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LVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILGVASDDMSVGQLVKWARESIGRTEKI DDAVFDRLAGRLSYLHGDVTDSQLYDSLAELIGSACRPLYYLEMPPALFAPIVENLANVRLLERARVAVE KPFGHDLASALELNARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEIHITMAED FGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLG YTEVAGVASDSATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFLPNRRPAEPN QIVLRIDPDPGMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLYAGLVGDHQLFAREDSIEQTWR IVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSPWLPRGTDA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1121 | zwf1 | - | 100% (466) | glucose-6-phosphate 1-dehydrogenase |
| M. tuberculosis H37Rv | Rv1447c | zwf2 | 7e-76 | 37.65% (486) | glucose-6-phosphate 1-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1152 | zwf1 | 0.0 | 100.00% (466) | glucose-6-phosphate 1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0266 | - | 7e-82 | 39.66% (464) | glucose-6-phosphate 1-dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2761 | - | 2e-78 | 37.11% (485) | glucose-6-phosphate 1-dehydrogenase |
| M. marinum M | MMAR_4339 | zwf1 | 0.0 | 80.51% (467) | glucose-6-phosphate 1-dehydrogenase Zwf1 |
| M. avium 104 | MAV_1252 | zwf | 0.0 | 78.71% (465) | glucose-6-phosphate 1-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3101 | zwf | 3e-79 | 36.70% (485) | glucose-6-phosphate 1-dehydrogenase |
| M. thermoresistible (build 8) | TH_0337 | zwf2 | 2e-79 | 38.07% (486) | PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF2 (G6PD) |
| M. ulcerans Agy99 | MUL_0149 | zwf1 | 1e-165 | 83.33% (336) | glucose-6-phosphate 1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2718 | - | 1e-81 | 38.14% (485) | glucose-6-phosphate 1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1121|M.tuberculosis_H37Rv ------------------------MVDGGGG------ASDLLVIFGITGD
Mb1152|M.bovis_AF2122/97 ------------------------MVDGGGG------ASDLLVIFGITGD
MMAR_4339|M.marinum_M ------------------------MANGGGQ------ASDLLVIFGITGD
MUL_0149|M.ulcerans_Agy99 --------------------------------------------------
MAV_1252|M.avium_104 ------------------------MADDDSH------PSDLLVIFGITGD
MSMEG_3101|M.smegmatis_MC2_155 ---------MTAVNDRPDTTWHNPLRDKRDKRMPRIAGPCGVVIFGVTGD
TH_0337|M.thermoresistible__bu MTDPAGFGPVAGLAEPAPPGWRNPLRDKRDKRMPRIAGPCSMVIFGVTGD
Mvan_2718|M.vanbaalenii_PYR-1 ----------------MPESWRNPLRDKRDKRMPRIAGPCSVVIFGVTGD
MAB_2761|M.abscessus_ATCC_1997 ---------MTEVLPPDSSLTANPLRDKRDKRLPRIAGPCSLVIFGVTGD
Mflv_0266|M.gilvum_PYR-GCK ------------------------MTDDDHP--------VILVLFGARGD
Rv1121|M.tuberculosis_H37Rv LARKMTFRALYRLERHQLL--DCPILGVAS-DDMSVGQLVKWARESIG-R
Mb1152|M.bovis_AF2122/97 LARKMTFRALYRLERHQLL--DCPILGVAS-DDMSVGQLVKWARESIG-R
MMAR_4339|M.marinum_M LARKMTFRALYRLERRGLL--DCPIVGVAS-DDMSVEQLVDRAREVIQGS
MUL_0149|M.ulcerans_Agy99 --------------------------------------------------
MAV_1252|M.avium_104 LARKMTFRALYRLERREEL--EHPIIGVAS-DDITLDQLLDRAREAIKAT
MSMEG_3101|M.smegmatis_MC2_155 LARKKLMPAIYDLANRGLLPASFALVGFAR-RDWEDEDFGQVVYDAVRQH
TH_0337|M.thermoresistible__bu LSRKKLMPAIYDLANRGLLPASFSLVGFAR-RDWADEDFGQVVYEAVKTH
Mvan_2718|M.vanbaalenii_PYR-1 LARKKLMPAIYDLANRGLLPPSFALVGFAR-RDWADEDFGEVVYEAVKKH
MAB_2761|M.abscessus_ATCC_1997 LARKKLMPAIYDLANRGLLPPSFALVGFAR-RDWANEDFGQIVLDAVKAH
Mflv_0266|M.gilvum_PYR-GCK LARRMLFPSLYRLAAAGRLPADHRIIGSGRSCPDSVEEFRDSVREGWSES
Rv1121|M.tuberculosis_H37Rv TEK-IDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELI-------GSACRP
Mb1152|M.bovis_AF2122/97 TEK-IDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELI-------GSACRP
MMAR_4339|M.marinum_M SEP-FDEAVFERFASRWSYLPGDVTDPALYTALAKQI-------GHDRHG
MUL_0149|M.ulcerans_Agy99 --------------------------------------------------
MAV_1252|M.avium_104 GET-FDDAVFDRLAGRLSYLSGDVTDTGLYSELAEKI-------GGDSRP
MSMEG_3101|M.smegmatis_MC2_155 ARTPFRQEVWDRLAEGIRFVQGTFDDDTAFTRLAETLDKLDIERGTGGNH
TH_0337|M.thermoresistible__bu ARTPFRQEVWDRLAEGFRFVQGTFDDDAAFARLTEVLEKLDVQRGTGGNH
Mvan_2718|M.vanbaalenii_PYR-1 ARTPFRQEVWDRLAEGFRFVQGTFDDDASFDRLSETLEKLDAERGTGGNH
MAB_2761|M.abscessus_ATCC_1997 SRTPFRQHVWDRLAEGIRFVQGSFDDDAAFEQLKKTLQTLDEERGTGGNH
Mflv_0266|M.gilvum_PYR-GCK IDD-LDDAVVEGLLQRLSFQSADADDGADLAAAVASAQK---ELGEDVRT
Rv1121|M.tuberculosis_H37Rv LYYLEMPPALFAPIVENLANVRLLER-----ARVAVEKPFGHDLASALEL
Mb1152|M.bovis_AF2122/97 LYYLEMPPALFAPIVENLANVRLLER-----ARVAVEKPFGHDLASALEL
MMAR_4339|M.marinum_M LYYLEMPPALFAPIVENLAKADLLRG-----ARVAVEKPFGHDLDSAREL
MUL_0149|M.ulcerans_Agy99 ----------------------MLRC-----ARVAVEKPFGHDLDSAREL
MAV_1252|M.avium_104 LYYLEMPPSLFAPIVENLAKADLLER-----ARVAVEKPFGHDLESARDL
MSMEG_3101|M.smegmatis_MC2_155 AFYLSIPPNAFPVVCEQLRKSGLAKPRDGRWSRVVIEKPFGHDLGSAREL
TH_0337|M.thermoresistible__bu AFYLSIPPKAFPLVCEQLRRSGLARPQPGRWSRVVVEKPFGHDLQSAVEL
Mvan_2718|M.vanbaalenii_PYR-1 AFYLSIPPNAFPVVCEQLQRSGLARQKDHSWSRVVIEKPFGHDLASAREL
MAB_2761|M.abscessus_ATCC_1997 GFYLSIPPNAFPTVCEQLSKSGLAQPVDGAWRRVVIEKPFGHDLASAREL
Mflv_0266|M.gilvum_PYR-GCK LIYLSVPPSAMKPMIAMLGREGMAEG-----ARLIVEKPFGTDLDSSREL
: . *: :***** ** *: :*
Rv1121|M.tuberculosis_H37Rv NARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEI
Mb1152|M.bovis_AF2122/97 NARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEI
MMAR_4339|M.marinum_M NSRLRAVLNEDQILRVDHFLGKQPVVELQYLRFANRGLAELWDRKSVSEI
MUL_0149|M.ulcerans_Agy99 NSRLRAVLNEDQILRVDHFLGKQPVVELQYLRFANRDLAELWDRKSVSEI
MAV_1252|M.avium_104 NARLRAVLDEDQILRVDHFLGKQPVEELQYLRFANNALAKLWDRDSISEI
MSMEG_3101|M.smegmatis_MC2_155 NSVVNSVFPEESVFRIDHYLGKETVQNILALRFANALYEPIWNNNYVDHV
TH_0337|M.thermoresistible__bu NAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPIWNNHYVDHV
Mvan_2718|M.vanbaalenii_PYR-1 NAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPVWNAHYVDHV
MAB_2761|M.abscessus_ATCC_1997 NAVVNEVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHFVDHV
Mflv_0266|M.gilvum_PYR-GCK GAATESVADEQRIYRIDHFLGKEAVQNILALRFANGLIEPAWNRHHIESV
.: . * *: : *:**:***:.* :: ***** *: . :. :
Rv1121|M.tuberculosis_H37Rv HITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADD
Mb1152|M.bovis_AF2122/97 HITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADD
MMAR_4339|M.marinum_M HVTMAENFGVEDRGKFYDAVGALRDVVQNHLLQVLALVAMEPPVGPGADD
MUL_0149|M.ulcerans_Agy99 HVTMAENFGVEDRGKFYDAVGALRDVVQNHLLQVLALVAMEPPVGPGADD
MAV_1252|M.avium_104 HITMAEDFGIEDRGKFYDAVGAVRDVVQNHLLQVLALVAMEPPVGAGADD
MSMEG_3101|M.smegmatis_MC2_155 QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTALEEPVSFSPHE
TH_0337|M.thermoresistible__bu QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPVSFHPRQ
Mvan_2718|M.vanbaalenii_PYR-1 QITMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALTAMEEPVNFSPHE
MAB_2761|M.abscessus_ATCC_1997 QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLAFTAMEEPINFSPAE
Mflv_0266|M.gilvum_PYR-GCK QIDVPEDIALEGRGSFYESTGCFRDMVSTHLCQVLGFLAMEPPSALDADG
:: :.*::.: .*. :*:. *. **::..** *:*.: ::* * .
Rv1121|M.tuberculosis_H37Rv LNDKKAEVFRAMAPLDP--DRCVRGQY----------LGYTEVAGVASDS
Mb1152|M.bovis_AF2122/97 LNDKKAEVFRAMAPLDP--DRCVRGQY----------LGYTEVAGVASDS
MMAR_4339|M.marinum_M LNDKKAEVFRAMPALQT--AHYVRGQY----------QGYGDVPGVAKDS
MUL_0149|M.ulcerans_Agy99 LNDKKAEVFRAMPALQT--AHYVRGQY----------QGYGDVPGVAKDS
MAV_1252|M.avium_104 LNDKKAEVFRAMPSLDP--EHCVRGQY----------RGYTEVPGVAKDS
MSMEG_3101|M.smegmatis_MC2_155 LQTEKIKILSAVKLAEPLDETTARGQYAAGWQGGEKVVGLLDEEGFAKDS
TH_0337|M.thermoresistible__bu LQAEKIKVLSAVRLAQPLDQTTARGQYTAGWQGGERVVGLLEEEGFAKDS
Mvan_2718|M.vanbaalenii_PYR-1 LQAEKIKVLSATRPLQPLDQTTARGQYAAGWQGSEKVPGLLEEGGFAHDS
MAB_2761|M.abscessus_ATCC_1997 LQAEKIKVLSATRLAEPLAETTARGQYGPGWQGSQQVPGLLEEEGFSKTS
Mflv_0266|M.gilvum_PYR-GCK LRNAKAQVFEDMRPLDP--ARVVFGQY----------AGYRDEDGVDDDS
*. * ::: :. . *** * : *. *
Rv1121|M.tuberculosis_H37Rv ATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFL
Mb1152|M.bovis_AF2122/97 ATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFL
MMAR_4339|M.marinum_M QTETYVALRTEIDNWRWAGVPVFLRAGKALPERVTEVRMFLHHVPGLAFL
MUL_0149|M.ulcerans_Agy99 QTETYVALRTEIDNWRWAGVPVFLRAGKALPERVTEVRMFLHHVPGLAFL
MAV_1252|M.avium_104 TTETYVALRTEIDNWRWAGVPIFLRAGKALPHKVTEVRMFLHHVPGFSFL
MSMEG_3101|M.smegmatis_MC2_155 TTETYAAITLEVNTRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLPFD
TH_0337|M.thermoresistible__bu TTETFAAITLEIDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFD
Mvan_2718|M.vanbaalenii_PYR-1 VTETFAAITLEVDTRRWAGVPFFLRTGKRLPRRVTEVALVFKRAPHLPFD
MAB_2761|M.abscessus_ATCC_1997 TTETFAAITLEVDSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLPFD
Mflv_0266|M.gilvum_PYR-GCK DVETFVALEAYVDNERWRDVPFYLRTGKAMGDNRRTVTLTFRTPPGELFG
.**:.*: ::. ** .**.::*:** : . : : :: * *
Rv1121|M.tuberculosis_H37Rv PNRRPAE-PNQIVLRIDPDPGMRLQISAHTDDS---WRDIHLDSSFAVD-
Mb1152|M.bovis_AF2122/97 PNRRPAE-PNQIVLRIDPDPGMRLQISAHTDDS---WRDIHLDSSFAVD-
MMAR_4339|M.marinum_M PNRRPAE-PNQIVLRIDPDPGMRLQISAQTGDS---WQGVHLDSSFAED-
MUL_0149|M.ulcerans_Agy99 PNRRPAE-PNQIVLRIDPDPGMRLQISAQTGDS---WQGVHLDSSFAED-
MAV_1252|M.avium_104 PNRRPPE-PNQIVLRIDPDPGMRLQLSAQVGDS---WHDVHLDSSFAVD-
MSMEG_3101|M.smegmatis_MC2_155 ATMTEELGQNALVIRVQPDEGITLRFGSKVPGSAMEVRDVNMDFSYGSA-
TH_0337|M.thermoresistible__bu ATMTEELGQNALVIRIQPDEGVTLRFGSKVPGSAMEVRDVNMDFSYGSA-
Mvan_2718|M.vanbaalenii_PYR-1 STMTEELGKNALVIRIQPDEGITMRFGSKVPGSAMEVRDVNMDFSYGSA-
MAB_2761|M.abscessus_ATCC_1997 STMTEELGANALVIRVQPDEGVTLRFGSKVPGSAMEVRDVNMDFSYEQA-
Mflv_0266|M.gilvum_PYR-GCK DTRRPDR----LVLDLTETPTAQLALNVKRPGPELTVERVGVPVALTPDG
. :*: : : :. : .. . : : :
Rv1121|M.tuberculosis_H37Rv LGEP-IRPYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLD---NPGEI
Mb1152|M.bovis_AF2122/97 LGEP-IRPYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLD---NPGEI
MMAR_4339|M.marinum_M LGEP-IRPYERLLYAGLIGDRQLFAREDAIEQTWRIVQPVLD---DPGEI
MUL_0149|M.ulcerans_Agy99 LGEP-IRPYERLLYAGLIGDRQLFAREDAIEQTWRIVQPVLD---DPGEI
MAV_1252|M.avium_104 LGEP-VRPYERLLYAAFNGDRQLFAREDAIEETWRIVQPVLD---KPSRI
MSMEG_3101|M.smegmatis_MC2_155 FAEDSPEAYERLILDVLLGEPSLFPVNEEVELSWEILDPVLEYWAQHGKP
TH_0337|M.thermoresistible__bu FAEDSPEAYERLILDVLLGEPSLFPVNAEVELSWKILDPILEYWASHGKP
Mvan_2718|M.vanbaalenii_PYR-1 FAEDSPEAYERLILDVLLGEPSLFPVNAEVELSWEILDPVLDNWSAQGRP
MAB_2761|M.abscessus_ATCC_1997 FTEESPEAYERLILDVLLGEPSLFPVNAEVELSWRILDPALDFWASQGRP
Mflv_0266|M.gilvum_PYR-GCK TGGDGLDAYERLLLDVLRGDQTLFARGDEVDRLWQVCQPVLD---DPPAV
.****: : *: **. :: *.: :* *:
Rv1121|M.tuberculosis_H37Rv HRYDRGSWGPEAAQSLLRG-HRGWQSPWLPRGTDA--
Mb1152|M.bovis_AF2122/97 HRYDRGSWGPEAAQSLLRG-HRGWQSPWLPRGTDA--
MMAR_4339|M.marinum_M HPYDRGSWGPEAAQTLLRG-HRNWQQPWLPRSAEARQ
MUL_0149|M.ulcerans_Agy99 HPYDRGSWGPEAAQTLLRG-HRNWQQPWLPRSAEARQ
MAV_1252|M.avium_104 HQYEQGSWGPEAAQALVHG-RHAWQQPWLPQSTSTKR
MSMEG_3101|M.smegmatis_MC2_155 EPYESGTWGPPSADAMLRRTGREWRRP----------
TH_0337|M.thermoresistible__bu DPYEAGTWGPESAFEMLRRTGREWRRP----------
Mvan_2718|M.vanbaalenii_PYR-1 EPYESGTWGPPSAYDMVHLLDREWRRP----------
MAB_2761|M.abscessus_ATCC_1997 DTYESGTWGPQSAVEMLARSGREWRRP----------
Mflv_0266|M.gilvum_PYR-GCK EAYDKGSWGPQSAVELPRS---GWWLPDDD-------
. *: *:*** :* : * *