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TVVPENFVPGLDGVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQRVTFGDVWALLVDGNFGSGLPPAEPF PLPIHSGDVRVDVQAGLAMLAPIWGYAPLLDIDDATARQQLARASVMALSYVAQSARGIYQPAVPQRIID ECSTVTARFMTRWQGEPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGAMSGPLH GGAPARVLPMLDEVERAGDARSVVKGILDRGEKLMGFGHRVYRAEDPRARVLRAAAERLGAPRYEVAVAV EQAALSELRERRPDRAIETNVEFWAAVVLDFARVPANMMPAMFTCGRTAGWCAHILEQKRLGKLVRPSAI YVGPGPRSPESVDGWERVLTTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0889c | citA | - | 100% (373) | citrate synthase 2 |
| M. tuberculosis H37Rv | Rv0896 | gltA | 6e-35 | 30.30% (396) | type II citrate synthase |
| M. tuberculosis H37Rv | Rv1131 | gltA1 | 1e-32 | 31.55% (374) | citrate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0913c | citA | 0.0 | 100.00% (373) | citrate synthase 2 |
| M. gilvum PYR-GCK | Mflv_1726 | - | 0.0 | 87.43% (366) | citrate synthase 2 |
| M. leprae Br4923 | MLBr_02130 | gltA | 1e-35 | 29.82% (399) | type II citrate synthase |
| M. abscessus ATCC 19977 | MAB_0932c | - | 0.0 | 82.64% (363) | citrate synthase 2 |
| M. marinum M | MMAR_4643 | citA | 0.0 | 93.30% (373) | citrate synthase II CitA |
| M. avium 104 | MAV_1016 | - | 0.0 | 92.76% (373) | citrate synthase 2 |
| M. smegmatis MC2 155 | MSMEG_5676 | - | 0.0 | 87.53% (369) | citrate synthase 2 |
| M. thermoresistible (build 8) | TH_3238 | - | 0.0 | 88.83% (367) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_0259 | citA | 1e-150 | 90.85% (284) | citrate synthase 2 |
| M. vanbaalenii PYR-1 | Mvan_5025 | - | 0.0 | 89.65% (367) | citrate synthase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0889c|M.tuberculosis_H37Rv -------------------------------------MTVVPENFVPGLD
Mb0913c|M.bovis_AF2122/97 -------------------------------------MTVVPENFVPGLD
MAV_1016|M.avium_104 -------------------------------------MTVVPENFVPGLE
MMAR_4643|M.marinum_M -------------------------------------MTVVPEDFVPGLN
MUL_0259|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1726|M.gilvum_PYR-GCK ------------------------------------MTTSVPKDFVAGLA
Mvan_5025|M.vanbaalenii_PYR-1 -------------------------------------MTAVSKDFVPGLA
MSMEG_5676|M.smegmatis_MC2_155 -------------------------------------MAAVPDDFIAGLE
TH_3238|M.thermoresistible__bu ---------------------------------------LVPEDFVPGLE
MAB_0932c|M.abscessus_ATCC_199 ----------------------------------MTVAAPLPADFAPGLE
MLBr_02130|M.leprae_Br4923 MADTDDTVTLKYPGGEIDLQIVRATEGNDGIAIVPVLAKTGYTTFDVGYG
Rv0889c|M.tuberculosis_H37Rv GVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQRVTFGDVWALLVDGNFGS
Mb0913c|M.bovis_AF2122/97 GVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQRVTFGDVWALLVDGNFGS
MAV_1016|M.avium_104 GVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQQVTFGDVWALLVDGKFGH
MMAR_4643|M.marinum_M GVVAFTTEIAEPDKDGGALRYRGVDIEDLVSLRVTFGDVWALLVDGEFGR
MUL_0259|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1726|M.gilvum_PYR-GCK GVVAFETEIAEPDKDGGALRYRGVDIEDLVAHRITFGDVWGLLVDGRFGD
Mvan_5025|M.vanbaalenii_PYR-1 GVVAFETEIAEPDKDGGALRYRGVDIQDLVSHRVTFGDVWGLLVDGRFGR
MSMEG_5676|M.smegmatis_MC2_155 GVVAFTTEIAEPDKDGGALRYRGVDIEELVDKKVTFADVWGLLVDGRFGN
TH_3238|M.thermoresistible__bu GVVAFTTEIAEPDKDGGALRYRGVDIEDLVARRVTFADVWALLVDGRFGE
MAB_0932c|M.abscessus_ATCC_199 GVTAFATEIAEPDKDGGSLRYRGVDIEDLVAQRVTFGDVWALLVDGKFGQ
MLBr_02130|M.leprae_Br4923 NTASTKSSITYIDGDAGILRYRGYPIEQLAEK-STFIEVCYLLIYGELPA
Rv0889c|M.tuberculosis_H37Rv GLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPLL------------
Mb0913c|M.bovis_AF2122/97 GLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPLL------------
MAV_1016|M.avium_104 GLPPAEPFPLPIHTGDVRVDVQAGLAMLAPIWGYKPLL------------
MMAR_4643|M.marinum_M GLPPAEPFPLPIHTGDVRVDVQAGLAMLAPIWGYAPLL------------
MUL_0259|M.ulcerans_Agy99 --------------------------MLAPIWGYAPLL------------
Mflv_1726|M.gilvum_PYR-GCK GLTPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYRPLL------------
Mvan_5025|M.vanbaalenii_PYR-1 GLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYPPIL------------
MSMEG_5676|M.smegmatis_MC2_155 GLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPML------------
TH_3238|M.thermoresistible__bu SLAPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYQPML------------
MAB_0932c|M.abscessus_ATCC_199 GLPPAEPFPIPVHTGDVRVDVQAGLAMLAPIWGFEPLL------------
MLBr_02130|M.leprae_Br4923 TDQLAEFTHRIQRHTMLHEDLKRFYDGFPRNAHPMPVLSSVVNALSAYYQ
:. *:*
Rv0889c|M.tuberculosis_H37Rv DIDDATARQQLARASVMALSYVAQSARGIYQPAVPQ--RIIDECSTVTAR
Mb0913c|M.bovis_AF2122/97 DIDDATARQQLARASVMALSYVAQSARGIYQPAVPQ--RIIDECSTVTAR
MAV_1016|M.avium_104 DTDDATARDQLARASVMALSYVAQSARGIYQPAVPQ--RVIDECETVTAR
MMAR_4643|M.marinum_M DIDDATAREQLARASVMALSYVAQSARGIYQPAVPQ--RVIDECSTVTAR
MUL_0259|M.ulcerans_Agy99 DIDDATAREQLARASVMALSYVAQSARGIYQPAVPQ--RVNDECSTVTAR
Mflv_1726|M.gilvum_PYR-GCK DIDDQTARDQLARASVMALSYVAQSARGIYRPAVPQ--RQVDECDTVTAR
Mvan_5025|M.vanbaalenii_PYR-1 DIEDETARDQLARASVMALSYVAQSARGIYQPAVPQ--RTVDECDTVTAR
MSMEG_5676|M.smegmatis_MC2_155 DIDDETAREHLARASVMALSYVAQSARGIYQPAVPQ--RTIDECPTVTAR
TH_3238|M.thermoresistible__bu DIDDETAREQLARASVMALSYVAQSARGIYQPAVPQ--RLIDECSTVTER
MAB_0932c|M.abscessus_ATCC_199 DTEDSVARSQLARASVMALSYVAQSARGNSLPAVPQ--HIVDECSTVTSR
MLBr_02130|M.leprae_Br4923 DALDPMDNGQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNAFSLVEN
* * . :: ::: *: :. * :* * *:. ::. .
Rv0889c|M.tuberculosis_H37Rv FMTRWQG------EPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGA
Mb0913c|M.bovis_AF2122/97 FMTRWQG------EPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGA
MAV_1016|M.avium_104 FMTRWQG------EPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGA
MMAR_4643|M.marinum_M FMTRWQG------EPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGA
MUL_0259|M.ulcerans_Agy99 FMTRWQG------EPDPRHIEAIGAYWVSAAEHGMNASTFTARVIASTGA
Mflv_1726|M.gilvum_PYR-GCK FMTRWKG------EPDPRHVEAIDAYWVSAAEHGMNASTFTARVIASTGA
Mvan_5025|M.vanbaalenii_PYR-1 FMTRWQG------EPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGA
MSMEG_5676|M.smegmatis_MC2_155 FMTRWQG------EPDPRHVEAIDAYWVTAAEHGMNASTFTARVIASTGA
TH_3238|M.thermoresistible__bu FMTRWKG------EPDPXHVEAIDAYWVSAAEHGMNASTFTARVIASTGA
MAB_0932c|M.abscessus_ATCC_199 FMTRWQG------DPDPKHVEAIDAYWVSAAEHGMNASTFTARVIASTGA
MLBr_02130|M.leprae_Br4923 FLRMTFGLPAEPYEPDPEVVRALDMLFILHADHEQNCSTSTVRLVGSSRA
*: * :*** :.*:. :: *:* *.** *.*::.*: *
Rv0889c|M.tuberculosis_H37Rv DVAAALSGAIGAMSGPLHGGAPARVLPMLDEVERAG-DARSVVKGILDRG
Mb0913c|M.bovis_AF2122/97 DVAAALSGAIGAMSGPLHGGAPARVLPMLDEVERAG-DARSVVKGILDRG
MAV_1016|M.avium_104 DVAAALSGAIGAMSGPLHGGAPARVLPMIEEVERTG-DARGLVKKILDSG
MMAR_4643|M.marinum_M DVAAALSGAIGAMSGPLHGGAPARVLPMIEQVERTG-DARGLVKGILDRG
MUL_0259|M.ulcerans_Agy99 DVAAALSGAIGAMSGPLHGGAPARVLPMIEQVELTG-DARGLVKGILDRG
Mflv_1726|M.gilvum_PYR-GCK DVAAALSGAVGAMSGPLHGGAPARVIPMIEEAEQTG-DARAVVKGILDRN
Mvan_5025|M.vanbaalenii_PYR-1 DVAAALSGAIGAMSGPLHGGAPARVIPMIEEAERTG-DARSVVKGILDRN
MSMEG_5676|M.smegmatis_MC2_155 DAAAALSGAVGAMSGPLHGGAPARVLPMIEEVENTG-DARAVVKGILDRG
TH_3238|M.thermoresistible__bu DVAAALSGAIGAMSGPLHGGAPARVLPMIEEVEKTG-DARKVVTGILDRG
MAB_0932c|M.abscessus_ATCC_199 DVAASLSGAVGAMSGPLHGGAPARVLPMIEQAEKTG-DARGVIRGILDRR
MLBr_02130|M.leprae_Br4923 NLFTSISGGINALWGPLHGGANQAVLEMLEGIRESGDDVGGFVQKVKNCQ
: :::**.:.*: ******* *: *:: . :* *. .: : :
Rv0889c|M.tuberculosis_H37Rv E--KLMGFGHRVYRAEDPRARVLRAAAERLGAPR------YEVAVAVEQA
Mb0913c|M.bovis_AF2122/97 E--KLMGFGHRVYRAEDPRARVLRAAAERLGAPR------YEVAVAVEQA
MAV_1016|M.avium_104 D--KLMGFGHRVYRAEDPRARVLRATAERLGAPR------HEVAVALEQA
MMAR_4643|M.marinum_M E--KLMGFGHRVYRAEDPRARVLRATAERLAAPR------YEVAAALEQA
MUL_0259|M.ulcerans_Agy99 E--KLMGFGHRVYRAEDPRARVLRATAKRLAAPR------YEVAAALEQA
Mflv_1726|M.gilvum_PYR-GCK E--KLMGFGHRVYRAEDPRARVLRATAERLAAPR------FEVAAALEQA
Mvan_5025|M.vanbaalenii_PYR-1 E--KLMGFGHRVYRAEDPRARVLRATAERLQAPR------YEVAAALEQA
MSMEG_5676|M.smegmatis_MC2_155 D--KLMGFGHRVYRAEDPRARVLRATAQRLGAPR------FEVASALEQA
TH_3238|M.thermoresistible__bu E--KLMGFGHRVYRAEDPRARVLRETAKRLGAPR------YDVAAALEQA
MAB_0932c|M.abscessus_ATCC_199 E--KLMGFGHRVYRAEDPRARVLRSTAKRLGAAR------YEVAAALEQA
MLBr_02130|M.leprae_Br4923 AGVKLMGFGHRVYKNYDPRARIVKEQADKILVKLGGDDDLLNIAKGLEEA
**********: *****::: *.:: . ::* .:*:*
Rv0889c|M.tuberculosis_H37Rv ALSELRERRPDRAIETNVEFWAAVVLDFARVPANMMPAMFTCGRTAGWCA
Mb0913c|M.bovis_AF2122/97 ALSELRERRPDRAIETNVEFWAAVVLDFARVPANMMPAMFTCGRTAGWCA
MAV_1016|M.avium_104 ALAELRERRPDRAIETNVEFWAAVILDFARVPANMMPAMFTCGRTAGWCA
MMAR_4643|M.marinum_M ALAELRERRPDRAIETNVEFWAAVILDFAGVPANMMPAMFTCGRTAGWCA
MUL_0259|M.ulcerans_Agy99 ALAELRERRPDRAIETNVDFWAAVILDFAGVPANRMPAMFTCGRTVGWCA
Mflv_1726|M.gilvum_PYR-GCK ALAELRERRPDRAIETNVEFWAAVILDFAEVPPTMMPAMFTCGRTAGWCA
Mvan_5025|M.vanbaalenii_PYR-1 ALTELRERRPDRAIETNVEFWAAVILDFAQVPPKMMPAMFTCGRTAGWCA
MSMEG_5676|M.smegmatis_MC2_155 ALAELRERRPDRAIETNVEFWAAVILDFAQVPASMMPAMFTCGRTAGWCA
TH_3238|M.thermoresistible__bu ALTELRERRPDRAIETNVEFWAAVILDFAEVPPRMMPAMFTCGRTAGWCA
MAB_0932c|M.abscessus_ATCC_199 ALAELRERRPDRVIETNVEFWAAVILDFAQVPTRMMPAMFTCARTAGWSA
MLBr_02130|M.leprae_Br4923 ALTD--DYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIA
**:: : :* : .**:*::.:: .*. :..:*: .* ** *
Rv0889c|M.tuberculosis_H37Rv HILEQKRLG--KLVRPSAIYVGPGPRSPESVDGWERVLTTA----
Mb0913c|M.bovis_AF2122/97 HILEQKRLG--KLVRPSAIYVGPGPRSPESVDGWERVLTTA----
MAV_1016|M.avium_104 HILEQKRLG--KLVRPSAIYVGPGPRSPESVEGWDRSLTNA----
MMAR_4643|M.marinum_M HILEQKRLG--KLVRPSAIYVGPAPRTPESVAGWDRVLTTA----
MUL_0259|M.ulcerans_Agy99 HILEQKRLG--KLVRPSAIYVGPAPRTPESVAGWDRVLTTA----
Mflv_1726|M.gilvum_PYR-GCK HILEQKRLG--KLVRPSAVYVGPAPRGPESVEGWD-SLTRR----
Mvan_5025|M.vanbaalenii_PYR-1 HILEQKRLG--KLVRPSAIYVGPEPRSPEAVEGWD-LLSH-----
MSMEG_5676|M.smegmatis_MC2_155 HILEQKRLG--KLVRPSAIYVGPEPRSAEAVEGWEKIAAAGSGAA
TH_3238|M.thermoresistible__bu HILEQKRLG--KLVRPSAVYVGPGPRSVESVEGWETIARP-----
MAB_0932c|M.abscessus_ATCC_199 HIMEQKRLG--KLVRPAALYVGPGPRPIESVEGFGLLHSRVGA--
MLBr_02130|M.leprae_Br4923 HWREMHDEGDSKIGRPRQIYTGYTERDYTAIETR-----------
* * : * *: ** :*.* * ::