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ATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQLVPRTPAALYWGARLTLVSRVDELATF DAVFASLFGVFGSAEPDGANRPPPPIAGPRTPVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPS RTLPDVLPSRIVARADEPFDQFDPDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRST GWESVLLARIRPRRRPRRVLLLCDVSRSMQPYAAIYLRLMRAAVLRRAGGHPEVFAFSTSLTRLTSVLSH RSAEMALHRANARVTDRYGGTFIGRSVAALLAPPHGNALRGAVVIIASDGWDSDPPDVLVHALTRVRRRA ELLVWLNPRAAHPEFQPRAGSMAAALPYCDLFLPAHSLAGLHQLLLALAGAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0368c | - | - | 100% (403) | hypothetical protein Rv0368c |
| M. tuberculosis H37Rv | Rv2425c | - | 2e-07 | 28.44% (218) | hypothetical protein Rv2425c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0375c | - | 0.0 | 99.50% (403) | hypothetical protein Mb0375c |
| M. gilvum PYR-GCK | Mflv_2646 | - | 6e-07 | 26.67% (225) | VWA containing CoxE family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1620 | - | 2e-05 | 32.56% (86) | hypothetical protein MAB_1620 |
| M. marinum M | MMAR_0662 | - | 1e-157 | 70.82% (401) | von Willebrand factor type A domain-containing protein |
| M. avium 104 | MAV_1749 | - | 6e-08 | 27.59% (203) | hypothetical protein MAV_1749 |
| M. smegmatis MC2 155 | MSMEG_0751 | - | 1e-122 | 57.14% (399) | hypothetical protein MSMEG_0751 |
| M. thermoresistible (build 8) | TH_1639 | - | 1e-107 | 67.01% (288) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0110 | - | 1e-157 | 70.82% (401) | von Willebrand factor type A domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3932 | - | 2e-06 | 26.46% (223) | VWA containing CoxE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0368c|M.tuberculosis_H37Rv ------MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQ
Mb0375c|M.bovis_AF2122/97 ------MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQ
MMAR_0662|M.marinum_M ------MTAPLLLRGVDLAAFAAALVARLRGVGVLVSASGQANFVQAMRQ
MUL_0110|M.ulcerans_Agy99 ------MTAPLLLRGVDLAAFAAALVARLRGVGVLVSASGQANFVQAMRQ
MSMEG_0751|M.smegmatis_MC2_155 ------MTAPLLLRGVDLAALAVALVDRLRAAGVAVSAVGPSTLVAAMHV
TH_1639|M.thermoresistible__bu --------------------------------------------------
Mflv_2646|M.gilvum_PYR-GCK MPPRR-TRPPQPPAPHGIPGHLVEFVEALRKQGIAVGPSETVDAGQVMAT
Mvan_3932|M.vanbaalenii_PYR-1 MPPRR-TRPPQPLAPHGIPGHLVEFVEALRGQGISVGPSETVDAGQVMAT
MAV_1749|M.avium_104 MATRR-IRPSRPLAPHGLPGHLVGFVEALRGAGISVGPSETVDAGRVMAT
MAB_1620|M.abscessus_ATCC_1997 MPPRKPPKAVLPLAPHGLPGHLVGFVEALREQGISVGPSETVDAGRVMTV
Rv0368c|M.tuberculosis_H37Rv LVPRTPAALYWGARLTLVSRVDELATFDAVFASLFG-VFGSAEPD-----
Mb0375c|M.bovis_AF2122/97 LVPRTPAALYWGARLTLVSRVDELATFDAVFASLFG-VFGSAEPD-----
MMAR_0662|M.marinum_M LVPDSRSALYWAARLTLVNRMEDLVAFDLAFAAVFG-ALDAAGPE-----
MUL_0110|M.ulcerans_Agy99 LVPDSRSALYWAARLTLVNRMEDLVAFDLAFAAVFG-ALDAAGPE-----
MSMEG_0751|M.smegmatis_MC2_155 VAPVRRSQLYWAARLTLVSRAEDLPAFDGVFDAVFSDAVLGVDPP-----
TH_1639|M.thermoresistible__bu --------------------------------------------------
Mflv_2646|M.gilvum_PYR-GCK LGLSDRNVLREGLACAVLRRSDHRETYDALFDLYFPAALGAKTVLDDDE-
Mvan_3932|M.vanbaalenii_PYR-1 LGLADRDVLREGLACAVLRRSDHRETYDALFDLYFPAALGSRTVLDDES-
MAV_1749|M.avium_104 LGLGNREVLREGLACAVLRRPDHRETYDAMFDLWFPAALGARAVVTDEDA
MAB_1620|M.abscessus_ATCC_1997 LGLQSRSELREGLACAVLRRADHRPTFDVLFDLWFPPALGARFVEVGEE-
Rv0368c|M.tuberculosis_H37Rv ---------------------------------------GANRPPPPIAG
Mb0375c|M.bovis_AF2122/97 ---------------------------------------GANRPPPPIAG
MMAR_0662|M.marinum_M ---------------------------------------AADAAR-PLPG
MUL_0110|M.ulcerans_Agy99 ---------------------------------------AADAAR-PLPG
MSMEG_0751|M.smegmatis_MC2_155 ---------------------------------------NLKRSQAPPGI
TH_1639|M.thermoresistible__bu --------------------------------------------------
Mflv_2646|M.gilvum_PYR-GCK ---DGE-GLPPEDIEALRSALVDLLADNEELANIDERLAAMIAQIVEAYG
Mvan_3932|M.vanbaalenii_PYR-1 ---DGESGLPPEDIEAMRQALLDMLTDNEELANLDERLAAMIAQIVEAYG
MAV_1749|M.avium_104 GPGSGEDALPPDDVEAMREMLLDLLTENPDLADMDERLVAMIARIVEAYG
MAB_1620|M.abscessus_ATCC_1997 -------GIDIDDIEQVRDELVDLLASDAG----DLPLNSLIAQIVEAYG
Rv0368c|M.tuberculosis_H37Rv PRTPVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGG----------
Mb0375c|M.bovis_AF2122/97 PRTPVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGG----------
MMAR_0662|M.marinum_M PKTPAAGIVHRNGGPSGAAGGQPLPWASR--IGDQDGSVR----------
MUL_0110|M.ulcerans_Agy99 PKTPAAGIVHRNGGPSGAAGGQPLPWASR--VGDQDGSVR----------
MSMEG_0751|M.smegmatis_MC2_155 PGQQYA------NGADSGESGDELPWTTRPASITAAAHPP----------
TH_1639|M.thermoresistible__bu ------------------VDAEGLPWATRPATVTASADTG----------
Mflv_2646|M.gilvum_PYR-GCK RYNSSRGPSYSSYQALKAMSLDDLEGRLLAGLLAPYGDEP--TPTQEQIA
Mvan_3932|M.vanbaalenii_PYR-1 RYNSSRGPSYSSYQALKAMSLDDLEGRLLAGLLAPYGDEP--TPTQEQIA
MAV_1749|M.avium_104 KYSSSRGPSFSSYQALKAMALDELEGKLLAGLLAPYGDEP--TPTQEEIA
MAB_1620|M.abscessus_ATCC_1997 KYNSTRGTSYSAYQAMKSLSLDQIEAKLLTGLLGGGDEDSPVSPTDQAVA
: :
Rv0368c|M.tuberculosis_H37Rv ----PSR--TLPDVLPSRIVARADEPFDQ-------------------FD
Mb0375c|M.bovis_AF2122/97 ----PSR--TLPDVLPSRIVARADEPFDQ-------------------FD
MMAR_0662|M.marinum_M ----PSI--QLPDLLPSRIAALAEEPFDQ-------------------FD
MUL_0110|M.ulcerans_Agy99 ----PSI--QLPDLLPSRIAALAEEPFDQ-------------------FD
MSMEG_0751|M.smegmatis_MC2_155 ----AGS--AIPDRAPSWLAGRTDESFDQ-------------------FD
TH_1639|M.thermoresistible__bu ----ADTPTRLPDLLPSHITARADEPFER-------------------FD
Mflv_2646|M.gilvum_PYR-GCK KAIAAQRIAQLRKMVEGETKRRTAEQLGRDHVQMYGVPQLSENVEFLRAS
Mvan_3932|M.vanbaalenii_PYR-1 KAVAAQRIAALRKMVESETKRRTAEQLGRDHVQMYGVPQLAENVEFLRAS
MAV_1749|M.avium_104 KALAAQRITQLRKLVDAETKRRTAEQLGRDHVQMYGIPQLSENVEFLRAS
MAB_1620|M.abscessus_ATCC_1997 KAIAKERISKVRQLVEAETKRRTAEQLGRERVTAYGVPQLAENVEFLRAS
: . . : * : : .
Rv0368c|M.tuberculosis_H37Rv PDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWE
Mb0375c|M.bovis_AF2122/97 PDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWE
MMAR_0662|M.marinum_M AEDLRRIGGWLESTVARWPRRRSLRFESSPHGKRIDLRATMNASRVTGWE
MUL_0110|M.ulcerans_Agy99 AEDLRRIGGWLESTVARWPRRRSLRFESSPHGKRIDLRATMNASRATGWE
MSMEG_0751|M.smegmatis_MC2_155 QDDLHRLGTWLQGAEAHWPRRRTLRHRRHPSGRRIDLRETIRASRTTGWE
TH_1639|M.thermoresistible__bu PDDLRLLGGWLEQAVAHWPRRRSLRRENHPHGKRIDLRETLRASRRTGFE
Mflv_2646|M.gilvum_PYR-GCK GEQLRQMRRVVGPLARTLATRLAARRRRSRAG-EIDLRKTLRKSMSTGGV
Mvan_3932|M.vanbaalenii_PYR-1 GEQLRQMRRVVGPLARTLATRLAARRRRSRAG-EIDLRKTLRKSMSTGGV
MAV_1749|M.avium_104 GEQLRQMQRVVAPLARTLATRLAARRRRSRAG-TIDLRKTLRKSMSTGGV
MAB_1620|M.abscessus_ATCC_1997 GEQLRNMRRVVHPLARMLASRLAARRRRAHTG-QIDLRRTLRKSMSTGGV
::*: : : . * : * . * **** *:. * **
Rv0368c|M.tuberculosis_H37Rv SVLLARIRPRRRPRRVLLLCDVSRSMQPYAAIYLRLMRAAVLR-----RA
Mb0375c|M.bovis_AF2122/97 SVLLARIRPRRRPRRVLLLCDVSRSMQPYAAIYLHLMRAAVLR-----RA
MMAR_0662|M.marinum_M AVRLARIRPRRRPRRVVLLCDVSRSMQPYAAIYLHLMRALVAR-----QP
MUL_0110|M.ulcerans_Agy99 AVRLARIRPRRRPRRVVLLCDVSRSMQPYAAIYLHLMRALVAR-----QP
MSMEG_0751|M.smegmatis_MC2_155 PVRLARTRRRTRPRRVVLVCDVSGSMQPYAVVYLHLMRAAAVS----RRG
TH_1639|M.thermoresistible__bu TLRLARTRPRRRDRPVVLICDVSRSMQPYTTVYLHLMRAAALHRNSRRRS
Mflv_2646|M.gilvum_PYR-GCK PIDVVLKKPHPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQ-------
Mvan_3932|M.vanbaalenii_PYR-1 PIDLVLKKPHPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQ-------
MAV_1749|M.avium_104 PIDVVLAKPRPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQ-------
MAB_1620|M.abscessus_ATCC_1997 PIDVVQKKPRPARPELVVLCDVSGSVAGFSHFTLLLVNALRQQ-------
.: :. : : ::::**** *: :: . * *:.*
Rv0368c|M.tuberculosis_H37Rv GGHPEVFAFSTSLTRLTSVLSHR---SAEMALHRANARVTDRYGGTFIGR
Mb0375c|M.bovis_AF2122/97 GGHPEVFAFSTSLTRLTSVLSHR---SAEMALHRANARVTDRYGGTFIGR
MMAR_0662|M.marinum_M GIRPEVFAFSTSLTRLTPVLAHR---SAEVALDRANAKVADRYGGTFIGR
MUL_0110|M.ulcerans_Agy99 GIRPEVFAFSTSLTRLTPVLAHR---SAEVALDRANAKVADRYGGTFIGR
MSMEG_0751|M.smegmatis_MC2_155 AAHPEVFAFATTLTRLTAALSHR---SPEVAVTRANAKVHDRYGGTRLGR
TH_1639|M.thermoresistible__bu GIRPEVFAFSTRLTRLTAVLAHR---SPEVARDRADAKVVDRYGGTHLGR
Mflv_2646|M.gilvum_PYR-GCK FSRVRVFAFIDTTDEVTELFGPDSDLAVAVQRITREAAVFTRDGHSDYGH
Mvan_3932|M.vanbaalenii_PYR-1 FSRVRVFAFIDTTDEVTELFGPDADLAVAVQRITREAAVYTRDGHSDYGH
MAV_1749|M.avium_104 FSRVRVFAFIDTTDEVTHMFGPEADLAVAIQRITREAGVYSRDGHSDYGN
MAB_1620|M.abscessus_ATCC_1997 FSRVRVFAFIDTTDEVTHLFTPDTDLAEAIVRITREAQVFTGDGHSDYGH
: .**** .:* : : : :* * * : *.
Rv0368c|M.tuberculosis_H37Rv SVAALLAPPHGNALRGAVVIIASDGWDSDPPDVLVHALTRVRRRAELLVW
Mb0375c|M.bovis_AF2122/97 SVAALLAPPHGNALRGAVVIIASDGWDSDPPDVLVHALTRVRRRAELLVW
MMAR_0662|M.marinum_M SVGALLEAPHGNALRGAVVIIASDGWDSEAPEVLCHALARVRRRAQLLVW
MUL_0110|M.ulcerans_Agy99 SVGALLEPPHGNALRGAVVIIASDGWDSEAPKVLCHALARVRRRAQLLVC
MSMEG_0751|M.smegmatis_MC2_155 SIAALLAAPHGNLLRGAVVVIASDGWDADAPEVLRHAMSRLRRRAHLVVW
TH_1639|M.thermoresistible__bu SLAELLASPHGNALRGAVVIIASDGWDSDPPELLGHTMARLRRRAQRVVW
Mflv_2646|M.gilvum_PYR-GCK AFVSFLDKFPNVLSPRSSLLVLGDGR-NNYRNPETDLLAHMVNAARHAHW
Mvan_3932|M.vanbaalenii_PYR-1 AFVSFLDKFPNVLSPRSSLLVLGDGR-NNYRNPEAHLLAHMVNASRHAHW
MAV_1749|M.avium_104 AFASFEQKFPNVLSPRTSLLVLGDGR-TNYRNPEVELLSHMVTASRHAHW
MAB_1620|M.abscessus_ATCC_1997 AFKTFVEKFPTVLSPRSALLILGDGR-TNYRNPAVEVLSSMVSSSRHAHW
:. : : ::: .** : . . :: : :.
Rv0368c|M.tuberculosis_H37Rv LNPRAAHPEFQPRAGSMAAALPYCDLFLPAHSLAGLHQLLLALAGAR--
Mb0375c|M.bovis_AF2122/97 LNPRAAHPEFQPRASSMAAALPYCDLFLPAHSLAGLHQLLLALAGAR--
MMAR_0662|M.marinum_M LNPRAAQSDFEPLTGSMAAALPYCDLFLPAHSLTGVQQLLRALGGDLR-
MUL_0110|M.ulcerans_Agy99 LNPRAAQSDFEPLTGSMAAALPYCDLFLPAHSLTGVQQLLRALGGDLR-
MSMEG_0751|M.smegmatis_MC2_155 LNPRAAAPGYEPLAGAMAAALPYCDHFLPAHTLTGLRELFDVLGA----
TH_1639|M.thermoresistible__bu LNPRAGRPGFAPLTGAMAAALPYCDAMLPAHSLTALHEVFVTLANQ---
Mflv_2646|M.gilvum_PYR-GCK LNPEPKH-----LWGSGDSAVPRYQDVITMHECRSAKQLASVIDALLPV
Mvan_3932|M.vanbaalenii_PYR-1 LNPEPRH-----LWGSGDSAVPRYQDVITMHECRSAKQLASVIDALLPV
MAV_1749|M.avium_104 LNPEPKH-----LWGSGDSAVPRYQQVIPMHECRSAKQLAAVIDQLLPV
MAB_1620|M.abscessus_ATCC_1997 LNPEPKN-----HWGTGDSAAKRYQDAITMHECRSAKQLAAVIDNLLPV
***.. .: :* : :. * . ::: .: