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M. tuberculosis H37Rv Rv0757 (phoP)

annotation: POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP
coordinates: 851608 - 852351
length: 247

MRKGVDLVTAGTPGENTTPEARVLVVDDEANIVELLSVSLKFQGFEVYTATNGAQALDRARETRPDAVIL
DVMMPGMDGFGVLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAG
KGNKEPRNVRLTFADIELDEETHEVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGD
VNVVESYVSYLRRKIDTGEKRLLHTLRGVGYVLREPR

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv0757 phoP - 100% (247) POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP
M. tuberculosis H37Rv Rv3765c - 2e-68 54.67% (225) two component transcriptional regulatory protein
M. tuberculosis H37Rv Rv1033c trcR 1e-59 47.56% (225) two component transcriptional regulator TRCR

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0780 phoP 1e-139 100.00% (247) two component system response transcriptional positive
M. gilvum PYR-GCK Mflv_1581 - 1e-119 89.79% (235) two component transcriptional regulator
M. leprae Br4923 MLBr_00174 - 9e-57 48.89% (225) putative two-component response regulator
M. abscessus ATCC 19977 MAB_0673 - 1e-114 86.50% (237) putative DNA-binding response regulator PhoP
M. marinum M MMAR_4942 phoP 1e-129 95.83% (240) two-component system response phosphate regulon
M. avium 104 MAV_0701 phoP 1e-126 94.17% (240) DNA-binding response regulator PhoP
M. smegmatis MC2 155 MSMEG_5872 phoP 1e-121 93.45% (229) DNA-binding response regulator PhoP
M. thermoresistible (build 8) TH_1732 phoP 3e-58 51.11% (225) DNA-binding response regulator PhoP
M. ulcerans Agy99 MUL_0463 phoP 1e-129 95.42% (240) two component system response phosphate regulon
M. vanbaalenii PYR-1 Mvan_5175 - 1e-121 90.21% (235) two component transcriptional regulator

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1581|M.gilvum_PYR-GCK          --------MAMP-VPENVPEARVLVVDDEANIVELLSVSLKFQGFEVHTA
Mvan_5175|M.vanbaalenii_PYR-1       ----------MP-VPENVPEARVLVVDDEANIVELLSVSLKFQGFEVHTA
MSMEG_5872|M.smegmatis_MC2_155      --------MAMPALPENVPEARVLVVDDEANIVELLSVSLKFQGFEVHTA
Rv0757|M.tuberculosis_H37Rv         MRKGVDLVTAGTPGENTTPEARVLVVDDEANIVELLSVSLKFQGFEVYTA
Mb0780|M.bovis_AF2122/97            MRKGVDLVTAGTPGENTTPEARVLVVDDEANIVELLSVSLKFQGFEVYTA
MMAR_4942|M.marinum_M               -------MTATTPGEATTPEARILVVDDEDNIVELLSVSLKFQGFEVHTA
MUL_0463|M.ulcerans_Agy99           -------MTATTPGEATTPEARILVVDDEDNIVELLSVSLKFQGFEVHTA
MAV_0701|M.avium_104                -------MTSATP-TDAKPEARVLVVDDEANIVELLSVSLKFQGFEVHTA
MAB_0673|M.abscessus_ATCC_1997      MVSITTETHQGTFSANGTTPAKVLVVDDESNIVELLSVSLKFQGFDVYTA
MLBr_00174|M.leprae_Br4923          --------------------MRILAVDDDRAVRESLRRSLSFNGYSVELA
TH_1732|M.thermoresistible__bu      ------------------VAVRILVVDDDRAVRESLRRSLSFNGYSVELA
                                                         ::*.***:  : * *  **.*:*:.*  *

Mflv_1581|M.gilvum_PYR-GCK          SNGPAALDKAREVRPDAIILDVMMPGMDGFGLLRRLRADGIDAPALFLTA
Mvan_5175|M.vanbaalenii_PYR-1       SNGPAALDKAREVRPDAIILDVMMPGMDGFGLLRRLRADGIDAPALFLTA
MSMEG_5872|M.smegmatis_MC2_155      SNGAAALDKAREVRPDAVILDVMMPGMDGFGLLRRLRADGIDAPALFLTA
Rv0757|M.tuberculosis_H37Rv         TNGAQALDRARETRPDAVILDVMMPGMDGFGVLRRLRADGIDAPALFLTA
Mb0780|M.bovis_AF2122/97            TNGAQALDRARETRPDAVILDVMMPGMDGFGVLRRLRADGIDAPALFLTA
MMAR_4942|M.marinum_M               TNGAQALDRARETRPDAVILDVMMPGMDGFGVLRRLRADGIDAPALFLTA
MUL_0463|M.ulcerans_Agy99           TNGAQALDRARETRPDAVILDVMMPGMDGFGVLRRLQADGIDAPALFLTA
MAV_0701|M.avium_104                TNGAQALDRAREARPDAVILDVMMPGMDGFGVLRRLRADGIDAPALFLTA
MAB_0673|M.abscessus_ATCC_1997      DSGAAALDLARTVRPDAVILDVMMPGMDGFGVLRRLRADGIDAPTLFLTA
MLBr_00174|M.leprae_Br4923          NDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTA
TH_1732|M.thermoresistible__bu      EDGVEALDLIANDRPDAVVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTA
                                     .*  **:     ****::****** :**: : *:*:: * * * *.***

Mflv_1581|M.gilvum_PYR-GCK          RDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRSGGRVQEPRTSR
Mvan_5175|M.vanbaalenii_PYR-1       RDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRSGRGHEEPRTSR
MSMEG_5872|M.smegmatis_MC2_155      RDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRSGRGVEETRNAR
Rv0757|M.tuberculosis_H37Rv         RDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGNKEPRNVR
Mb0780|M.bovis_AF2122/97            RDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGNKEPRNVR
MMAR_4942|M.marinum_M               RDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGSAEPRNSR
MUL_0463|M.ulcerans_Agy99           RDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGSAEPRNSR
MAV_0701|M.avium_104                RDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGGAEPRSAR
MAB_0673|M.abscessus_ATCC_1997      RDGLQDKIAGLTLGADDYVTKPFSLEEVVARLRVILRRSGMGSEPARKSR
MLBr_00174|M.leprae_Br4923          RDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRT-KPDDAAESVA
TH_1732|M.thermoresistible__bu      RDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRRT-TPDDAADSQK
                                    **.:.:::***  *.***:.***:***::**:*.:***:      . .  

Mflv_1581|M.gilvum_PYR-GCK          LTFADIELDEDTHEVWKAGEPVSLSPTEFTLLRYFIINAGTVLSKPKILD
Mvan_5175|M.vanbaalenii_PYR-1       LTFADIELDEDTHEVWKAGEPVSLSPTEFTLLRYFIINAGTVLSKPKILD
MSMEG_5872|M.smegmatis_MC2_155      LTFADIELDEDTHEVWKAGEPVSLSPTEFTLLRYFIINAGTVLSKPKILD
Rv0757|M.tuberculosis_H37Rv         LTFADIELDEETHEVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILD
Mb0780|M.bovis_AF2122/97            LTFADIELDEETHEVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILD
MMAR_4942|M.marinum_M               LTFADIELDEETHEVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILD
MUL_0463|M.ulcerans_Agy99           LTFADIELDEETHEVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILD
MAV_0701|M.avium_104                LTFADIELDEETHEVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILD
MAB_0673|M.abscessus_ATCC_1997      LSFADIELDEDTHEVWKAGEPVALSPTEFTLLRYFMINAGTVLSKPKILD
MLBr_00174|M.leprae_Br4923          MSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANPRRVLTRSRILE
TH_1732|M.thermoresistible__bu      LTFADLTLDPVTREVTRGNRQISLTRTEFALLELLIANPRRVLSRSRILE
                                    ::*:*: **  *:** :. . ::*: ***:**. :: *.  **::.:**:

Mflv_1581|M.gilvum_PYR-GCK          HVWRYDFGGDVNVVESYVSYLRRKIDT-GDKRLLHTLRGVGYVLREPR-
Mvan_5175|M.vanbaalenii_PYR-1       HVWRYDFGGDVNVVESYVSYLRRKIDT-GDKRLLHTLRGVGYVLREPR-
MSMEG_5872|M.smegmatis_MC2_155      HVWRYDFGGDVNVVESYVSYLRRKIDT-GEKRLLHTLRGVGYVLREPR-
Rv0757|M.tuberculosis_H37Rv         HVWRYDFGGDVNVVESYVSYLRRKIDT-GEKRLLHTLRGVGYVLREPR-
Mb0780|M.bovis_AF2122/97            HVWRYDFGGDVNVVESYVSYLRRKIDT-GEKRLLHTLRGVGYVLREPR-
MMAR_4942|M.marinum_M               HVWRYDFGGDVNVVESYVSYLRRKIDT-GDKRLLHTLRGVGYVLREPR-
MUL_0463|M.ulcerans_Agy99           HVWRYDFGGDVNVVESYVSYLRRKIDT-GDKRLLHTLRGVGYVLREPR-
MAV_0701|M.avium_104                HVWRYDFGGDVNVVESYVSYLRRKIDT-GEKRLLHTLRGVGYVLREPR-
MAB_0673|M.abscessus_ATCC_1997      HVWRYDFGGDVNVVESYVSYLRRKIDN-GEKRLLHTLRGVGYVLREPR-
MLBr_00174|M.leprae_Br4923          EVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGVGYVLRETPP
TH_1732|M.thermoresistible__bu      EVWGFDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
                                    .** :**  . *.:* *:.***** :  *: **:**:*********.

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv0757	phoP	-	100% (247)	POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP
M. tuberculosis H37Rv	Rv3765c	-	2e-68	54.67% (225)	two component transcriptional regulatory protein
M. tuberculosis H37Rv	Rv1033c	trcR	1e-59	47.56% (225)	two component transcriptional regulator TRCR