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VADTDDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTFDVGFANTAAAKSSITYIDGDAGILR YRGYPIDQLAEKSTFIEVCYLLIYGELPDTDQLAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSV VNALSAYYQDALDPMDNGQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNSLTLVENFLRLTFGFPAE PYQADPEVVRALDMLFILHADHEQNCSTSTVRLVGSSRANLFTSISGGINALWGPLHGGANQAVLEMLEG IRDSGDDVSEFVRKVKNREAGVKLMGFGHRVYKNYDPRARIVKEQADKILAKLGGDDSLLGIAKELEEAA LTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWREMHDEGDSKIGRPRQIYTGY TERDYVTIDAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0896 | gltA | - | 100% (431) | type II citrate synthase |
| M. tuberculosis H37Rv | Rv1131 | gltA1 | 2e-47 | 31.93% (379) | citrate synthase |
| M. tuberculosis H37Rv | Rv0889c | citA | 7e-35 | 30.30% (396) | citrate synthase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0920 | gltA | 0.0 | 99.77% (431) | type II citrate synthase |
| M. gilvum PYR-GCK | Mflv_1729 | gltA | 0.0 | 85.14% (424) | type II citrate synthase |
| M. leprae Br4923 | MLBr_02130 | gltA | 0.0 | 91.18% (431) | type II citrate synthase |
| M. abscessus ATCC 19977 | MAB_0944 | gltA | 0.0 | 84.71% (425) | type II citrate synthase |
| M. marinum M | MMAR_4640 | gltA | 0.0 | 95.36% (431) | citrate synthase I GltA2 |
| M. avium 104 | MAV_0344 | - | 6e-47 | 32.80% (378) | methylcitrate synthase |
| M. smegmatis MC2 155 | MSMEG_5672 | gltA | 0.0 | 86.32% (424) | type II citrate synthase |
| M. thermoresistible (build 8) | TH_3084 | - | 0.0 | 86.18% (427) | PUTATIVE citrate synthase I |
| M. ulcerans Agy99 | MUL_0255 | gltA | 0.0 | 95.13% (431) | type II citrate synthase |
| M. vanbaalenii PYR-1 | Mvan_5022 | gltA | 0.0 | 83.91% (435) | type II citrate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0896|M.tuberculosis_H37Rv MADT----DDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTFD
Mb0920|M.bovis_AF2122/97 MADT----DDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTFD
MMAR_4640|M.marinum_M MSDT----DDTATLKYPGGEIDLQIAHATEGADGIALGPLLSKTGHTTFD
MUL_0255|M.ulcerans_Agy99 MSDT----DDTATLKYPGGEIDLQIAHATEGADGIALGPLLSKTGHTTFD
MLBr_02130|M.leprae_Br4923 MADT----DDTVTLKYPGGEIDLQIVRATEGNDGIAIVPVLAKTGYTTFD
Mflv_1729|M.gilvum_PYR-GCK MADNAEAGQEHATLSYPGGELELDIVKASEGSDGIALGSLLAKTGYTTFD
Mvan_5022|M.vanbaalenii_PYR-1 MADNADAGQEHATLVYPGGELELDIVKASEGADGIALGSLLAKSGYTTFD
MSMEG_5672|M.smegmatis_MC2_155 MAEKPSNGQEHATVKYPGGELDLEIVHATEGADGIALGSLLAKTGYTTYD
MAB_0944|M.abscessus_ATCC_1997 MADN----NDFATLQYPGGETKLDIVRATEGADGFALGKLLADTGYTTFD
TH_3084|M.thermoresistible__bu VAENASSGDKHATLIYPGGQIDLEIVRATEGADGIALGSMLAETGYTTFD
MAV_0344|M.avium_104 --------------------------------------MSTLEDNQPRIH
. . . .
Rv0896|M.tuberculosis_H37Rv VGFANTAAAKSSITYIDGDAGILRYRGYPIDQLAEKSTFIEVCYLLIYGE
Mb0920|M.bovis_AF2122/97 VGFANTAAAKSSITYIDGDAGILRYRGYPIDQLAEKSTFIEVCYLLIYGE
MMAR_4640|M.marinum_M NGFVNTASCKSSITYIDGDAGILRYRGYPIDQLAEKSTFIEVCYLLIYGE
MUL_0255|M.ulcerans_Agy99 NGFANTASCKSSITYIDGDAGILRYRGYPIDQLAEKSTFIEVCYLLIYGE
MLBr_02130|M.leprae_Br4923 VGYGNTASTKSSITYIDGDAGILRYRGYPIEQLAEKSTFIEVCYLLIYGE
Mflv_1729|M.gilvum_PYR-GCK GGFVNTASTKSAITYIDGDAGILRYRGYPIEQLAEKSTFIEVSYLLIYGE
Mvan_5022|M.vanbaalenii_PYR-1 GGFVNTASTKSAITYIDGDAGILRYRGYPIEQLAEKSNFIEVSYLLIYGE
MSMEG_5672|M.smegmatis_MC2_155 GGFVNTASTKSAITYIDGDAGILRYRGYPIEQLAEKSTFIEVSYLLIYGE
MAB_0944|M.abscessus_ATCC_1997 AGFVNTASTKSAITYIDGDAGILRYRGYPIEQLADKSTFIEVSYLLIYGE
TH_3084|M.thermoresistible__bu SGFVNTASTKSSITYIDGEAGILRYRGYPIEQLAEKSTFIEVCFLLIYGE
MAV_0344|M.avium_104 KGLAGVVVDTTAISKVVPETNSLTYRGYAVQDLAAHCSFEQVAYLLWYGE
* ... .::*: : ::. * ****.:::** :..* :*.:** ***
Rv0896|M.tuberculosis_H37Rv LPDTDQLAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSA
Mb0920|M.bovis_AF2122/97 LPDTDQLAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSA
MMAR_4640|M.marinum_M LPNTDQLAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSA
MUL_0255|M.ulcerans_Agy99 LPNTDQLAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSA
MLBr_02130|M.leprae_Br4923 LPATDQLAEFTHRIQRHTMLHEDLKRFYDGFPRNAHPMPVLSSVVNALSA
Mflv_1729|M.gilvum_PYR-GCK LPTAEQLEDFTTKIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAVNALSA
Mvan_5022|M.vanbaalenii_PYR-1 LPTADQLEDFTTKIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAVNALSA
MSMEG_5672|M.smegmatis_MC2_155 LPTAEQLETFTNQIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAVNALSA
MAB_0944|M.abscessus_ATCC_1997 LPTPQQLEDFTTKIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAANALSA
TH_3084|M.thermoresistible__bu LPNTDQLAEFTTRIQRHTLLHEDLKRFFDGFPREAHPMPVLSSAVNALSA
MAV_0344|M.avium_104 LPDDQQLALFSQRERAARRLNRSQLSLLHKLPDTCHPMDVVRTFISSMGA
** :** *: : : *:.. : . :* .*** *: : .::.*
Rv0896|M.tuberculosis_H37Rv YYQDALDPMDNGQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNSLTL
Mb0920|M.bovis_AF2122/97 YYQDALDPMDNGQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNSLTL
MMAR_4640|M.marinum_M YYQDALDPMDSEQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPENSLTL
MUL_0255|M.ulcerans_Agy99 YYQDALDPMDSEQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPENSLTL
MLBr_02130|M.leprae_Br4923 YYQDALDPMDNGQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNAFSL
Mflv_1729|M.gilvum_PYR-GCK YYQDSLDPFDPHQVELSTIRLLAKLPTIAAYAYKKSEGQPFLYPDNSLTL
Mvan_5022|M.vanbaalenii_PYR-1 YYQDSLDPFDPKQVELSTIRLLAKLPTIAAYAYKKSEGQPFLYPDNSLTL
MSMEG_5672|M.smegmatis_MC2_155 YYQDSLDPLDNKQVELSTIRLLAKLPTIAAYAYKKSEGQPFLYPDNSLSL
MAB_0944|M.abscessus_ATCC_1997 YYQDSLDPHDDAQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNTLTL
TH_3084|M.thermoresistible__bu YYPDSLDPNDTRQVELSTIRLLAKLPTIAAYAYKKSEGQPFLYPDNSLTL
MAV_0344|M.avium_104 EDPDEDD-NSASANHAKALRMFAVLPTIVAADMRRRRGLEPIAPHSHMSY
* * . . .::*::* ****.* :: * : *.. ::
Rv0896|M.tuberculosis_H37Rv VENFLRLTFGFPAEPYQADPEVVRALDMLFILHADHEQNCSTSTVRLVGS
Mb0920|M.bovis_AF2122/97 VENFLRLTFGFPAEPYQADPEVVRALDMLFILHADHEQNCSTSTVRLVGS
MMAR_4640|M.marinum_M VENFLRMTFGFPAEPYHPDPEVVRALDMLFILHADHEQNCSTSTVRLVGS
MUL_0255|M.ulcerans_Agy99 VENFLRMTFGFPAEPYHPDPEVVRALDMLFILHADHEQNCSTSTVRLVGS
MLBr_02130|M.leprae_Br4923 VENFLRMTFGLPAEPYEPDPEVVRALDMLFILHADHEQNCSTSTVRLVGS
Mflv_1729|M.gilvum_PYR-GCK VENFLRMTFGFPAEPYEVDPEIVRALDMLFILHADHEQNCSTSTVRLVGS
Mvan_5022|M.vanbaalenii_PYR-1 VENFLRMTFGFPAEPYEVDPEIVRALDMLFILHADHEQNCSTSTVRLVGS
MSMEG_5672|M.smegmatis_MC2_155 VENFLRMTFGFPAEPYEVDPEIVRALDMLLILHADHEQNCSTSTVRLVGS
MAB_0944|M.abscessus_ATCC_1997 VENFLRMTFGLPAEPYEVDPEIVRALDMLLILHADHEQNCSTSTVRLVGS
TH_3084|M.thermoresistible__bu VENFLRMTFGFPAEPYQVDPEVVRALDMLLILHADHEQNCSTSTVRLVGS
MAV_0344|M.avium_104 AQNFLHMCFG-----DVPEQVIVDAFEQSMILYAEHSFNASTFAARVVTS
.:***:: ** : :* *:: :**:*:*. *.** :.*:* *
Rv0896|M.tuberculosis_H37Rv SRANLFTSISGGINALWGPLHGGANQAVLEMLEGIRDSGDDVSEFVRKVK
Mb0920|M.bovis_AF2122/97 SRANLFTSISGGINALWGPLHGGANQAVLEMLEGIRDSGDDVSEFVRKVK
MMAR_4640|M.marinum_M SRANLFTSISGGINALWGPLHGGANQAVLEMLEQIRDSGDDVSEFVRKVK
MUL_0255|M.ulcerans_Agy99 SRANLFTSISGGINALWGPLHGGANQAVLEMLEQIRDSGDDVSEFVRKVK
MLBr_02130|M.leprae_Br4923 SRANLFTSISGGINALWGPLHGGANQAVLEMLEGIRESGDDVGGFVQKVK
Mflv_1729|M.gilvum_PYR-GCK SQANLFTSISGGINALWGPLHGGANQAVLEMLSKIRDGDDDVATFVKKVK
Mvan_5022|M.vanbaalenii_PYR-1 SQANLFTSISGGINALWGPLHGGANQAVLEMLSKIRAEGGDVKEFVRKVK
MSMEG_5672|M.smegmatis_MC2_155 SQANLFTSISGGINALWGPLHGGANQAVLEMLEKIRSQGGDVSDFVRKVK
MAB_0944|M.abscessus_ATCC_1997 SDANLFTSVSGGINALWGPLHGGANQAVLEMLERIRSEGGDTHDFVRRVK
TH_3084|M.thermoresistible__bu SQANLFTSISGGINALWGPLHGGANQAVLEMLEKIRVEGGDVRDFVRRVK
MAV_0344|M.avium_104 TQSDIYSAVTAAIGALKGSLHGGANEAVMHDMLEIGTPDRAAEWLQGKLS
: ::::::::..*.** *.******:**:. : * . . : ::.
Rv0896|M.tuberculosis_H37Rv NREAGVKLMGFGHRVYKNYDPRARIVKEQADKILAKLGGDDSLLGIAKEL
Mb0920|M.bovis_AF2122/97 NREAGVKLMGFGHRVYKNYDPRARIVKEQADKILAKLGGDDSLLGIAKEL
MMAR_4640|M.marinum_M NREAGVKLMGFGHRVYKNYDPRARIVKEQADKILSKLGGDDSLLGIAKEL
MUL_0255|M.ulcerans_Agy99 NREAGVKLMGFGHRVYKNYDPRARIVKEQADKILSKLGGDDSLLGIAKEV
MLBr_02130|M.leprae_Br4923 NCQAGVKLMGFGHRVYKNYDPRARIVKEQADKILVKLGGDDDLLNIAKGL
Mflv_1729|M.gilvum_PYR-GCK NREDNVKLMGFGHRVYKNYDPRARIVKEQADKILGKIGVHDPLLDIAKEL
Mvan_5022|M.vanbaalenii_PYR-1 NREDGVKLMGFGHRVYKNYDPRARIVKEQADKILGKIGVQDDLLDIAKSL
MSMEG_5672|M.smegmatis_MC2_155 NREDGVKLMGFGHRVYKNYDPRARIVKEQADKILGKLGGDDELLDIAKQL
MAB_0944|M.abscessus_ATCC_1997 NREDGVKLMGFGHRVYKNYDPRARICKEQADKILGKLGGDDQLLEIAKAL
TH_3084|M.thermoresistible__bu NREDNVRLMGFGHRVYKNYDPRARIVKEQADKILGKLGGDDELLNIAKEL
MAV_0344|M.avium_104 RKE---KVMGFGHRVYKNGDSRVPTMKQALQRVAAVRDGQ-KWLDIYQIL
. : ::********** *.*. *: ::: . . * * : :
Rv0896|M.tuberculosis_H37Rv EEAALTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWI
Mb0920|M.bovis_AF2122/97 EEAALTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWI
MMAR_4640|M.marinum_M EEAALTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWI
MUL_0255|M.ulcerans_Agy99 EEAALTDDYFIERKLYPNVDFYTGLIYRALAFPTRMFTVLFALGRLPGWI
MLBr_02130|M.leprae_Br4923 EEAALTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWI
Mflv_1729|M.gilvum_PYR-GCK EEIALTDDFFVERKLYPNVDYYTGVIYRAMGFPTRMFTVLFALGRLPGWI
Mvan_5022|M.vanbaalenii_PYR-1 EEIALTDDFFVERKLYPNVDYYTGVIYRAMGFPTRMFTVLFALGRLPGWI
MSMEG_5672|M.smegmatis_MC2_155 EEIALTDDFFIERKLYPNVDYYTGVIYRAMGFPTRMFTVLFALGRLPGWI
MAB_0944|M.abscessus_ATCC_1997 EEAALTDDYFVERKLYPNVDFYTGLIYRAIGFPTRMFTVLFALGRLPGWI
TH_3084|M.thermoresistible__bu EETALTDEFFIERKLYPNVDFYTGLIYRAMGFPTRMFTVLFALGRLPGWI
MAV_0344|M.avium_104 ERGMARAN-----GIKPNLDFPTGPAYYLMGFDIGAFTPIFVMSRITGWT
*. : : **:*: ** * :.* ** :*.:.*:.**
Rv0896|M.tuberculosis_H37Rv AHWREMHDEGDSKIGRPRQIYTGYTERDYVTIDAR
Mb0920|M.bovis_AF2122/97 AHWREMHDEGDSKIGRPRQIYTGYAERDYVTIDAR
MMAR_4640|M.marinum_M AHWREMHDEGDSKIGRPRQIYTGYTERDYVAMDGR
MUL_0255|M.ulcerans_Agy99 AHWREMHDEGDSKIGRPRQIYTGYTERDYVAMDGR
MLBr_02130|M.leprae_Br4923 AHWREMHDEGDSKIGRPRQIYTGYTERDYTAIETR
Mflv_1729|M.gilvum_PYR-GCK AHWREMHGE-PNKIGRPRQIYTGYTERDYAGIDTR
Mvan_5022|M.vanbaalenii_PYR-1 AHWREMHGE-PNKIGRPRQIYTGYTERDYAGFDSR
MSMEG_5672|M.smegmatis_MC2_155 AHWREMHSE-PNKIGRPRQIYTGYTERGYTDIAGR
MAB_0944|M.abscessus_ATCC_1997 AHWREMHSE-PGKIGRPRQIYTGYGERQYP-----
TH_3084|M.thermoresistible__bu AHWREMHNEGNNKIGRPRQIYTGYGERDYTPLSER
MAV_0344|M.avium_104 AHIIEQTAS--NALIRPLSEYVGPPQRALS-----
** * . . : ** . *.* :*