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M. tuberculosis H37Rv Rv1384 (carB)

annotation: carbamoyl phosphate synthase large subunit
coordinates: 1557101 - 1560448
length: 1115

VPRRTDLHHVLVIGSGPIVIGQACEFDYSGTQACRVLRAEGLQVSLVNSNPATIMTDPEFADHTYVEPIT
PAFVERVIAQQAERGNKIDALLATLGGQTALNTAVALYESGVLEKYGVELIGADFDAIQRGEDRQRFKDI
VAKAGGESARSRVCFTMAEVRETVAELGLPVVVRPSFTMGGLGSGIAYSTDEVDRMAGAGLAASPSANVL
IEESIYGWKEFELELMRDGHDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAILREV
GVDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYTLDEIVNDITGETPA
CFEPTLDYVVVKAPRFAFEKFPGADPTLTTTMKSVGEAMSLGRNFVEALGKVMRSLETTRAGFWTAPDPD
GGIEEALTRLRTPAEGRLYDIELALRLGATVERVAEASGVDPWFIAQINELVNLRNELVAAPVLNAELLR
RAKHSGLSDHQIASLRPELAGEAGVRSLRVRLGIHPVYKTVDTCAAEFEAQTPYHYSSYELDPAAETEVA
PQTERPKVLILGSGPNRIGQGIEFDYSCVHAATTLSQAGFETVMVNCNPETVSTDYDTADRLYFEPLTFE
DVLEVYHAEMESGSGGPGVAGVIVQLGGQTPLGLAHRLADAGVPIVGTPPEAIDLAEDRGAFGDLLSAAG
LPAPKYGTATTFAQARRIAEEIGYPVLVRPSYVLGGRGMEIVYDEETLQGYITRATQLSPEHPVLVDRFL
EDAVEIDVDALCDGAEVYIGGIMEHIEEAGIHSGDSACALPPVTLGRSDIAKVRKATEAIAHGIGVVGLL
NVQYALKDDVLYVLEANPRASRTVPFVSKATAVPLAKACARIMLGATIAQLRAEGLLAVTGDGAHAARNA
PIAVKEAVLPFHRFRRADGAAIDSLLGPEMKSTGEVMGIDRDFGSAFAKSQTAAYGSLPAQGTVFVSVAN
RDKRSLVFPVKRLADLGFRVLATEGTAEMLRRNGIPCDDVRKHFEPAQPGRPTMSAVDAIRAGEVNMVIN
TPYGNSGPRIDGYEIRSAAVAGNIPCITTVQGASAAVQGIEAGIRGDIGVRSLQELHRVIGGVER
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1384carB-100% (1115)carbamoyl phosphate synthase large subunit
M. tuberculosis H37RvRv2501caccA18e-0825.71% (315) acetyl-/propionyl-coenzyme A carboxylase subunit alpha
M. tuberculosis H37RvRv3285accA33e-0724.47% (188) bifunctional acetyl-/propionyl-coenzyme A carboxylase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1419carB0.099.91% (1115) carbamoyl phosphate synthase large subunit
M. gilvum PYR-GCKMflv_3743carB0.087.12% (1110) carbamoyl phosphate synthase large subunit
M. leprae Br4923MLBr_00536carB0.088.93% (1111) carbamoyl phosphate synthase large subunit
M. abscessus ATCC 19977MAB_2827ccarB0.086.37% (1108) carbamoyl phosphate synthase large subunit
M. marinum MMMAR_2199carB0.091.89% (1110) carbamoyl-phosphate synthase large chain CarB
M. avium 104MAV_3389carB0.092.25% (1110) carbamoyl phosphate synthase large subunit
M. smegmatis MC2 155MSMEG_3047carB0.088.66% (1111) carbamoyl phosphate synthase large subunit
M. thermoresistible (build 8)TH_0818-0.088.88% (1115) PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN CARB
M. ulcerans Agy99MUL_1784carB0.091.71% (1110) carbamoyl phosphate synthase large subunit
M. vanbaalenii PYR-1Mvan_2664carB0.087.85% (1111) carbamoyl phosphate synthase large subunit

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3743|M.gilvum_PYR-GCK          ------------------------MPRRSDLNHVLVIGSGPILIGQAAEF
Mvan_2664|M.vanbaalenii_PYR-1       ------------------------MPRRPDLNHVLVIGSGPILIGQAAEF
MSMEG_3047|M.smegmatis_MC2_155      ------------------------MPRRSDLNHVLVIGSGPIVIGQACEF
Rv1384|M.tuberculosis_H37Rv         ------------------------MPRRTDLHHVLVIGSGPIVIGQACEF
Mb1419|M.bovis_AF2122/97            ------------------------MPRRTDLHHVLVIGSGPIVIGQACEF
MLBr_00536|M.leprae_Br4923          ----------------MRPERGTLVPRRTDLNHVLVIGSGPIVIGQACEF
MAV_3389|M.avium_104                ------------------------MPRRTDLNHVLVIGSGPIVIGQACEF
MMAR_2199|M.marinum_M               MPPADTLGSAQDRAPSRPNLRGLLVPRRTDLHHILVIGSGPIVIGQACEF
MUL_1784|M.ulcerans_Agy99           ------------------------MPRRTDLHHILVIGSGPIVIGQACEF
TH_0818|M.thermoresistible__bu      ------------------------MPRRTDINHVLVIGSGPIVIGQAAEF
MAB_2827c|M.abscessus_ATCC_199      ------------------------MPRRTDLNHILVIGSGPIVIGQACEF
                                                            :***.*::*:********:****.**

Mflv_3743|M.gilvum_PYR-GCK          DYSGTQACRVLRAEGLQVTLINSNPATIMTDPEYADHTYVEPITADFVEK
Mvan_2664|M.vanbaalenii_PYR-1       DYSGTQACRVLRAEGLQVTLINSNPATIMTDPEYADHTYVEPITAEFVEK
MSMEG_3047|M.smegmatis_MC2_155      DYSGTQACRVLRSEGIQVSLVNSNPATIMTDPEYADNTYVEPITAAFVEK
Rv1384|M.tuberculosis_H37Rv         DYSGTQACRVLRAEGLQVSLVNSNPATIMTDPEFADHTYVEPITPAFVER
Mb1419|M.bovis_AF2122/97            DYSGTQACRVLRAEGLQVSLVNSNPATIMTDPEFADHTYVEPITPAFVER
MLBr_00536|M.leprae_Br4923          DYAGTQACRVLRAEGLQVSLVNSNPATIMTDPEFADHTYVEPITPAFVER
MAV_3389|M.avium_104                DYSGTQACRVLKAEGLQVSLVNSNPATIMTDPEYADHTYVEPITPAFVER
MMAR_2199|M.marinum_M               DYSGTQACRVLRAEGLQVSLVNSNPATIMTDPEYADFTYVEPITPEFVER
MUL_1784|M.ulcerans_Agy99           DYSGTQACRVLRAEGLQVSLVNSNPATIMTDPEYADFTYVEPITPEFVER
TH_0818|M.thermoresistible__bu      DYSGTQACRVLRAEGLQVSLINSNPATIMTDPEYADHTYVEPITPDFVER
MAB_2827c|M.abscessus_ATCC_199      DYSGTQACRVLRSEGLQVSLVNSNPATIMTDPEYADNTYVEPITAEFVEK
                                    **:********::**:**:*:************:** *******. ***:

Mflv_3743|M.gilvum_PYR-GCK          VIAQQAERGNKIDALLPTLGGQTALNTAVKLYENGALERYDVELIGANFD
Mvan_2664|M.vanbaalenii_PYR-1       VIAQQAERGNKIDALLATLGGQTALNTAVKLSENGALERYGVELIGADFE
MSMEG_3047|M.smegmatis_MC2_155      VIAQQAARGNKIDALLATLGGQTALNTAVALHENGVLERYGVELIGADFE
Rv1384|M.tuberculosis_H37Rv         VIAQQAERGNKIDALLATLGGQTALNTAVALYESGVLEKYGVELIGADFD
Mb1419|M.bovis_AF2122/97            VIAQQAERGNKIDALLATLGGQTALNTAVALYESGVLEKYGVELIGADFD
MLBr_00536|M.leprae_Br4923          VIVQQAERGNRIDALLATLGGQTALNTAVALYENGVLERYGVELIGADFE
MAV_3389|M.avium_104                VIAQQAERGNKIDALLATLGGQTALNTAVALYENGALDRYGVELIGADFD
MMAR_2199|M.marinum_M               VIAQQAERGNKIDAVLATLGGQTALNTAVALHENGALERYGVELIGADFE
MUL_1784|M.ulcerans_Agy99           VIAQQAERGNKIDAVLATLGGQTALNTAVALHENGALERYGVELIGADFE
TH_0818|M.thermoresistible__bu      VIIQQAERGNKIDALLATLGGQTALNTAVALHENGALQRHGVELIGADID
MAB_2827c|M.abscessus_ATCC_199      VIAAQAEKGNKIDALLPTLGGQTALNTAVALYENGALDRYGVELIGANFE
                                    **  ** :**:***:*.************ * *.*.*:::.******:::

Mflv_3743|M.gilvum_PYR-GCK          AIQRGEDRQKFKDIVTKVGGESAKSRVCFTMDEVRDTVAELGLPVVVRPS
Mvan_2664|M.vanbaalenii_PYR-1       AIQRGEDRQKFKDIVTKVGGESARSRVCFTMDEVRDTVADLGLPVVVRPS
MSMEG_3047|M.smegmatis_MC2_155      AIQRGEDRQKFKDIVAKVGGESARSRVCFTMDEVRETVAELGLPVVVRPS
Rv1384|M.tuberculosis_H37Rv         AIQRGEDRQRFKDIVAKAGGESARSRVCFTMAEVRETVAELGLPVVVRPS
Mb1419|M.bovis_AF2122/97            AIQRGEDRQRFKDIVAKAGGESARSRVCFTMAEVRETVAELGLPVVVRPS
MLBr_00536|M.leprae_Br4923          AIQRGEDRQRFKDLVAKVGGESARSKVCFTMDEVRETVEDLGLPVVVRPS
MAV_3389|M.avium_104                AIQRGEDRQRFKDIVAKVGGESARSRVCFTMDEVRETVAELGLPVVVRPS
MMAR_2199|M.marinum_M               AIQRGEDRQRFKDIVAKVGGESARSRVCFTMDEVRETVAELGLPVVVRPS
MUL_1784|M.ulcerans_Agy99           AIQRGEDRQRFKDIVAKFGGESARSRVCFTMDEVRETVAELGLPVVVRPS
TH_0818|M.thermoresistible__bu      AIQRGEDRQRFKDIVAKVGGESARSRVCYTMDEVRETVAELGLPVVVRPS
MAB_2827c|M.abscessus_ATCC_199      AIQRGEDRQRFKDIVAKVGGESAKSRVCFTMEEVRETVADLGLPVVVRPS
                                    *********:***:*:* *****:*:**:** ***:** :**********

Mflv_3743|M.gilvum_PYR-GCK          FTMGGLGSGMAYSADDVERMAGEGLAASPSANVLIEESIYGWKEYELELM
Mvan_2664|M.vanbaalenii_PYR-1       FTMGGLGSGMAYSAEDVERMAGDGLAASPSANVLIEESIYGWKEYELELM
MSMEG_3047|M.smegmatis_MC2_155      FTMGGLGSGMAYSAEDVERMAGDGLAASPSANVLIEESIYGWKEYELELM
Rv1384|M.tuberculosis_H37Rv         FTMGGLGSGIAYSTDEVDRMAGAGLAASPSANVLIEESIYGWKEFELELM
Mb1419|M.bovis_AF2122/97            FTMGGLGSGIAYSTDEVDRMAGAGLAASPSANVLIEESIYGWKEFELELM
MLBr_00536|M.leprae_Br4923          FTMGGLGSGMAHSDEEVGRMAGAGLVASPSANVLIEESVYGWKEFELELM
MAV_3389|M.avium_104                FTMGGLGSGMARSVEEVDRMAGAGLAESPSANVLIEESIYGWKEFELELM
MMAR_2199|M.marinum_M               FTMGGLGSGMAYSADEVDRMAGAGLAASPSANVLIEESIYGWKEFELELM
MUL_1784|M.ulcerans_Agy99           FTMGGLGSGMAYSADEVDRMAGAGLAASPSANVLIEESIYGWKEFELELM
TH_0818|M.thermoresistible__bu      FTMGGLGSGIAHSVEDVDRMAGDGLAASPSANVLIEESIVGWKEYELELM
MAB_2827c|M.abscessus_ATCC_199      FTMGGLGSGMAYTADDVERMAGEGLSASPSANVLIEESIYGWKEFELELM
                                    *********:* : ::* **** **  ***********: ****:*****

Mflv_3743|M.gilvum_PYR-GCK          RDGRDNVVVVCSIENFDPMGVHTGDSVTVAPAMTLTDREYQKMRTLGIEI
Mvan_2664|M.vanbaalenii_PYR-1       RDGHDNVVVVCSIENFDPMGVHTGDSVTVAPAMTLTDREYQTMRTLGIEI
MSMEG_3047|M.smegmatis_MC2_155      RDGRDNVVVVCSIENFDPMGVHTGDSVTVAPAMTLTDREYQKMRDLGIAI
Rv1384|M.tuberculosis_H37Rv         RDGHDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAI
Mb1419|M.bovis_AF2122/97            RDGHDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAI
MLBr_00536|M.leprae_Br4923          RDGHDSVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDWEYQRMRDLGIAI
MAV_3389|M.avium_104                RDGNDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAI
MMAR_2199|M.marinum_M               RDGHDNVVVVCSIENLDPMGVHTGDSVTVAPAMTLTDREYQRLRDLGIAI
MUL_1784|M.ulcerans_Agy99           RDGHDNVVVVCSIENLDPMGVHTGDSVTVAPAMTLTDREYQRLRDLGIAI
TH_0818|M.thermoresistible__bu      RDGNDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAI
MAB_2827c|M.abscessus_ATCC_199      RDGRDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQKMRDLGIAI
                                    ***.*.*********.********************* *** :* *** *

Mflv_3743|M.gilvum_PYR-GCK          LREVGVDTGGCNIQFAVNPKDGRLIVIEMNPRVSRSSALASKATGFPIAK
Mvan_2664|M.vanbaalenii_PYR-1       LREVGVDTGGCNIQFAVNPKDGRLIVIEMNPRVSRSSALASKATGFPIAK
MSMEG_3047|M.smegmatis_MC2_155      LREVGVDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAK
Rv1384|M.tuberculosis_H37Rv         LREVGVDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAK
Mb1419|M.bovis_AF2122/97            LREVGVDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAK
MLBr_00536|M.leprae_Br4923          LREVGVDTGGCNIQFAINPHDGRLIVIEMNPRVSRSSALASKATGFPIAK
MAV_3389|M.avium_104                LREVGVDTGGCNIQFAVNPKDGRLIVIEMNPRVSRSSALASKATGFPIAK
MMAR_2199|M.marinum_M               LREVGVDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAK
MUL_1784|M.ulcerans_Agy99           LREVGVDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAK
TH_0818|M.thermoresistible__bu      LREVGVATGGCNIQFAVNPKTGRLIVIEMNPRVSRSSALASKATGFPIAK
MAB_2827c|M.abscessus_ATCC_199      LREVGVDTGGCNIQFAINPRDGRLIVIEMNPRVSRSSALASKATGFPIAK
                                    ****** *********:**: *****************************

Mflv_3743|M.gilvum_PYR-GCK          IAAKLAIGYTLDEIVNDITKETPACFEPTLDYVVVKAPRFAFEKFPGADA
Mvan_2664|M.vanbaalenii_PYR-1       IAAKLAIGYTLDEIVNDITKETPACFEPTLDYVVVKAPRFAFEKFPGADG
MSMEG_3047|M.smegmatis_MC2_155      IAAKLAIGYTLDEILNDITKETPACFEPTLDYVVVKAPRFAFEKFPGADA
Rv1384|M.tuberculosis_H37Rv         IAAKLAIGYTLDEIVNDITGETPACFEPTLDYVVVKAPRFAFEKFPGADP
Mb1419|M.bovis_AF2122/97            IAAKLAIGYTLDEIVNDITGETPACFEPTLDYVVVKAPRFAFEKFPGADP
MLBr_00536|M.leprae_Br4923          IAVKLAVGYTLDEILNDITKETPACFEPALDYVVVKAPRFAFEKFPGADP
MAV_3389|M.avium_104                IAAKLAIGYTLDEIVNDITKETPACFEPTLDYVVVKAPRFAFEKFPGADP
MMAR_2199|M.marinum_M               IAAKLAIGYTLDEIVNDITKETPACFEPTLDYVVVKAPRFAFEKFPGADA
MUL_1784|M.ulcerans_Agy99           IAAKLAIGYTLDEIVNDITKETPACFEPTLDYVVVKAPRFAFEKFPGADA
TH_0818|M.thermoresistible__bu      IAAKLAIGYTLDEIVNDITGETPACFEPTLDYVVVKAPRFAFEKFPGADP
MAB_2827c|M.abscessus_ATCC_199      IAAKLAIGYTLDEIVNDITKETPACFEPTLDYVVVKAPRFAFEKFPGADA
                                    **.***:*******:**** ********:******************** 

Mflv_3743|M.gilvum_PYR-GCK          TLTTTMKSVGEAMSLGRNFIEALGKVMRSLETGRAGFWTG-EDPVGELGE
Mvan_2664|M.vanbaalenii_PYR-1       TLTTTMKSVGEAMSLGRNFIEALGKVMRSLETGRAGFWTG-PDPEGSVDE
MSMEG_3047|M.smegmatis_MC2_155      TLTTTMKSVGEAMSLGRNFIEALGKVMRSLETTRAGFWTA-PDPDTTVEQ
Rv1384|M.tuberculosis_H37Rv         TLTTTMKSVGEAMSLGRNFVEALGKVMRSLETTRAGFWTA-PDPDGGIEE
Mb1419|M.bovis_AF2122/97            TLTTTMKSVGEAMSLGRNFVEALGKVMRSLETTRAGFWTA-PDPDGGIEE
MLBr_00536|M.leprae_Br4923          TLTTTMKSVGEAMSLGRNFVEALGKVMRSLETGRFGFWTA-PDPQGDVDQ
MAV_3389|M.avium_104                TLTTTMKSVGEAMSLGRNFIEALGKVMRSLETSRAGFWTK-PDPDGGLDD
MMAR_2199|M.marinum_M               TLTTTMKSVGEAMSLGRNFVEALGKVMRSLETSRAGFWTA-TDPEGGLDD
MUL_1784|M.ulcerans_Agy99           TLTTTMKSVGEAMSLGRNFVKALGKVMRSLETSRAGFWTA-TDPEGGLDD
TH_0818|M.thermoresistible__bu      LLTTTMKSVGEAMSLGRNFIEALGKVMRSVETKRAGFWTA-PDDDVTLDE
MAB_2827c|M.abscessus_ATCC_199      TLTTTMKSVGEAMSLGRNFAEALGKVMRSLETSAAGFWTDKAEPIEDLDA
                                     ****************** :********:**   ****   :    :  

Mflv_3743|M.gilvum_PYR-GCK          VLARLRTPTDGRLYDIEYALRIGATVEEVAEASGVDPWFVDQIGGLVELR
Mvan_2664|M.vanbaalenii_PYR-1       VLTRLHTATDGRLYDIEYALRLGATVEQVAVASGVDPWFVEQIGRLVALR
MSMEG_3047|M.smegmatis_MC2_155      LLTNLRTAQDGRIYDMELALRLGASVEQVSEASGVDPWFVEQIAGLVDLR
Rv1384|M.tuberculosis_H37Rv         ALTRLRTPAEGRLYDIELALRLGATVERVAEASGVDPWFIAQINELVNLR
Mb1419|M.bovis_AF2122/97            ALTRLRTPAEGRLYDIELALRLGATVERVAEASGVDPWFIAQINELVNLR
MLBr_00536|M.leprae_Br4923          VLLRLKTPTEGRLYDVELALRLGASTEKVAQVSGIDPWFVAQIGELVKLR
MAV_3389|M.avium_104                VLARLQTPTEGRLYDLELALRLGAPVERVAQASGVDPWFIAQIGELVALR
MMAR_2199|M.marinum_M               VLTRLQTPTEGRLYDLELALRLGASVDRVAEASGVDPWFVAQIDELVGLR
MUL_1784|M.ulcerans_Agy99           VLTRLQTPTEGRLYDLELALRLGASVDRVAEASGVDPWFVAQIDELVGLR
TH_0818|M.thermoresistible__bu      LLERLKVPTDGRLYDIEHALRLGGTVEQVAQASGVDPWFVAQIEELVRLR
MAB_2827c|M.abscessus_ATCC_199      FLKELRVPRDGRLYGIERALAAGVPVEQVAEVTGVDPWFVEEIAQINQLG
                                     * .*:.. :**:*.:* **  * ..:.*: .:*:****: :*  :  * 

Mflv_3743|M.gilvum_PYR-GCK          AELTDAPVLGEELLRRSKHHGLSDRQIAALRPELAGEMGVRALRQRLGIH
Mvan_2664|M.vanbaalenii_PYR-1       AELIDAPVLGEELLRRSKHNGLSDRQIAALRPELAGEMGVRVLRQRLGIH
MSMEG_3047|M.smegmatis_MC2_155      AELVEAPVLDADLLRRAKYSGLSDRQISALRPELAGEAGVRALRQRLGIH
Rv1384|M.tuberculosis_H37Rv         NELVAAPVLNAELLRRAKHSGLSDHQIASLRPELAGEAGVRSLRVRLGIH
Mb1419|M.bovis_AF2122/97            NELVAAPVLNAELLRRAKHSGLSDHQIASLRPELAGEAGVRSLRVRLGIH
MLBr_00536|M.leprae_Br4923          DELVAAPVLDAELLRRAKHNGLSDRQITALRPELLGEDGVRSLRKRLGIH
MAV_3389|M.avium_104                GELIGAPVLDADLLRRAKHHGLSDRQIAALRPELAGENGVRSLRERLGVH
MMAR_2199|M.marinum_M               AELVDAPVLDADLLRHAKHSGLSDRQIASLRPELAGEDGVRSLRERLGIH
MUL_1784|M.ulcerans_Agy99           AELVDAPVLDADLLRHAKHSGLSDRQIASLRPELAGEDGVRSLRERLGIH
TH_0818|M.thermoresistible__bu      SELVDAPVLNADLLRRAKHCGLSDRQIAALRPELAGELGVRALRQRLGIH
MAB_2827c|M.abscessus_ATCC_199      TELREAPILDEELLRRAKHYGLSDRQIAALRPELAGENGVRSLRHRMGIR
                                     **  **:*. :***::*: ****:**::***** ** *** ** *:*::

Mflv_3743|M.gilvum_PYR-GCK          PVFKTVDTCAAEFEAKTPYHYSSYEMDPAAETEVAPQTERGKVLILGSGP
Mvan_2664|M.vanbaalenii_PYR-1       PVFKTVDTCAAEFEARTPYHYSSYELDPSAETEVAPQAERPKVLILGSGP
MSMEG_3047|M.smegmatis_MC2_155      PVFKTVDTCAAEFDAKTPYHYSSYELDPAAETEVAPQTEKPKVLILGSGP
Rv1384|M.tuberculosis_H37Rv         PVYKTVDTCAAEFEAQTPYHYSSYELDPAAETEVAPQTERPKVLILGSGP
Mb1419|M.bovis_AF2122/97            PVYKTVDTCAAEFEAQTPYHYSSYELDPAAETEVAPQTERPKVLILGSGP
MLBr_00536|M.leprae_Br4923          PVYKTVDTCAAEFEAKTPYHYSSYELDPAAETEVVPQTEKPKVLILGSGP
MAV_3389|M.avium_104                PVYKTVDTCAAEFEAKTPYHYSSYELDPAAETEVAPQPQRPKVLILGSGP
MMAR_2199|M.marinum_M               PVYKTVDTCAAEFEAKTPYHYSSYELDPAAETEVAPQIDKPKVLILGSGP
MUL_1784|M.ulcerans_Agy99           PVYKTVDTCAAEFEAKTPYHYSSYELDPAAETEVAPQIDKPKVLILGSGP
TH_0818|M.thermoresistible__bu      PVFKTVDTCAAEFEAKTPYHYSSYELDPAAETEVAPQTERPKVLILGSGP
MAB_2827c|M.abscessus_ATCC_199      PVYKTVDTCAAEFEAKTPYHYSSYELDPAAESEVAPQTERPKVLILGSGP
                                    **:**********:*:*********:**:**:**.** :: *********

Mflv_3743|M.gilvum_PYR-GCK          NRIGQGIEFDYSCVHAATTLSEAGFETVMINCNPETVSTDYDTADRLYFE
Mvan_2664|M.vanbaalenii_PYR-1       NRIGQGIEFDYSCVHAATTLTEAGFETVMINCNPETVSTDYDTADRLYFE
MSMEG_3047|M.smegmatis_MC2_155      NRIGQGIEFDYSCVHAATTLSDAGFETVMVNCNPETVSTDYDTADRLYFE
Rv1384|M.tuberculosis_H37Rv         NRIGQGIEFDYSCVHAATTLSQAGFETVMVNCNPETVSTDYDTADRLYFE
Mb1419|M.bovis_AF2122/97            NRIGQGIEFDYSCVHAATTLSQAGFETVMVNCNPETVSTDYDTADRLYFE
MLBr_00536|M.leprae_Br4923          NRIGQGIEFDYSCVHAAITLSHNGFETVMVNCNPETVSTDYDTADRLYFE
MAV_3389|M.avium_104                NRIGQGIEFDYSCVHAATTLSQAGFETVMVNCNPETVSTDYDTADRLYFE
MMAR_2199|M.marinum_M               NRIGQGIEFDYSCVHAATTLSQAGFETVMINCNPETVSTDYDTADRLYFE
MUL_1784|M.ulcerans_Agy99           NRIGQGIEFDYSCVHAATTLSQAGFETVMINCNPETVSTDYDTADRLYFE
TH_0818|M.thermoresistible__bu      NRIGQGIEFDYSCVHAATTLSEAGFETVMINCNPETVSTDYDTADRLYFE
MAB_2827c|M.abscessus_ATCC_199      NRIGQGIEFDYSCVHAATTLSQAGFETIMVNCNPETVSTDYDTADRLYFE
                                    ***************** **:. ****:*:********************

Mflv_3743|M.gilvum_PYR-GCK          PLTFEDVLEIYYAEQRSGEG----GPGVIGVIVQLGGQTPLGLAERLEKA
Mvan_2664|M.vanbaalenii_PYR-1       PLTFEDVLEIYYAEQASGEG----GPGVVGVIVQLGGQTPLGLAERLEKA
MSMEG_3047|M.smegmatis_MC2_155      PLTFEDVLEIYHAESLSGEG----GPGVVGVIVQLGGQTPLGLAKRLEDA
Rv1384|M.tuberculosis_H37Rv         PLTFEDVLEVYHAEMESGSG----GPGVAGVIVQLGGQTPLGLAHRLADA
Mb1419|M.bovis_AF2122/97            PLTFEDVLEVYHAEMESGSG----GPGVAGVIVQLGGQTPLGLAHRLADA
MLBr_00536|M.leprae_Br4923          PLTFEDVLEVFYAEEQSAAG----GAGVAGVIVQLGGQTPLGLAQRLADA
MAV_3389|M.avium_104                PLTFEDVLEVFRAEQQSGAG----GPGVVGVIVQLGGQTPLGLAQRLADA
MMAR_2199|M.marinum_M               PLTFEDVLEVFHAEEQSAAG----GAGVVGVIVQLGGQTPLGLAERLANA
MUL_1784|M.ulcerans_Agy99           PLTFEDVLEVFHAEEQSAAG----GAGVVGVIVQLGGQTPLGLAERLANA
TH_0818|M.thermoresistible__bu      PLTFEDVLEVYYAEDASGRGPDGTGPGVVGVIVQLGGQTPLGLAQRLADA
MAB_2827c|M.abscessus_ATCC_199      PLTFEDVLEVYHAESESGRG----GPGVVGVIVQLGGQTPLGLAKRLADA
                                    *********:: **  *. *    *.** ***************.** .*

Mflv_3743|M.gilvum_PYR-GCK          GVPIVGTKPEAIDLAEDRGEFGEVLRRAGLPAPRFGMATSFDQARRIAAE
Mvan_2664|M.vanbaalenii_PYR-1       GVPIVGTLPEAIDLAEDRGEFGEVLRRAGLPAPRFGMATSFDQARRIAAE
MSMEG_3047|M.smegmatis_MC2_155      GVPIVGTSPKAIDLAEDRGHFGEVLTAAGLPAPKYGMATSFDQARRIAAD
Rv1384|M.tuberculosis_H37Rv         GVPIVGTPPEAIDLAEDRGAFGDLLSAAGLPAPKYGTATTFAQARRIAEE
Mb1419|M.bovis_AF2122/97            GVPIVGTPPEAIDLAEDRGAFGDLLSAAGLPAPKYGTATTFAQARRIAEE
MLBr_00536|M.leprae_Br4923          GVPIVGTSPEAIDLAEDRGAFGDVLTAAGLPAPKYGTATTFAQARRIAAE
MAV_3389|M.avium_104                GVPIVGTPPEAIDLAEDRGSFGDVLTAAGLPAPKYGTATTFAQARRIAVD
MMAR_2199|M.marinum_M               GVPIVGTPPAAIDLAEDRGAFGDVLTAAGLPAPRYGTATTFAQARRIAED
MUL_1784|M.ulcerans_Agy99           GVPIVGTPPAAIDLAEDRGAFGDVLTAAGLPAPRYGTATTFAQARRIAED
TH_0818|M.thermoresistible__bu      GVPIVGTRPEAIDLAEDRGLFGDVLTRAGLPAPKYGMATSFEQAREIAER
MAB_2827c|M.abscessus_ATCC_199      GVPVVGTSPAAIDRAEDRGVFGDLLVSAGLPAPRFGTATTFEQAKQIAAD
                                    ***:*** * *** ***** **::*  ******::* **:* **:.**  

Mflv_3743|M.gilvum_PYR-GCK          IGYPVLVRPSYVLGGRGMEIVYDEDTLEGYITRATQLSPEHPVLVDRFLE
Mvan_2664|M.vanbaalenii_PYR-1       IGYPVLVRPSYVLGGRGMEIVYDEETLEGYITRATELSPEHPVLVDRFLE
MSMEG_3047|M.smegmatis_MC2_155      IGYPVLVRPSYVLGGRGMEIVYDEETLRGYITRATQLSPEHPVLVDRFLE
Rv1384|M.tuberculosis_H37Rv         IGYPVLVRPSYVLGGRGMEIVYDEETLQGYITRATQLSPEHPVLVDRFLE
Mb1419|M.bovis_AF2122/97            IGYPVLVRPSYVLGGRGMEIVYDEETLQGYITRATQLSPEHPVLVDRFLE
MLBr_00536|M.leprae_Br4923          IGYPVLVRPSYVLGGRGMEIVYDEETLKDYITRATALSHEHPVLVDRFLE
MAV_3389|M.avium_104                IGYPVLVRPSYVLGGRGMEIVYDEETLRDYITRATELSPEHPVLVDRFLE
MMAR_2199|M.marinum_M               IGYPVLVRPSYVLGGRGMEIVYDEETLRGYITRATELSPAHPVLVDRFLE
MUL_1784|M.ulcerans_Agy99           IGYPVLVRPSYVLGGRGMEIVYDEETLRGYITRATELSPAHPVLVDRFLE
TH_0818|M.thermoresistible__bu      IGYPVLVRPSYVLGGRGMEIVYDEETLHAYITRATELSPEHPVLVDRFLE
MAB_2827c|M.abscessus_ATCC_199      IGYPVLVRPSYVLGGRGMEIVYDEETLHGYIARATQLSPEHPVLVDRFLE
                                    ************************:**. **:*** **  **********

Mflv_3743|M.gilvum_PYR-GCK          DAIEIDVDALCDGTEVYIGGVMEHIEEAGIHSGDSACALPPVTLGRSDIE
Mvan_2664|M.vanbaalenii_PYR-1       DAIEIDVDALCDGTEVYIGGVMEHIEEAGIHSGDSACALPPVTLGRSDIE
MSMEG_3047|M.smegmatis_MC2_155      DAIEIDVDALCDGTEVYIGGIMEHIEEAGIHSGDSACALPPVTLGRSDIE
Rv1384|M.tuberculosis_H37Rv         DAVEIDVDALCDGAEVYIGGIMEHIEEAGIHSGDSACALPPVTLGRSDIA
Mb1419|M.bovis_AF2122/97            DAVEIDVDALCDGAEVYIGGIMEHIEEAGIHSGDSACALPPVTLGRSDIE
MLBr_00536|M.leprae_Br4923          DAVEIDVDALCDGTEVYIGGVMEHIEEAGIHSGDSACALPPVTLGRSDLE
MAV_3389|M.avium_104                DAVEIDVDALCDGTEVYIGGIMEHIEEAGIHSGDSACALPPVTLGRSDIE
MMAR_2199|M.marinum_M               DAVEIDVDALCDGTEVYIGGVMEHIEEAGIHSGDSACALPPVTLGRSDIE
MUL_1784|M.ulcerans_Agy99           DAVEIDVDALCDGTEVYIGGVMEHIEEAGIHSGDSACALPRVTLGRSDIE
TH_0818|M.thermoresistible__bu      DAIEIDVDALCDGTEVYIGGVMEHIEEAGIHSGDSACALPPVTLGRSDID
MAB_2827c|M.abscessus_ATCC_199      DAIEIDVDALCDGTEVYLGGVMEHIEEAGIHSGDSACALPPVTLGRSDIE
                                    **:**********:***:**:******************* *******: 

Mflv_3743|M.gilvum_PYR-GCK          AVRRATEAIAFGVGVVGLLNVQYALKDDVLYVLEANPRASRTVPFVSKAT
Mvan_2664|M.vanbaalenii_PYR-1       AVRRATEAIAFGIGVVGLLNVQYALKDDVLYVLEANPRASRTVPFVSKAT
MSMEG_3047|M.smegmatis_MC2_155      AVRRATEAIAHGIGVVGLLNVQYALKDDVLYVLEANPRASRTVPFVSKAT
Rv1384|M.tuberculosis_H37Rv         KVRKATEAIAHGIGVVGLLNVQYALKDDVLYVLEANPRASRTVPFVSKAT
Mb1419|M.bovis_AF2122/97            KVRKATEAIAHGIGVVGLLNVQYALKDDVLYVLEANPRASRTVPFVSKAT
MLBr_00536|M.leprae_Br4923          KVRQATEAIARGIGVVGLLNVQYALKEDVLYVLEANPRASRTVPFVSKAT
MAV_3389|M.avium_104                KVRRATEAIAHGIGVVGLLNVQYALKDDVLYVLEANPRASRTVPFVSKAT
MMAR_2199|M.marinum_M               NVRKATEAIAHGIGVVGLLNVQYALKDDILYVLEANPRASRTVPFVSKAT
MUL_1784|M.ulcerans_Agy99           KVRKATEAIAHGIGVVGLLNVQYALKDDILYVLEANPRASRTVPFVSKAT
TH_0818|M.thermoresistible__bu      AVRRATEAIAHGIGVVGLLNVQYALKDDKLYVLEANPRASRTVPFVSKAT
MAB_2827c|M.abscessus_ATCC_199      KVRKATEAIAHGIGVVGLLNVQYALKDDVLYVLEANPRASRTVPFVSKAT
                                     **:****** *:*************:* *********************

Mflv_3743|M.gilvum_PYR-GCK          AVPLAKACARIMLGASIAELREEGVLARTGDGAATARNAPVAVKEAVLPF
Mvan_2664|M.vanbaalenii_PYR-1       AVPLAKACARIMLGATIAQLREEGVLASTGDGAVTARNAPVAVKEAVLPF
MSMEG_3047|M.smegmatis_MC2_155      AVPLAKACARVMLGATITQLRDEGLLSKAGDGAHVGRSTPVAVKEAVLPF
Rv1384|M.tuberculosis_H37Rv         AVPLAKACARIMLGATIAQLRAEGLLAVTGDGAHAARNAPIAVKEAVLPF
Mb1419|M.bovis_AF2122/97            AVPLAKACARIMLGATIAQLRAEGLLAVTGDGAHAARNAPIAVKEAVLPF
MLBr_00536|M.leprae_Br4923          AIPLAKACARIMLGSSISQLRFEGMLAASGDGGNVASHAPIAVKEAVLPF
MAV_3389|M.avium_104                AIPLAKACARIMLGATISQLRAEEMLAASGDGAHAALNAPIAVKEAVLPF
MMAR_2199|M.marinum_M               AVPLAKACARVMLGASISQLRAEGMLARTGDGANADPRAPIAVKEAVLPF
MUL_1784|M.ulcerans_Agy99           AVPLAKACARVMLGASISQLRAEGMLARTGDGANADPRAPIAVKEAVLPF
TH_0818|M.thermoresistible__bu      AVPLAKACARIMLGATIAELRAEGLLAADGDGATPAPDAPIAVKEAVLPF
MAB_2827c|M.abscessus_ATCC_199      AVPLAKACARIMLGATIAGLREEGLLPAEGDGATSLPGAPVAVKEAVLPF
                                    *:********:***::*: ** * :*.  ***.     :*:*********

Mflv_3743|M.gilvum_PYR-GCK          HRFRKADGAQIDSLLGPEMKSTGEVMGIAHDFGSAFAKSQTAAYGSLPAS
Mvan_2664|M.vanbaalenii_PYR-1       HRFRKADGSQIDSLLGPEMKSTGEVMGIAADFGSAFAKSQTAAYGSLPAQ
MSMEG_3047|M.smegmatis_MC2_155      HRFRRADGAQIDSLLGPEMKSTGEVMGIDHDFGTAFAKSQTAAYGSLPTE
Rv1384|M.tuberculosis_H37Rv         HRFRRADGAAIDSLLGPEMKSTGEVMGIDRDFGSAFAKSQTAAYGSLPAQ
Mb1419|M.bovis_AF2122/97            HRFRRADGAAIDSLLGPEMKSTGEVMGIDRDFGSAFAKSQTAAYGSLPAQ
MLBr_00536|M.leprae_Br4923          NRLRRADGAAIDSLLGPEMKSTGEVMGIDHDFGRAFAKSQTAAYGSLPTQ
MAV_3389|M.avium_104                HRFRTVEGAGIDSLLGPEMKSTGEVMGIDRDFGSAFAKSQTAAYGSLPAQ
MMAR_2199|M.marinum_M               HRFRRADGAAIDSLLGPEMKSTGEVMGIDRDFGSAFAKSQTAAYGSLPAA
MUL_1784|M.ulcerans_Agy99           HRFRRADGAAIDSLLGPEMKSTGEVMGIDRDFGSAFAKSQTAAYGSLPAA
TH_0818|M.thermoresistible__bu      HRFRRADGTGIDNLLGPEMKSTGEVMGIDSDFGSAFAKSQTAAYGSLPVE
MAB_2827c|M.abscessus_ATCC_199      HRFRKADGSGVDSLLGPEMKSTGEVMGIDADFGSAFAKSQTAAYGSLPKE
                                    :*:* .:*: :*.***************  *** **************  

Mflv_3743|M.gilvum_PYR-GCK          GTVFVSVANRDKRSLVFPVKRLADLGFKILATEGTAEMLRRNGIPCEEVR
Mvan_2664|M.vanbaalenii_PYR-1       GTVFVSVANRDKRSLVFPVKRLADLGFRVLATEGTAEMLRRNGIPCEEVR
MSMEG_3047|M.smegmatis_MC2_155      GTVFVSVANRDKRSLVFPVKRLADLGFRVLATEGTAEMLRRNGIPCDEVR
Rv1384|M.tuberculosis_H37Rv         GTVFVSVANRDKRSLVFPVKRLADLGFRVLATEGTAEMLRRNGIPCDDVR
Mb1419|M.bovis_AF2122/97            GTVFVSVANRDKRSLVFPVKRLADLGFRVLATEGTAEMLRRNGIPCDDVR
MLBr_00536|M.leprae_Br4923          GTVFVSVANRDKRLLVFPVKRLADLGFHVIATEGTAEMLRRKGIPCDEVR
MAV_3389|M.avium_104                GTVFVSVANRDKRSLVFPVKRLADLGFRVLATEGTAEMLRRNGIPCDEVR
MMAR_2199|M.marinum_M               GTVFVSVANRDKRSLVFPVKRLADLGFRVLATEGTAEMLRRNGIPCDEVR
MUL_1784|M.ulcerans_Agy99           GTVFVSVANRDKRSLVFPVKRLADLGFRVLATEGTAEMLRRNGIPCDEVR
TH_0818|M.thermoresistible__bu      GTVFVSVANRDKRSLVFPVKRMADLGFRVLATEGTAEMLRRNGIPCDVVR
MAB_2827c|M.abscessus_ATCC_199      GTIFVSVANRDKRSLVFPVKRLADLGFTVLATEGTAEMLRRNGIPCEEVR
                                    **:********** *******:***** ::***********:****: **

Mflv_3743|M.gilvum_PYR-GCK          KHFEEPSADRPLRSAVEAIKAGDVDMVLNTPYGNSGPRIDGYEIRSAAVS
Mvan_2664|M.vanbaalenii_PYR-1       KHFQEFSEGLPQMSAVDAIKAGHVDMVINTPYGNSGPRIDGYEIRSAAVS
MSMEG_3047|M.smegmatis_MC2_155      KHYEDPSAADPRPSAVEVIKAGEVNMVINTPYGNSGPRVDGYEIRSAAVS
Rv1384|M.tuberculosis_H37Rv         KHFEPAQPGRPTMSAVDAIRAGEVNMVINTPYGNSGPRIDGYEIRSAAVA
Mb1419|M.bovis_AF2122/97            KHFEPAQPGRPTMSAVDAIRAGEVNMVINTPYGNSGPRIDGYEIRSAAVA
MLBr_00536|M.leprae_Br4923          KHFEPPKAGRPALSAVDAIRAGDVDMVINTPYGNSGPRIDGYEIRSAAVS
MAV_3389|M.avium_104                KHFEDPQPGRPEMSAVDAIKAGEVDMVINTPYGNSGPRIDGYEIRSAAVS
MMAR_2199|M.marinum_M               KHFEAPQPGRPAISAVDAIRAGEVDMVINTPYGNSGPRVDGYEIRSVAVS
MUL_1784|M.ulcerans_Agy99           KHFEAPQPGRPAISAVDAIRAGEVDMVINTPYGNSGPRVDGYEIRSVAVS
TH_0818|M.thermoresistible__bu      KHFEEPSPDRPAMSAVDAIRAGEVDIVINTPYGNSGPRRDGYEIRAAAVS
MAB_2827c|M.abscessus_ATCC_199      KHYQEPGGTLPALSAVDVIKAGDVAMVINTPYGNSGPRVDGYEIRSAAVS
                                    **::      *  ***:.*:**.* :*:********** ******:.**:

Mflv_3743|M.gilvum_PYR-GCK          MNIPCVTTVQGASAAVQGIEAGIRGDIGVMSLQELHSTLVS---------
Mvan_2664|M.vanbaalenii_PYR-1       MNIPCVTTVQGASAAVQGIEAGIRGDIGVRSLQELHSALGS---------
MSMEG_3047|M.smegmatis_MC2_155      MNIPCVTTVQGASAAVQGIEAGIRGDIGVMSLQELHSELGSRRS------
Rv1384|M.tuberculosis_H37Rv         GNIPCITTVQGASAAVQGIEAGIRGDIGVRSLQELHRVIGGVER------
Mb1419|M.bovis_AF2122/97            GNIPCITTVQGASAAVQGIEAGIRGDIGVRSLQELHRVIGGVER------
MLBr_00536|M.leprae_Br4923          VNIPCVTTVQGASAAVQGIEAGIRGDIGVRSLQELHSAIGAGIAADNEVQ
MAV_3389|M.avium_104                VNIPCVTTVQGASAAVQGIEAGIRGDIGVRSLQELHSQIASDKGPR----
MMAR_2199|M.marinum_M               ANIPCVTTVQGASAAVQGIEAGIRGDIGVRSLQELHRAIEQQSAADGGAR
MUL_1784|M.ulcerans_Agy99           VNIPCVTTVQGALAAVQGIEAGIRGDIGVRSLQELHRAIEQQSAADGGAR
TH_0818|M.thermoresistible__bu      MNIPCVTTVQGASAAVQGIEAAIRGDIGVRSLQELHRTLGSA--------
MAB_2827c|M.abscessus_ATCC_199      MNIPCITTVQGASAAVQGIEAGIRGDIGVRSLQELHAGLR----------
                                     ****:****** ********.******* ******  :