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MPVLPTGGHPFGSAQLSRRGFIGAGIAGGLALAGCGHSQTTQTGETAMADAIAAAERARPHTGRTVTASL TPQQAQIDLGGPVVQTLAFGNTVPGPLIRASVGDEVVVAVSNRLDRTTSVHWHGIALRNDMDGAEPATPN IGADQDFTYRFSVPNAGTYWAHPHVGLEDDHGLYLPFIVDDPTEPNRYDAEWIVVLDDWTDGVGKSPQQL FDAFVDPNKPRMQELPGSSTAPSTSTSTTTTTTTPTTKTSTTTTTTGTSKTSPTTTTSATGKPDEESGEV GSSDLLGGDAGDIAYPYYLVNGRIPAAPTSFKAKPGQRIRIRIINVASDTAFRVALAGHTMTVTHTDGYP VIPTQVDALLIGMAERYDVIVTAADGVFPLVASAEGKNALARALLSTGSGTAPDPQFRPAELNKRVGTVE MFTATTAVNLGRPDPQMSLPITLGGTMAKYDWTINGEPYSKTHPLTVRLGERPTLMFDNPTMMYHPIHLH GHTFQMIKPDGTPGARKDTVIVLPGQQLRAVLVADNPGYWVLHCHNSYHREAGMMTLLDYIF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0341 | - | - | 100% (552) | oxidase |
| M. ulcerans Agy99 | MUL_0583 | - | 2e-10 | 64.58% (48) | hypothetical protein MUL_0583 |
| M. ulcerans Agy99 | MUL_0582 | - | 1e-07 | 52.17% (46) | hypothetical protein MUL_0582 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0869c | - | 0.0 | 70.42% (551) | oxidase |
| M. gilvum PYR-GCK | Mflv_0308 | - | 2e-08 | 70.00% (40) | hypothetical protein Mflv_0308 |
| M. tuberculosis H37Rv | Rv0846c | - | 0.0 | 70.60% (551) | oxidase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0463c | - | 1e-113 | 42.31% (546) | oxidase (copper-binding protein) |
| M. marinum M | MMAR_4770 | - | 0.0 | 99.64% (552) | oxidase |
| M. avium 104 | MAV_3048 | - | 1e-35 | 26.50% (517) | multicopper oxidase family protein |
| M. smegmatis MC2 155 | MSMEG_0692 | - | 3e-10 | 49.30% (71) | hypothetical protein MSMEG_0692 |
| M. thermoresistible (build 8) | TH_2748 | - | 3e-07 | 54.35% (46) | PUTATIVE - |
| M. vanbaalenii PYR-1 | Mvan_3672 | - | 0.0 | 60.52% (542) | multicopper oxidase, type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0341|M.ulcerans_Agy99 --------MPVLPTGGHPFGSAQLSRRGFIGAG---------------IA
MMAR_4770|M.marinum_M --------MPVLPTGGHPFGSAQLSRRGFIGAG---------------IA
Mb0869c|M.bovis_AF2122/97 --------MPELATSGNAFDKRRFSRRGFLGAG---------------IA
Rv0846c|M.tuberculosis_H37Rv --------MPELATSGNAFDKRRFSRRGFLGAG---------------IA
Mvan_3672|M.vanbaalenii_PYR-1 -------------MNRQSVGTKILTRRTFLAAT---------------LA
MAB_0463c|M.abscessus_ATCC_199 ----------------MAVSRSQWGRRGFLQLG---------------AA
Mflv_0308|M.gilvum_PYR-GCK MSDALGLSIGSTNLVAATVGNEPVLRRSVLTVYGHAAPQVGDGADAGGAT
MSMEG_0692|M.smegmatis_MC2_155 MTDSLGLSIGITNLVAAREGRAPVVRRSILNLYRDRAPEVGELGGDG-LA
TH_2748|M.thermoresistible__bu --------------------------------------------------
MAV_3048|M.avium_104 -------------------MMVAVTRRDFCKWG-----------------
MUL_0341|M.ulcerans_Agy99 GG--LALAGCGHSQTTQTGET---AMADAIAAAERARPHTG-RTVTASLT
MMAR_4770|M.marinum_M GG--LALAGCGHSQTTQTGET---AMADAIAAAERARPHTG-RTVTASLT
Mb0869c|M.bovis_AF2122/97 SG--FALAAC-ASKPTASGAA---GMTAAIDAAEAARPHSG-RTVTATLT
Rv0846c|M.tuberculosis_H37Rv SG--FALAAC-ASKPTASGAA---GMTAAIDAAEAARPHSG-RTVTATLT
Mvan_3672|M.vanbaalenii_PYR-1 AST-AAMAACGKPTSVNP-------ATDPIAVAEAARPHTG-RTVTAALT
MAB_0463c|M.abscessus_ATCC_199 TAAAGVLAACGTRPVRGPSGQPVGPSSPRVGALEAVRRDGGGRLVPVNLA
Mflv_0308|M.gilvum_PYR-GCK LTDFVERVGDPVPLVASDGATYPAEQLLVEALETMAGLATSQRLADVVIA
MSMEG_0692|M.smegmatis_MC2_155 LTGFVERTGDPVPIVAADGSQHRGELALAEALDAMAREVGGG--APVAIA
TH_2748|M.thermoresistible__bu --------------------------------------------------
MAV_3048|M.avium_104 ---------------------------GIAALAACAGPPHGKADYTLRIA
MUL_0341|M.ulcerans_Agy99 PQQAQIDLGGPVVQTLAFGNTVPGPLIRASVGDEVVVAVSNRLDRTTSVH
MMAR_4770|M.marinum_M PQQAQIDLGGPVVQTLAFGNTVPGPLIRASVGDEVVVAVSNRLDRATSVH
Mb0869c|M.bovis_AF2122/97 PQPARIDLGGPIVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVH
Rv0846c|M.tuberculosis_H37Rv PQPARIDLGGPIVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVH
Mvan_3672|M.vanbaalenii_PYR-1 PGPADIDLGGPVARTLAYNNSVPGPLIRANVGDELAISVTNGLDHPSSLH
MAB_0463c|M.abscessus_ATCC_199 ARPLQLDLAGTTVSTWGYGDQIPGPTIRARKGEVLRVAVANGLPAPTTVH
Mflv_0308|M.gilvum_PYR-GCK VPSYWTVEATRALAQTVTASDLLAPSGAPPRLISDTEAALTALNANPGLD
MSMEG_0692|M.smegmatis_MC2_155 TPAYWGPAALGALRGALRNKPAFAPDGIPAALVPDSMAALAALKADPGLP
TH_2748|M.thermoresistible__bu --------------------------------------------------
MAV_3048|M.avium_104 TGTVELAPG-RVVSTLTYNGQFPGPLLRFMQGRRTWVDVYNDTDAPEQLH
MUL_0341|M.ulcerans_Agy99 WHGIALRNDMDGAEPAT-PNIGADQDFTYRFSVPNAGTYWAHPHVG----
MMAR_4770|M.marinum_M WHGIALRNDMDGAEPAT-PNIGADQDFTYRFSVPNAGTYWAHPHVG----
Mb0869c|M.bovis_AF2122/97 WHGIALRNDMDGTEPAT-ANIGPGGDFTYRFSVPDPGTYWAHPHVG----
Rv0846c|M.tuberculosis_H37Rv WHGIALRNDMDGTEPAT-ANIGPGGDFTYRFSVPDPGTYWAHPHVG----
Mvan_3672|M.vanbaalenii_PYR-1 WHGIALRNDMDGATPAT-PNIDPSSTFTYRFSAPHPGTYWAHPHTG----
MAB_0463c|M.abscessus_ATCC_199 WHGIALRNDMDGVPDLTQPQIAAAGSFTYEFALAHAGTYWFHPHVG----
Mflv_0308|M.gilvum_PYR-GCK RRGVAVLLDFGGSGTSITAVDAAA-FTVIG-THRHPDFAGDQIDQA----
MSMEG_0692|M.smegmatis_MC2_155 ADGVVVLCDFGGSGTSVTLADAAADYATLGQTVRYPEFSGDQIDQA----
TH_2748|M.thermoresistible__bu --------------------------------------------------
MAV_3048|M.avium_104 WHGQHIGADVDGAAEEGTPYVPAHGMRRISFVPGPAGFRFYHTHVVPRAD
MUL_0341|M.ulcerans_Agy99 --LEDDHGLYLPFIVDD-PTEPNRYDAEWIVVLDDWTDGVGKSPQQLFDA
MMAR_4770|M.marinum_M --LEDDHGLYLPFIVDD-PTEPNRYDAEWIVVLDDWTDGVGKSPQQLFDA
Mb0869c|M.bovis_AF2122/97 --LQGDHGLYLPVVVDD-PTEPGHYDAEWIIILDDWTDGIGKSPQQLYGE
Rv0846c|M.tuberculosis_H37Rv --LQGDHGLYLPVVVDD-PTEPGHYDAEWIIILDDWTDGIGKSPQQLYGE
Mvan_3672|M.vanbaalenii_PYR-1 --LDADYGLYAPVIIDD-AAEPGRYDAEWIVVLDDWTDGIGSSPQQLYDG
MAB_0463c|M.abscessus_ATCC_199 --TQLDRGLYAPLIVED-PDERADYDTELVVALDDWIDGTGTDPDKVLAG
Mflv_0308|M.gilvum_PYR-GCK --LLGHVLA--AAGGDT-DPAQTAAVGSLARLRDDCRVAKERLSNQTATQ
MSMEG_0692|M.smegmatis_MC2_155 --LLNHVLTGIAAANDA-DPAGTAAVGSLAHLRSDCRNAKEALSADTVAT
TH_2748|M.thermoresistible__bu --------------------------------------------------
MAV_3048|M.avium_104 LSRGQYSGLVGPVHIASKDDDAGAFDQETFLTLKEFEPSLSRGGDMAVDF
MUL_0341|M.ulcerans_Agy99 FVDPN--------KPRMQELPGSSTAPSTSTSTTTTTTTPTTKTSTTTTT
MMAR_4770|M.marinum_M LVDPN--------KPRMQELPGSSTAPSTSTSTTTTTTTPTTKTSTTTTT
Mb0869c|M.bovis_AF2122/97 LTDPN--------KPTMQNT------------------------------
Rv0846c|M.tuberculosis_H37Rv LTDPN--------KPTMQNT------------------------------
Mvan_3672|M.vanbaalenii_PYR-1 LRPVTGAGGHSGGMPGMSGTPG----------------------------
MAB_0463c|M.abscessus_ATCC_199 LRDKG--------MPGMGHSMG----------------------------
Mflv_0308|M.gilvum_PYR-GCK LTVELPG---AGTEIRVTRAELD---------------------------
MSMEG_0692|M.smegmatis_MC2_155 ISADLPG---YTSEVRVTRPELE---------------------------
TH_2748|M.thermoresistible__bu --------------VAVSRPP-----------------------------
MAV_3048|M.avium_104 LAGAQ--------EPDLRERGES---------------------------
:
MUL_0341|M.ulcerans_Agy99 TGTSKTSPTTTTSATGKPDEESGEVGSSDLLGGDAGDIAYPYYLVNGRIP
MMAR_4770|M.marinum_M TGTSKTSPTTTTSATGKPDEESGEVGSSDLLGGDAGDIAYPYYLVNGRIP
Mb0869c|M.bovis_AF2122/97 --------------TGMPE---GEGVDSNLLGGDGGDIAYPYYLINGRIP
Rv0846c|M.tuberculosis_H37Rv --------------TGMPE---GEGVDSNLLGGDGGDIAYPYYLINGRIP
Mvan_3672|M.vanbaalenii_PYR-1 -------------MPGVPG--VGGVGASQLLGGDAGDVSYPFYLANGRIP
MAB_0463c|M.abscessus_ATCC_199 ------------DMPGMSIG-SMGVSAQAPLGADGGDVTYPYYLINGRVA
Mflv_0308|M.gilvum_PYR-GCK ------------DLLRRPLDGVFTALDDLLSRNGIAPDAVTSVAMVGGGA
MSMEG_0692|M.smegmatis_MC2_155 ------------QLISAPLDGFLNAVEDTLQRNNIALSSVTAVATVGGGA
TH_2748|M.thermoresistible__bu --------------------------EDPSNYSDSEPTAYSDYTAGGSGG
MAV_3048|M.avium_104 ----------------------SMAASRGRGEQPGYEVGYRAFAINGRML
*
MUL_0341|M.ulcerans_Agy99 AAPTSFKAKPGQRIRIRIINVASDTAFRVALAGHTMTVTHTDGYPVI---
MMAR_4770|M.marinum_M AAPTSFKAKPGQRIRIRIINVASDTAFRVALAGHTMTVTHTDGYPVI---
Mb0869c|M.bovis_AF2122/97 VAATSFKAKPGQRIRIRIINSAADTAFRIALAGHSMTVTHTDGYPVI---
Rv0846c|M.tuberculosis_H37Rv VAATSFKAKPGQRIRIRIINSAADTAFRIALAGHSMTVTHTDGYPVI---
Mvan_3672|M.vanbaalenii_PYR-1 AAPTTLTARPGQRIRMRIINAASDTAFRVALAGHRMTVTHTDGFPVV---
MAB_0463c|M.abscessus_ATCC_199 ADPQSVDYRPGTRVRLRIINAAGDSAFRVAIPGTPLTVTHTDGFPVQ---
Mflv_0308|M.gilvum_PYR-GCK SIPL-IGQQVSQRLQVPVITTARPALDGAVGAAMFAAYGRSADTST----
MSMEG_0692|M.smegmatis_MC2_155 AIPY-VTQRLSERLRAPVVTSPQPQLVAAAGAALLADRAVDAGAPTGLAP
TH_2748|M.thermoresistible__bu YVP-----------------------------------------------
MAV_3048|M.avium_104 GHGDPIRVRTGQLVLLHVLNAGATETRSLALPGHAFTVVALDGNPVPN--
MUL_0341|M.ulcerans_Agy99 -----------PTQVDALLIGMAER------------YDVIVTAADGVFP
MMAR_4770|M.marinum_M -----------PTQVDALLIGMAER------------YDVIVTAADGVFP
Mb0869c|M.bovis_AF2122/97 -----------PTEVDALLIGMAER------------YDVMVTAAGGVFP
Rv0846c|M.tuberculosis_H37Rv -----------PTEVDALLIGMAER------------YDVMVTAAGGVFP
Mvan_3672|M.vanbaalenii_PYR-1 -----------PTEVDALLIGMGER------------YDALITTGDGVFP
MAB_0463c|M.abscessus_ATCC_199 -----------PRQTDALLIGMGER------------IDAIITVGEVSVP
Mflv_0308|M.gilvum_PYR-GCK ---VAAAPVVLPPGVDSGDSGDATY---------ALAWSQDDPSADDIVP
MSMEG_0692|M.smegmatis_MC2_155 GVAAADAPTGLGPTAALGAAGAAGTDGPESSTFRALAWSEDDAPAGEPVP
TH_2748|M.thermoresistible__bu -------------------------------------------------G
MAV_3048|M.avium_104 -----------RAPVPVLWLGAGER-----------VSALVSMTNPGVWV
MUL_0341|M.ulcerans_Agy99 LVASAEGKNALARALL--------STGSGTAPDPQFRPAELNKRVG-TVE
MMAR_4770|M.marinum_M LVASAEGKNALARALL--------STGSGTAPDPQFRPAELNKRVG-TVE
Mb0869c|M.bovis_AF2122/97 LVALAEGKNALARALL--------STGAGSPPDPQFRPDELNWRVG-TVE
Rv0846c|M.tuberculosis_H37Rv LVALAEGKNALARALL--------STGAGSPPDPQFRPDELNWRVG-TVE
Mvan_3672|M.vanbaalenii_PYR-1 FVASAEGKNALARALL--------STGAGAAPDPTFMPPELQRRVG-TVG
MAB_0463c|M.abscessus_ATCC_199 LLAAPYGKDGYAQLVLR-------SSGTPVSGSAAEAAAALPKLAALDTA
Mflv_0308|M.gilvum_PYR-GCK YTGEEPAERPNPYVLSDPYG-PTEVIAQEAPPADEPRPRVPLTLTG-ILA
MSMEG_0692|M.smegmatis_MC2_155 YAGPDYETQAGATAARPPVEFSHEEEMYDAGPAPLPWYKRPPILFG-AAA
TH_2748|M.thermoresistible__bu YGGGEYGGPPGP---------------PEEPPVPWYRKPAALVAFG-ALG
MAV_3048|M.avium_104 LGDLSDDDREHGLGVV--------VEYAGRAGEPQWVPPPP---FTWDYR
MUL_0341|M.ulcerans_Agy99 MFTATTAVNLGRPDPQMSLPITLGGTMAK--YDWTINGEPYSKTHP---L
MMAR_4770|M.marinum_M MFTATTAVNLGRPDPQMSLPITLGGTMAK--YDWTINGEPYSKTHP---L
Mb0869c|M.bovis_AF2122/97 MFTAATTANLGRPEPTHDLPVTLGGTMAK--YDWTINGEPHSTTNP---L
Rv0846c|M.tuberculosis_H37Rv MFTAATTANLGRPEPTHDLPVTLGGTMAK--YDWTINGEPYSTTNP---L
Mvan_3672|M.vanbaalenii_PYR-1 VFTAAPEAVLDVSRADVALSARLSGSMAS--YDWTINGRPFEDTVP---L
MAB_0463c|M.abscessus_ATCC_199 SLSATEEVTLAVGEPDITYDLRLAGPGNK--YSWTINEKTYNPAEG---L
Mflv_0308|M.gilvum_PYR-GCK AVALLAVGGAAIALTSVQTSDRTPPKPAN--APLSSPFVPPSAAPE---T
MSMEG_0692|M.smegmatis_MC2_155 VAALLAAGGLAVTLTSTS-GDSTPVTETS--TTYSMGPSPEGPPPE---P
TH_2748|M.thermoresistible__bu AVLLGLIVFALIRLTSGDDASSETATTTT--TTTTTTGAPVAPPPA---T
MAV_3048|M.avium_104 LFAGPHPAPVAPPDHTIDLLIEKRNAADNGFNVWTVNGTPFAMDSNQPVL
. : .
MUL_0341|M.ulcerans_Agy99 TVRLGERPTLMFDNPTMMYHPIHLHG----------HTFQMIKPDGTPGA
MMAR_4770|M.marinum_M TVRLGERPTLMFDNPTMMYHPIHLHG----------HTFQMIKPDGTPGA
Mb0869c|M.bovis_AF2122/97 HVRLGQRPTLMFDNTTMMYHPIHLHG----------HTFQMIKADGSPGA
Rv0846c|M.tuberculosis_H37Rv HVRLGQRPTLMFDNTTMMYHPIHLHG----------HTFQMIKADGSPGA
Mvan_3672|M.vanbaalenii_PYR-1 TVMQGQKATLTFTNTTMMWHPMHLHG----------HTFQVIKPDGTPGP
MAB_0463c|M.abscessus_ATCC_199 PVREGQRVRLRFINNSMMFHPMHLHG----------HTFAVRTASGAYGA
Mflv_0308|M.gilvum_PYR-GCK VTVPQQQDEPAPPPATAEAPPPVVVTTAPPAAPETTTATTTTTTTTTTSP
MSMEG_0692|M.smegmatis_MC2_155 VTTVTVGPD-GQQTTTVVVPPPVT--------------TTTTEPTSTTSP
TH_2748|M.thermoresistible__bu VTQT--------------VPPATT-----------------TPAEEPSPP
MAV_3048|M.avium_104 DVERGRRYRLRLRNASDDLHPMHLHR----------HTFEITRFAGTPTA
. * . .
MUL_0341|M.ulcerans_Agy99 --RKDTVIVLPGQQLRAVLVADNPGYWVLHCHNSYHREAGMMTLLDYIF-
MMAR_4770|M.marinum_M --RKDTVIVLPGQQLRAVLVADNPGYWVLHCHNSYHREAGMMTLLDYIF-
Mb0869c|M.bovis_AF2122/97 --RKDTVIVLPKQKMRAVLVADNPGVWVMHCHNNYHQVAGMATRLDYIL-
Rv0846c|M.tuberculosis_H37Rv --RKDTVIVLPKQKMRAVLVADNPGVWVMHCHNNYHQVAGMATRLDYIL-
Mvan_3672|M.vanbaalenii_PYR-1 --RKDTVIVLPMQELTVALAADNPGVWMMHCHNTYHQEAGMMTSLNYSPQ
MAB_0463c|M.abscessus_ATCC_199 --RKDTVLVAPMQTVEVDFDADNPGQWLTHCHNIYHGEAGMMTVVSYRQ-
Mflv_0308|M.gilvum_PYR-GCK --TTTTTTTTTTTTTPPTTTTTAPTTTTAPPTTTAPTTTVPPTTVPPTTT
MSMEG_0692|M.smegmatis_MC2_155 --TTTTTTTTTTTTT--TTTTTTPTTTRT--TTTQPTTTAPTTTAPPTTT
TH_2748|M.thermoresistible__bu --PTTTQTPTTTTTTTTTTTTESPTTTTTTETVTQTETETQTVTAPPDEG
MAV_3048|M.avium_104 GVRKDVAMLGGYQSMEIDFVADQPGLSLLHCHQQIHMDYGLMLLLNGV--
. . : *
MUL_0341|M.ulcerans_Agy99 -----------------------------
MMAR_4770|M.marinum_M -----------------------------
Mb0869c|M.bovis_AF2122/97 -----------------------------
Rv0846c|M.tuberculosis_H37Rv -----------------------------
Mvan_3672|M.vanbaalenii_PYR-1 PGAAPSHGQRQ------------------
MAB_0463c|M.abscessus_ATCC_199 -----------------------------
Mflv_0308|M.gilvum_PYR-GCK GGIATTTTYLTVPFVPVPIPILVPDVP--
MSMEG_0692|M.smegmatis_MC2_155 QAPITTT---TVEIPDVPDDPDVPDDGGA
TH_2748|M.thermoresistible__bu E----------------------------
MAV_3048|M.avium_104 -----------------------------