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VLPCLNEEESLPAVLAAIPAGYRALVVDNNSTDDTATVAARHGAQVVVEPRPGYGSAVHAGVLAATTPIV AVIDADGSMDAGDLPKLVAELDKGADLVTGRRRPVAGLHWPWVARVGTVVMSWRLRTRHRLPVHDIAPMR VARREALLDLGVVDRRSGYPLELLVRAAAAGWRVVELDVSYGPRTGGKSKVSGSLRGSIIAILDFWKVIS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0539 | - | - | 100% (210) | PROBABLE DOLICHYL-PHOSPHATE SUGAR SYNTHASE (DOLICHOL-PHOSPHATE SUGAR SYNTHETASE) (DOLICHOL-PHOSPHATE SUGAR TRANSFERASE) (SUGAR PHOSPHORYLDOLICHOL SYNTHASE) |
| M. tuberculosis H37Rv | Rv2051c | ppm1 | 1e-16 | 32.74% (223) | polyprenol-monophosphomannose synthase Ppm1 |
| M. tuberculosis H37Rv | Rv3631 | - | 2e-08 | 28.10% (210) | transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0553 | - | 1e-118 | 100.00% (210) | dolichyl-phosphate sugar synthase |
| M. gilvum PYR-GCK | Mflv_3118 | - | 4e-16 | 31.98% (222) | dolichyl-phosphate beta-D-mannosyltransferase |
| M. leprae Br4923 | MLBr_01440 | - | 1e-14 | 29.28% (222) | putative glycosyl transferase |
| M. abscessus ATCC 19977 | MAB_2207 | - | 8e-18 | 32.31% (229) | polyprenol phosphate mannosyl transferase 1 |
| M. marinum M | MMAR_0885 | - | 1e-105 | 88.10% (210) | glycosyl transferase - dolichol-P-sugar synthase |
| M. avium 104 | MAV_4605 | - | 1e-104 | 88.57% (210) | glycosyltransferase |
| M. smegmatis MC2 155 | MSMEG_0995 | - | 6e-92 | 78.47% (209) | glycosyl transferase, family protein 2 |
| M. thermoresistible (build 8) | TH_0733 | - | 3e-11 | 31.03% (203) | Polyprenol-monophosphomannose synthase Ppm1 |
| M. ulcerans Agy99 | MUL_0638 | - | 1e-105 | 87.62% (210) | glycosyl transferase - dolichol-P-sugar synthase |
| M. vanbaalenii PYR-1 | Mvan_0886 | - | 7e-85 | 72.38% (210) | glycosyl transferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0539|M.tuberculosis_H37Rv -----------------------MLPCLNEEESLPAVLAAIPAG---YRA
Mb0553|M.bovis_AF2122/97 -----------------------MLPCLNEEESLPAVLAAIPAG---YRA
MMAR_0885|M.marinum_M -------------MPGET--VTVVLPCLNEAESLPGVLAAIPGS---YRA
MUL_0638|M.ulcerans_Agy99 -------------MPGET--VTVVLPCLNEAESLPGVLAAIPGS---YRA
MAV_4605|M.avium_104 -------------MPGADGRVTVVLPCLNEEESLPGVLATIPPG---YRA
MSMEG_0995|M.smegmatis_MC2_155 -------------MAPRSATVTVVLPCLDEEQSLPAVLAAIPHG---YQA
Mvan_0886|M.vanbaalenii_PYR-1 -------------MPDR--AVTVVLPCRDEAASLPGVLQAIPRG---YVA
Mflv_3118|M.gilvum_PYR-GCK MSVPGGVTGREEPAGRPSARTLVIIPTYNERDNLLSIVSRVNDAAPDVHV
TH_0733|M.thermoresistible__bu -----------------------------------------------VHV
MLBr_01440|M.leprae_Br4923 --MITGQPARKISGNRPSQCVLVIIPTFNELENLPVTHGRLKDAYPEIHV
MAB_2207|M.abscessus_ATCC_1997 ---------MDPVTERPSARTLVIIPTYNERENLPLILGRLHKAQPDVHV
.
Rv0539|M.tuberculosis_H37Rv LVVDNNSTDDTATVAARHG-------AQVVVEPRPGYGSAVHAG---VLA
Mb0553|M.bovis_AF2122/97 LVVDNNSTDDTATVAARHG-------AQVVVEPRPGYGSAVHAG---VLA
MMAR_0885|M.marinum_M LVVDNNSTDDTAAVAARHG-------AEVVAEAQPGYGAAVHAG---VVA
MUL_0638|M.ulcerans_Agy99 LVVDNNSTDDTAAVAARHG-------AEVVAESQPGYGAAVHAG---VVA
MAV_4605|M.avium_104 LVVDNNSTDDTAGVARRHG-------AQVVTETRAGYGAAVHAG---VLA
MSMEG_0995|M.smegmatis_MC2_155 LVVDNNSTDRTAEVARAHG-------AVVVHEPRPGYGSAVHAG---VLA
Mvan_0886|M.vanbaalenii_PYR-1 LVVDNASSDGTAAVARRHG-------AEVVTEHRPGYGSAVHAG---VVA
Mflv_3118|M.gilvum_PYR-GCK LIVDDGSPDGTGELADELALGDPDRIHVMHRTSKDGLGAAYLAGFAWGLN
TH_0733|M.thermoresistible__bu LIVDDGSPDGTGELADELALADPDRVHVMHRASKAGLGAAYLAGFRWGLN
MLBr_01440|M.leprae_Br4923 LIVDDGSPDGTGELADELAQVDPGCTHVMHRTTKDGLGTAYLAGFAWGMS
MAB_2207|M.abscessus_ATCC_1997 LIVDDGSPDGTGELADEAALADPDRVHVMHRKEKGGLGAAYIAGFGWGLA
*:**: *.* *. :* . : : * *:* ** :
Rv0539|M.tuberculosis_H37Rv ATTPIVAVIDADGSMDAGDLPKLVAELDKGADLVTGRRRPVAG--LHWPW
Mb0553|M.bovis_AF2122/97 ATTPIVAVIDADGSMDAGDLPKLVAELDKGADLVTGRRRPVAG--LHWPW
MMAR_0885|M.marinum_M AKTPIVAVIDADGSMDPADLPRLVAELDRGADLVTGRRRPIPG--LHWPW
MUL_0638|M.ulcerans_Agy99 AKTPIVAVIDADGSMDPADLPRLVAELDRGADLVTGRRRPIPG--LHWPW
MAV_4605|M.avium_104 ATTPIVAVLDADGSMDGADLPRLVAALEAGADLVTGRRRPVRG--LRWPW
MSMEG_0995|M.smegmatis_MC2_155 AQTPVVAVLDGDGSLDPAALPALVSALDDGADMVIGRRRPVAG--LRWPW
Mvan_0886|M.vanbaalenii_PYR-1 ATTPIVAVLDADGSLDPQELPALVGDVERGADMAIGRRRPQPG--LRWPW
Mflv_3118|M.gilvum_PYR-GCK REYTVLVEMDADGSHAPEDLHRLLAEIDAGADVVIGSRYVEGGDVRNWPR
TH_0733|M.thermoresistible__bu RQYSVLVEMDADGSHAPEELHRLLDAVDAGADLAIGSRYVDGGQVRNWPR
MLBr_01440|M.leprae_Br4923 RDYSVLVEMDADGSHAPEQLHRLLGAVDAGADLAIGSRYVNGGTVRNWPW
MAB_2207|M.abscessus_ATCC_1997 RQYSVLVEMDADGSHAPEQLSRLLDAVDAGADLAIGSRYVPGGTVVNWPW
.::. :*.*** * *: :: ***:. * * * .**
Rv0539|M.tuberculosis_H37Rv VARVGTVVMSWRLRTRHRLPVHDIAP-MRVARREALLDLGVVDRRS---G
Mb0553|M.bovis_AF2122/97 VARVGTVVMSWRLRTRHRLPVHDIAP-MRVARREALLDLGVVDRRS---G
MMAR_0885|M.marinum_M VARIGTVVMSWRLRTRHGLPVHDIAP-MRVARRDALLALGVVDRRS---G
MUL_0638|M.ulcerans_Agy99 VARIGTVVMSWRLRTRHGLPVHDIAP-MRVARRDVLLALGVVDRRS---G
MAV_4605|M.avium_104 VARVGTVVMSWRLRTRHGLPVHDIAP-MRVARRDALLGLGVADRRS---G
MSMEG_0995|M.smegmatis_MC2_155 HARLGTAAVCWRLRRRYGLPVHDIAP-MRVARREALLDLGVTDRRS---G
Mvan_0886|M.vanbaalenii_PYR-1 HARLGTAAVCWRLRRRHGLQVHDIAP-MRVARRDALLSLGVTDRRS---G
Mflv_3118|M.gilvum_PYR-GCK RRMVLSRTANAYSRILLGVDIHDITAGYRAYRREVLEKIDLAAVDSKGYG
TH_0733|M.thermoresistible__bu RRLLLSRTANTYSRLLLGVDIRDITAGYRAYRREVLEKIDLDAVDSKGYC
MLBr_01440|M.leprae_Br4923 QRLALSKTANKYSRLALGIDVHDITAGYRAYRREVLEAIDLDSVASKGYC
MAB_2207|M.abscessus_ATCC_1997 RRLVLSRSANVYARLVLGVKPHDITAGYRAYRREVLEKLDLGAVESHGYC
: * : :**:. *. **:.* :.: *
Rv0539|M.tuberculosis_H37Rv YPLELLVRAAAAGWRVVELDVSYGPRTGGKSKVSGSLRGSIIAILDFWKV
Mb0553|M.bovis_AF2122/97 YPLELLVRAAAAGWRVVELDVSYGPRTGGKSKVSGSLRGSIIAILDFWKV
MMAR_0885|M.marinum_M YPLELLVRAAAAGWRVAEFDVSYGPRTGGKSKVSGSLRGSMIAILDFWKV
MUL_0638|M.ulcerans_Agy99 YPLELLVRAAAAGWRVAEFDVSYGPRTGGKSKVSGSLRGSMIAILDFWKV
MAV_4605|M.avium_104 YPLELLVRAAAAGWRVVELDVRYGPRTGGKSKVSGSLRGSITAILDFWKV
MSMEG_0995|M.smegmatis_MC2_155 YPLELLVRAAQAGWRVVEHDVTYGARTGGRSKVSGSLRGSVIAAVDFWRA
Mvan_0886|M.vanbaalenii_PYR-1 YPLELLVRAAAAGWSVTERDVAYGPRTGGTSKVSGSVRGSATAAWDFWRA
Mflv_3118|M.gilvum_PYR-GCK FQVDLTWRSINAGFTVVEVPITFTEREHGVSKMDGSTIREAIIKVAQWGM
TH_0733|M.thermoresistible__bu FQIDLTWRAINHGFKVVEVPITFTERELGQSKMSGSNIREAIFKVAEWGI
MLBr_01440|M.leprae_Br4923 FQIDLTWRTVNNGFVIIEVPITFTEREFGLSKMSGSNIREALVKVTRWGI
MAB_2207|M.abscessus_ATCC_1997 FQIDLTLRTIAHGFEVAEVPITFTERAIGESKMSGSIINEALVKVTKWGV
: ::* *: *: : * : : * * **:.** . *
Rv0539|M.tuberculosis_H37Rv IS---------------------------
Mb0553|M.bovis_AF2122/97 IS---------------------------
MMAR_0885|M.marinum_M IS---------------------------
MUL_0638|M.ulcerans_Agy99 IS---------------------------
MAV_4605|M.avium_104 IS---------------------------
MSMEG_0995|M.smegmatis_MC2_155 I----------------------------
Mvan_0886|M.vanbaalenii_PYR-1 IS---------------------------
Mflv_3118|M.gilvum_PYR-GCK RARIDRAR--------------GNTP---
TH_0733|M.thermoresistible__bu RGRLDRAR--------------GIVR---
MLBr_01440|M.leprae_Br4923 DGRIQRARTGRAYNSVSRGGGTGSSPSAP
MAB_2207|M.abscessus_ATCC_1997 QSRLDRAR--------------GVNR---