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MTDDDHPVILVLFGARGDLARRMLFPSLYRLAAAGRLPADHRIIGSGRSCPDSVEEFRDSVREGWSESID DLDDAVVEGLLQRLSFQSADADDGADLAAAVASAQKELGEDVRTLIYLSVPPSAMKPMIAMLGREGMAEG ARLIVEKPFGTDLDSSRELGAATESVADEQRIYRIDHFLGKEAVQNILALRFANGLIEPAWNRHHIESVQ IDVPEDIALEGRGSFYESTGCFRDMVSTHLCQVLGFLAMEPPSALDADGLRNAKAQVFEDMRPLDPARVV FGQYAGYRDEDGVDDDSDVETFVALEAYVDNERWRDVPFYLRTGKAMGDNRRTVTLTFRTPPGELFGDTR RPDRLVLDLTETPTAQLALNVKRPGPELTVERVGVPVALTPDGTGGDGLDAYERLLLDVLRGDQTLFARG DEVDRLWQVCQPVLDDPPAVEAYDKGSWGPQSAVELPRSGWWLPDDD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0266 | - | - | 100% (467) | glucose-6-phosphate 1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4263 | - | e-101 | 42.83% (474) | glucose-6-phosphate 1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3694 | - | 8e-75 | 37.45% (486) | glucose-6-phosphate 1-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1152 | zwf1 | 5e-82 | 39.66% (464) | glucose-6-phosphate 1-dehydrogenase |
| M. tuberculosis H37Rv | Rv1121 | zwf1 | 5e-82 | 39.66% (464) | glucose-6-phosphate 1-dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2761 | - | 3e-76 | 37.27% (491) | glucose-6-phosphate 1-dehydrogenase |
| M. marinum M | MMAR_4339 | zwf1 | 4e-87 | 40.95% (464) | glucose-6-phosphate 1-dehydrogenase Zwf1 |
| M. avium 104 | MAV_2733 | zwf | 1e-104 | 44.19% (473) | glucose-6-phosphate 1-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0314 | zwf | 5e-78 | 37.39% (476) | glucose-6-phosphate 1-dehydrogenase |
| M. thermoresistible (build 8) | TH_0337 | zwf2 | 2e-74 | 36.80% (481) | PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF2 (G6PD) |
| M. ulcerans Agy99 | MUL_1842 | zwf2 | 3e-73 | 35.43% (477) | glucose-6-phosphate 1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2718 | - | 2e-75 | 37.24% (478) | glucose-6-phosphate 1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_0337|M.thermoresistible__bu MTDPAGFGPVAGLAEPAPPGWRNPLRDKRDKRMPRIAGPCSMVIFGVTGD
Mvan_2718|M.vanbaalenii_PYR-1 ----------------MPESWRNPLRDKRDKRMPRIAGPCSVVIFGVTGD
MUL_1842|M.ulcerans_Agy99 MSPPH--------SESGVAQWQNPLRDKLDKRLPRIAGSCGMVIFGVTGD
MAB_2761|M.abscessus_ATCC_1997 MTEVLP---------PDSSLTANPLRDKRDKRLPRIAGPCSLVIFGVTGD
MSMEG_0314|M.smegmatis_MC2_155 -----------------------------MNRTPSPVDPCDFVIFGGTGD
Mb1152|M.bovis_AF2122/97 ------------------------------MVDGGGGASDLLVIFGITGD
Rv1121|M.tuberculosis_H37Rv ------------------------------MVDGGGGASDLLVIFGITGD
MMAR_4339|M.marinum_M ------------------------------MANGGGQASDLLVIFGITGD
Mflv_0266|M.gilvum_PYR-GCK --------------------------------MTDDDHPVILVLFGARGD
MAV_2733|M.avium_104 -----------MATQKPQTISYPAPEARPRRHHTDPLDPHVIVLFGATGD
. .*:** **
TH_0337|M.thermoresistible__bu LSRKKLMPAIYDLANRGLLPASFSLVGFA-RRDWADEDFGQVVYEAVKTH
Mvan_2718|M.vanbaalenii_PYR-1 LARKKLMPAIYDLANRGLLPPSFALVGFA-RRDWADEDFGEVVYEAVKKH
MUL_1842|M.ulcerans_Agy99 LARKKVMPAIYDLANRGLLPPTFALVGFA-RRDWDTEDFGQVVYQAVKEH
MAB_2761|M.abscessus_ATCC_1997 LARKKLMPAIYDLANRGLLPPSFALVGFA-RRDWANEDFGQIVLDAVKAH
MSMEG_0314|M.smegmatis_MC2_155 LAARKLLPALYLRDRDGQLAGATRIIGVA-KAGLDDAGYRNTVRAGLARH
Mb1152|M.bovis_AF2122/97 LARKMTFRALYRLERHQLLD--CPILGVA-SDDMSVGQLVKWARESI-GR
Rv1121|M.tuberculosis_H37Rv LARKMTFRALYRLERHQLLD--CPILGVA-SDDMSVGQLVKWARESI-GR
MMAR_4339|M.marinum_M LARKMTFRALYRLERRGLLD--CPIVGVA-SDDMSVEQLVDRAREVIQGS
Mflv_0266|M.gilvum_PYR-GCK LARRMLFPSLYRLAAAGRLPADHRIIGSGRSCPDSVEEFRDSVREGW-SE
MAV_2733|M.avium_104 LAKRKLIPGLAYLDQS-ELAPDIQIVATS-LEDLSNDEFRELAKNAI-DS
*: : : .: * ::. . . .
TH_0337|M.thermoresistible__bu AR-TPFRQEVWDRLAEGFRFVQGTFDDDAAFARLTEVLEKLDVQRGTGGN
Mvan_2718|M.vanbaalenii_PYR-1 AR-TPFRQEVWDRLAEGFRFVQGTFDDDASFDRLSETLEKLDAERGTGGN
MUL_1842|M.ulcerans_Agy99 CR-TPFRQANWDRLAEGFRFVSGSFDDDEAFGRLAETLEKLDTERGTGGN
MAB_2761|M.abscessus_ATCC_1997 SR-TPFRQHVWDRLAEGIRFVQGSFDDDAAFEQLKKTLQTLDEERGTGGN
MSMEG_0314|M.smegmatis_MC2_155 VEPDLLDSDVVDRFLSRLRFVSVDLTEPSDYAAVGDVLTSPDGGSGHD-I
Mb1152|M.bovis_AF2122/97 TE--KIDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELIG-------SACR
Rv1121|M.tuberculosis_H37Rv TE--KIDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELIG-------SACR
MMAR_4339|M.marinum_M SE--PFDEAVFERFASRWSYLPGDVTDPALYTALAKQIG-------HDRH
Mflv_0266|M.gilvum_PYR-GCK S-IDDLDDAVVEGLLQRLSFQSADADDG---ADLAAAVASAQKELGEDVR
MAV_2733|M.avium_104 FGTHKLTPDQWRNFADIITYIPQSAGS----DALAAAVAEAEAKLGPNVR
: : : . : :
TH_0337|M.thermoresistible__bu HAFYLSIPPKAFPLVCEQLRRSGLARPQPGRWSRVVVEKPFGHDLQSAVE
Mvan_2718|M.vanbaalenii_PYR-1 HAFYLSIPPNAFPVVCEQLQRSGLARQKDHSWSRVVIEKPFGHDLASARE
MUL_1842|M.ulcerans_Agy99 HAFYLAIPPKSFPVVCGQLHKSGLARPQGDRWSRVVIEKPFGHDLQSARD
MAB_2761|M.abscessus_ATCC_1997 HGFYLSIPPNAFPTVCEQLSKSGLAQPVDGAWRRVVIEKPFGHDLASARE
MSMEG_0314|M.smegmatis_MC2_155 RVFYLACAPALFGPICGALGAQGLVTES----SRVVLEKPIGRDLASAQQ
Mb1152|M.bovis_AF2122/97 PLYYLEMPPALFAPIVENLANVRLLERA-----RVAVEKPFGHDLASALE
Rv1121|M.tuberculosis_H37Rv PLYYLEMPPALFAPIVENLANVRLLERA-----RVAVEKPFGHDLASALE
MMAR_4339|M.marinum_M GLYYLEMPPALFAPIVENLAKADLLRGA-----RVAVEKPFGHDLDSARE
Mflv_0266|M.gilvum_PYR-GCK TLIYLSVPPSAMKPMIAMLGREGMAEGA-----RLIVEKPFGTDLDSSRE
MAV_2733|M.avium_104 RLHYLSVPPKAARAVITMLRDAKLVERS-----RVVMEKPFGTDLASAVA
** .* : * : *: :***:* ** *:
TH_0337|M.thermoresistible__bu LNAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPIWNNHYVDH
Mvan_2718|M.vanbaalenii_PYR-1 LNAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPVWNAHYVDH
MUL_1842|M.ulcerans_Agy99 LNRAVNAVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDH
MAB_2761|M.abscessus_ATCC_1997 LNAVVNEVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHFVDH
MSMEG_0314|M.smegmatis_MC2_155 INEAVGAVFAEHQIFRIDHYLGKESVQQLLVTRFGNTWLEPLWNSSRIDH
Mb1152|M.bovis_AF2122/97 LNARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISE
Rv1121|M.tuberculosis_H37Rv LNARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISE
MMAR_4339|M.marinum_M LNSRLRAVLNEDQILRVDHFLGKQPVVELQYLRFANRGLAELWDRKSVSE
Mflv_0266|M.gilvum_PYR-GCK LGAATESVADEQRIYRIDHFLGKEAVQNILALRFANGLIEPAWNRHHIES
MAV_2733|M.avium_104 LNDFVHQTFEESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFIDH
:. . * : *:**:***:.. :: **.* *: :.
TH_0337|M.thermoresistible__bu VQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPVSFHPR
Mvan_2718|M.vanbaalenii_PYR-1 VQITMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALTAMEEPVNFSPH
MUL_1842|M.ulcerans_Agy99 VQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFNPT
MAB_2761|M.abscessus_ATCC_1997 VQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLAFTAMEEPINFSPA
MSMEG_0314|M.smegmatis_MC2_155 VQITAAESLGVGARGDYYDQSGALRDMLQNHLLQVLCLVAMEPPTHVNRE
Mb1152|M.bovis_AF2122/97 IHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSAD
Rv1121|M.tuberculosis_H37Rv IHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSAD
MMAR_4339|M.marinum_M IHVTMAENFGVEDRGKFYDAVGALRDVVQNHLLQVLALVAMEPPVGPGAD
Mflv_0266|M.gilvum_PYR-GCK VQIDVPEDIALEGRGSFYESTGCFRDMVSTHLCQVLGFLAMEPPSALDAD
MAV_2733|M.avium_104 IQIDIPEALGLDQRASFYEDTGAYKDMVVTHLFQVMAFVVMEPPTALEPF
::: .* :.: *. :*: *. :*:: .** *:: : .** *
TH_0337|M.thermoresistible__bu QLQAEKIKVLSAVR--LAQPLDQTTARGQYTAGWQGGERVVGLLEEEGFA
Mvan_2718|M.vanbaalenii_PYR-1 ELQAEKIKVLSATR--PLQPLDQTTARGQYAAGWQGSEKVPGLLEEGGFA
MUL_1842|M.ulcerans_Agy99 ALQTEKIKVLSATQ--LAEPLDETTSRGQYTTGWQGGEKVVGLLDEEGFS
MAB_2761|M.abscessus_ATCC_1997 ELQAEKIKVLSATR--LAEPLAETTARGQYGPGWQGSQQVPGLLEEEGFS
MSMEG_0314|M.smegmatis_MC2_155 SVRDEKRKVLEALEPLTAEQTQRDTVTGQYGPGLVG-DEVVGSYREEVAD
Mb1152|M.bovis_AF2122/97 DLNDKKAEVFRAMA----PLDPDRCVRGQY----------LGYTEVAGVA
Rv1121|M.tuberculosis_H37Rv DLNDKKAEVFRAMA----PLDPDRCVRGQY----------LGYTEVAGVA
MMAR_4339|M.marinum_M DLNDKKAEVFRAMP----ALQTAHYVRGQY----------QGYGDVPGVA
Mflv_0266|M.gilvum_PYR-GCK GLRNAKAQVFEDMR----PLDPARVVFGQY----------AGYRDEDGVD
MAV_2733|M.avium_104 AISEEKNKVFRSML----PVKPSNVVRGQY----------IGYREEDGVA
: * :*: *** *
TH_0337|M.thermoresistible__bu KDSTTETFAAITLEIDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHL
Mvan_2718|M.vanbaalenii_PYR-1 HDSVTETFAAITLEVDTRRWAGVPFFLRTGKRLPRRVTEVALVFKRAPHL
MUL_1842|M.ulcerans_Agy99 KTSTTETFAAITLEVNSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHL
MAB_2761|M.abscessus_ATCC_1997 KTSTTETFAAITLEVDSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHL
MSMEG_0314|M.smegmatis_MC2_155 PHSRTETFVAVKAHIRNWRWAGVPFYLRTGKRMSQRFSEIVVQFKPVP-L
Mb1152|M.bovis_AF2122/97 SDSATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPAL
Rv1121|M.tuberculosis_H37Rv SDSATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPAL
MMAR_4339|M.marinum_M KDSQTETYVALRTEIDNWRWAGVPVFLRAGKALPERVTEVRMFLHHVPGL
Mflv_0266|M.gilvum_PYR-GCK DDSDVETFVALEAYVDNERWRDVPFYLRTGKAMGDNRRTVTLTFRTPPGE
MAV_2733|M.avium_104 KDSDTETFIALKVGIDNWRWAGVPVYLRTGKRMAEGIRIISIAFKEAPRT
* .**: *: : . ** .**.::*:** : : : :: *
TH_0337|M.thermoresistible__bu PFDAT-MTEELGQNALVIRIQPDEGVTLRFGSKVPGSAMEVRDVNMDFSY
Mvan_2718|M.vanbaalenii_PYR-1 PFDST-MTEELGKNALVIRIQPDEGITMRFGSKVPGSAMEVRDVNMDFSY
MUL_1842|M.ulcerans_Agy99 PFDAT-MTDELGTNALVIRVQPDEGMTLRFGSKVPGSAMEVRDVNMDFSY
MAB_2761|M.abscessus_ATCC_1997 PFDST-MTEELGANALVIRVQPDEGVTLRFGSKVPGSAMEVRDVNMDFSY
MSMEG_0314|M.smegmatis_MC2_155 PMFPG-IEGTSEPNRLIISLQPDEAIRLEMTAKEPGSGGRLRPVSLALNY
Mb1152|M.bovis_AF2122/97 AFLP--NRRPAEPNQIVLRIDPDPGMRLQISAHTDDS---WRDIHLDSSF
Rv1121|M.tuberculosis_H37Rv AFLP--NRRPAEPNQIVLRIDPDPGMRLQISAHTDDS---WRDIHLDSSF
MMAR_4339|M.marinum_M AFLP--NRRPAEPNQIVLRIDPDPGMRLQISAQTGDS---WQGVHLDSSF
Mflv_0266|M.gilvum_PYR-GCK LFG-----DTRRPDRLVLDLTETPTAQLALNVKRPGPELTVERVGVPVAL
MAV_2733|M.avium_104 MFPPGSGVGTQGPDHLTFDLADNSRVSLSFYGKRPGPGMKLDKLSMQFST
: : : : : : : : .. : :
TH_0337|M.thermoresistible__bu GSAFAE-DSPEAYERLILDVLLGEPSLFPVNAEVELSWKILDPILEYWAS
Mvan_2718|M.vanbaalenii_PYR-1 GSAFAE-DSPEAYERLILDVLLGEPSLFPVNAEVELSWEILDPVLDNWSA
MUL_1842|M.ulcerans_Agy99 GSAFAE-DSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPVLDNWAS
MAB_2761|M.abscessus_ATCC_1997 EQAFTE-ESPEAYERLILDVLLGEPSLFPVNAEVELSWRILDPALDFWAS
MSMEG_0314|M.smegmatis_MC2_155 TEAFPE-RSPDAYERLLMDVVRGDPTLFMRRDEVEAAWAWAEPILRHWQD
Mb1152|M.bovis_AF2122/97 AVDLGE-PIR-PYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLDNPGE
Rv1121|M.tuberculosis_H37Rv AVDLGE-PIR-PYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLDNPGE
MMAR_4339|M.marinum_M AEDLGE-PIR-PYERLLYAGLIGDRQLFAREDAIEQTWRIVQPVLDDPGE
Mflv_0266|M.gilvum_PYR-GCK TPDGTGGDGLDAYERLLLDVLRGDQTLFARGDEVDRLWQVCQPVLDDPPA
MAV_2733|M.avium_104 QEIETAVDVLEAYERLILDAMRGDHTLFTTAEGIESLWERSEELLNDPPP
.****: : *: ** :: * : *
TH_0337|M.thermoresistible__bu HGK-PDPYEAGTWGPESAFEMLRRTGREWRRP--------------
Mvan_2718|M.vanbaalenii_PYR-1 QGR-PEPYESGTWGPPSAYDMVHLLDREWRRP--------------
MUL_1842|M.ulcerans_Agy99 SGK-PDPYEAGTWGPESAFEMLRRTGREWRRP--------------
MAB_2761|M.abscessus_ATCC_1997 QGR-PDTYESGTWGPQSAVEMLARSGREWRRP--------------
MSMEG_0314|M.smegmatis_MC2_155 ADRVPRTYPAGTDGPVDAATLIERDGRRWHGGAA------------
Mb1152|M.bovis_AF2122/97 IHR----YDRGSWGPEAAQSLLRG-HRGWQSPWLPRGTDA------
Rv1121|M.tuberculosis_H37Rv IHR----YDRGSWGPEAAQSLLRG-HRGWQSPWLPRGTDA------
MMAR_4339|M.marinum_M IHP----YDRGSWGPEAAQTLLRG-HRNWQQPWLPRSAEARQ----
Mflv_0266|M.gilvum_PYR-GCK VEA----YDKGSWGPQSAVELPRS-GWWLPDDD-------------
MAV_2733|M.avium_104 AKL----YQPGTWGPNAIHQLIAPNAWRLPFEREWRDPRPYPGVGG
* *: ** :