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MSRPEVLTPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVAAEAAAAGAERLVIVTSEGKDGVV AHFVEDLVLEGTLEARGKIAMLAKVRRAPALIKVESVVQAEPLGLGHAIGCVEPTLSPDEDAVAVLLPDD LVLPTGVLETMSKVRASRGGTVLCAIEVAREEISAYGVFDVEPVPDGDYTDDPNVLKVRGMVEKPKAETA PSRYAAAGRYVLDRAIFDALRRIDQGAGGEVQLTDAIALLIAEGHPVHVVVHQGSRHDLGNPGGYLKAAV DFALDRDDYGPDLRRWLVARLGLTEQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0993 | galU | - | 100% (306) | PROBABLE UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE GALU (UDP-GLUCOSE PYROPHOSPHORYLASE) (UDPGP) (ALPHA-D-GLUCOSYL-1-PHOSPHATE URIDYLYLTRANSFERASE) (URIDINE DIPHOSPHOGLUCOSE PYROPHOSPHORYLASE) |
| M. tuberculosis H37Rv | Rv3264c | manB | 1e-10 | 25.56% (270) | D-alpha-D-mannose-1-phosphate guanylyltransferase MANB |
| M. tuberculosis H37Rv | Rv0334 | rmlA | 9e-10 | 26.49% (268) | alpha-D-glucose-1-phosphate thymidylyltransferase RmlA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1020 | galU | 1e-172 | 99.67% (306) | UTP--glucose-1-phosphate uridylyltransferase GalU |
| M. gilvum PYR-GCK | Mflv_1897 | - | 1e-146 | 85.81% (303) | nucleotidyl transferase |
| M. leprae Br4923 | MLBr_00182 | galU | 1e-151 | 89.74% (302) | putative UTP-glucose-1-phosphate uridylyltransferase |
| M. abscessus ATCC 19977 | MAB_1086 | - | 1e-140 | 83.77% (302) | putative UTP-glucose-1-phosphate uridylyltransferase (GalU) |
| M. marinum M | MMAR_4521 | galU | 1e-154 | 91.06% (302) | UTP--glucose-1-phosphate uridylyltransferase GalU |
| M. avium 104 | MAV_1102 | - | 1e-147 | 88.70% (301) | GalU protein |
| M. smegmatis MC2 155 | MSMEG_5471 | galU | 1e-139 | 82.72% (301) | UTP-glucose-1-phosphate uridylyltransferase |
| M. thermoresistible (build 8) | TH_0940 | galU | 1e-138 | 79.93% (304) | PROBABLE UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE GALU |
| M. ulcerans Agy99 | MUL_4693 | galU | 1e-155 | 91.39% (302) | UTP--glucose-1-phosphate uridylyltransferase GalU |
| M. vanbaalenii PYR-1 | Mvan_4833 | - | 1e-146 | 86.47% (303) | nucleotidyl transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0993|M.tuberculosis_H37Rv ---MSRPEVLTPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVA
Mb1020|M.bovis_AF2122/97 ---MSRPEVLTPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVA
MLBr_00182|M.leprae_Br4923 MSLLLSAQVPIPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVA
MMAR_4521|M.marinum_M ----MSQEVAIPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVA
MUL_4693|M.ulcerans_Agy99 ----MSQEVAIPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVA
MAV_1102|M.avium_104 --------MVVPRTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVA
Mflv_1897|M.gilvum_PYR-GCK ---MNRPEVPVPRTAVVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVA
Mvan_4833|M.vanbaalenii_PYR-1 ---MNRAEVPIPRTAVVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVA
MSMEG_5471|M.smegmatis_MC2_155 ---MS-----IPHTAVVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVA
TH_0940|M.thermoresistible__bu ---MSESRAPVPRTAVVPAAGLGTRFLPVTKTVPKELLPVVDTPGIELVA
MAB_1086|M.abscessus_ATCC_1997 ---MTGPDVLIPRTAVVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVA
* **:************.*********************
Rv0993|M.tuberculosis_H37Rv AEAAAAGAERLVIVTSEGKDGVVAHFVEDLVLEGTLEARGKIAMLAKVRR
Mb1020|M.bovis_AF2122/97 AEAAAAGAERLVIVTSEGKDGVVAHFVEDLVLEGTLEARGKIAMLAKVRR
MLBr_00182|M.leprae_Br4923 AEAAAAGAERLVIVTSEGKDGVVAHFVQDLVLEGTLLARGNKAMLAKVRR
MMAR_4521|M.marinum_M AEAAAAGAERLVIVTSEGKDGVVAHFVEDLVLEGTLEARGKTAMLAKVRR
MUL_4693|M.ulcerans_Agy99 AEAAAAGAERLVIVTSEGKDGVVAHFVEDLVLEGTLEARGKTAMLAKVRR
MAV_1102|M.avium_104 AEAAEAGAERLVIVTSEGKDGVVAHFVEDLVLESTLEERGKTAMLDKVRR
Mflv_1897|M.gilvum_PYR-GCK AEAAEAGAERLIIITSEGKDGVVAHFVEDLVLEGTLEARGKKTMLEKVRR
Mvan_4833|M.vanbaalenii_PYR-1 AEAAEAGAERLIIVTSEGKDGVVAHFVEDLVLEGTLEARGKKTMLEKVRR
MSMEG_5471|M.smegmatis_MC2_155 AEAAEAGAERLVIVTSEGKDGVVAHFVQDLVLEGTLEARGKKTMLEKVRR
TH_0940|M.thermoresistible__bu EEAAEAGAQRLIIITSEGKDSVVAHFVQDLVLEGVLEARGKKTMLEKVRR
MAB_1086|M.abscessus_ATCC_1997 EEAAEAGAERLVIVTSEGKDGVVAHFVEDLVLEGTLEARGKHAMLEKVRK
*** ***:**:*:******.******:*****..* **: :** ***:
Rv0993|M.tuberculosis_H37Rv APALIKVESVVQAEPLGLGHAIGCVEPTLSPDEDAVAVLLPDDLVLPTGV
Mb1020|M.bovis_AF2122/97 APALIKVESVVQAEPLGLGHAIGCVEPTLSPDEDAVAVLLPDDLVLPTGV
MLBr_00182|M.leprae_Br4923 APELIKVESVVQAEPLGLGHAIGCAEPTLAPDEDAVSVLLPDDLVLPTGV
MMAR_4521|M.marinum_M APALIKVESVVQAEPLGLGHAISCVEPTLSDDEDAVSVLLPDDLVLPTGV
MUL_4693|M.ulcerans_Agy99 APALIKVESVVQAEPLGLGHAISCVEPTLSDDEDAVSVLLPDDLVLPTGV
MAV_1102|M.avium_104 APRLIKVESVVQSEPLGLGHAIGCVEPRLADDEDAVAVLLPDDLVLPTGV
Mflv_1897|M.gilvum_PYR-GCK APALIKVESVVQAEPLGLGHAVGCVEASLAPDEDAIAVLLPDDLVLPTGV
Mvan_4833|M.vanbaalenii_PYR-1 APALIKVESVVQAEPLGLGHAISCVEASLAPDEDAIAVLLPDDLVLPTGV
MSMEG_5471|M.smegmatis_MC2_155 APALIKVESVVQAEPLGLGHAVSCVESVLAADEDAISVLLPDDLVLPTGV
TH_0940|M.thermoresistible__bu APELIRVESVIQQEPLGLGHAVSCVESSLEPDEDAIAVLLPDDLVLPTGI
MAB_1086|M.abscessus_ATCC_1997 APALIKVQSVVQAEPLGLGHAVGCVESVLDDDEDAVAVLLPDDLVWPRGV
** **:*:**:* ********:.*.*. * ****::******** * *:
Rv0993|M.tuberculosis_H37Rv LETMSKVRASRGGTVLCAIEVAREEISAYGVFDVEPVPDGDYTDDPNVLK
Mb1020|M.bovis_AF2122/97 LETMSKVRASRGGTVLCAIEVAREEISAYGVFDVEPVPDGDYTDDPNVLK
MLBr_00182|M.leprae_Br4923 LETMSKVRASRGGTVLCAIEVASEEISSYGVFDVEPVPGG---DNPNVLK
MMAR_4521|M.marinum_M LETMSKVRARLGGTVLCAIEVSPDEISAYGVFDVEPVPGGEWAANPDVLK
MUL_4693|M.ulcerans_Agy99 LETMSKVRARLGGTVLCAIEVSPDEISAYGVFDVEPVPGGEWAANPNVLK
MAV_1102|M.avium_104 LGTMSKVRAHYGGTVLCAIEVTPEEISAYGVFDVEPVPDD----DPDVLR
Mflv_1897|M.gilvum_PYR-GCK LETMAKVRAKRGGSVLCAIEVDREDISAYGVFDVETVPDAA---NPNVLR
Mvan_4833|M.vanbaalenii_PYR-1 LETMSKVRAKRGGSVLCAIEVDREDISAYGVIDVEPLPDAN---NPNVLK
MSMEG_5471|M.smegmatis_MC2_155 LETMSKVRAKRGGSVLCAIEVPGDKISAYGVFDVETVPDAA---NPNVLR
TH_0940|M.thermoresistible__bu LETMSRVRAKRGGSVLCAIEVPGDEISAYGVFDVEPVPDST---NPDVLR
MAB_1086|M.abscessus_ATCC_1997 LETMAKVRAKRGGSVLCAIEVPPHEISSYGAFDVEIVPDAA---NPNVLR
* **::*** **:******* ..**:**.:*** :*. :*:**:
Rv0993|M.tuberculosis_H37Rv VRGMVEKPKAETAPSRYAAAGRYVLDRAIFDALRRIDQGAGGEVQLTDAI
Mb1020|M.bovis_AF2122/97 VRGMVEKPKAETAPSRYAAAGRYVLDRAIFDALRRIDRGAGGEVQLTDAI
MLBr_00182|M.leprae_Br4923 VIGMVEKPKAEDAPSTFAAAGRYVLDRAIFDALRRVSRGTGGEVQITDAI
MMAR_4521|M.marinum_M VKGMVEKPKTQDAPSMFAAAGRYVLDRAIFDALRRIERGAGGEVQLTDAI
MUL_4693|M.ulcerans_Agy99 VKGMVEKPKTQDAPSMFAAAGRYVLDRAIFDALRRIERGAGGEVQLTDAI
MAV_1102|M.avium_104 VKGMVEKPKAEDAPSMFAAAGRYVLDRAIFDALRRIDRGAGGEVQLTDGI
Mflv_1897|M.gilvum_PYR-GCK VKGMVEKPKAEDAPSLFAAAGRYILDRAIFDALKRIPRGAGGELQLTDAI
Mvan_4833|M.vanbaalenii_PYR-1 VKGMVEKPKPEDAPSLYAAAGRYVLDRAIFDALRRIPRGAGGELQLTDAI
MSMEG_5471|M.smegmatis_MC2_155 VKGMVEKPRPEDAPSHFAAAGRYVLDRAIFDALRRVPRGTGGEIQLTDAI
TH_0940|M.thermoresistible__bu VKGMVEKPKPEDAPSPYAAAGRYVLDRAIFDALRRVPRGAGGEIQLTDAI
MAB_1086|M.abscessus_ATCC_1997 VKGMVEKPKTEEAPSNYAAAGRYLLDRAIFDALKRIPRGAGGELQLTDAI
* ******:.: *** :******:*********:*: :*:***:*:**.*
Rv0993|M.tuberculosis_H37Rv ALLIAEGHPVHVVVHQGSRHDLGNPGGYLKAAVDFALDRDDYGPDLRRWL
Mb1020|M.bovis_AF2122/97 ALLIAEGHPVHVVVHQGSRHDLGNPGGYLKAAVDFALDRDDYGPDLRRWL
MLBr_00182|M.leprae_Br4923 ALLIKEGHPVHVVVHRGSRHDLGNPGGYLKAAVDFALDRDDYGPDLRRWL
MMAR_4521|M.marinum_M ALLIAEGHPVHVVVHRGSRHDLGNPGGYLKAAVDFALDRDDYGPDLRRWL
MUL_4693|M.ulcerans_Agy99 ALLIAEGHPVHVVVHRGSRHDLGNPGGYLKAAVDFALDRDDYGPDLRRWL
MAV_1102|M.avium_104 ALLISEGHPVHVVVHRGSRHDLGNPGGYLKAAVDFALDRDDYGPDLRQWL
Mflv_1897|M.gilvum_PYR-GCK ALLIEEGHPVHVVVHRGSRHDLGNPGGYLKAAVDFALERDDYGPELRRWL
Mvan_4833|M.vanbaalenii_PYR-1 ALLIQEGHPVHVVIHRGSRHDLGNPGGYLKAAVDFALERDDYGPELRRWL
MSMEG_5471|M.smegmatis_MC2_155 ALLIEEDHPVHVVVHRGARHDLGNPGGYLKAAVDFALERDDYGPELRQWL
TH_0940|M.thermoresistible__bu ALLIEEGHPVHAVVHRGTRHDLGNPGGYLKAAVDFALERDDYGPDLREWL
MAB_1086|M.abscessus_ATCC_1997 ALLIDEGHPVHVVVHRGSRHDLGNPGGYLKAAVDFALDRDDYGPGLREWL
**** *.****.*:*:*:*******************:****** **.**
Rv0993|M.tuberculosis_H37Rv VARLGLTEQ------
Mb1020|M.bovis_AF2122/97 VARLGLTEQ------
MLBr_00182|M.leprae_Br4923 VERLGLIEQ------
MMAR_4521|M.marinum_M VARLGLTEQ------
MUL_4693|M.ulcerans_Agy99 VARLGLTEQ------
MAV_1102|M.avium_104 VARLGLSEQ------
Mflv_1897|M.gilvum_PYR-GCK VERLGLPAGTEG---
Mvan_4833|M.vanbaalenii_PYR-1 VERLGLAPATSGQ--
MSMEG_5471|M.smegmatis_MC2_155 VERLGLAEK------
TH_0940|M.thermoresistible__bu LERLGLT--------
MAB_1086|M.abscessus_ATCC_1997 VERLGRESSVLPESE
: ***