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MVAVTRRDFCKWGGIAALAACAGPPHGKADYTLRIATGTVELAPGRVVSTLTYNGQFPGPLLRFMQGRRT WVDVYNDTDAPEQLHWHGQHIGADVDGAAEEGTPYVPAHGMRRISFVPGPAGFRFYHTHVVPRADLSRGQ YSGLVGPVHIASKDDDAGAFDQETFLTLKEFEPSLSRGGDMAVDFLAGAQEPDLRERGESSMAASRGRGE QPGYEVGYRAFAINGRMLGHGDPIRVRTGQLVLLHVLNAGATETRSLALPGHAFTVVALDGNPVPNRAPV PVLWLGAGERVSALVSMTNPGVWVLGDLSDDDREHGLGVVVEYAGRAGEPQWVPPPPFTWDYRLFAGPHP APVAPPDHTIDLLIEKRNAADNGFNVWTVNGTPFAMDSNQPVLDVERGRRYRLRLRNASDDLHPMHLHRH TFEITRFAGTPTAGVRKDVAMLGGYQSMEIDFVADQPGLSLLHCHQQIHMDYGLMLLLNGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3048 | - | - | 100% (482) | multicopper oxidase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0869c | - | 2e-41 | 28.79% (514) | oxidase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0846c | - | 7e-42 | 28.79% (514) | oxidase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0463c | - | 4e-44 | 30.74% (462) | oxidase (copper-binding protein) |
| M. marinum M | MMAR_4770 | - | 5e-36 | 26.69% (517) | oxidase |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0341 | - | 1e-35 | 26.50% (517) | oxidase |
| M. vanbaalenii PYR-1 | Mvan_3672 | - | 6e-45 | 28.52% (519) | multicopper oxidase, type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0869c|M.bovis_AF2122/97 MPELATSGNAFDKRRFSRRGFLGAGIASG--FALAAC-ASKPTASGAA--
Rv0846c|M.tuberculosis_H37Rv MPELATSGNAFDKRRFSRRGFLGAGIASG--FALAAC-ASKPTASGAA--
MMAR_4770|M.marinum_M MPVLPTGGHPFGSAQLSRRGFIGAGIAGG--LALAGCGHSQTTQTGET--
MUL_0341|M.ulcerans_Agy99 MPVLPTGGHPFGSAQLSRRGFIGAGIAGG--LALAGCGHSQTTQTGET--
Mvan_3672|M.vanbaalenii_PYR-1 -----MNRQSVGTKILTRRTFLAATLAAST-AAMAACGKPTSVNP-----
MAB_0463c|M.abscessus_ATCC_199 --------MAVSRSQWGRRGFLQLGAATAAAGVLAACGTRPVRGPSGQPV
MAV_3048|M.avium_104 ------MMVAVTRRDFCKWGGIAALAACAG--------------------
.. : : * .
Mb0869c|M.bovis_AF2122/97 -GMTAAIDAAEAARPHSG-RTVTATLTPQPARIDLGGPIVSTLTYGNTIP
Rv0846c|M.tuberculosis_H37Rv -GMTAAIDAAEAARPHSG-RTVTATLTPQPARIDLGGPIVSTLTYGNTIP
MMAR_4770|M.marinum_M -AMADAIAAAERARPHTG-RTVTASLTPQQAQIDLGGPVVQTLAFGNTVP
MUL_0341|M.ulcerans_Agy99 -AMADAIAAAERARPHTG-RTVTASLTPQQAQIDLGGPVVQTLAFGNTVP
Mvan_3672|M.vanbaalenii_PYR-1 --ATDPIAVAEAARPHTG-RTVTAALTPGPADIDLGGPVARTLAYNNSVP
MAB_0463c|M.abscessus_ATCC_199 GPSSPRVGALEAVRRDGGGRLVPVNLAARPLQLDLAGTTVSTWGYGDQIP
MAV_3048|M.avium_104 --------------PPHGKADYTLRIATGTVELAPG-RVVSTLTYNGQFP
* . ::. : . . * :.. .*
Mb0869c|M.bovis_AF2122/97 GPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRNDMDGTEPAT-ANIGP
Rv0846c|M.tuberculosis_H37Rv GPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRNDMDGTEPAT-ANIGP
MMAR_4770|M.marinum_M GPLIRASVGDEVVVAVSNRLDRATSVHWHGIALRNDMDGAEPAT-PNIGA
MUL_0341|M.ulcerans_Agy99 GPLIRASVGDEVVVAVSNRLDRTTSVHWHGIALRNDMDGAEPAT-PNIGA
Mvan_3672|M.vanbaalenii_PYR-1 GPLIRANVGDELAISVTNGLDHPSSLHWHGIALRNDMDGATPAT-PNIDP
MAB_0463c|M.abscessus_ATCC_199 GPTIRARKGEVLRVAVANGLPAPTTVHWHGIALRNDMDGVPDLTQPQIAA
MAV_3048|M.avium_104 GPLLRFMQGRRTWVDVYNDTDAPEQLHWHGQHIGADVDGAAEEGTPYVPA
** :* * : * * . :**** : *:**. . : .
Mb0869c|M.bovis_AF2122/97 GGDFTYRFSVPDPGTYWAHPHVGLQGDH------GLYLPVVVDDPTE-PG
Rv0846c|M.tuberculosis_H37Rv GGDFTYRFSVPDPGTYWAHPHVGLQGDH------GLYLPVVVDDPTE-PG
MMAR_4770|M.marinum_M DQDFTYRFSVPNAGTYWAHPHVGLEDDH------GLYLPFIVDDPTE-PN
MUL_0341|M.ulcerans_Agy99 DQDFTYRFSVPNAGTYWAHPHVGLEDDH------GLYLPFIVDDPTE-PN
Mvan_3672|M.vanbaalenii_PYR-1 SSTFTYRFSAPHPGTYWAHPHTGLDADY------GLYAPVIIDDAAE-PG
MAB_0463c|M.abscessus_ATCC_199 AGSFTYEFALAHAGTYWFHPHVGTQLDR------GLYAPLIVEDPDE-RA
MAV_3048|M.avium_104 HGMRRISFVPGPAGFRFYHTHVVPRADLSRGQYSGLVGPVHIASKDDDAG
* .* : *.*. * ** *. : . :
Mb0869c|M.bovis_AF2122/97 HYDAEWIIILDDWTDGIGKSPQQLYGELTDPN--------KPTMQNT---
Rv0846c|M.tuberculosis_H37Rv HYDAEWIIILDDWTDGIGKSPQQLYGELTDPN--------KPTMQNT---
MMAR_4770|M.marinum_M RYDAEWIVVLDDWTDGVGKSPQQLFDALVDPN--------KPRMQELPGS
MUL_0341|M.ulcerans_Agy99 RYDAEWIVVLDDWTDGVGKSPQQLFDAFVDPN--------KPRMQELPGS
Mvan_3672|M.vanbaalenii_PYR-1 RYDAEWIVVLDDWTDGIGSSPQQLYDGLRPVTGAGGHSGGMPGMSGTPG-
MAB_0463c|M.abscessus_ATCC_199 DYDTELVVALDDWIDGTGTDPDKVLAGLRDKG--------MPGMGHSMG-
MAV_3048|M.avium_104 AFDQETFLTLKEFEPSLSRGGDMAVDFLAGAQ--------EPDLRERGE-
:* * .: *.:: . . . : : * :
Mb0869c|M.bovis_AF2122/97 -----------------------------------------TGMPE---G
Rv0846c|M.tuberculosis_H37Rv -----------------------------------------TGMPE---G
MMAR_4770|M.marinum_M STAPSTSTSTTTTTTTPTTKTSTTTTTTGTSKTSPTTTTSATGKPDEESG
MUL_0341|M.ulcerans_Agy99 STAPSTSTSTTTTTTTPTTKTSTTTTTTGTSKTSPTTTTSATGKPDEESG
Mvan_3672|M.vanbaalenii_PYR-1 ----------------------------------------MPGVPG--VG
MAB_0463c|M.abscessus_ATCC_199 ---------------------------------------DMPGMSIG-SM
MAV_3048|M.avium_104 ------------------------------------------------SS
Mb0869c|M.bovis_AF2122/97 EGVDSNLLGGDGGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRIINSAA
Rv0846c|M.tuberculosis_H37Rv EGVDSNLLGGDGGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRIINSAA
MMAR_4770|M.marinum_M EVGSSDLLGGDAGDIAYPYYLVNGRIPAAPTSFKAKPGQRIRIRIINVAS
MUL_0341|M.ulcerans_Agy99 EVGSSDLLGGDAGDIAYPYYLVNGRIPAAPTSFKAKPGQRIRIRIINVAS
Mvan_3672|M.vanbaalenii_PYR-1 GVGASQLLGGDAGDVSYPFYLANGRIPAAPTTLTARPGQRIRMRIINAAS
MAB_0463c|M.abscessus_ATCC_199 GVSAQAPLGADGGDVTYPYYLINGRVAADPQSVDYRPGTRVRLRIINAAG
MAV_3048|M.avium_104 MAASRGRGEQPGYEVGYRAFAINGRMLGHGDPIRVRTGQLVLLHVLNAGA
. :: * : ***: .. :.* : ::::* ..
Mb0869c|M.bovis_AF2122/97 DTAFRIALAGHSMTVTHTDGYPVIPTE-VDALLIGMAERYDVMVTAAGGV
Rv0846c|M.tuberculosis_H37Rv DTAFRIALAGHSMTVTHTDGYPVIPTE-VDALLIGMAERYDVMVTAAGGV
MMAR_4770|M.marinum_M DTAFRVALAGHTMTVTHTDGYPVIPTQ-VDALLIGMAERYDVIVTAADGV
MUL_0341|M.ulcerans_Agy99 DTAFRVALAGHTMTVTHTDGYPVIPTQ-VDALLIGMAERYDVIVTAADGV
Mvan_3672|M.vanbaalenii_PYR-1 DTAFRVALAGHRMTVTHTDGFPVVPTE-VDALLIGMGERYDALITTGDGV
MAB_0463c|M.abscessus_ATCC_199 DSAFRVAIPGTPLTVTHTDGFPVQPRQ-TDALLIGMGERIDAIITVGEVS
MAV_3048|M.avium_104 TETRSLALPGHAFTVVALDGNPVPNRAPVPVLWLGAGERVSALVSMTNPG
: :*:.* :**. ** ** . .* :* .** ..:::
Mb0869c|M.bovis_AF2122/97 FPLVALAEGKNALARALL-STGAGSPPDPQFRPDELNWRVG-TVEMFTAA
Rv0846c|M.tuberculosis_H37Rv FPLVALAEGKNALARALL-STGAGSPPDPQFRPDELNWRVG-TVEMFTAA
MMAR_4770|M.marinum_M FPLVASAEGKNALARALL-STGSGTAPDPQFRPAELNKRVG-TVEMFTAT
MUL_0341|M.ulcerans_Agy99 FPLVASAEGKNALARALL-STGSGTAPDPQFRPAELNKRVG-TVEMFTAT
Mvan_3672|M.vanbaalenii_PYR-1 FPFVASAEGKNALARALL-STGAGAAPDPTFMPPELQRRVG-TVGVFTAA
MAB_0463c|M.abscessus_ATCC_199 VPLLAAPYGKDGYAQLVLRSSGTPVSGSAAEAAAALPKLAALDTASLSAT
MAV_3048|M.avium_104 VWVLGDLSDDDREHGLGVVVEYAGRAGEPQWVPPPP---FTWDYRLFAGP
. .:. ..: : : . .. . ::..
Mb0869c|M.bovis_AF2122/97 TTANLGRPEPTHDLPVTLGGTMAK--YDWTINGEPHSTTNP---LHVRLG
Rv0846c|M.tuberculosis_H37Rv TTANLGRPEPTHDLPVTLGGTMAK--YDWTINGEPYSTTNP---LHVRLG
MMAR_4770|M.marinum_M TAVNLGRPDPQMSLPITLGGTMAK--YDWTINGEPYSKTHP---LTVRLG
MUL_0341|M.ulcerans_Agy99 TAVNLGRPDPQMSLPITLGGTMAK--YDWTINGEPYSKTHP---LTVRLG
Mvan_3672|M.vanbaalenii_PYR-1 PEAVLDVSRADVALSARLSGSMAS--YDWTINGRPFEDTVP---LTVMQG
MAB_0463c|M.abscessus_ATCC_199 EEVTLAVGEPDITYDLRLAGPGNK--YSWTINEKTYNPAEG---LPVREG
MAV_3048|M.avium_104 HPAPVAPPDHTIDLLIEKRNAADNGFNVWTVNGTPFAMDSNQPVLDVERG
. : .. . **:* .. * * *
Mb0869c|M.bovis_AF2122/97 QRPTLMFDNTTMMYHPIHLHGHTFQMIKADGSP--GARKDTVIVLPKQKM
Rv0846c|M.tuberculosis_H37Rv QRPTLMFDNTTMMYHPIHLHGHTFQMIKADGSP--GARKDTVIVLPKQKM
MMAR_4770|M.marinum_M ERPTLMFDNPTMMYHPIHLHGHTFQMIKPDGTP--GARKDTVIVLPGQQL
MUL_0341|M.ulcerans_Agy99 ERPTLMFDNPTMMYHPIHLHGHTFQMIKPDGTP--GARKDTVIVLPGQQL
Mvan_3672|M.vanbaalenii_PYR-1 QKATLTFTNTTMMWHPMHLHGHTFQVIKPDGTP--GPRKDTVIVLPMQEL
MAB_0463c|M.abscessus_ATCC_199 QRVRLRFINNSMMFHPMHLHGHTFAVRTASGAY--GARKDTVLVAPMQTV
MAV_3048|M.avium_104 RRYRLRLRNASDDLHPMHLHRHTFEITRFAGTPTAGVRKDVAMLGGYQSM
.: * : * : **:*** *** : *: * ***..:: * :
Mb0869c|M.bovis_AF2122/97 RAVLVADNPGVWVMHCHNNYHQVAGMATRLDYIL------------
Rv0846c|M.tuberculosis_H37Rv RAVLVADNPGVWVMHCHNNYHQVAGMATRLDYIL------------
MMAR_4770|M.marinum_M RAVLVADNPGYWVLHCHNSYHREAGMMTLLDYIF------------
MUL_0341|M.ulcerans_Agy99 RAVLVADNPGYWVLHCHNSYHREAGMMTLLDYIF------------
Mvan_3672|M.vanbaalenii_PYR-1 TVALAADNPGVWMMHCHNTYHQEAGMMTSLNYSPQPGAAPSHGQRQ
MAB_0463c|M.abscessus_ATCC_199 EVDFDADNPGQWLTHCHNIYHGEAGMMTVVSYRQ------------
MAV_3048|M.avium_104 EIDFVADQPGLSLLHCHQQIHMDYGLMLLLNGV-------------
: **:** : ***: * *: :.