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PELATSGNAFDKRRFSRRGFLGAGIASGFALAACASKPTASGAAGMTAAIDAAEAARPHSGRTVTATLTP QPARIDLGGPIVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRNDMDGTEPATANIG PGGDFTYRFSVPDPGTYWAHPHVGLQGDHGLYLPVVVDDPTEPGHYDAEWIIILDDWTDGIGKSPQQLYG ELTDPNKPTMQNTTGMPEGEGVDSNLLGGDGGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRIINSAAD TAFRIALAGHSMTVTHTDGYPVIPTEVDALLIGMAERYDVMVTAAGGVFPLVALAEGKNALARALLSTGA GSPPDPQFRPDELNWRVGTVEMFTAATTANLGRPEPTHDLPVTLGGTMAKYDWTINGEPYSTTNPLHVRL GQRPTLMFDNTTMMYHPIHLHGHTFQMIKADGSPGARKDTVIVLPKQKMRAVLVADNPGVWVMHCHNNYH QVAGMATRLDYIL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0846c | - | - | 100% (504) | PROBABLE OXIDASE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0869c | - | 0.0 | 99.80% (504) | oxidase |
| M. gilvum PYR-GCK | Mflv_3489 | - | 1e-05 | 25.62% (160) | multicopper oxidase, type 3 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0463c | - | 1e-118 | 45.31% (512) | oxidase (copper-binding protein) |
| M. marinum M | MMAR_4770 | - | 0.0 | 70.78% (551) | oxidase |
| M. avium 104 | MAV_3048 | - | 9e-42 | 28.79% (514) | multicopper oxidase family protein |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0341 | - | 0.0 | 70.60% (551) | oxidase |
| M. vanbaalenii PYR-1 | Mvan_3672 | - | 0.0 | 64.46% (498) | multicopper oxidase, type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0846c|M.tuberculosis_H37Rv --------------------MPELATSGNAFDKRRFSRRGFLGAGIASG-
Mb0869c|M.bovis_AF2122/97 --------------------MPELATSGNAFDKRRFSRRGFLGAGIASG-
MMAR_4770|M.marinum_M --------------------MPVLPTGGHPFGSAQLSRRGFIGAGIAGG-
MUL_0341|M.ulcerans_Agy99 --------------------MPVLPTGGHPFGSAQLSRRGFIGAGIAGG-
Mvan_3672|M.vanbaalenii_PYR-1 -------------------------MNRQSVGTKILTRRTFLAATLAAST
MAB_0463c|M.abscessus_ATCC_199 ----------------------------MAVSRSQWGRRGFLQLGAATAA
MAV_3048|M.avium_104 --------------------------MMVAVTRRDFCKWGGIAALAACAG
Mflv_3489|M.gilvum_PYR-GCK MKRSSWHLRAGSVVLGWLVALVMAAIAHPYIALSNWLLIHLLGLGAASNA
. : *
Rv0846c|M.tuberculosis_H37Rv -FALAAC-ASKPTASGAA--------------------------------
Mb0869c|M.bovis_AF2122/97 -FALAAC-ASKPTASGAA--------------------------------
MMAR_4770|M.marinum_M -LALAGCGHSQTTQTGET--------------------------------
MUL_0341|M.ulcerans_Agy99 -LALAGCGHSQTTQTGET--------------------------------
Mvan_3672|M.vanbaalenii_PYR-1 -AAMAACGKPTSVNP-----------------------------------
MAB_0463c|M.abscessus_ATCC_199 AGVLAACGTRPVRGPSGQP------------------------------V
MAV_3048|M.avium_104 --------------------------------------------------
Mflv_3489|M.gilvum_PYR-GCK ILIWSRHFADALLRRSPDPPYPGQVIRLLAFNIGAVTVITGMLGGWWPVV
Rv0846c|M.tuberculosis_H37Rv -GMTAAIDAAEAARPHSG-RTVTATLTPQP-ARIDLGGPIVSTLTYGNTI
Mb0869c|M.bovis_AF2122/97 -GMTAAIDAAEAARPHSG-RTVTATLTPQP-ARIDLGGPIVSTLTYGNTI
MMAR_4770|M.marinum_M -AMADAIAAAERARPHTG-RTVTASLTPQQ-AQIDLGGPVVQTLAFGNTV
MUL_0341|M.ulcerans_Agy99 -AMADAIAAAERARPHTG-RTVTASLTPQQ-AQIDLGGPVVQTLAFGNTV
Mvan_3672|M.vanbaalenii_PYR-1 --ATDPIAVAEAARPHTG-RTVTAALTPGP-ADIDLGGPVARTLAYNNSV
MAB_0463c|M.abscessus_ATCC_199 GPSSPRVGALEAVRRDGGGRLVPVNLAARP-LQLDLAGTTVSTWGYGDQI
MAV_3048|M.avium_104 --------------PPHGKADYTLRIATGT-VELAPG-RVVSTLTYNGQF
Mflv_3489|M.gilvum_PYR-GCK LAGGVLVAAVAAVHAGDLMRFLRAALPARFSITVHYYVAAAACLAVGAGL
:.. : . . .
Rv0846c|M.tuberculosis_H37Rv PGPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRNDMDGT-EPATANIG
Mb0869c|M.bovis_AF2122/97 PGPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRNDMDGT-EPATANIG
MMAR_4770|M.marinum_M PGPLIRASVGDEVVVAVSNRLDRATSVHWHGIALRNDMDGA-EPATPNIG
MUL_0341|M.ulcerans_Agy99 PGPLIRASVGDEVVVAVSNRLDRTTSVHWHGIALRNDMDGA-EPATPNIG
Mvan_3672|M.vanbaalenii_PYR-1 PGPLIRANVGDELAISVTNGLDHPSSLHWHGIALRNDMDGA-TPATPNID
MAB_0463c|M.abscessus_ATCC_199 PGPTIRARKGEVLRVAVANGLPAPTTVHWHGIALRNDMDGVPDLTQPQIA
MAV_3048|M.avium_104 PGPLLRFMQGRRTWVDVYNDTDAPEQLHWHGQHIGADVDGAAEEGTPYVP
Mflv_3489|M.gilvum_PYR-GCK GVAMANSALPGILAERFRTAHAVLNLFGWVGLTVLGTLVTLWPTMLRTRM
. . . . . * * : :
Rv0846c|M.tuberculosis_H37Rv PG----------GDFTYRFSVPDPGTYWAHPHVGLQGDH------GLYLP
Mb0869c|M.bovis_AF2122/97 PG----------GDFTYRFSVPDPGTYWAHPHVGLQGDH------GLYLP
MMAR_4770|M.marinum_M AD----------QDFTYRFSVPNAGTYWAHPHVGLEDDH------GLYLP
MUL_0341|M.ulcerans_Agy99 AD----------QDFTYRFSVPNAGTYWAHPHVGLEDDH------GLYLP
Mvan_3672|M.vanbaalenii_PYR-1 PS----------STFTYRFSAPHPGTYWAHPHTGLDADY------GLYAP
MAB_0463c|M.abscessus_ATCC_199 AA----------GSFTYEFALAHAGTYWFHPHVGTQLDR------GLYAP
MAV_3048|M.avium_104 AH----------GMRRISFVPGPAGFRFYHTHVVPRADLSRGQYSGLVGP
Mflv_3489|M.gilvum_PYR-GCK ADGVERAARRGLPALVLSVAVAVAGAILGSSRVVGVGALSFLTAVGFVLW
. . .* .:. *:
Rv0846c|M.tuberculosis_H37Rv VVVDDPTE--PGHYDAEWIIILDDWTDG---------------------I
Mb0869c|M.bovis_AF2122/97 VVVDDPTE--PGHYDAEWIIILDDWTDG---------------------I
MMAR_4770|M.marinum_M FIVDDPTE--PNRYDAEWIVVLDDWTDG---------------------V
MUL_0341|M.ulcerans_Agy99 FIVDDPTE--PNRYDAEWIVVLDDWTDG---------------------V
Mvan_3672|M.vanbaalenii_PYR-1 VIIDDAAE--PGRYDAEWIVVLDDWTDG---------------------I
MAB_0463c|M.abscessus_ATCC_199 LIVEDPDE--RADYDTELVVALDDWIDG---------------------T
MAV_3048|M.avium_104 VHIASKDDD-AGAFDQETFLTLKEFEPS---------------------L
Mflv_3489|M.gilvum_PYR-GCK PHIDEVRRKRPADFPTLSVLCGVVWLAGSLGYLSVGLLTAPNSMAAATVT
: . : .: : .
Rv0846c|M.tuberculosis_H37Rv GKSPQQLYGELTDPN--------KPTMQNT--------------------
Mb0869c|M.bovis_AF2122/97 GKSPQQLYGELTDPN--------KPTMQNT--------------------
MMAR_4770|M.marinum_M GKSPQQLFDALVDPN--------KPRMQELPGSSTAPSTSTST-------
MUL_0341|M.ulcerans_Agy99 GKSPQQLFDAFVDPN--------KPRMQELPGSSTAPSTSTST-------
Mvan_3672|M.vanbaalenii_PYR-1 GSSPQQLYDGLRPVTGAGGHSGGMPGMSGTPG------------------
MAB_0463c|M.abscessus_ATCC_199 GTDPDKVLAGLRDKG--------MPGMGHSMG------------------
MAV_3048|M.avium_104 SRGGDMAVDFLAGAQ--------EPDLRERGE------------------
Mflv_3489|M.gilvum_PYR-GCK AAAGPALLAGFLVQVLFGSLAYLIPMVVGGRASALAATAELERGAPWRLS
. : * :
Rv0846c|M.tuberculosis_H37Rv ---------------------------------------TGMPE---GEG
Mb0869c|M.bovis_AF2122/97 ---------------------------------------TGMPE---GEG
MMAR_4770|M.marinum_M --------TTTTTTPTTKTSTTTTTTGTSKTSPTTTTSATGKPDEESGEV
MUL_0341|M.ulcerans_Agy99 --------TTTTTTPTTKTSTTTTTTGTSKTSPTTTTSATGKPDEESGEV
Mvan_3672|M.vanbaalenii_PYR-1 --------------------------------------MPGVPG--VGGV
MAB_0463c|M.abscessus_ATCC_199 -------------------------------------DMPGMSIG-SMGV
MAV_3048|M.avium_104 ----------------------------------------------SSMA
Mflv_3489|M.gilvum_PYR-GCK VANFGLLICVLPVPNLVRVAVSALVLVAYGAFLPLLVRAVWLAQRNTGVR
Rv0846c|M.tuberculosis_H37Rv VDSNLLGGD-------GGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRI
Mb0869c|M.bovis_AF2122/97 VDSNLLGGD-------GGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRI
MMAR_4770|M.marinum_M GSSDLLGGD-------AGDIAYPYYLVNGRIPAAPTSFKAKPGQRIRIRI
MUL_0341|M.ulcerans_Agy99 GSSDLLGGD-------AGDIAYPYYLVNGRIPAAPTSFKAKPGQRIRIRI
Mvan_3672|M.vanbaalenii_PYR-1 GASQLLGGD-------AGDVSYPFYLANGRIPAAPTTLTARPGQRIRMRI
MAB_0463c|M.abscessus_ATCC_199 SAQAPLGAD-------GGDVTYPYYLINGRVAADPQSVDYRPGTRVRLRI
MAV_3048|M.avium_104 ASRGRGEQP-------GYEVGYRAFAINGRMLGHGDPIRVRTGQLVLLHV
Mflv_3489|M.gilvum_PYR-GCK STPGRLDPPPLRQRLGIAAAGFGVVILTAAAGVAADPATLGIGSAPTVTA
: .. . * :
Rv0846c|M.tuberculosis_H37Rv INSAADTAFRIALAGH-----SMTVTHTDGYPVIPTE----VDALLIGMA
Mb0869c|M.bovis_AF2122/97 INSAADTAFRIALAGH-----SMTVTHTDGYPVIPTE----VDALLIGMA
MMAR_4770|M.marinum_M INVASDTAFRVALAGH-----TMTVTHTDGYPVIPTQ----VDALLIGMA
MUL_0341|M.ulcerans_Agy99 INVASDTAFRVALAGH-----TMTVTHTDGYPVIPTQ----VDALLIGMA
Mvan_3672|M.vanbaalenii_PYR-1 INAASDTAFRVALAGH-----RMTVTHTDGFPVVPTE----VDALLIGMG
MAB_0463c|M.abscessus_ATCC_199 INAAGDSAFRVAIPGT-----PLTVTHTDGFPVQPRQ----TDALLIGMG
MAV_3048|M.avium_104 LNAGATETRSLALPGH-----AFTVVALDGNPVPNRAP---VPVLWLGAG
Mflv_3489|M.gilvum_PYR-GCK APTGHTTEVRVRVDGMRYVPDTITVPAGDRLRITFHNTGTDRHDLVLANG
. : : * :** * : * :. .
Rv0846c|M.tuberculosis_H37Rv ERYDVMVT---------------------AAGGVFPLVALAEGKNALARA
Mb0869c|M.bovis_AF2122/97 ERYDVMVT---------------------AAGGVFPLVALAEGKNALARA
MMAR_4770|M.marinum_M ERYDVIVT---------------------AADGVFPLVASAEGKNALARA
MUL_0341|M.ulcerans_Agy99 ERYDVIVT---------------------AADGVFPLVASAEGKNALARA
Mvan_3672|M.vanbaalenii_PYR-1 ERYDALIT---------------------TGDGVFPFVASAEGKNALARA
MAB_0463c|M.abscessus_ATCC_199 ERIDAIIT---------------------VGEVSVPLLAAPYGKDGYAQL
MAV_3048|M.avium_104 ERVSALVS---------------------MTNPGVWVLGDLSDDDREHGL
Mflv_3489|M.gilvum_PYR-GCK ARTDRVAPGVTAVLDAGVIGSDLAGWCSIAGHRQMGMTLTIKAIGTPPVS
* . : . . . .
Rv0846c|M.tuberculosis_H37Rv LL-STGAGSPPDPQFRPDELNWRVG--TVEMFTAATTANLGRPEPTHDLP
Mb0869c|M.bovis_AF2122/97 LL-STGAGSPPDPQFRPDELNWRVG--TVEMFTAATTANLGRPEPTHDLP
MMAR_4770|M.marinum_M LL-STGSGTAPDPQFRPAELNKRVG--TVEMFTATTAVNLGRPDPQMSLP
MUL_0341|M.ulcerans_Agy99 LL-STGSGTAPDPQFRPAELNKRVG--TVEMFTATTAVNLGRPDPQMSLP
Mvan_3672|M.vanbaalenii_PYR-1 LL-STGAGAAPDPTFMPPELQRRVG--TVGVFTAAPEAVLDVSRADVALS
MAB_0463c|M.abscessus_ATCC_199 VLRSSGTPVSGSAAEAAAALPKLAAL-DTASLSATEEVTLAVGEPDITYD
MAV_3048|M.avium_104 GVVVEYAGRAGEPQWVPPPP---FTW-DYRLFAGPHPAPVAPPDHTIDLL
Mflv_3489|M.gilvum_PYR-GCK GHEHELPGHGPDPSLTATDIARSLGGRPGPGFAARDPKLSAAETAEHRVT
. .. . ::.
Rv0846c|M.tuberculosis_H37Rv VTLGGTMAK--YDWTINGEPYSTTNP---LHVRLGQRPTLMFDNTTMMYH
Mb0869c|M.bovis_AF2122/97 VTLGGTMAK--YDWTINGEPHSTTNP---LHVRLGQRPTLMFDNTTMMYH
MMAR_4770|M.marinum_M ITLGGTMAK--YDWTINGEPYSKTHP---LTVRLGERPTLMFDNPTMMYH
MUL_0341|M.ulcerans_Agy99 ITLGGTMAK--YDWTINGEPYSKTHP---LTVRLGERPTLMFDNPTMMYH
Mvan_3672|M.vanbaalenii_PYR-1 ARLSGSMAS--YDWTINGRPFEDTVP---LTVMQGQKATLTFTNTTMMWH
MAB_0463c|M.abscessus_ATCC_199 LRLAGPGNK--YSWTINEKTYNPAEG---LPVREGQRVRLRFINNSMMFH
MAV_3048|M.avium_104 IEKRNAADNGFNVWTVNGTPFAMDSNQPVLDVERGRRYRLRLRNASDDLH
Mflv_3489|M.gilvum_PYR-GCK LTVSEVEREVSPGITQRLWTFGGSAPGPTLRGRVGDVFEITLINDGTIGH
. * . .. * * : : * *
Rv0846c|M.tuberculosis_H37Rv PIHLHGHTFQMIKADGSP--------------------------------
Mb0869c|M.bovis_AF2122/97 PIHLHGHTFQMIKADGSP--------------------------------
MMAR_4770|M.marinum_M PIHLHGHTFQMIKPDGTP--------------------------------
MUL_0341|M.ulcerans_Agy99 PIHLHGHTFQMIKPDGTP--------------------------------
Mvan_3672|M.vanbaalenii_PYR-1 PMHLHGHTFQVIKPDGTP--------------------------------
MAB_0463c|M.abscessus_ATCC_199 PMHLHGHTFAVRTASGAY--------------------------------
MAV_3048|M.avium_104 PMHLHRHTFEITRFAGTPTA------------------------------
Mflv_3489|M.gilvum_PYR-GCK SIDFHAGSLAPDRPMRTIEPGAQLVYRFTATRAGVWLYHCATMPMSVHIA
.:.:* :: :
Rv0846c|M.tuberculosis_H37Rv ---------------GARKDTVIVLPKQKMRAV--------LVADNPGVW
Mb0869c|M.bovis_AF2122/97 ---------------GARKDTVIVLPKQKMRAV--------LVADNPGVW
MMAR_4770|M.marinum_M ---------------GARKDTVIVLPGQQLRAV--------LVADNPGYW
MUL_0341|M.ulcerans_Agy99 ---------------GARKDTVIVLPGQQLRAV--------LVADNPGYW
Mvan_3672|M.vanbaalenii_PYR-1 ---------------GPRKDTVIVLPMQELTVA--------LAADNPGVW
MAB_0463c|M.abscessus_ATCC_199 ---------------GARKDTVLVAPMQTVEVD--------FDADNPGQW
MAV_3048|M.avium_104 ---------------GVRKDVAMLGGYQSMEID--------FVADQPGLS
Mflv_3489|M.gilvum_PYR-GCK NGMFGAVVIDPPDLSTVDREYLMVQSEFYLGADGGEVDADKVAADTPDLV
:: :: : . ** *.
Rv0846c|M.tuberculosis_H37Rv VMHCHNNYHQVAGMATRLDYIL----------------------------
Mb0869c|M.bovis_AF2122/97 VMHCHNNYHQVAGMATRLDYIL----------------------------
MMAR_4770|M.marinum_M VLHCHNSYHREAGMMTLLDYIF----------------------------
MUL_0341|M.ulcerans_Agy99 VLHCHNSYHREAGMMTLLDYIF----------------------------
Mvan_3672|M.vanbaalenii_PYR-1 MMHCHNTYHQEAGMMTSLNYSPQPGAAPSHGQRQ----------------
MAB_0463c|M.abscessus_ATCC_199 LTHCHNIYHGEAGMMTVVSYRQ----------------------------
MAV_3048|M.avium_104 LLHCHQQIHMDYGLMLLLNGV-----------------------------
Mflv_3489|M.gilvum_PYR-GCK VFNGYAQQYDHAPLTARVGERVRIWVLAAGPNRGSAFHVVGGQFDTVWAE
: : : : : :.
Rv0846c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0869c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4770|M.marinum_M --------------------------------------------------
MUL_0341|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3672|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0463c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3048|M.avium_104 --------------------------------------------------
Mflv_3489|M.gilvum_PYR-GCK GAYRLRPGAGGSQTLGLFPAQGGFVELSFPEPGNYPFVSHAMVDAERGAH
Rv0846c|M.tuberculosis_H37Rv -------
Mb0869c|M.bovis_AF2122/97 -------
MMAR_4770|M.marinum_M -------
MUL_0341|M.ulcerans_Agy99 -------
Mvan_3672|M.vanbaalenii_PYR-1 -------
MAB_0463c|M.abscessus_ATCC_199 -------
MAV_3048|M.avium_104 -------
Mflv_3489|M.gilvum_PYR-GCK GVIAVGN