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LADDDSHPSDLLVIFGITGDLARKMTFRALYRLERREELEHPIIGVASDDITLDQLLDRAREAIKATGET FDDAVFDRLAGRLSYLSGDVTDTGLYSELAEKIGGDSRPLYYLEMPPSLFAPIVENLAKADLLERARVAV EKPFGHDLESARDLNARLRAVLDEDQILRVDHFLGKQPVEELQYLRFANNALAKLWDRDSISEIHITMAE DFGIEDRGKFYDAVGAVRDVVQNHLLQVLALVAMEPPVGAGADDLNDKKAEVFRAMPSLDPEHCVRGQYR GYTEVPGVAKDSTTETYVALRTEIDNWRWAGVPIFLRAGKALPHKVTEVRMFLHHVPGFSFLPNRRPPEP NQIVLRIDPDPGMRLQLSAQVGDSWHDVHLDSSFAVDLGEPVRPYERLLYAAFNGDRQLFAREDAIEETW RIVQPVLDKPSRIHQYEQGSWGPEAAQALVHGRHAWQQPWLPQSTSTKR
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_1252 | zwf | - | 100% (469) | glucose-6-phosphate 1-dehydrogenase |
M. avium 104 | MAV_3329 | zwf | 9e-76 | 36.84% (475) | glucose-6-phosphate 1-dehydrogenase |
M. avium 104 | MAV_2733 | zwf | 9e-76 | 35.24% (471) | glucose-6-phosphate 1-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1152 | zwf1 | 0.0 | 78.71% (465) | glucose-6-phosphate 1-dehydrogenase |
M. gilvum PYR-GCK | Mflv_0266 | - | 9e-90 | 40.55% (471) | glucose-6-phosphate 1-dehydrogenase |
M. tuberculosis H37Rv | Rv1121 | zwf1 | 0.0 | 78.71% (465) | glucose-6-phosphate 1-dehydrogenase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_2761 | - | 2e-80 | 37.19% (484) | glucose-6-phosphate 1-dehydrogenase |
M. marinum M | MMAR_4339 | zwf1 | 0.0 | 78.89% (469) | glucose-6-phosphate 1-dehydrogenase Zwf1 |
M. smegmatis MC2 155 | MSMEG_3101 | zwf | 3e-80 | 36.49% (485) | glucose-6-phosphate 1-dehydrogenase |
M. thermoresistible (build 8) | TH_0337 | zwf2 | 9e-79 | 36.98% (484) | PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF2 (G6PD) |
M. ulcerans Agy99 | MUL_0149 | zwf1 | 1e-167 | 82.25% (338) | glucose-6-phosphate 1-dehydrogenase |
M. vanbaalenii PYR-1 | Mvan_2718 | - | 7e-82 | 38.02% (484) | glucose-6-phosphate 1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment Mb1152|M.bovis_AF2122/97 ------------------------MVDGGGG------ASDLLVIFGITGD Rv1121|M.tuberculosis_H37Rv ------------------------MVDGGGG------ASDLLVIFGITGD MMAR_4339|M.marinum_M ------------------------MANGGGQ------ASDLLVIFGITGD MUL_0149|M.ulcerans_Agy99 -------------------------------------------------- MAV_1252|M.avium_104 ------------------------MADDDSH------PSDLLVIFGITGD MSMEG_3101|M.smegmatis_MC2_155 ---------MTAVNDRPDTTWHNPLRDKRDKRMPRIAGPCGVVIFGVTGD TH_0337|M.thermoresistible__bu MTDPAGFGPVAGLAEPAPPGWRNPLRDKRDKRMPRIAGPCSMVIFGVTGD Mvan_2718|M.vanbaalenii_PYR-1 ----------------MPESWRNPLRDKRDKRMPRIAGPCSVVIFGVTGD MAB_2761|M.abscessus_ATCC_1997 ---------MTEVLPPDSSLTANPLRDKRDKRLPRIAGPCSLVIFGVTGD Mflv_0266|M.gilvum_PYR-GCK ------------------------MTDDDHP--------VILVLFGARGD Mb1152|M.bovis_AF2122/97 LARKMTFRALYRLERHQLL--DCPILGVAS-DDMSVGQLVKWARESIG-R Rv1121|M.tuberculosis_H37Rv LARKMTFRALYRLERHQLL--DCPILGVAS-DDMSVGQLVKWARESIG-R MMAR_4339|M.marinum_M LARKMTFRALYRLERRGLL--DCPIVGVAS-DDMSVEQLVDRAREVIQGS MUL_0149|M.ulcerans_Agy99 -------------------------------------------------- MAV_1252|M.avium_104 LARKMTFRALYRLERREEL--EHPIIGVAS-DDITLDQLLDRAREAIKAT MSMEG_3101|M.smegmatis_MC2_155 LARKKLMPAIYDLANRGLLPASFALVGFAR-RDWEDEDFGQVVYDAVRQH TH_0337|M.thermoresistible__bu LSRKKLMPAIYDLANRGLLPASFSLVGFAR-RDWADEDFGQVVYEAVKTH Mvan_2718|M.vanbaalenii_PYR-1 LARKKLMPAIYDLANRGLLPPSFALVGFAR-RDWADEDFGEVVYEAVKKH MAB_2761|M.abscessus_ATCC_1997 LARKKLMPAIYDLANRGLLPPSFALVGFAR-RDWANEDFGQIVLDAVKAH Mflv_0266|M.gilvum_PYR-GCK LARRMLFPSLYRLAAAGRLPADHRIIGSGRSCPDSVEEFRDSVREGWSES Mb1152|M.bovis_AF2122/97 TEK-IDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELI-------GSACRP Rv1121|M.tuberculosis_H37Rv TEK-IDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELI-------GSACRP MMAR_4339|M.marinum_M SEP-FDEAVFERFASRWSYLPGDVTDPALYTALAKQI-------GHDRHG MUL_0149|M.ulcerans_Agy99 -------------------------------------------------- MAV_1252|M.avium_104 GET-FDDAVFDRLAGRLSYLSGDVTDTGLYSELAEKI-------GGDSRP MSMEG_3101|M.smegmatis_MC2_155 ARTPFRQEVWDRLAEGIRFVQGTFDDDTAFTRLAETLDKLDIERGTGGNH TH_0337|M.thermoresistible__bu ARTPFRQEVWDRLAEGFRFVQGTFDDDAAFARLTEVLEKLDVQRGTGGNH Mvan_2718|M.vanbaalenii_PYR-1 ARTPFRQEVWDRLAEGFRFVQGTFDDDASFDRLSETLEKLDAERGTGGNH MAB_2761|M.abscessus_ATCC_1997 SRTPFRQHVWDRLAEGIRFVQGSFDDDAAFEQLKKTLQTLDEERGTGGNH Mflv_0266|M.gilvum_PYR-GCK IDD-LDDAVVEGLLQRLSFQSADADDGADLAAAVASAQK---ELGEDVRT Mb1152|M.bovis_AF2122/97 LYYLEMPPALFAPIVENLANVRLLER-----ARVAVEKPFGHDLASALEL Rv1121|M.tuberculosis_H37Rv LYYLEMPPALFAPIVENLANVRLLER-----ARVAVEKPFGHDLASALEL MMAR_4339|M.marinum_M LYYLEMPPALFAPIVENLAKADLLRG-----ARVAVEKPFGHDLDSAREL MUL_0149|M.ulcerans_Agy99 ----------------------MLRC-----ARVAVEKPFGHDLDSAREL MAV_1252|M.avium_104 LYYLEMPPSLFAPIVENLAKADLLER-----ARVAVEKPFGHDLESARDL MSMEG_3101|M.smegmatis_MC2_155 AFYLSIPPNAFPVVCEQLRKSGLAKPRDGRWSRVVIEKPFGHDLGSAREL TH_0337|M.thermoresistible__bu AFYLSIPPKAFPLVCEQLRRSGLARPQPGRWSRVVVEKPFGHDLQSAVEL Mvan_2718|M.vanbaalenii_PYR-1 AFYLSIPPNAFPVVCEQLQRSGLARQKDHSWSRVVIEKPFGHDLASAREL MAB_2761|M.abscessus_ATCC_1997 GFYLSIPPNAFPTVCEQLSKSGLAQPVDGAWRRVVIEKPFGHDLASAREL Mflv_0266|M.gilvum_PYR-GCK LIYLSVPPSAMKPMIAMLGREGMAEG-----ARLIVEKPFGTDLDSSREL : . *: :***** ** *: :* Mb1152|M.bovis_AF2122/97 NARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEI Rv1121|M.tuberculosis_H37Rv NARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEI MMAR_4339|M.marinum_M NSRLRAVLNEDQILRVDHFLGKQPVVELQYLRFANRGLAELWDRKSVSEI MUL_0149|M.ulcerans_Agy99 NSRLRAVLNEDQILRVDHFLGKQPVVELQYLRFANRDLAELWDRKSVSEI MAV_1252|M.avium_104 NARLRAVLDEDQILRVDHFLGKQPVEELQYLRFANNALAKLWDRDSISEI MSMEG_3101|M.smegmatis_MC2_155 NSVVNSVFPEESVFRIDHYLGKETVQNILALRFANALYEPIWNNNYVDHV TH_0337|M.thermoresistible__bu NAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPIWNNHYVDHV Mvan_2718|M.vanbaalenii_PYR-1 NAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPVWNAHYVDHV MAB_2761|M.abscessus_ATCC_1997 NAVVNEVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHFVDHV Mflv_0266|M.gilvum_PYR-GCK GAATESVADEQRIYRIDHFLGKEAVQNILALRFANGLIEPAWNRHHIESV .: . * *: : *:**:***:.* :: ***** *: . :. : Mb1152|M.bovis_AF2122/97 HITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADD Rv1121|M.tuberculosis_H37Rv HITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADD MMAR_4339|M.marinum_M HVTMAENFGVEDRGKFYDAVGALRDVVQNHLLQVLALVAMEPPVGPGADD MUL_0149|M.ulcerans_Agy99 HVTMAENFGVEDRGKFYDAVGALRDVVQNHLLQVLALVAMEPPVGPGADD MAV_1252|M.avium_104 HITMAEDFGIEDRGKFYDAVGAVRDVVQNHLLQVLALVAMEPPVGAGADD MSMEG_3101|M.smegmatis_MC2_155 QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTALEEPVSFSPHE TH_0337|M.thermoresistible__bu QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPVSFHPRQ Mvan_2718|M.vanbaalenii_PYR-1 QITMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALTAMEEPVNFSPHE MAB_2761|M.abscessus_ATCC_1997 QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLAFTAMEEPINFSPAE Mflv_0266|M.gilvum_PYR-GCK QIDVPEDIALEGRGSFYESTGCFRDMVSTHLCQVLGFLAMEPPSALDADG :: :.*::.: .*. :*:. *. **::..** *:*.: ::* * . Mb1152|M.bovis_AF2122/97 LNDKKAEVFRAMAPLDP--DRCVRGQY----------LGYTEVAGVASDS Rv1121|M.tuberculosis_H37Rv LNDKKAEVFRAMAPLDP--DRCVRGQY----------LGYTEVAGVASDS MMAR_4339|M.marinum_M LNDKKAEVFRAMPALQT--AHYVRGQY----------QGYGDVPGVAKDS MUL_0149|M.ulcerans_Agy99 LNDKKAEVFRAMPALQT--AHYVRGQY----------QGYGDVPGVAKDS MAV_1252|M.avium_104 LNDKKAEVFRAMPSLDP--EHCVRGQY----------RGYTEVPGVAKDS MSMEG_3101|M.smegmatis_MC2_155 LQTEKIKILSAVKLAEPLDETTARGQYAAGWQGGEKVVGLLDEEGFAKDS TH_0337|M.thermoresistible__bu LQAEKIKVLSAVRLAQPLDQTTARGQYTAGWQGGERVVGLLEEEGFAKDS Mvan_2718|M.vanbaalenii_PYR-1 LQAEKIKVLSATRPLQPLDQTTARGQYAAGWQGSEKVPGLLEEGGFAHDS MAB_2761|M.abscessus_ATCC_1997 LQAEKIKVLSATRLAEPLAETTARGQYGPGWQGSQQVPGLLEEEGFSKTS Mflv_0266|M.gilvum_PYR-GCK LRNAKAQVFEDMRPLDP--ARVVFGQY----------AGYRDEDGVDDDS *. * ::: :. . *** * : *. * Mb1152|M.bovis_AF2122/97 ATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFL Rv1121|M.tuberculosis_H37Rv ATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFL MMAR_4339|M.marinum_M QTETYVALRTEIDNWRWAGVPVFLRAGKALPERVTEVRMFLHHVPGLAFL MUL_0149|M.ulcerans_Agy99 QTETYVALRTEIDNWRWAGVPVFLRAGKALPERVTEVRMFLHHVPGLAFL MAV_1252|M.avium_104 TTETYVALRTEIDNWRWAGVPIFLRAGKALPHKVTEVRMFLHHVPGFSFL MSMEG_3101|M.smegmatis_MC2_155 TTETYAAITLEVNTRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLPFD TH_0337|M.thermoresistible__bu TTETFAAITLEIDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFD Mvan_2718|M.vanbaalenii_PYR-1 VTETFAAITLEVDTRRWAGVPFFLRTGKRLPRRVTEVALVFKRAPHLPFD MAB_2761|M.abscessus_ATCC_1997 TTETFAAITLEVDSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLPFD Mflv_0266|M.gilvum_PYR-GCK DVETFVALEAYVDNERWRDVPFYLRTGKAMGDNRRTVTLTFRTPPGELFG .**:.*: ::. ** .**.::*:** : . : : :: * * Mb1152|M.bovis_AF2122/97 PNRRPAE-PNQIVLRIDPDPGMRLQISAHTDDS---WRDIHLDSSFAVD- Rv1121|M.tuberculosis_H37Rv PNRRPAE-PNQIVLRIDPDPGMRLQISAHTDDS---WRDIHLDSSFAVD- MMAR_4339|M.marinum_M PNRRPAE-PNQIVLRIDPDPGMRLQISAQTGDS---WQGVHLDSSFAED- MUL_0149|M.ulcerans_Agy99 PNRRPAE-PNQIVLRIDPDPGMRLQISAQTGDS---WQGVHLDSSFAED- MAV_1252|M.avium_104 PNRRPPE-PNQIVLRIDPDPGMRLQLSAQVGDS---WHDVHLDSSFAVD- MSMEG_3101|M.smegmatis_MC2_155 ATMTEELGQNALVIRVQPDEGITLRFGSKVPGSAMEVRDVNMDFSYGSA- TH_0337|M.thermoresistible__bu ATMTEELGQNALVIRIQPDEGVTLRFGSKVPGSAMEVRDVNMDFSYGSA- Mvan_2718|M.vanbaalenii_PYR-1 STMTEELGKNALVIRIQPDEGITMRFGSKVPGSAMEVRDVNMDFSYGSA- MAB_2761|M.abscessus_ATCC_1997 STMTEELGANALVIRVQPDEGVTLRFGSKVPGSAMEVRDVNMDFSYEQA- Mflv_0266|M.gilvum_PYR-GCK DTRRPDR----LVLDLTETPTAQLALNVKRPGPELTVERVGVPVALTPDG . :*: : : :. : .. . : : : Mb1152|M.bovis_AF2122/97 LGEP-IRPYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLD---NPGEI Rv1121|M.tuberculosis_H37Rv LGEP-IRPYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLD---NPGEI MMAR_4339|M.marinum_M LGEP-IRPYERLLYAGLIGDRQLFAREDAIEQTWRIVQPVLD---DPGEI MUL_0149|M.ulcerans_Agy99 LGEP-IRPYERLLYAGLIGDRQLFAREDAIEQTWRIVQPVLD---DPGEI MAV_1252|M.avium_104 LGEP-VRPYERLLYAAFNGDRQLFAREDAIEETWRIVQPVLD---KPSRI MSMEG_3101|M.smegmatis_MC2_155 FAEDSPEAYERLILDVLLGEPSLFPVNEEVELSWEILDPVLEYWAQHGKP TH_0337|M.thermoresistible__bu FAEDSPEAYERLILDVLLGEPSLFPVNAEVELSWKILDPILEYWASHGKP Mvan_2718|M.vanbaalenii_PYR-1 FAEDSPEAYERLILDVLLGEPSLFPVNAEVELSWEILDPVLDNWSAQGRP MAB_2761|M.abscessus_ATCC_1997 FTEESPEAYERLILDVLLGEPSLFPVNAEVELSWRILDPALDFWASQGRP Mflv_0266|M.gilvum_PYR-GCK TGGDGLDAYERLLLDVLRGDQTLFARGDEVDRLWQVCQPVLD---DPPAV .****: : *: **. :: *.: :* *: Mb1152|M.bovis_AF2122/97 HRYDRGSWGPEAAQSLLRG-HRGWQSPWLPRGTDA-- Rv1121|M.tuberculosis_H37Rv HRYDRGSWGPEAAQSLLRG-HRGWQSPWLPRGTDA-- MMAR_4339|M.marinum_M HPYDRGSWGPEAAQTLLRG-HRNWQQPWLPRSAEARQ MUL_0149|M.ulcerans_Agy99 HPYDRGSWGPEAAQTLLRG-HRNWQQPWLPRSAEARQ MAV_1252|M.avium_104 HQYEQGSWGPEAAQALVHG-RHAWQQPWLPQSTSTKR MSMEG_3101|M.smegmatis_MC2_155 EPYESGTWGPPSADAMLRRTGREWRRP---------- TH_0337|M.thermoresistible__bu DPYEAGTWGPESAFEMLRRTGREWRRP---------- Mvan_2718|M.vanbaalenii_PYR-1 EPYESGTWGPPSAYDMVHLLDREWRRP---------- MAB_2761|M.abscessus_ATCC_1997 DTYESGTWGPQSAVEMLARSGREWRRP---------- Mflv_0266|M.gilvum_PYR-GCK EAYDKGSWGPQSAVELPRS---GWWLPDDD------- . *: *:*** :* : * *