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M. avium 104 MAV_1252 (zwf)

annotation: glucose-6-phosphate 1-dehydrogenase
coordinates: 1194419 - 1195828
length: 469

LADDDSHPSDLLVIFGITGDLARKMTFRALYRLERREELEHPIIGVASDDITLDQLLDRAREAIKATGET
FDDAVFDRLAGRLSYLSGDVTDTGLYSELAEKIGGDSRPLYYLEMPPSLFAPIVENLAKADLLERARVAV
EKPFGHDLESARDLNARLRAVLDEDQILRVDHFLGKQPVEELQYLRFANNALAKLWDRDSISEIHITMAE
DFGIEDRGKFYDAVGAVRDVVQNHLLQVLALVAMEPPVGAGADDLNDKKAEVFRAMPSLDPEHCVRGQYR
GYTEVPGVAKDSTTETYVALRTEIDNWRWAGVPIFLRAGKALPHKVTEVRMFLHHVPGFSFLPNRRPPEP
NQIVLRIDPDPGMRLQLSAQVGDSWHDVHLDSSFAVDLGEPVRPYERLLYAAFNGDRQLFAREDAIEETW
RIVQPVLDKPSRIHQYEQGSWGPEAAQALVHGRHAWQQPWLPQSTSTKR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_1252zwf-100% (469)glucose-6-phosphate 1-dehydrogenase
M. avium 104MAV_3329zwf9e-7636.84% (475) glucose-6-phosphate 1-dehydrogenase
M. avium 104MAV_2733zwf9e-7635.24% (471) glucose-6-phosphate 1-dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1152zwf10.078.71% (465) glucose-6-phosphate 1-dehydrogenase
M. gilvum PYR-GCKMflv_0266-9e-9040.55% (471) glucose-6-phosphate 1-dehydrogenase
M. tuberculosis H37RvRv1121zwf10.078.71% (465) glucose-6-phosphate 1-dehydrogenase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2761-2e-8037.19% (484) glucose-6-phosphate 1-dehydrogenase
M. marinum MMMAR_4339zwf10.078.89% (469) glucose-6-phosphate 1-dehydrogenase Zwf1
M. smegmatis MC2 155MSMEG_3101zwf3e-8036.49% (485) glucose-6-phosphate 1-dehydrogenase
M. thermoresistible (build 8)TH_0337zwf29e-7936.98% (484) PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF2 (G6PD)
M. ulcerans Agy99MUL_0149zwf11e-16782.25% (338) glucose-6-phosphate 1-dehydrogenase
M. vanbaalenii PYR-1Mvan_2718-7e-8238.02% (484) glucose-6-phosphate 1-dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1152|M.bovis_AF2122/97            ------------------------MVDGGGG------ASDLLVIFGITGD
Rv1121|M.tuberculosis_H37Rv         ------------------------MVDGGGG------ASDLLVIFGITGD
MMAR_4339|M.marinum_M               ------------------------MANGGGQ------ASDLLVIFGITGD
MUL_0149|M.ulcerans_Agy99           --------------------------------------------------
MAV_1252|M.avium_104                ------------------------MADDDSH------PSDLLVIFGITGD
MSMEG_3101|M.smegmatis_MC2_155      ---------MTAVNDRPDTTWHNPLRDKRDKRMPRIAGPCGVVIFGVTGD
TH_0337|M.thermoresistible__bu      MTDPAGFGPVAGLAEPAPPGWRNPLRDKRDKRMPRIAGPCSMVIFGVTGD
Mvan_2718|M.vanbaalenii_PYR-1       ----------------MPESWRNPLRDKRDKRMPRIAGPCSVVIFGVTGD
MAB_2761|M.abscessus_ATCC_1997      ---------MTEVLPPDSSLTANPLRDKRDKRLPRIAGPCSLVIFGVTGD
Mflv_0266|M.gilvum_PYR-GCK          ------------------------MTDDDHP--------VILVLFGARGD
                                                                                      

Mb1152|M.bovis_AF2122/97            LARKMTFRALYRLERHQLL--DCPILGVAS-DDMSVGQLVKWARESIG-R
Rv1121|M.tuberculosis_H37Rv         LARKMTFRALYRLERHQLL--DCPILGVAS-DDMSVGQLVKWARESIG-R
MMAR_4339|M.marinum_M               LARKMTFRALYRLERRGLL--DCPIVGVAS-DDMSVEQLVDRAREVIQGS
MUL_0149|M.ulcerans_Agy99           --------------------------------------------------
MAV_1252|M.avium_104                LARKMTFRALYRLERREEL--EHPIIGVAS-DDITLDQLLDRAREAIKAT
MSMEG_3101|M.smegmatis_MC2_155      LARKKLMPAIYDLANRGLLPASFALVGFAR-RDWEDEDFGQVVYDAVRQH
TH_0337|M.thermoresistible__bu      LSRKKLMPAIYDLANRGLLPASFSLVGFAR-RDWADEDFGQVVYEAVKTH
Mvan_2718|M.vanbaalenii_PYR-1       LARKKLMPAIYDLANRGLLPPSFALVGFAR-RDWADEDFGEVVYEAVKKH
MAB_2761|M.abscessus_ATCC_1997      LARKKLMPAIYDLANRGLLPPSFALVGFAR-RDWANEDFGQIVLDAVKAH
Mflv_0266|M.gilvum_PYR-GCK          LARRMLFPSLYRLAAAGRLPADHRIIGSGRSCPDSVEEFRDSVREGWSES
                                                                                      

Mb1152|M.bovis_AF2122/97            TEK-IDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELI-------GSACRP
Rv1121|M.tuberculosis_H37Rv         TEK-IDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELI-------GSACRP
MMAR_4339|M.marinum_M               SEP-FDEAVFERFASRWSYLPGDVTDPALYTALAKQI-------GHDRHG
MUL_0149|M.ulcerans_Agy99           --------------------------------------------------
MAV_1252|M.avium_104                GET-FDDAVFDRLAGRLSYLSGDVTDTGLYSELAEKI-------GGDSRP
MSMEG_3101|M.smegmatis_MC2_155      ARTPFRQEVWDRLAEGIRFVQGTFDDDTAFTRLAETLDKLDIERGTGGNH
TH_0337|M.thermoresistible__bu      ARTPFRQEVWDRLAEGFRFVQGTFDDDAAFARLTEVLEKLDVQRGTGGNH
Mvan_2718|M.vanbaalenii_PYR-1       ARTPFRQEVWDRLAEGFRFVQGTFDDDASFDRLSETLEKLDAERGTGGNH
MAB_2761|M.abscessus_ATCC_1997      SRTPFRQHVWDRLAEGIRFVQGSFDDDAAFEQLKKTLQTLDEERGTGGNH
Mflv_0266|M.gilvum_PYR-GCK          IDD-LDDAVVEGLLQRLSFQSADADDGADLAAAVASAQK---ELGEDVRT
                                                                                      

Mb1152|M.bovis_AF2122/97            LYYLEMPPALFAPIVENLANVRLLER-----ARVAVEKPFGHDLASALEL
Rv1121|M.tuberculosis_H37Rv         LYYLEMPPALFAPIVENLANVRLLER-----ARVAVEKPFGHDLASALEL
MMAR_4339|M.marinum_M               LYYLEMPPALFAPIVENLAKADLLRG-----ARVAVEKPFGHDLDSAREL
MUL_0149|M.ulcerans_Agy99           ----------------------MLRC-----ARVAVEKPFGHDLDSAREL
MAV_1252|M.avium_104                LYYLEMPPSLFAPIVENLAKADLLER-----ARVAVEKPFGHDLESARDL
MSMEG_3101|M.smegmatis_MC2_155      AFYLSIPPNAFPVVCEQLRKSGLAKPRDGRWSRVVIEKPFGHDLGSAREL
TH_0337|M.thermoresistible__bu      AFYLSIPPKAFPLVCEQLRRSGLARPQPGRWSRVVVEKPFGHDLQSAVEL
Mvan_2718|M.vanbaalenii_PYR-1       AFYLSIPPNAFPVVCEQLQRSGLARQKDHSWSRVVIEKPFGHDLASAREL
MAB_2761|M.abscessus_ATCC_1997      GFYLSIPPNAFPTVCEQLSKSGLAQPVDGAWRRVVIEKPFGHDLASAREL
Mflv_0266|M.gilvum_PYR-GCK          LIYLSVPPSAMKPMIAMLGREGMAEG-----ARLIVEKPFGTDLDSSREL
                                                          : .       *: :***** ** *: :*

Mb1152|M.bovis_AF2122/97            NARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEI
Rv1121|M.tuberculosis_H37Rv         NARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEI
MMAR_4339|M.marinum_M               NSRLRAVLNEDQILRVDHFLGKQPVVELQYLRFANRGLAELWDRKSVSEI
MUL_0149|M.ulcerans_Agy99           NSRLRAVLNEDQILRVDHFLGKQPVVELQYLRFANRDLAELWDRKSVSEI
MAV_1252|M.avium_104                NARLRAVLDEDQILRVDHFLGKQPVEELQYLRFANNALAKLWDRDSISEI
MSMEG_3101|M.smegmatis_MC2_155      NSVVNSVFPEESVFRIDHYLGKETVQNILALRFANALYEPIWNNNYVDHV
TH_0337|M.thermoresistible__bu      NAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPIWNNHYVDHV
Mvan_2718|M.vanbaalenii_PYR-1       NAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPVWNAHYVDHV
MAB_2761|M.abscessus_ATCC_1997      NAVVNEVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHFVDHV
Mflv_0266|M.gilvum_PYR-GCK          GAATESVADEQRIYRIDHFLGKEAVQNILALRFANGLIEPAWNRHHIESV
                                    .:  . *  *: : *:**:***:.* ::  *****      *: . :. :

Mb1152|M.bovis_AF2122/97            HITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADD
Rv1121|M.tuberculosis_H37Rv         HITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADD
MMAR_4339|M.marinum_M               HVTMAENFGVEDRGKFYDAVGALRDVVQNHLLQVLALVAMEPPVGPGADD
MUL_0149|M.ulcerans_Agy99           HVTMAENFGVEDRGKFYDAVGALRDVVQNHLLQVLALVAMEPPVGPGADD
MAV_1252|M.avium_104                HITMAEDFGIEDRGKFYDAVGAVRDVVQNHLLQVLALVAMEPPVGAGADD
MSMEG_3101|M.smegmatis_MC2_155      QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTALEEPVSFSPHE
TH_0337|M.thermoresistible__bu      QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPVSFHPRQ
Mvan_2718|M.vanbaalenii_PYR-1       QITMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALTAMEEPVNFSPHE
MAB_2761|M.abscessus_ATCC_1997      QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLAFTAMEEPINFSPAE
Mflv_0266|M.gilvum_PYR-GCK          QIDVPEDIALEGRGSFYESTGCFRDMVSTHLCQVLGFLAMEPPSALDADG
                                    :: :.*::.: .*. :*:. *. **::..** *:*.: ::* *    .  

Mb1152|M.bovis_AF2122/97            LNDKKAEVFRAMAPLDP--DRCVRGQY----------LGYTEVAGVASDS
Rv1121|M.tuberculosis_H37Rv         LNDKKAEVFRAMAPLDP--DRCVRGQY----------LGYTEVAGVASDS
MMAR_4339|M.marinum_M               LNDKKAEVFRAMPALQT--AHYVRGQY----------QGYGDVPGVAKDS
MUL_0149|M.ulcerans_Agy99           LNDKKAEVFRAMPALQT--AHYVRGQY----------QGYGDVPGVAKDS
MAV_1252|M.avium_104                LNDKKAEVFRAMPSLDP--EHCVRGQY----------RGYTEVPGVAKDS
MSMEG_3101|M.smegmatis_MC2_155      LQTEKIKILSAVKLAEPLDETTARGQYAAGWQGGEKVVGLLDEEGFAKDS
TH_0337|M.thermoresistible__bu      LQAEKIKVLSAVRLAQPLDQTTARGQYTAGWQGGERVVGLLEEEGFAKDS
Mvan_2718|M.vanbaalenii_PYR-1       LQAEKIKVLSATRPLQPLDQTTARGQYAAGWQGSEKVPGLLEEGGFAHDS
MAB_2761|M.abscessus_ATCC_1997      LQAEKIKVLSATRLAEPLAETTARGQYGPGWQGSQQVPGLLEEEGFSKTS
Mflv_0266|M.gilvum_PYR-GCK          LRNAKAQVFEDMRPLDP--ARVVFGQY----------AGYRDEDGVDDDS
                                    *.  * :::      :.     . ***           *  :  *.   *

Mb1152|M.bovis_AF2122/97            ATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFL
Rv1121|M.tuberculosis_H37Rv         ATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFL
MMAR_4339|M.marinum_M               QTETYVALRTEIDNWRWAGVPVFLRAGKALPERVTEVRMFLHHVPGLAFL
MUL_0149|M.ulcerans_Agy99           QTETYVALRTEIDNWRWAGVPVFLRAGKALPERVTEVRMFLHHVPGLAFL
MAV_1252|M.avium_104                TTETYVALRTEIDNWRWAGVPIFLRAGKALPHKVTEVRMFLHHVPGFSFL
MSMEG_3101|M.smegmatis_MC2_155      TTETYAAITLEVNTRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLPFD
TH_0337|M.thermoresistible__bu      TTETFAAITLEIDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFD
Mvan_2718|M.vanbaalenii_PYR-1       VTETFAAITLEVDTRRWAGVPFFLRTGKRLPRRVTEVALVFKRAPHLPFD
MAB_2761|M.abscessus_ATCC_1997      TTETFAAITLEVDSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLPFD
Mflv_0266|M.gilvum_PYR-GCK          DVETFVALEAYVDNERWRDVPFYLRTGKAMGDNRRTVTLTFRTPPGELFG
                                     .**:.*:   ::. ** .**.::*:** :  .   : : ::  *   * 

Mb1152|M.bovis_AF2122/97            PNRRPAE-PNQIVLRIDPDPGMRLQISAHTDDS---WRDIHLDSSFAVD-
Rv1121|M.tuberculosis_H37Rv         PNRRPAE-PNQIVLRIDPDPGMRLQISAHTDDS---WRDIHLDSSFAVD-
MMAR_4339|M.marinum_M               PNRRPAE-PNQIVLRIDPDPGMRLQISAQTGDS---WQGVHLDSSFAED-
MUL_0149|M.ulcerans_Agy99           PNRRPAE-PNQIVLRIDPDPGMRLQISAQTGDS---WQGVHLDSSFAED-
MAV_1252|M.avium_104                PNRRPPE-PNQIVLRIDPDPGMRLQLSAQVGDS---WHDVHLDSSFAVD-
MSMEG_3101|M.smegmatis_MC2_155      ATMTEELGQNALVIRVQPDEGITLRFGSKVPGSAMEVRDVNMDFSYGSA-
TH_0337|M.thermoresistible__bu      ATMTEELGQNALVIRIQPDEGVTLRFGSKVPGSAMEVRDVNMDFSYGSA-
Mvan_2718|M.vanbaalenii_PYR-1       STMTEELGKNALVIRIQPDEGITMRFGSKVPGSAMEVRDVNMDFSYGSA-
MAB_2761|M.abscessus_ATCC_1997      STMTEELGANALVIRVQPDEGVTLRFGSKVPGSAMEVRDVNMDFSYEQA-
Mflv_0266|M.gilvum_PYR-GCK          DTRRPDR----LVLDLTETPTAQLALNVKRPGPELTVERVGVPVALTPDG
                                     .         :*: :       : :. :  ..    . : :  :     

Mb1152|M.bovis_AF2122/97            LGEP-IRPYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLD---NPGEI
Rv1121|M.tuberculosis_H37Rv         LGEP-IRPYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLD---NPGEI
MMAR_4339|M.marinum_M               LGEP-IRPYERLLYAGLIGDRQLFAREDAIEQTWRIVQPVLD---DPGEI
MUL_0149|M.ulcerans_Agy99           LGEP-IRPYERLLYAGLIGDRQLFAREDAIEQTWRIVQPVLD---DPGEI
MAV_1252|M.avium_104                LGEP-VRPYERLLYAAFNGDRQLFAREDAIEETWRIVQPVLD---KPSRI
MSMEG_3101|M.smegmatis_MC2_155      FAEDSPEAYERLILDVLLGEPSLFPVNEEVELSWEILDPVLEYWAQHGKP
TH_0337|M.thermoresistible__bu      FAEDSPEAYERLILDVLLGEPSLFPVNAEVELSWKILDPILEYWASHGKP
Mvan_2718|M.vanbaalenii_PYR-1       FAEDSPEAYERLILDVLLGEPSLFPVNAEVELSWEILDPVLDNWSAQGRP
MAB_2761|M.abscessus_ATCC_1997      FTEESPEAYERLILDVLLGEPSLFPVNAEVELSWRILDPALDFWASQGRP
Mflv_0266|M.gilvum_PYR-GCK          TGGDGLDAYERLLLDVLRGDQTLFARGDEVDRLWQVCQPVLD---DPPAV
                                           .****:   : *:  **.    ::  *.: :* *:        

Mb1152|M.bovis_AF2122/97            HRYDRGSWGPEAAQSLLRG-HRGWQSPWLPRGTDA--
Rv1121|M.tuberculosis_H37Rv         HRYDRGSWGPEAAQSLLRG-HRGWQSPWLPRGTDA--
MMAR_4339|M.marinum_M               HPYDRGSWGPEAAQTLLRG-HRNWQQPWLPRSAEARQ
MUL_0149|M.ulcerans_Agy99           HPYDRGSWGPEAAQTLLRG-HRNWQQPWLPRSAEARQ
MAV_1252|M.avium_104                HQYEQGSWGPEAAQALVHG-RHAWQQPWLPQSTSTKR
MSMEG_3101|M.smegmatis_MC2_155      EPYESGTWGPPSADAMLRRTGREWRRP----------
TH_0337|M.thermoresistible__bu      DPYEAGTWGPESAFEMLRRTGREWRRP----------
Mvan_2718|M.vanbaalenii_PYR-1       EPYESGTWGPPSAYDMVHLLDREWRRP----------
MAB_2761|M.abscessus_ATCC_1997      DTYESGTWGPQSAVEMLARSGREWRRP----------
Mflv_0266|M.gilvum_PYR-GCK          EAYDKGSWGPQSAVELPRS---GWWLPDDD-------
                                    . *: *:*** :*  :       *  *