGHGIEVMRR---
TH_2849|M.thermoresistible__bu      ----------MTAQLTEPAVLRITDLETEPSRELVGGKALSLWRMSR---
Mflv_4990|M.gilvum_PYR-GCK          -----------MESGTRNTHVCDISALSIGDAEEAGGKGANMGELVA---
MSMEG_3934|M.smegmatis_MC2_155      -----------MDIMS-DRYVRTLDILTIADAEEAGGKGANLGELVA---
Mvan_4106|M.vanbaalenii_PYR-1       --------------MGTSEYVRFFEDFGIEDVPLVGGKNASLGEMIQNLS
                                                        :              *.*  .:  :     

Rv1127c|M.tuberculosis_H37Rv        -HHLPVPPAFCITTEVGVRYLAAPGSTIAAIWDDVLDRMSWLETETSCTF
Mb1158c|M.bovis_AF2122/97           -HHLPVPPAFCITTEVGVRYLAAPESTIAAIWDDVLDRMSWLETETSCTF
MMAR_4331|M.marinum_M               -NNLPVPPAFCITSEVGVRYLADPAPTLDAIWDDVVDRIRWLEAETGRTF
MUL_0141|M.ulcerans_Agy99           -NNLPVPPAFCITSEVGVRYLADPAPTLDAIWDDVVDRIRWLEAETGRTF
MLBr_00955|M.leprae_Br4923          -HQLAVPPAFCITTEVGVRYLAAPTPTMEAIWNDVLDQMRWLEAETSRTF
MAV_1259|M.avium_104                -HHLPVPPAFCLTTAVGLRYLADPAATMDAVWDDVLDRIGWLQAQTSRAF
TH_2849|M.thermoresistible__bu      -LGLRVPPAVVITTRSCAEYFSRGRTLSDELFEEIVSGIGYLEEKTGRRL
Mflv_4990|M.gilvum_PYR-GCK          -AKLPVPPGFVLLRDCYRDSMRAGG-VDAELASLHREALDDVADTARLGE
MSMEG_3934|M.smegmatis_MC2_155      -ADLPVPHGFVVMRSAYLDSVRMGG-VEAELAALHTEALTHAADTARLSE
Mvan_4106|M.vanbaalenii_PYR-1       AQGVRVPHGFAITAAAYRHMLDEAG-AWERLHAELDDLDPD--DVAALAR
                                       : ** .. :        .         :     .        :    

Rv1127c|M.tuberculosis_H37Rv        GRGPNPLLVSVRSGATQSMPGMMDTILDVGMTDAVERVLARPG----AAD
Mb1158c|M.bovis_AF2122/97           GRGPNPLLVSVRSGATQSMPGMMDTILDVGMTDAVERVLARPG----AAD
MMAR_4331|M.marinum_M               GSGPHPLLVSVRSGANQSMPGMMDTILDLGMNDTVEQALASPG----TGD
MUL_0141|M.ulcerans_Agy99           GSGPHPLLVSVRSGANQSMPGMMDTILDLGMNDTVEQALASPG----TGD
MLBr_00955|M.leprae_Br4923          GWGPRPLLVSIRSGAVQSMPGMMDTILNLGINDPVEQALAAASPSPIPQT
MAV_1259|M.avium_104                GRGPHPLLVSVRSGATQSMPGMMDTLLNLGINDSVEQALAAEH----GPA
TH_2849|M.thermoresistible__bu      GASDKPLFVSVRSGAAVSMPGMMDTILNLGINETTEAALAAESG---NPQ
Mflv_4990|M.gilvum_PYR-GCK          LCERMQGLVRKAGVDDATAADMLAAYHAMG----PGAVVAVRS----SAT
MSMEG_3934|M.smegmatis_MC2_155      LCRRMQSLVNKAGLSPSVRDATLAAYRALG----TDVVVAVRS----SAT
Mvan_4106|M.vanbaalenii_PYR-1       KAKRAREIVYGAGLPDDLAAEILDGYRALQREYGEEVSLAVRS----SAT
                                           :*   .         :     :         :*          

Rv1127c|M.tuberculosis_H37Rv        FAHDTRRRFTSMYRRIVG----------------------SAGPITDDPY
Mb1158c|M.bovis_AF2122/97           FAHDTRRRFTSMYRRIVG----------------------SAGPITDDPY
MMAR_4331|M.marinum_M               FARDTRRRFTRMYRRIVA----------------------GSDPP-DDPY
MUL_0141|M.ulcerans_Agy99           FARDTRRRFTRMYRRIVA----------------------GSDPP-DDPY
MLBr_00955|M.leprae_Br4923          FARDTRLRFIRTYRRIVD----------------------PLNPPPANTY
MAV_1259|M.avium_104                FARDTHRRFREMYRRIVG----------------------VERPVPSDPY
TH_2849|M.thermoresistible__bu      FAADVRRRFSALYGKLVAGCLEDLEDLPDTAAVLQAISEETGSAVPDDPY
Mflv_4990|M.gilvum_PYR-GCK          GEDGADASFAGMNATLTN----------------------------ITGD
MSMEG_3934|M.smegmatis_MC2_155      GEDGRDASFAGMNRTITN----------------------------VMGE
Mvan_4106|M.vanbaalenii_PYR-1       AEDLPTASFAGQQDSYLN----------------------------IKGE
                                            *                                         

Rv1127c|M.tuberculosis_H37Rv        AQLRASIEAVFASWNSPRAVAYRDHHGLDD-QGGTAVVVQAMVFGNLTAN
Mb1158c|M.bovis_AF2122/97           AQLRASIEAVFASWNSPRAVAYRDHHGLDD-QGGTAVVVQAMVFGNLTAN
MMAR_4331|M.marinum_M               EQLRAGIGAVFASWNSPRAIAYRNHYSLDD-QGGTAVVVQAMVFGNRSAD
MUL_0141|M.ulcerans_Agy99           EQLRAGIGAVFASWNSPRAIAYRNHYSLDD-QGGTAVVVQAMVFGNRSAD
MLBr_00955|M.leprae_Br4923          DQLRAAIESIFSSWNSPRAVAYRTHYGLDD-QSGTAVIVQAMVFGNQGAY
MAV_1259|M.avium_104                TQLRAGIEAVFASWNSPRARAYRAHYGFAD-RHGTAVVVQAMVFGNHGPN
TH_2849|M.thermoresistible__bu      EALRGAVCAVFDSSQSRRAKAYRAHYGIPD-DIGTAVTIQAMVFGNLDDD
Mflv_4990|M.gilvum_PYR-GCK          DGLVTAVTRCWMSLFSPRVITYRASRGFLG-TPAMAVVVQKMIDSEKS--
MSMEG_3934|M.smegmatis_MC2_155      VALLDAVTQCWMSLFSPRVITYRASRGFTA-APAMAVVVQQMLSADRA--
Mvan_4106|M.vanbaalenii_PYR-1       ESLLDTCRRCFASLFTDRAIHYRIDQGFDHFKVSLSIGVMKMVRSDIAS-
                                      *       : *  : *.  **   .:     . :: :  *: .:    

Rv1127c|M.tuberculosis_H37Rv        SGAGVLSSRNPITGANEPFGEWLPGGQGDDVVSGLVAVAPITALRDQ---
Mb1158c|M.bovis_AF2122/97           SGAGVLSSRNPITGANEPFGEWLPGGQGDDVVSGLVAVAPITALRDQ---
MMAR_4331|M.marinum_M               SGAGVLSSRNPITGASEPFGEWLPGGQGDDVVSGLLKVEPITALHDR---
MUL_0141|M.ulcerans_Agy99           SGAGVLSSRNPITGASEPFGEWLPGGQGDDVVSGLLKVEPITALRDR---
MLBr_00955|M.leprae_Br4923          SGAGTLFSRNPITRESKLFGEWLPGGQGDDVVSGLVEVQPITSLRDE---
MAV_1259|M.avium_104                SGAGAFFSRNPITGDDEPFGEWLPGGQGDDVVSGSVDVEPIAALRDE---
TH_2849|M.thermoresistible__bu      SGTGVVFTRNPLTGSREPYGEYLPRGQGEDVVSGRVTPRPLSWLAEN---
Mflv_4990|M.gilvum_PYR-GCK          ---GVAFTADPSTGARDRVVIEAAFGLGEVVVSGSVEPDTYVVSKET---
MSMEG_3934|M.smegmatis_MC2_155      ---GVAFTSDPSTGDADHIVIEAAFGQGEVVVSGKVEPDTYVIDKRT---
Mvan_4106|M.vanbaalenii_PYR-1       --SGVMFSIDTESGFRDAVFITGAYGLGENVVQGAVDPDEFYVHKPTYLA
                                       *.  : :. :   .      . * *: **.* :              

Rv1127c|M.tuberculosis_H37Rv        ------QPAVYDQLMAAARSLERMAGDVQEIEFTVEDSQLWLLQTRGAER
Mb1158c|M.bovis_AF2122/97           ------QPAVYDQLMAAARSLERMAGDVQEIEFTVEDSQLWLLQTRGAER
MMAR_4331|M.marinum_M               ------LPKIYLELLDAARGLERLAAEVQEVEFTVESGKLWLLQTRSAER
MUL_0141|M.ulcerans_Agy99           ------LPKIYLELLDAARGLERLAAEVQEVEFTVESGKLWLLQTRSAER
MLBr_00955|M.leprae_Br4923          ------QPTVYDELVDTAGRLERLGSDVQEIEFTTEDSKLWLLQTRVAER
MAV_1259|M.avium_104                ------QPAVYDQLMAAARTLERLDRDVQEIEFTVEDGALWLLQTRAAER
TH_2849|M.thermoresistible__bu      ------RPELHAELVSAAELLDREGRDAQDIEFTVQHGTLYLLQSRAAKR
Mflv_4990|M.gilvum_PYR-GCK          --MEPIDVRLGNKTFKIVRGE-DGSDTVVQLDDATAASR--VLTDEELHS
MSMEG_3934|M.smegmatis_MC2_155      --LEVRDVRIGFKAIKIVRGD-DGADSMVQLERSQAEAR--VLDDDALRK
Mvan_4106|M.vanbaalenii_PYR-1       GHRAVLRRLLGDKAVKMILVEGETKNTTRNIPTPKADRARFCLTDDDALE
                                             :  : .              ::  .        *       

Rv1127c|M.tuberculosis_H37Rv        SAQAAVRLALQLHH----EGLIDDTETLRRVTPTHIETLLRPSLQTETRL
Mb1158c|M.bovis_AF2122/97           SAQAAVRLALQLHH----EGLIDDTETLRRVTPTHIETLLRPSLQPETRL
MMAR_4331|M.marinum_M               SAQAAVRLALQLRG----AGLIDDAETLRRITPTHVETLLLPTLQPEERL
MUL_0141|M.ulcerans_Agy99           SAQAAVRLALQLRG----AGLIDDGETLRRITPTHVETLLLPTLHPDERL
MLBr_00955|M.leprae_Br4923          SAQVAVRLALQLWQ----EGLIDDAEALRRVTPVHVETVLLPVLQPENHL
MAV_1259|M.avium_104                SAQAAVRSALQLRR----EGLIDDAETLRRVTPAHVRSLLMPALQPEIRL
TH_2849|M.thermoresistible__bu      TAQAAVRIATAMVE----EGSIDPATACSRVTAEQVRHLLRPAIDPDRIG
Mflv_4990|M.gilvum_PYR-GCK          VAELAVATERHNGCPQDTEWAIA--DGAAYLVQARPITTLGHTTPPARTE
MSMEG_3934|M.smegmatis_MC2_155      IATLAVATETHNGCPQDIEWVIA--DGAVWLVQARPITTLGSAGSTAGDE
Mvan_4106|M.vanbaalenii_PYR-1       LAGYACAIEAHYGRPMDMEWAKDGLDGKLYIVQARPETVASQHSVTALES
                                     *  *                         :.  :          .    

Rv1127c|M.tuberculosis_H37Rv        AAP-----LLAKGLPACPGVVSGTAYTEVDEALDAADRGEPVILVRDHTR
Mb1158c|M.bovis_AF2122/97           AAP-----LLAKGLPACPGVVSGTAYTEVDEALDAADRGEPVILVRDHTR
MMAR_4331|M.marinum_M               AAS-----LLAKGLPACPGVAAGLAYTDVDEALDAADRGEQVILVRDHTR
MUL_0141|M.ulcerans_Agy99           AAS-----LLAKGLPACPGVAAGLAYTDVDEALDAADRGEQVILVRDHTR
MLBr_00955|M.leprae_Br4923          SAT-----LLAKGTPTCPGVISGKAYTEVDEALDAAESAEQVILVRDHTR
MAV_1259|M.avium_104                TAP-----LLAKGLPACPGVVSGTAYADVDEALHAAERGEPVILVRDHTR
TH_2849|M.thermoresistible__bu      DAE-----PIVTGTSASPGYAVGIAVGTAEEAQAKPGS----ILVREATS
Mflv_4990|M.gilvum_PYR-GCK          HV------VLARGLAAAPGIASG-KVRVLQTPDEGHRLQEGEILVAQMTN
MSMEG_3934|M.smegmatis_MC2_155      PS------VLIRGLPAAPGVASG-RVRVLLAPDDGDKLTDGEILVAPTTN
Mvan_4106|M.vanbaalenii_PYR-1       YVLDGHGDILTEGRSVGEKIASG-AVRRIEHLAQLSEFKPGEVLVADTTT
                                             :  * ..      *                   :**   * 

Rv1127c|M.tuberculosis_H37Rv        PEDVMGMLAAQGIVTEVGGAASHAAVVSRELGRVAVVGCGPGVAAALAGK
Mb1158c|M.bovis_AF2122/97           PEDVMGMLAAQGIVTEVGGAASHAAVVSRELGRVAVVGCGPGVAAALAGK
MMAR_4331|M.marinum_M               PEDVSGMLAAQGIVTEIGGAASHAAVVSRELGRVAVVGCGDGVATSLAGK
MUL_0141|M.ulcerans_Agy99           PEDVSGMLAAQGIVTEIGGAASHAAVVSRELGRVAVVGCGDGVAASLAGK
MLBr_00955|M.leprae_Br4923          PDDVLGMLASQGVVTEVGGAASHAAVVSRELSRVAVVGCGQGTAVSLAGK
MAV_1259|M.avium_104                PEDVSGMLAARGIVTEVGGAASHAAVVSRELGRVAVVGCGAGVAAMLAGR
TH_2849|M.thermoresistible__bu      PEDVHGMIAAAAVVTEKGGSTSHAAVVSRALDTPCVVGCGEGTSSALVGK
Mflv_4990|M.gilvum_PYR-GCK          PDWLPTIRRAAALVTDTGGMTCHAAIVARELGVPCIVGTRTGTRDLHDGT
MSMEG_3934|M.smegmatis_MC2_155      PDWLPTIRRAAALVTETGGMTCHAAIVARELGVPCVVGARSATVALAVGS
Mvan_4106|M.vanbaalenii_PYR-1       PDWEPVMKTAAAIVTNRGGRTCHASIIARELGIPAVVGTGDGTTSVPNGA
                                    *:    :  : .:**: ** :.**::::* *.  .:**   ..     * 

Rv1127c|M.tuberculosis_H37Rv        EITVDGYEGEVRQGVLALSAWSESDTPE----------------------
Mb1158c|M.bovis_AF2122/97           EITVDGYEGEVRQGVLALSAWSESDTPE----------------------
MMAR_4331|M.marinum_M               RITVDGYTGEVREGILAPSAWSEDDTPE----------------------
MUL_0141|M.ulcerans_Agy99           RITVDGYTGEVREGILAPSAWSEDDTPE----------------------
MLBr_00955|M.leprae_Br4923          QITVDGDKGEVRQGNLTLSAWSENETPE----------------------
MAV_1259|M.avium_104                RITVDGAEGEVREGELSLSAWSENDTPE----------------------
TH_2849|M.thermoresistible__bu      LVTVDATGGRIYPGEIPGRATTVDDDED----------------------
Mflv_4990|M.gilvum_PYR-GCK          TVTVDGARGEVASGVTEPAPQMTVSPRSAPAPVTAEVTGTRVYVNLAMPE
MSMEG_3934|M.smegmatis_MC2_155      MVTVDGTRGEVTTGRLPETVRTTTTPQEPAPHITGEATGTKVYVNLAMPD
Mvan_4106|M.vanbaalenii_PYR-1       VVTVSCAEGDTGR-VYDGAVGFHVDRTEVGDIAR---PRTEIMLNLGNPD
                                     :**.   *                  .                      

Rv1127c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1158c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_4331|M.marinum_M               --------------------------------------------------
MUL_0141|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00955|M.leprae_Br4923          --------------------------------------------------
MAV_1259|M.avium_104                --------------------------------------------------
TH_2849|M.thermoresistible__bu      --------------------------------------------------
Mflv_4990|M.gilvum_PYR-GCK          SAETVAAQPVDGVGLLRAEFMLTEALGGR-----HPR--------DLIAR
MSMEG_3934|M.smegmatis_MC2_155      SAEAVAAQDVDGVGLLRAEFMLTEALAGR-----HPR--------DLITK
Mvan_4106|M.vanbaalenii_PYR-1       LAFKTSFLPNDGVGLARMEFIISEYIKVHPLALLHPERVADSEASRTIAR
                                                                                      

Rv1127c|M.tuberculosis_H37Rv        ------------LRELADIAQRISS-------------------------
Mb1158c|M.bovis_AF2122/97           ------------LRELADIAQRISS-------------------------
MMAR_4331|M.marinum_M               ------------LRDLTTIALKISPLRAH-------------------AS
MUL_0141|M.ulcerans_Agy99           ------------LRDLTTIALKISPLRAH-------------------AS
MLBr_00955|M.leprae_Br4923          ------------LRELADIARRISPLRVH-------------------MT
MAV_1259|M.avium_104                ------------LRELAEIARLISPLRAH-------------------SG
TH_2849|M.thermoresistible__bu      ------------LATLLRWARDLAPIRVVPTADEVDGPVFDADQALIESG
Mflv_4990|M.gilvum_PYR-GCK          GEQ------NMLVEKMVDSVGRIAAAFSPRPVVYRATDFRSNEFRGLTGG
MSMEG_3934|M.smegmatis_MC2_155      GEQ------DTLVDAMAAAVTRIGTAFAPRPVIYRAMDFRTNEFRGLAGG
Mvan_4106|M.vanbaalenii_PYR-1       LTQGYADGSEFFVERLSEGIGTIAAAFWPKPVVVRMSDFKTNEYASLVGG
                                                :  :      :..                         

Rv1127c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1158c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_4331|M.marinum_M               GDYPKLDD-----------------PSEAGVLTAMAAGYTDVVSDAPLIT
MUL_0141|M.ulcerans_Agy99           GDYPKLDD-----------------PSEAGVLTAMAAGYTDVVSDAPLIT
MLBr_00955|M.leprae_Br4923          EDHTRLDD-----------------SSDTAVRLAINTGHADVVSATPLIV
MAV_1259|M.avium_104                GDHPRLDD-----------------DSESAVRAALAAGQTDVVSPTPLLV
TH_2849|M.thermoresistible__bu      EELPTIPNGTHA-------VSGAYFDTDEGVQAALDAGVSVIVSTNPLPV
Mflv_4990|M.gilvum_PYR-GCK          AEYEPVEHNPMIGFRGCYRYVK--EPELFALELEALARVRERS--PNVAL
MSMEG_3934|M.smegmatis_MC2_155      EQFEPVEHNPMIGYRGCYRYIK--EPDLFALELSALARAREHT--PNIHL
Mvan_4106|M.vanbaalenii_PYR-1       QSFEPLESNPMLGFRGASRYAHPAYAEGFALECRAMRRVRDEMGLTNVII
                                                                                      

Rv1127c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1158c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_4331|M.marinum_M               MLNALRVQDGL---------------------------------------
MUL_0141|M.ulcerans_Agy99           MLNALRVQDGL---------------------------------------
MLBr_00955|M.leprae_Br4923          MMTTLRLQDSKDSSAKS---------------------------------
MAV_1259|M.avium_104                MLTALRQGAP----------------------------------------
TH_2849|M.thermoresistible__bu      LLAAIAYRKDSDD-------------------------------------
Mflv_4990|M.gilvum_PYR-GCK          MIPFVRTRWELEECLSLVDASPLGR-QRGLHRWVMAEVPSVVHWLPEYIG
MSMEG_3934|M.smegmatis_MC2_155      MIPFVRTRWELEECLALVDASPLRR-HRNLHRWVMAEVPSVVHWLPEYVG
Mvan_4106|M.vanbaalenii_PYR-1       MLPFVRRVAEADLVLQTMADLGLKRGENGLKVYAMCEIPNNVILIDQFAK
                                                                                      

Rv1127c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1158c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_4331|M.marinum_M               --------------------------------------------------
MUL_0141|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00955|M.leprae_Br4923          --------------------------------------------------
MAV_1259|M.avium_104                --------------------------------------------------
TH_2849|M.thermoresistible__bu      --------------------------------------------------
Mflv_4990|M.gilvum_PYR-GCK          MGIDGVSIGSNDLTQLLLGVDRDSDVCAELFDESDPAVLHAIRRIVDTAN
MSMEG_3934|M.smegmatis_MC2_155      MGIDGVSIGSNDLTQLMLGVDRDSETCAELFDESDAAVLDAISRIISTAN
Mvan_4106|M.vanbaalenii_PYR-1       R-FDGFSIGSNDLTQLTLGVDRDSEVVAFDYDERDEGVKEMIRLAVEGCR
                                                                                      

Rv1127c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1158c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_4331|M.marinum_M               --------------------------------------------------
MUL_0141|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00955|M.leprae_Br4923          --------------------------------------------------
MAV_1259|M.avium_104                --------------------------------------------------
TH_2849|M.thermoresistible__bu      --------------------------------------------------
Mflv_4990|M.gilvum_PYR-GCK          KFGITSSLCGQAPSTNPAFAEHLVRLGITSVSVNPDAVDATRRVIAAAER
MSMEG_3934|M.smegmatis_MC2_155      RLGITSSLCGQAPSTRPEFAEHLVRMGITSVSVNPDAAGAARRAVAAAER
Mvan_4106|M.vanbaalenii_PYR-1       RNGIHSGLCGQAPSDYPDMAEFLVRIGIDSMSLNPDTVVKTTRQVLELER
                                                                                      

Rv1127c|M.tuberculosis_H37Rv        ----------------------
Mb1158c|M.bovis_AF2122/97           ----------------------
MMAR_4331|M.marinum_M               ----------------------
MUL_0141|M.ulcerans_Agy99           ----------------------
MLBr_00955|M.leprae_Br4923          ----------------------
MAV_1259|M.avium_104                ----------------------
TH_2849|M.thermoresistible__bu      ----------------------
Mflv_4990|M.gilvum_PYR-GCK          RIMLAAARSLPEDQ--------
MSMEG_3934|M.smegmatis_MC2_155      RLLLDSVRHPRHAPTASPRNPL
Mvan_4106|M.vanbaalenii_PYR-1       --QLASAR--------------