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MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAGIRDIQLITTPHDAPGFHRLLGDGAH LGVNISYATQDQPDGLAQAFVIGANHIGADSVALVLGDNIFYGPGLGTSLKRFQSISGGAIFAYWVANPS AYGVVEFGAEGMALSLEEKPVTPKSNYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVNQVYLNQGRLA VEVLARGTAWLDTGTFDSLLDAADFVRTLERRQGLKVSIPEEVAWRMGWIDDEQLVQRARALVKSGYGNY LLELLERN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0334 | rmlA | - | 100% (288) | ALPHA-D-GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE RMLA (DTDP-GLUCOSE SYNTHASE) (DTDP-GLUCOSE PYROPHOSPHORYLASE) |
| M. tuberculosis H37Rv | Rv3264c | manB | 4e-17 | 27.24% (246) | D-alpha-D-mannose-1-phosphate guanylyltransferase MANB |
| M. tuberculosis H37Rv | Rv0993 | galU | 8e-10 | 26.49% (268) | UTP--glucose-1-phosphate uridylyltransferase GalU |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0341 | rmlA | 1e-166 | 100.00% (288) | glucose-1-phosphate thymidylyltransferase |
| M. gilvum PYR-GCK | Mflv_0285 | - | 1e-135 | 79.09% (287) | glucose-1-phosphate thymidylyltransferase |
| M. leprae Br4923 | MLBr_02503 | rfbA | 1e-146 | 87.11% (287) | glucose-1-phosphate thymidyltransferase |
| M. abscessus ATCC 19977 | MAB_4113 | - | 1e-134 | 77.35% (287) | glucose-1-phosphate thymidylyltransferase |
| M. marinum M | MMAR_0606 | rmlA | 1e-154 | 91.32% (288) | alpha-D-glucose-1-phosphate thymidylyl- transferase, RmlA |
| M. avium 104 | MAV_4820 | rfbA | 1e-143 | 83.68% (288) | glucose-1-phosphate thymidylyltransferase |
| M. smegmatis MC2 155 | MSMEG_0384 | rfbA | 1e-135 | 79.09% (287) | glucose-1-phosphate thymidylyltransferase |
| M. thermoresistible (build 8) | TH_1924 | rmlA | 1e-137 | 81.18% (287) | ALPHA-D-GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE RMLA |
| M. ulcerans Agy99 | MUL_0568 | rmlA | 1e-153 | 90.97% (288) | alpha-D-glucose-1-phosphate thymidylyl- transferase, RmlA |
| M. vanbaalenii PYR-1 | Mvan_0603 | - | 1e-143 | 84.67% (287) | glucose-1-phosphate thymidylyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0285|M.gilvum_PYR-GCK MRGIVLAGGSGTRLYPITLGVSKQLMPVYDKPLIYYPLSTLMMAGIRDIL
Mvan_0603|M.vanbaalenii_PYR-1 MRGIILAGGSGTRLYPITLGISKQLVPVYDKPLVYYPLSTLMMAGIRDIL
Rv0334|M.tuberculosis_H37Rv MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAGIRDIQ
Mb0341|M.bovis_AF2122/97 MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAGIRDIQ
MMAR_0606|M.marinum_M MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAGIRDIQ
MUL_0568|M.ulcerans_Agy99 MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAGIRDIQ
MLBr_02503|M.leprae_Br4923 MRGIILAGGSGTRLYPITLGISKQLLPVYDKPMIYYPLSTLMMAGIRDIL
MAV_4820|M.avium_104 MRGIILAGGSGTRLHPITTGISKQLLPVYDKPMVYYPLSTLMMAGIRDIL
MSMEG_0384|M.smegmatis_MC2_155 MRGIILAGGSGTRLHPLTIGVSKQLLPVYDKPLVYYPLSTLIMAGIRDIL
TH_1924|M.thermoresistible__bu MRGIILAGGSGTRLHPITMGVSKQLLPVYDKPLIYYPLSTLIMAGIRDIL
MAB_4113|M.abscessus_ATCC_1997 MRGIILAGGSGTRLHPITTGVSKQLLPVYDKPLVYYPLSTLIMAGVRDIL
****:*********:*:* *:****:******::****:**:***:***
Mflv_0285|M.gilvum_PYR-GCK IITTPRDAPDFHRLLGDGSAFGVNLTYAEQEEPEGLAQAFVIGASHIGSD
Mvan_0603|M.vanbaalenii_PYR-1 VITTAHDAPDFRRLLGDGSDLGVNLSYAVQDEPDGLAQAFVIGASHIGTD
Rv0334|M.tuberculosis_H37Rv LITTPHDAPGFHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGAD
Mb0341|M.bovis_AF2122/97 LITTPHDAPGFHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGAD
MMAR_0606|M.marinum_M LITTPHDAAGFHRLLGDGTHFGVNITYATQDQPDGLAQAFVIGADHIGTD
MUL_0568|M.ulcerans_Agy99 LITTPHDAAGFHRLLGDGTHFGVNITYATQDQPDGLAQAFVIGADHIGTD
MLBr_02503|M.leprae_Br4923 VITTAHDAPGFKRLLGDGTQFGVNISYATQDHPDGLAQAFVIGANHIGAD
MAV_4820|M.avium_104 VITTPHDAAGFVRLLGDGSQFGINITYVTQERPDGLAQAFVLGADHIGND
MSMEG_0384|M.smegmatis_MC2_155 VITTPADAPAFRRLLGDGSDFGVNLSYAAQNEPEGLAQAFLIGADHIGND
TH_1924|M.thermoresistible__bu VITTPTDAPAFQRLLGDGSAFGVNLRYAEQQEPEGLAQAFVIGADHIGDD
MAB_4113|M.abscessus_ATCC_1997 VITTPADAPAFERLLGDGSAFGINLSYAVQPQPEGLAQAFVIGAQHIGTD
:***. **. * ******: :*:*: *. * .*:******::**.*** *
Mflv_0285|M.gilvum_PYR-GCK PVALVLGDNIFYGPGLGTGLQRFQNVTGASIFAYWVADPAAYGVVEFDAD
Mvan_0603|M.vanbaalenii_PYR-1 SVALVLGDNIFYGPGLGTSLQRFQNVSGGAIFAYWVANPSAYGVVEFAED
Rv0334|M.tuberculosis_H37Rv SVALVLGDNIFYGPGLGTSLKRFQSISGGAIFAYWVANPSAYGVVEFGAE
Mb0341|M.bovis_AF2122/97 SVALVLGDNIFYGPGLGTSLKRFQSISGGAIFAYWVANPSAYGVVEFGAE
MMAR_0606|M.marinum_M SVALVLGDNIFYGPGLGTSLRRFQDISGGTIFAYWVANPTAYGVVEFSAD
MUL_0568|M.ulcerans_Agy99 SVALVLGDNIFYGPGLGTSLRRFQDISGGTIFAYWVANPTAYGVVEFSAD
MLBr_02503|M.leprae_Br4923 TVALVLGDNIFYGPGLGTSLRRFQYVSGGAIFAYCVANPSSYGIVELGID
MAV_4820|M.avium_104 SVALVLGDNIFYGPGLGTSLRRFQTITGGAVFAYWVANPSAYGVVEFSDD
MSMEG_0384|M.smegmatis_MC2_155 TVALALGDNIFYGPGLGTSLRRFEHVSGGAIFAYWVANPSAYGVVEFDAD
TH_1924|M.thermoresistible__bu TVALALGDNIFYGPGLGTSLRRFQNVTGGAIFAYWVANPSAYGVVEFGPD
MAB_4113|M.abscessus_ATCC_1997 TAMLALGDNVFYGPGLGTSLRRFENIDGGAIFAYWVANPSAYGVVEFDAA
.. *.****:********.*:**: : *.::*** **:*::**:**:
Mflv_0285|M.gilvum_PYR-GCK GNALSLQEKPARPRSHYAVPGLYFYDNDVVEIARHLKKSDRGEYEITEVN
Mvan_0603|M.vanbaalenii_PYR-1 GTALSLEEKPATPKSHYAVPGLYFYDNDVIEIARGLRRSARGEYEITEVN
Rv0334|M.tuberculosis_H37Rv GMALSLEEKPVTPKSNYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVN
Mb0341|M.bovis_AF2122/97 GMALSLEEKPVTPKSNYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVN
MMAR_0606|M.marinum_M GTALSLEEKPATPKSHYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVN
MUL_0568|M.ulcerans_Agy99 GTALSLEEKPATPKSHYAVPGLYFYDNDVIEIARSLKKSARGEYEITEVN
MLBr_02503|M.leprae_Br4923 GIALSLEEKPATPKSQYAVPGLYFYDNDVVEIARGLTKSARGEYEITEVN
MAV_4820|M.avium_104 GMALSLEEKPKTPKSNYAVPGLYFYDNDVIEIAKGLKKSERGEYEITEVN
MSMEG_0384|M.smegmatis_MC2_155 GKAVSLEEKPKTPKSHYAVPGLYFYDNTVIDIARSLKKSARGEYEITEVN
TH_1924|M.thermoresistible__bu GKAVSLEEKPKVPKSNYAVPGLYFYDNDVIEIARSLRKSARGEYEITEVN
MAB_4113|M.abscessus_ATCC_1997 GVPLSLEEKPATPKSHYAVPGLYFYDNDVIEIARSLQKSARGEYEITEIN
* .:**:*** *:*:*********** *::**: * :* ********:*
Mflv_0285|M.gilvum_PYR-GCK QTYLDQGRLRVEVLARGTAWLDTGTFDSLLDASDYVRTLERRQGLKISVP
Mvan_0603|M.vanbaalenii_PYR-1 QTYLNQGRLSVEVLARGTAWLDTGTFDSLLDAADFVRTIERRQGLKISVP
Rv0334|M.tuberculosis_H37Rv QVYLNQGRLAVEVLARGTAWLDTGTFDSLLDAADFVRTLERRQGLKVSIP
Mb0341|M.bovis_AF2122/97 QVYLNQGRLAVEVLARGTAWLDTGTFDSLLDAADFVRTLERRQGLKVSIP
MMAR_0606|M.marinum_M QAYLNHGRLNVEMLARGTAWLDTGTFDSLLDAADFVRTLERRQGLKVSVP
MUL_0568|M.ulcerans_Agy99 QAYLNHGRLNVEMLARGTAWLDTGTFDSLLDAADFVRTLERRQGLKVSVP
MLBr_02503|M.leprae_Br4923 QIYLNQGRLTVEVLARGTAWLDTGTFDSLLDASDFVRTLERRQGLKVSVP
MAV_4820|M.avium_104 QIYLSRGRLSVEVMARGTAWLDTGTFDSLLDASDFVRTLERRQGLKVSVP
MSMEG_0384|M.smegmatis_MC2_155 QIYLNRGQLSVEVLARGTAWLDTGTFDSLLDASDFVRTIELRQGLKVGAP
TH_1924|M.thermoresistible__bu QIYLERGQLSVEVLARGTAWLDTGTFDSLLDASDFVRTIERRQGLKIGAP
MAB_4113|M.abscessus_ATCC_1997 QIYLDQGRLSVEVLPRGTAWLDTGTFDSLLDASDYVRTIERRQGLKIGVP
* **.:*:* **::.*****************:*:***:* *****:. *
Mflv_0285|M.gilvum_PYR-GCK EEVAWRVGFIDDATLEARGKALLKSGYGAYLLELLDR------
Mvan_0603|M.vanbaalenii_PYR-1 EEVAWRVGFIDDDALEARAKTLLKSGYGAYLLELLQR------
Rv0334|M.tuberculosis_H37Rv EEVAWRMGWIDDEQLVQRARALVKSGYGNYLLELLERN-----
Mb0341|M.bovis_AF2122/97 EEVAWRMGWIDDEQLVQRARALVKSGYGNYLLELLERN-----
MMAR_0606|M.marinum_M EEVAWRLGWIDDEQLMRRARSLVKSGYGSYLLELLERN-----
MUL_0568|M.ulcerans_Agy99 EEVAWRLGWIDDEQLMRRARSLVKSGYGSYLLELLERN-----
MLBr_02503|M.leprae_Br4923 EEVSWRMGWIDDEQLALRAHSLAKSGYGCYLSELLERG-----
MAV_4820|M.avium_104 EEVAWQQGWITDEQLSERAQSLLKSGYGGYLLDLLERSRFH--
MSMEG_0384|M.smegmatis_MC2_155 EEIAWRAGFIDDDQLATRAKELLKSGYGHYLLQLLDRE-----
TH_1924|M.thermoresistible__bu EEIAWRAGFIDDEQLAARARQLLKSGYGTYLLELLGRERREPF
MAB_4113|M.abscessus_ATCC_1997 EEIAWRAGFINDDQLAARAQKLLKSGYGSYLLQLLQRK-----
**::*: *:* * * *.: * ***** ** :** *