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M. thermoresistible (build 8) TH_1264 (purD)

annotation: PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE)
coordinates: 2412919 - 2414163
length: 415

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_1264 purD - 100% (415) PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE)
M. thermoresistible (build 8) TH_0818 - 1e-07 25.60% (250) PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN CARB
M. thermoresistible (build 8) TH_1229 pyc 1e-06 29.06% (382) pyruvate carboxylase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0795 purD 1e-180 76.35% (406) phosphoribosylamine--glycine ligase
M. gilvum PYR-GCK Mflv_1608 - 0.0 81.37% (408) phosphoribosylamine--glycine ligase
M. tuberculosis H37Rv Rv0772 purD 1e-180 76.35% (406) phosphoribosylamine--glycine ligase
M. leprae Br4923 MLBr_02235 purD 1e-173 71.43% (406) phosphoribosylamine--glycine ligase
M. abscessus ATCC 19977 MAB_0682 - 0.0 79.80% (406) phosphoribosylamine--glycine ligase
M. marinum M MMAR_4924 purD 0.0 77.48% (404) phosphoribosylamine-glycine ligase, PurD
M. avium 104 MAV_0718 purD 0.0 76.85% (406) phosphoribosylamine--glycine ligase
M. smegmatis MC2 155 MSMEG_5852 purD 0.0 81.68% (393) phosphoribosylamine--glycine ligase
M. ulcerans Agy99 MUL_0481 purD 0.0 76.98% (404) phosphoribosylamine--glycine ligase
M. vanbaalenii PYR-1 Mvan_5150 - 0.0 80.84% (407) phosphoribosylamine--glycine ligase

CLUSTAL 2.0.9 multiple sequence alignment


TH_1264|M.thermoresistible__bu      -----------------------MALRRDPGVDSLAIAPGNAGTAAIADQ
MAB_0682|M.abscessus_ATCC_1997      ----MESLRVLIIGSGGREHALAIALKRDPRVDYLAIAPGNAGTAAVAEQ
Mflv_1608|M.gilvum_PYR-GCK          -------MHVLVVGSGAREHALLLALRRDPEVDALSVAPGNAGTSAVADQ
Mvan_5150|M.vanbaalenii_PYR-1       MLLGCASVHVLVVGSGAREHALLLALRRDPEVEALSVAPGNAGTAAVADQ
MSMEG_5852|M.smegmatis_MC2_155      ------------------------------------MAPGNAGTSSIADQ
Mb0795|M.bovis_AF2122/97            -------MRVLVIGSGAREHALLLALGKDPQVSGLIVAPGNAGTARIAEQ
Rv0772|M.tuberculosis_H37Rv         -------MRVLVIGSGAREHALLLALGKDPQVSGLIVAPGNAGTARIAEQ
MMAR_4924|M.marinum_M               -------MRVLVIGSGAREHALLLALARDPQVSGLVVAPGNAGTARLAEQ
MUL_0481|M.ulcerans_Agy99           -------MRVLVIGSGAREHALLLALARDPQVSGLVVAPGNAGTARLAEQ
MLBr_02235|M.leprae_Br4923          -------MRVLVIGSGAREHALLLALSRDPQVKGLVVAPGNAGTARLAEQ
MAV_0718|M.avium_104                -------MRVLVIGSGAREHALLLALRKDPQVTGLAIAPGNAGTARLAEQ
                                                                        :*******: :*:*

TH_1264|M.thermoresistible__bu      YDVDIASGDAVARLAKEIQADLVVIGPEVPLVLGVADAVRAAGIACFGPT
MAB_0682|M.abscessus_ATCC_1997      HAVDIGSGAEVAALATTLNIDLVVIGPEVPLVLGVADAVRAAGIACFGPS
Mflv_1608|M.gilvum_PYR-GCK          YDLDVTSGDAVVALARRIGADLVVIGPEVPLVLGVADAVRAAGIACFGPS
Mvan_5150|M.vanbaalenii_PYR-1       YEVDVTSGEAVTALARRIGADLVVIGPEVPLVLGVADAVRAAGIACFGPS
MSMEG_5852|M.smegmatis_MC2_155      YDVDVTSGEAVVKLAQRIGADLVVIGPEVPLVLGVADAVREAGIACFGPT
Mb0795|M.bovis_AF2122/97            HDVDITSAEAVVALAREVGADMVVIGPEVPLVLGVADAVRAAGIVCFGPG
Rv0772|M.tuberculosis_H37Rv         HDVDITSAEAVVALAREVGADMVVIGPEVPLVLGVADAVRAAGIVCFGPG
MMAR_4924|M.marinum_M               HDVDVTSGDDVVALAREVRADLVVIGPEVPLVLGVADAVRAAGIVCFGPS
MUL_0481|M.ulcerans_Agy99           HDVDVTSGDDVVALAREVRADLVVIGPEVPLVLGVADAVRAAGIVCFGPS
MLBr_02235|M.leprae_Br4923          YDVDISSGEDIVALARDVRADMVVIGPELPLVLGVADAVRAAGIVCFGPS
MAV_0718|M.avium_104                HDVDITSAPDVVALARAVRADLVVIGPEVPLVLGVADALRAAGIVCFGPG
                                    : :*: *.  :. **  :  *:******:*********:* ***.**** 

TH_1264|M.thermoresistible__bu      REAARIEGSKSFAKDVMTAAGVRTAGSELIDNPAHLDAALDRFGPPAGDP
MAB_0682|M.abscessus_ATCC_1997      AAAARIEGSKAFAKDVMTAAGVRTARSEIVDNPAHLDAALDRF---ASEP
Mflv_1608|M.gilvum_PYR-GCK          KDAARIEGSKAFAKDVMSAAGVRTAGSEIVDNPAHLDAALDRFGPPAGQA
Mvan_5150|M.vanbaalenii_PYR-1       KDASRIEGSKAFAKDVMTAAGVRTAVSEIVDNPAHLDAALDRFGPPAGQA
MSMEG_5852|M.smegmatis_MC2_155      KDAARIEGSKAFAKDVMSAAGVRTATSEVVDNPGHLDAALDRFGPPAGQA
Mb0795|M.bovis_AF2122/97            KDAARIEGSKAFAKDVMAAAGVRTANSEIVDSPAHLDAALDRFGPPAGDP
Rv0772|M.tuberculosis_H37Rv         KDAARIEGSKAFAKDVMAAAGVRTANSEIVDSPAHLDAALDRFGPPAGDP
MMAR_4924|M.marinum_M               KDAARIEGSKAFAKEVMAAAGVRTASSEIVDNPARLDAALDRFGPPAGDP
MUL_0481|M.ulcerans_Agy99           KDAARIEGSKAFAKEVMAAAGVRTASSEIVDNPARLDAALDRFGPPAGDP
MLBr_02235|M.leprae_Br4923          KDAARIEGSKAFAKEVMAAAGVRTSRSEIVNSPARLDAALDRFGPPVGDL
MAV_0718|M.avium_104                KDAARIEGSKAFAKEVMAAAGVRTAASEIVDTPAHLDAALDRFGPPAGEA
                                      *:******:***:**:******: **:::.*.:********   ..: 

TH_1264|M.thermoresistible__bu      AWVVKDDGLAAGKGVVVTADRAAARAHAAALLDAGHPVLLETFLDGPEVS
MAB_0682|M.abscessus_ATCC_1997      AWVVKDDGLAAGKGVVVTDDRAAARAHAASLLDDGHPVLLESFLDGPEVS
Mflv_1608|M.gilvum_PYR-GCK          AWVVKDDGLAAGKGVVVTTDRDAARAHAAGLLDAGHPVLLESFLDGPEVS
Mvan_5150|M.vanbaalenii_PYR-1       AWVVKDDGLAAGKGVVVTTDRDAARAHAASLLDAGHPVLLESFLDGPEVS
MSMEG_5852|M.smegmatis_MC2_155      AWVVKDDGLAAGKGVVVTADRDAARAHAASLLDSGHPVLLESFLDGPEVS
Mb0795|M.bovis_AF2122/97            AWVVKDDRLAAGKGVVVTADRDVARAHGAALLEAGHPVLLESYLDGPEVS
Rv0772|M.tuberculosis_H37Rv         AWVVKDDRLAAGKGVVVTADRDVARAHGAALLEAGHPVLLESYLDGPEVS
MMAR_4924|M.marinum_M               AWVVKDDHLAAGKGVVVTPERDAARAHAAGLLEAGHPVLLESYLDGPEVS
MUL_0481|M.ulcerans_Agy99           AWVVKDDHLAAGKGVVVTPERDVARPHAAGLLEAGHPVLLESYLDGPEVS
MLBr_02235|M.leprae_Br4923          SWVVKDDRLAAGKGVVVTSDRDVARTHAAGLLEAGHPVLLESYLDGPEVS
MAV_0718|M.avium_104                AWVVKDDRLAAGKGVVVTADREVARAHAAALLEAGHPVLLESFLDGPEVS
                                    :****** ********** :* .**.*.*.**: *******::*******

TH_1264|M.thermoresistible__bu      LLCLVDGETVVPMLPAQDFKRVGDGDAGPNTGGMGACAPLPWLPDQTVTR
MAB_0682|M.abscessus_ATCC_1997      LLCIVDGETVVPLLPAQDHKRVGDGDTGPNTGGMGAYTPLPWLPAETVSE
Mflv_1608|M.gilvum_PYR-GCK          LFCVVDGDTVVPLLPAQDFKRVGDGDTGPNTGGMGAYAPLPWLPDEVTKQ
Mvan_5150|M.vanbaalenii_PYR-1       LFCVVDGETVVPLLPAQDFKRVGDGDTGPNTGGMGAYTPLPWLPADVTRR
MSMEG_5852|M.smegmatis_MC2_155      LFCVVDGETVVPLLPAQDFKRVGDNDSGPNTGGMGAYAPLPWLPDSVTTQ
Mb0795|M.bovis_AF2122/97            LFCVVDRTVVVPLLPAQDFKRVGEDDTGLNTGGMGAYAPLPWLPDNIYRE
Rv0772|M.tuberculosis_H37Rv         LFCVVDRTVVVPLLPAQDFKRVGEDDTGLNTGGMGAYAPLPWLPDNIYRE
MMAR_4924|M.marinum_M               LFCVIDGETVVPLLPAQDFKRVGEGDTGPNTGGMGAYAPLPWLPDDSYRQ
MUL_0481|M.ulcerans_Agy99           LFCVIDGETVVPLLPAQDFKRVGEGDTGPNTGGMGAYAPLPWLPDDSYRQ
MLBr_02235|M.leprae_Br4923          LFCVVDGRTVLPLLPAQDFKRVGEGDTGPNTGGMGAYAPLPWLPDEVCQQ
MAV_0718|M.avium_104                LFCIVDGETVVPLLPAQDFKRVGDADSGPNTGGMGAYAPVPWLPDRVYRD
                                    *:*::*  .*:*:*****.****: *:* ******* :*:****      

TH_1264|M.thermoresistible__bu      IVDDIVKPVAAELVRRGSPFSGVLYAGLAITSAGPAVVEFNCRFGDPETQ
MAB_0682|M.abscessus_ATCC_1997      IVDTIVKPVAAELVKRDSTFTGVLYAGLAITSNGPSVVEFNCRFGDPETQ
Mflv_1608|M.gilvum_PYR-GCK          IVDEIVKPVAAEMVRRGSSFSGLLYAGLAITSRGPAVVEFNCRFGDPETQ
Mvan_5150|M.vanbaalenii_PYR-1       IVDEIVKPVAAELVRRGSAFSGLLYAGLAITSNGPAVVEFNCRFGDPETQ
MSMEG_5852|M.smegmatis_MC2_155      IVDEIVKPVAAELVRRGSSFSGLLYAGLAITSNGPAVVEFNCRFGDPETQ
Mb0795|M.bovis_AF2122/97            VVSRIVEPVAAELVRRGSSFCGLLYVGLAITARGPAVVEFNCRFGDPETQ
Rv0772|M.tuberculosis_H37Rv         VVSRIVEPVAAELVRRGSSFCGLLYVGLAITARGPAVVEFNCRFGDPETQ
MMAR_4924|M.marinum_M               VVTEIIEPVAAELVRRGCPFSGLLYAGLAITAKGPAVVEFNCRFGDPETQ
MUL_0481|M.ulcerans_Agy99           VVTEIIEPVAAELVRRGCPFSGLLYAGLAITAKGPAVVEFNCRFGDPETQ
MLBr_02235|M.leprae_Br4923          ALTSIVEPVAAELVQRGSPFRGLLYVGLAVTASGPAVVEFNCRFGDPETQ
MAV_0718|M.avium_104                IVHRIVEPVAAEMVARGCPFSGLLYAGLAITSNGPAVVEFNCRFGDPETQ
                                     :  *::*****:* *...* *:**.***:*: **:**************

TH_1264|M.thermoresistible__bu      AVLALLESPLGQLLHAVATGRLAEQPALRWRDGAAVTVVLAAENYPGRPR
MAB_0682|M.abscessus_ATCC_1997      AVLALLESPLGQLLNAAAIGNLQNFGPLRWRDGSAVTVVLAAENYPLRPR
Mflv_1608|M.gilvum_PYR-GCK          AVLALLESPLGRLLHAAATGELAAQPPLHWQDGSAVTVVVAAENYPGRPR
Mvan_5150|M.vanbaalenii_PYR-1       AVLALLESPLGQLLRAAAIGELAGQPPLQWRDGAAVTVVVAAENYPGRPR
MSMEG_5852|M.smegmatis_MC2_155      AVLALLESPLGQLLRAAATGELASFGELQWHDGYAVTIVVAAENYPGRPR
Mb0795|M.bovis_AF2122/97            AVLALLESPLGQLLHAAATGKLADFGELRWRDGVAVTVVLAAENYPGRPR
Rv0772|M.tuberculosis_H37Rv         AVLALLESPLGQLLHAAATGKLADFGELRWRDGVAVTVVLAAENYPGRPR
MMAR_4924|M.marinum_M               AVLALLDSPLGQLLHAAGSGKLAEFGELRWREGAAVAVVLAAENYPGRPR
MUL_0481|M.ulcerans_Agy99           AVLALLDSPLGQLLHAAGSGKLAEFGELRWREGAAVAVVLAAENYPGRPR
MLBr_02235|M.leprae_Br4923          VVLALLDSPLGQLLYAAGTGSLADFGELHWRSGAAVAVVLAAENYPRRPR
MAV_0718|M.avium_104                AVLALLESPLGQLLYAAGSGTLADFGELRWHNGAAVTVVLAAENYPGRPR
                                    .*****:****:** *.. * *     *:*:.* **::*:****** ***

TH_1264|M.thermoresistible__bu      VGDVIVG-AEADGVLHAGTARGSDGSVVSAGGRLLSIVGTGEDLAAARDQ
MAB_0682|M.abscessus_ATCC_1997      TGDVITG-AEAEGVLHAGTARREDGAVVSSGGRVLSVVGTGTDLQAARAD
Mflv_1608|M.gilvum_PYR-GCK          VGDVIHG-ADAPAVLHAGTARRDDGSVVSSGGRVLSVVGTGKDLAAARES
Mvan_5150|M.vanbaalenii_PYR-1       VGDVIHGAADGDTVLHAGTARRDDGALVSAGGRVLSVVGTGADLVAAREA
MSMEG_5852|M.smegmatis_MC2_155      VGDPIHG-ADADGVLHAGTARRDDGAVVSSGGRVLSVVGTGADLSAAREA
Mb0795|M.bovis_AF2122/97            VGDVVVG-SEAEGVLHAGTTRRDDGAIVSSGGRVLSVVGTGADLSAARAH
Rv0772|M.tuberculosis_H37Rv         VGDVVVG-SEAEGVLHAGTTRRDDGAIVSSGGRVLSVVGTGADLSAARAH
MMAR_4924|M.marinum_M               LGDVIVG-ADADGILHAGTARRDDGAIVSSGGRVLSAVGTGADLAAARAD
MUL_0481|M.ulcerans_Agy99           LGDVIVG-ADADGILHAGTARRDDGAIVSSGGRVLSAVGTGADLAAARAD
MLBr_02235|M.leprae_Br4923          VGDIVFG-SEIEGVLHAGTTRRDDGVIVSSGGRVLSVVATGDDLSAARSQ
MAV_0718|M.avium_104                VGDVITG-SEAEGVLHAGTARREDGEIVSSGGRVLSVVGTGPDLAAARAK
                                     ** : * ::   :*****:* .** :**:***:** *.** ** ***  

TH_1264|M.thermoresistible__bu      AYRVIKSIRLPGSHFRSDIALAAAENRIELPGTRQKES
MAB_0682|M.abscessus_ATCC_1997      AYAKIEAIRLPGSHFRSDIGLAAAEGRISI--------
Mflv_1608|M.gilvum_PYR-GCK          AYAAVAAIRLPGSHFRSDIGQAAAEGRISPVGGSG---
Mvan_5150|M.vanbaalenii_PYR-1       AYATLAAIRLPGSHFRHDIGQAAAEGRIAL--------
MSMEG_5852|M.smegmatis_MC2_155      AYGLAKSIRLPGSHFRSDIGLAAAEGRISV--------
Mb0795|M.bovis_AF2122/97            AYEILSSIRLPGGHFRSDIGLRAAEGKISV--------
Rv0772|M.tuberculosis_H37Rv         AYEILSSIRLPGGHFRSDIGLRAAEGKISV--------
MMAR_4924|M.marinum_M               AYRILGSIRLPGSHFRNDIGLLAAQGRVGG--------
MUL_0481|M.ulcerans_Agy99           AYRILGSIRLPGSHFRNDIGLLAAQGRVGG--------
MLBr_02235|M.leprae_Br4923          AYRIIGSIRLLGSHFRKDIGFSAAKGRIHI--------
MAV_0718|M.avium_104                AYQILGSIRLPGSHFRTDIAQSAADGKIRV--------
                                    **    :*** *.*** **.  **..::

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_1264	purD	-	100% (415)	PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE)
M. thermoresistible (build 8)	TH_0818	-	1e-07	25.60% (250)	PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN CARB
M. thermoresistible (build 8)	TH_1229	pyc	1e-06	29.06% (382)	pyruvate carboxylase