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VRVLVIGSGAREHALLLALGKDPQVSGLIVAPGNAGTARIAEQHDVDITSAEAVVALAREVGADMVVIGP EVPLVLGVADAVRAAGIVCFGPGKDAARIEGSKAFAKDVMAAAGVRTANSEIVDSPAHLDAALDRFGPPA GDPAWVVKDDRLAAGKGVVVTADRDVARAHGAALLEAGHPVLLESYLDGPEVSLFCVVDRTVVVPLLPAQ DFKRVGEDDTGLNTGGMGAYAPLPWLPDNIYREVVSRIVEPVAAELVRRGSSFCGLLYVGLAITARGPAV VEFNCRFGDPETQAVLALLESPLGQLLHAAATGKLADFGELRWRDGVAVTVVLAAENYPGRPRVGDVVVG SEAEGVLHAGTTRRDDGAIVSSGGRVLSVVGTGADLSAARAHAYEILSSIRLPGGHFRSDIGLRAAEGKI SV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0772 | purD | - | 100% (422) | phosphoribosylamine--glycine ligase |
| M. tuberculosis H37Rv | Rv0973c | accA2 | 4e-07 | 38.00% (100) | acetyl-/propionyl-coenzyme A carboxylase subunit alpha |
| M. tuberculosis H37Rv | Rv1384 | carB | 6e-05 | 23.58% (318) | carbamoyl phosphate synthase large subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0795 | purD | 0.0 | 100.00% (422) | phosphoribosylamine--glycine ligase |
| M. gilvum PYR-GCK | Mflv_1608 | - | 0.0 | 79.81% (421) | phosphoribosylamine--glycine ligase |
| M. leprae Br4923 | MLBr_02235 | purD | 0.0 | 81.99% (422) | phosphoribosylamine--glycine ligase |
| M. abscessus ATCC 19977 | MAB_0682 | - | 1e-180 | 75.83% (422) | phosphoribosylamine--glycine ligase |
| M. marinum M | MMAR_4924 | purD | 0.0 | 85.00% (420) | phosphoribosylamine-glycine ligase, PurD |
| M. avium 104 | MAV_0718 | purD | 0.0 | 84.60% (422) | phosphoribosylamine--glycine ligase |
| M. smegmatis MC2 155 | MSMEG_5852 | purD | 0.0 | 81.42% (393) | phosphoribosylamine--glycine ligase |
| M. thermoresistible (build 8) | TH_1264 | purD | 1e-180 | 76.35% (406) | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) |
| M. ulcerans Agy99 | MUL_0481 | purD | 0.0 | 85.00% (420) | phosphoribosylamine--glycine ligase |
| M. vanbaalenii PYR-1 | Mvan_5150 | - | 0.0 | 78.72% (423) | phosphoribosylamine--glycine ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1608|M.gilvum_PYR-GCK -------MHVLVVGSGAREHALLLALRRDPEVDALSVAPGNAGTSAVADQ
Mvan_5150|M.vanbaalenii_PYR-1 MLLGCASVHVLVVGSGAREHALLLALRRDPEVEALSVAPGNAGTAAVADQ
MSMEG_5852|M.smegmatis_MC2_155 ------------------------------------MAPGNAGTSSIADQ
MAB_0682|M.abscessus_ATCC_1997 ----MESLRVLIIGSGGREHALAIALKRDPRVDYLAIAPGNAGTAAVAEQ
TH_1264|M.thermoresistible__bu -----------------------MALRRDPGVDSLAIAPGNAGTAAIADQ
Rv0772|M.tuberculosis_H37Rv -------MRVLVIGSGAREHALLLALGKDPQVSGLIVAPGNAGTARIAEQ
Mb0795|M.bovis_AF2122/97 -------MRVLVIGSGAREHALLLALGKDPQVSGLIVAPGNAGTARIAEQ
MMAR_4924|M.marinum_M -------MRVLVIGSGAREHALLLALARDPQVSGLVVAPGNAGTARLAEQ
MUL_0481|M.ulcerans_Agy99 -------MRVLVIGSGAREHALLLALARDPQVSGLVVAPGNAGTARLAEQ
MLBr_02235|M.leprae_Br4923 -------MRVLVIGSGAREHALLLALSRDPQVKGLVVAPGNAGTARLAEQ
MAV_0718|M.avium_104 -------MRVLVIGSGAREHALLLALRKDPQVTGLAIAPGNAGTARLAEQ
:*******: :*:*
Mflv_1608|M.gilvum_PYR-GCK YDLDVTSGDAVVALARRIGADLVVIGPEVPLVLGVADAVRAAGIACFGPS
Mvan_5150|M.vanbaalenii_PYR-1 YEVDVTSGEAVTALARRIGADLVVIGPEVPLVLGVADAVRAAGIACFGPS
MSMEG_5852|M.smegmatis_MC2_155 YDVDVTSGEAVVKLAQRIGADLVVIGPEVPLVLGVADAVREAGIACFGPT
MAB_0682|M.abscessus_ATCC_1997 HAVDIGSGAEVAALATTLNIDLVVIGPEVPLVLGVADAVRAAGIACFGPS
TH_1264|M.thermoresistible__bu YDVDIASGDAVARLAKEIQADLVVIGPEVPLVLGVADAVRAAGIACFGPT
Rv0772|M.tuberculosis_H37Rv HDVDITSAEAVVALAREVGADMVVIGPEVPLVLGVADAVRAAGIVCFGPG
Mb0795|M.bovis_AF2122/97 HDVDITSAEAVVALAREVGADMVVIGPEVPLVLGVADAVRAAGIVCFGPG
MMAR_4924|M.marinum_M HDVDVTSGDDVVALAREVRADLVVIGPEVPLVLGVADAVRAAGIVCFGPS
MUL_0481|M.ulcerans_Agy99 HDVDVTSGDDVVALAREVRADLVVIGPEVPLVLGVADAVRAAGIVCFGPS
MLBr_02235|M.leprae_Br4923 YDVDISSGEDIVALARDVRADMVVIGPELPLVLGVADAVRAAGIVCFGPS
MAV_0718|M.avium_104 HDVDITSAPDVVALARAVRADLVVIGPEVPLVLGVADALRAAGIVCFGPG
: :*: *. :. ** : *:******:*********:* ***.****
Mflv_1608|M.gilvum_PYR-GCK KDAARIEGSKAFAKDVMSAAGVRTAGSEIVDNPAHLDAALDRFGPPAGQA
Mvan_5150|M.vanbaalenii_PYR-1 KDASRIEGSKAFAKDVMTAAGVRTAVSEIVDNPAHLDAALDRFGPPAGQA
MSMEG_5852|M.smegmatis_MC2_155 KDAARIEGSKAFAKDVMSAAGVRTATSEVVDNPGHLDAALDRFGPPAGQA
MAB_0682|M.abscessus_ATCC_1997 AAAARIEGSKAFAKDVMTAAGVRTARSEIVDNPAHLDAALDRF---ASEP
TH_1264|M.thermoresistible__bu REAARIEGSKSFAKDVMTAAGVRTAGSELIDNPAHLDAALDRFGPPAGDP
Rv0772|M.tuberculosis_H37Rv KDAARIEGSKAFAKDVMAAAGVRTANSEIVDSPAHLDAALDRFGPPAGDP
Mb0795|M.bovis_AF2122/97 KDAARIEGSKAFAKDVMAAAGVRTANSEIVDSPAHLDAALDRFGPPAGDP
MMAR_4924|M.marinum_M KDAARIEGSKAFAKEVMAAAGVRTASSEIVDNPARLDAALDRFGPPAGDP
MUL_0481|M.ulcerans_Agy99 KDAARIEGSKAFAKEVMAAAGVRTASSEIVDNPARLDAALDRFGPPAGDP
MLBr_02235|M.leprae_Br4923 KDAARIEGSKAFAKEVMAAAGVRTSRSEIVNSPARLDAALDRFGPPVGDL
MAV_0718|M.avium_104 KDAARIEGSKAFAKEVMAAAGVRTAASEIVDTPAHLDAALDRFGPPAGEA
*:******:***:**:******: **:::.*.:******** ..:
Mflv_1608|M.gilvum_PYR-GCK AWVVKDDGLAAGKGVVVTTDRDAARAHAAGLLDAGHPVLLESFLDGPEVS
Mvan_5150|M.vanbaalenii_PYR-1 AWVVKDDGLAAGKGVVVTTDRDAARAHAASLLDAGHPVLLESFLDGPEVS
MSMEG_5852|M.smegmatis_MC2_155 AWVVKDDGLAAGKGVVVTADRDAARAHAASLLDSGHPVLLESFLDGPEVS
MAB_0682|M.abscessus_ATCC_1997 AWVVKDDGLAAGKGVVVTDDRAAARAHAASLLDDGHPVLLESFLDGPEVS
TH_1264|M.thermoresistible__bu AWVVKDDGLAAGKGVVVTADRAAARAHAAALLDAGHPVLLETFLDGPEVS
Rv0772|M.tuberculosis_H37Rv AWVVKDDRLAAGKGVVVTADRDVARAHGAALLEAGHPVLLESYLDGPEVS
Mb0795|M.bovis_AF2122/97 AWVVKDDRLAAGKGVVVTADRDVARAHGAALLEAGHPVLLESYLDGPEVS
MMAR_4924|M.marinum_M AWVVKDDHLAAGKGVVVTPERDAARAHAAGLLEAGHPVLLESYLDGPEVS
MUL_0481|M.ulcerans_Agy99 AWVVKDDHLAAGKGVVVTPERDVARPHAAGLLEAGHPVLLESYLDGPEVS
MLBr_02235|M.leprae_Br4923 SWVVKDDRLAAGKGVVVTSDRDVARTHAAGLLEAGHPVLLESYLDGPEVS
MAV_0718|M.avium_104 AWVVKDDRLAAGKGVVVTADREVARAHAAALLEAGHPVLLESFLDGPEVS
:****** ********** :* .**.*.*.**: *******::*******
Mflv_1608|M.gilvum_PYR-GCK LFCVVDGDTVVPLLPAQDFKRVGDGDTGPNTGGMGAYAPLPWLPDEVTKQ
Mvan_5150|M.vanbaalenii_PYR-1 LFCVVDGETVVPLLPAQDFKRVGDGDTGPNTGGMGAYTPLPWLPADVTRR
MSMEG_5852|M.smegmatis_MC2_155 LFCVVDGETVVPLLPAQDFKRVGDNDSGPNTGGMGAYAPLPWLPDSVTTQ
MAB_0682|M.abscessus_ATCC_1997 LLCIVDGETVVPLLPAQDHKRVGDGDTGPNTGGMGAYTPLPWLPAETVSE
TH_1264|M.thermoresistible__bu LLCLVDGETVVPMLPAQDFKRVGDGDAGPNTGGMGACAPLPWLPDQTVTR
Rv0772|M.tuberculosis_H37Rv LFCVVDRTVVVPLLPAQDFKRVGEDDTGLNTGGMGAYAPLPWLPDNIYRE
Mb0795|M.bovis_AF2122/97 LFCVVDRTVVVPLLPAQDFKRVGEDDTGLNTGGMGAYAPLPWLPDNIYRE
MMAR_4924|M.marinum_M LFCVIDGETVVPLLPAQDFKRVGEGDTGPNTGGMGAYAPLPWLPDDSYRQ
MUL_0481|M.ulcerans_Agy99 LFCVIDGETVVPLLPAQDFKRVGEGDTGPNTGGMGAYAPLPWLPDDSYRQ
MLBr_02235|M.leprae_Br4923 LFCVVDGRTVLPLLPAQDFKRVGEGDTGPNTGGMGAYAPLPWLPDEVCQQ
MAV_0718|M.avium_104 LFCIVDGETVVPLLPAQDFKRVGDADSGPNTGGMGAYAPVPWLPDRVYRD
*:*::* .*:*:*****.****: *:* ******* :*:****
Mflv_1608|M.gilvum_PYR-GCK IVDEIVKPVAAEMVRRGSSFSGLLYAGLAITSRGPAVVEFNCRFGDPETQ
Mvan_5150|M.vanbaalenii_PYR-1 IVDEIVKPVAAELVRRGSAFSGLLYAGLAITSNGPAVVEFNCRFGDPETQ
MSMEG_5852|M.smegmatis_MC2_155 IVDEIVKPVAAELVRRGSSFSGLLYAGLAITSNGPAVVEFNCRFGDPETQ
MAB_0682|M.abscessus_ATCC_1997 IVDTIVKPVAAELVKRDSTFTGVLYAGLAITSNGPSVVEFNCRFGDPETQ
TH_1264|M.thermoresistible__bu IVDDIVKPVAAELVRRGSPFSGVLYAGLAITSAGPAVVEFNCRFGDPETQ
Rv0772|M.tuberculosis_H37Rv VVSRIVEPVAAELVRRGSSFCGLLYVGLAITARGPAVVEFNCRFGDPETQ
Mb0795|M.bovis_AF2122/97 VVSRIVEPVAAELVRRGSSFCGLLYVGLAITARGPAVVEFNCRFGDPETQ
MMAR_4924|M.marinum_M VVTEIIEPVAAELVRRGCPFSGLLYAGLAITAKGPAVVEFNCRFGDPETQ
MUL_0481|M.ulcerans_Agy99 VVTEIIEPVAAELVRRGCPFSGLLYAGLAITAKGPAVVEFNCRFGDPETQ
MLBr_02235|M.leprae_Br4923 ALTSIVEPVAAELVQRGSPFRGLLYVGLAVTASGPAVVEFNCRFGDPETQ
MAV_0718|M.avium_104 IVHRIVEPVAAEMVARGCPFSGLLYAGLAITSNGPAVVEFNCRFGDPETQ
: *::*****:* *...* *:**.***:*: **:**************
Mflv_1608|M.gilvum_PYR-GCK AVLALLESPLGRLLHAAATGELAAQPPLHWQDGSAVTVVVAAENYPGRPR
Mvan_5150|M.vanbaalenii_PYR-1 AVLALLESPLGQLLRAAAIGELAGQPPLQWRDGAAVTVVVAAENYPGRPR
MSMEG_5852|M.smegmatis_MC2_155 AVLALLESPLGQLLRAAATGELASFGELQWHDGYAVTIVVAAENYPGRPR
MAB_0682|M.abscessus_ATCC_1997 AVLALLESPLGQLLNAAAIGNLQNFGPLRWRDGSAVTVVLAAENYPLRPR
TH_1264|M.thermoresistible__bu AVLALLESPLGQLLHAVATGRLAEQPALRWRDGAAVTVVLAAENYPGRPR
Rv0772|M.tuberculosis_H37Rv AVLALLESPLGQLLHAAATGKLADFGELRWRDGVAVTVVLAAENYPGRPR
Mb0795|M.bovis_AF2122/97 AVLALLESPLGQLLHAAATGKLADFGELRWRDGVAVTVVLAAENYPGRPR
MMAR_4924|M.marinum_M AVLALLDSPLGQLLHAAGSGKLAEFGELRWREGAAVAVVLAAENYPGRPR
MUL_0481|M.ulcerans_Agy99 AVLALLDSPLGQLLHAAGSGKLAEFGELRWREGAAVAVVLAAENYPGRPR
MLBr_02235|M.leprae_Br4923 VVLALLDSPLGQLLYAAGTGSLADFGELHWRSGAAVAVVLAAENYPRRPR
MAV_0718|M.avium_104 AVLALLESPLGQLLYAAGSGTLADFGELRWHNGAAVTVVLAAENYPGRPR
.*****:****:** *.. * * *:*:.* **::*:****** ***
Mflv_1608|M.gilvum_PYR-GCK VGDVIHG-ADAPAVLHAGTARRDDGSVVSSGGRVLSVVGTGKDLAAARES
Mvan_5150|M.vanbaalenii_PYR-1 VGDVIHGAADGDTVLHAGTARRDDGALVSAGGRVLSVVGTGADLVAAREA
MSMEG_5852|M.smegmatis_MC2_155 VGDPIHG-ADADGVLHAGTARRDDGAVVSSGGRVLSVVGTGADLSAAREA
MAB_0682|M.abscessus_ATCC_1997 TGDVITG-AEAEGVLHAGTARREDGAVVSSGGRVLSVVGTGTDLQAARAD
TH_1264|M.thermoresistible__bu VGDVIVG-AEADGVLHAGTARGSDGSVVSAGGRLLSIVGTGEDLAAARDQ
Rv0772|M.tuberculosis_H37Rv VGDVVVG-SEAEGVLHAGTTRRDDGAIVSSGGRVLSVVGTGADLSAARAH
Mb0795|M.bovis_AF2122/97 VGDVVVG-SEAEGVLHAGTTRRDDGAIVSSGGRVLSVVGTGADLSAARAH
MMAR_4924|M.marinum_M LGDVIVG-ADADGILHAGTARRDDGAIVSSGGRVLSAVGTGADLAAARAD
MUL_0481|M.ulcerans_Agy99 LGDVIVG-ADADGILHAGTARRDDGAIVSSGGRVLSAVGTGADLAAARAD
MLBr_02235|M.leprae_Br4923 VGDIVFG-SEIEGVLHAGTTRRDDGVIVSSGGRVLSVVATGDDLSAARSQ
MAV_0718|M.avium_104 VGDVITG-SEAEGVLHAGTARREDGEIVSSGGRVLSVVGTGPDLAAARAK
** : * :: :*****:* .** :**:***:** *.** ** ***
Mflv_1608|M.gilvum_PYR-GCK AYAAVAAIRLPGSHFRSDIGQAAAEGRISPVGGSG---
Mvan_5150|M.vanbaalenii_PYR-1 AYATLAAIRLPGSHFRHDIGQAAAEGRIAL--------
MSMEG_5852|M.smegmatis_MC2_155 AYGLAKSIRLPGSHFRSDIGLAAAEGRISV--------
MAB_0682|M.abscessus_ATCC_1997 AYAKIEAIRLPGSHFRSDIGLAAAEGRISI--------
TH_1264|M.thermoresistible__bu AYRVIKSIRLPGSHFRSDIALAAAENRIELPGTRQKES
Rv0772|M.tuberculosis_H37Rv AYEILSSIRLPGGHFRSDIGLRAAEGKISV--------
Mb0795|M.bovis_AF2122/97 AYEILSSIRLPGGHFRSDIGLRAAEGKISV--------
MMAR_4924|M.marinum_M AYRILGSIRLPGSHFRNDIGLLAAQGRVGG--------
MUL_0481|M.ulcerans_Agy99 AYRILGSIRLPGSHFRNDIGLLAAQGRVGG--------
MLBr_02235|M.leprae_Br4923 AYRIIGSIRLLGSHFRKDIGFSAAKGRIHI--------
MAV_0718|M.avium_104 AYQILGSIRLPGSHFRTDIAQSAADGKIRV--------
** :*** *.*** **. **..::