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PPRRTRPPQPLAPHGIPGHLVEFVEALRGQGISVGPSETVDAGQVMATLGLADRDVLREGLACAVLRRSD HRETYDALFDLYFPAALGSRTVLDDESDGESGLPPEDIEAMRQALLDMLTDNEELANLDERLAAMIAQIV EAYGRYNSSRGPSYSSYQALKAMSLDDLEGRLLAGLLAPYGDEPTPTQEQIAKAVAAQRIAALRKMVESE TKRRTAEQLGRDHVQMYGVPQLAENVEFLRASGEQLRQMRRVVGPLARTLATRLAARRRRSRAGEIDLRK TLRKSMSTGGVPIDLVLKKPHPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFSRVRVFAFIDTTDEV TELFGPDADLAVAVQRITREAAVYTRDGHSDYGHAFVSFLDKFPNVLSPRSSLLVLGDGRNNYRNPEAHL LAHMVNASRHAHWLNPEPRHLWGSGDSAVPRYQDVITMHECRSAKQLASVIDALLPV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3932 | - | - | 100% (478) | VWA containing CoxE family protein |
| M. vanbaalenii PYR-1 | Mvan_5477 | - | 5e-36 | 29.01% (486) | VWA containing CoxE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2449c | - | 0.0 | 82.81% (477) | hypothetical protein Mb2449c |
| M. gilvum PYR-GCK | Mflv_2646 | - | 0.0 | 94.35% (478) | VWA containing CoxE family protein |
| M. tuberculosis H37Rv | Rv2425c | - | 0.0 | 82.81% (477) | hypothetical protein Rv2425c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1620 | - | 0.0 | 71.07% (484) | hypothetical protein MAB_1620 |
| M. marinum M | MMAR_3751 | - | 0.0 | 83.30% (479) | hypothetical protein MMAR_3751 |
| M. avium 104 | MAV_1749 | - | 0.0 | 83.20% (482) | hypothetical protein MAV_1749 |
| M. smegmatis MC2 155 | MSMEG_4582 | - | 0.0 | 87.01% (485) | hypothetical protein MSMEG_4582 |
| M. thermoresistible (build 8) | TH_0790 | - | 0.0 | 87.29% (480) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3694 | - | 0.0 | 82.67% (479) | hypothetical protein MUL_3694 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2449c|M.bovis_AF2122/97 MAARR-IRAARPLAPHGLPGHLVGFVEALRGSGISVGPSETVDAGRVMAT
Rv2425c|M.tuberculosis_H37Rv MAARR-IRAARPLAPHGLPGHLVGFVEALRGSGISVGPSETVDAGRVMAT
MMAR_3751|M.marinum_M MATRR-IRPSYPLAPHGLPGHLVGFVEALRGSGISVGPSETVDAGRVMAA
MUL_3694|M.ulcerans_Agy99 MATRR-IRPSYPLAPHGLPGHLVGFVEALRGSGISVGPSETVDAGRVMAA
MAV_1749|M.avium_104 MATRR-IRPSRPLAPHGLPGHLVGFVEALRGAGISVGPSETVDAGRVMAT
Mvan_3932|M.vanbaalenii_PYR-1 MPPRR-TRPPQPLAPHGIPGHLVEFVEALRGQGISVGPSETVDAGQVMAT
Mflv_2646|M.gilvum_PYR-GCK MPPRR-TRPPQPPAPHGIPGHLVEFVEALRKQGIAVGPSETVDAGQVMAT
MSMEG_4582|M.smegmatis_MC2_155 MAPRR-VRPPQPLAPHGLPGHLVEFVEALRGQGISVGPSETVDAGRVLTV
TH_0790|M.thermoresistible__bu MAVRR-TRPPQPLAPHGIPGHLVEFIEALRAQGIYVGPSETVDAGRVVSV
MAB_1620|M.abscessus_ATCC_1997 MPPRKPPKAVLPLAPHGLPGHLVGFVEALREQGISVGPSETVDAGRVMTV
*. *: :. * ****:***** *:**** ** **********:*::.
Mb2449c|M.bovis_AF2122/97 LGLGDREVLREGIACAVLRRPDHRDTYDAMFDLWFPAALGARAVITTEDE
Rv2425c|M.tuberculosis_H37Rv LGLGDREVLREGIACAVLRRPDHRDTYDAMFDLWFPAALGARAVITTEDE
MMAR_3751|M.marinum_M LGFEDREVLREGIACAVLRRPDHRDTYDAMFDLWFPAALGARAVIT-EEQ
MUL_3694|M.ulcerans_Agy99 LGFEDREVLREGIACAVLRRPDHRDTYDAMFDLWFPAALGARAVIT-EEQ
MAV_1749|M.avium_104 LGLGNREVLREGLACAVLRRPDHRETYDAMFDLWFPAALGARAVVTDEDA
Mvan_3932|M.vanbaalenii_PYR-1 LGLADRDVLREGLACAVLRRSDHRETYDALFDLYFPAALGSRTVLDDE--
Mflv_2646|M.gilvum_PYR-GCK LGLSDRNVLREGLACAVLRRSDHRETYDALFDLYFPAALGAKTVLDDD--
MSMEG_4582|M.smegmatis_MC2_155 LGLGNREALREGIACAVLRRADHRDTYDALFDLFFPAALGARTVLDDESD
TH_0790|M.thermoresistible__bu LGLGDREVLREGIACAVLRRPDHRDTYDALFDLYFPAALGARTVLDE---
MAB_1620|M.abscessus_ATCC_1997 LGLQSRSELREGLACAVLRRADHRPTFDVLFDLWFPPALGARFVEVGEE-
**: .*. ****:*******.*** *:*.:***:**.***:: *
Mb2449c|M.bovis_AF2122/97 SA---GSG--GLPPDDVEAMRQLLLDLLANNQDLAGKDERLVEMIARIVE
Rv2425c|M.tuberculosis_H37Rv SA---GSG--GLPPDDVEAMRQLLLDLLANNQDLAGKDERLVEMIARIVE
MMAR_3751|M.marinum_M AG---QSE--GLPPDDVEAMRQLLLDLLTDNPDLADMDQRLVGMIARIVE
MUL_3694|M.ulcerans_Agy99 AG---QSE--GLPPDDVEAMRQMLLDLLTDNPDLADMDQRLVGMIARIVE
MAV_1749|M.avium_104 GP---GSGEDALPPDDVEAMREMLLDLLTENPDLADMDERLVAMIARIVE
Mvan_3932|M.vanbaalenii_PYR-1 -----SDGESGLPPEDIEAMRQALLDMLTDNEELANLDERLAAMIAQIVE
Mflv_2646|M.gilvum_PYR-GCK -----EDGE-GLPPEDIEALRSALVDLLADNEELANIDERLAAMIAQIVE
MSMEG_4582|M.smegmatis_MC2_155 ADGEGTGKTPQLPPEDIEAMREMLVQMLADNEELANLDDRLATLIAQIVE
TH_0790|M.thermoresistible__bu -DGEPT-DDPGLPAEDIEAMRAALLDLLADNEELANLDERLAMMIAKIVE
MAB_1620|M.abscessus_ATCC_1997 ----------GIDIDDIEQVRDELVDLLASDAG----DLPLNSLIAQIVE
: :*:* :* *:::*:.: * * :**:***
Mb2449c|M.bovis_AF2122/97 AYGKYSSSRGPSFSSYQALKAMALDELEGKLLAGLLAPYGDEP--TATQE
Rv2425c|M.tuberculosis_H37Rv AYGKYSSSRGPSFSSYQALKAMALDELEGKLLAGLLAPYGDEP--TATQE
MMAR_3751|M.marinum_M TYGKYNSSRGPSFSSYQALKAMALDELEGKLLAGLLAPYGDEP--TPTQE
MUL_3694|M.ulcerans_Agy99 TYGKYNSSQGPSFSSYQALKAMALDELEGKLLAGLLAPYGDEL--TPTQE
MAV_1749|M.avium_104 AYGKYSSSRGPSFSSYQALKAMALDELEGKLLAGLLAPYGDEP--TPTQE
Mvan_3932|M.vanbaalenii_PYR-1 AYGRYNSSRGPSYSSYQALKAMSLDDLEGRLLAGLLAPYGDEP--TPTQE
Mflv_2646|M.gilvum_PYR-GCK AYGRYNSSRGPSYSSYQALKAMSLDDLEGRLLAGLLAPYGDEP--TPTQE
MSMEG_4582|M.smegmatis_MC2_155 AYGRYTSSRGPSYSSYQALKAMSLDDLEGRLLAGLLAPYGDEP--MPTQE
TH_0790|M.thermoresistible__bu AYGRYNSSRGPSYSSYQALKAMALDDLEGRLLAGLLAPYGDEP--TPSQE
MAB_1620|M.abscessus_ATCC_1997 AYGKYNSTRGTSYSAYQAMKSLSLDQIEAKLLTGLLGGGDEDSPVSPTDQ
:**:*.*::*.*:*:***:*:::**::*.:**:***. .:: .:::
Mb2449c|M.bovis_AF2122/97 QIAKALAAQKIAQLRRMVDAETKRRTAEQLGREHVQMYGIPQLSENVEFL
Rv2425c|M.tuberculosis_H37Rv QIAKALAAQKIAQLRRMVDAETKRRTAEQLGREHVQMYGIPQLSENVEFL
MMAR_3751|M.marinum_M QIAKAIAAQRVSQLRKMVDAETKRRTAEQLGRDHVQMYGIPQLSENVEFL
MUL_3694|M.ulcerans_Agy99 QIAKAIAAQRVSQLRKMVDAETKRRTAEQLGRDHVQMYGIPQLSENVEFL
MAV_1749|M.avium_104 EIAKALAAQRITQLRKLVDAETKRRTAEQLGRDHVQMYGIPQLSENVEFL
Mvan_3932|M.vanbaalenii_PYR-1 QIAKAVAAQRIAALRKMVESETKRRTAEQLGRDHVQMYGVPQLAENVEFL
Mflv_2646|M.gilvum_PYR-GCK QIAKAIAAQRIAQLRKMVEGETKRRTAEQLGRDHVQMYGVPQLSENVEFL
MSMEG_4582|M.smegmatis_MC2_155 EIAKALAAQRIAQLRKMVENETKRRTAEQLGRGHVQMYGVPQLSENVEFL
TH_0790|M.thermoresistible__bu QIAKAIAAQRILQLKQMVEAETKRRTAEQLGREHVQMYGVPQLAENVEFL
MAB_1620|M.abscessus_ATCC_1997 AVAKAIAKERISKVRQLVEAETKRRTAEQLGRERVTAYGVPQLAENVEFL
:***:* ::: ::::*: ************ :* **:***:******
Mb2449c|M.bovis_AF2122/97 RASGEQLRQMRRVVAPLARTLATRLAARRRRARAGSIDLRKTLRKSMSTG
Rv2425c|M.tuberculosis_H37Rv RASGEQLRQMRRVVAPLARTLATRLAARRRRARAGSIDLRKTLRKSMSTG
MMAR_3751|M.marinum_M RASGEQLRQMRRVVAPLARTLATRLAARRRRARAGSIDLRKTLRKSMSTG
MUL_3694|M.ulcerans_Agy99 RASGEQLRQMRRVVAPLARTLATRLAARRRRARAGSIDLRKTLRKSMSTG
MAV_1749|M.avium_104 RASGEQLRQMQRVVAPLARTLATRLAARRRRSRAGTIDLRKTLRKSMSTG
Mvan_3932|M.vanbaalenii_PYR-1 RASGEQLRQMRRVVGPLARTLATRLAARRRRSRAGEIDLRKTLRKSMSTG
Mflv_2646|M.gilvum_PYR-GCK RASGEQLRQMRRVVGPLARTLATRLAARRRRSRAGEIDLRKTLRKSMSTG
MSMEG_4582|M.smegmatis_MC2_155 RASGEQLRQMRKTVQPLARTLATRLAARRRRARAGEIDLRKTLRKSMSTG
TH_0790|M.thermoresistible__bu RASGEQLRQMQRVVAPLARMLATRLAARRRRARAGEIDLRKTLRRSMSTG
MAB_1620|M.abscessus_ATCC_1997 RASGEQLRNMRRVVHPLARMLASRLAARRRRAHTGQIDLRRTLRKSMSTG
********:*::.* **** **:********:::* ****:***:*****
Mb2449c|M.bovis_AF2122/97 GVPIDLVLHKPRPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFSRVR
Rv2425c|M.tuberculosis_H37Rv GVPIDLVLHKPRPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFSRVR
MMAR_3751|M.marinum_M GVPIDVVLRKPRPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFSRVR
MUL_3694|M.ulcerans_Agy99 GVPIDVVLRKPRPARPELVVLCDVSGSVAGFSHFTLLLVHALRRQFSRVR
MAV_1749|M.avium_104 GVPIDVVLAKPRPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFSRVR
Mvan_3932|M.vanbaalenii_PYR-1 GVPIDLVLKKPHPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFSRVR
Mflv_2646|M.gilvum_PYR-GCK GVPIDVVLKKPHPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFSRVR
MSMEG_4582|M.smegmatis_MC2_155 GVPIDVVLKKPHPARPELAVLCDVSGSVAGFSHFTLMLVSALRQQFSRVR
TH_0790|M.thermoresistible__bu GVPIDLVLKKPHPARPELAVLCDVSGSVAGFSHFTLMLVHALRQQFSRVR
MAB_1620|M.abscessus_ATCC_1997 GVPIDVVQKKPRPARPELVVLCDVSGSVAGFSHFTLLLVNALRQQFSRVR
*****:* **:******.*****************:** ***:******
Mb2449c|M.bovis_AF2122/97 VFAFIDSTDEVTHMFGPESDLAIAIQRITREAGVYARDGHSDYGNAFVSF
Rv2425c|M.tuberculosis_H37Rv VFAFIDSTDEVTHMFGPESDLAIAIQRITREAGVYARDGHSDYGNAFVSF
MMAR_3751|M.marinum_M VFAFIDTTDEVTHMFGPDADLAVAIQRITREAGVYSRDGHSDYGNAFVSF
MUL_3694|M.ulcerans_Agy99 VFAFIDTTDEVTHMFGPDADLAVAIQRITREAGVYSRDGHSDYGNAFVSF
MAV_1749|M.avium_104 VFAFIDTTDEVTHMFGPEADLAVAIQRITREAGVYSRDGHSDYGNAFASF
Mvan_3932|M.vanbaalenii_PYR-1 VFAFIDTTDEVTELFGPDADLAVAVQRITREAAVYTRDGHSDYGHAFVSF
Mflv_2646|M.gilvum_PYR-GCK VFAFIDTTDEVTELFGPDSDLAVAVQRITREAAVFTRDGHSDYGHAFVSF
MSMEG_4582|M.smegmatis_MC2_155 VFAFIDTTDEVTDLFGPEADLAVAVQRITREAGVYTRDGHSDYGHAFVSF
TH_0790|M.thermoresistible__bu VFAFIDTTDEVTDLFGPDADLAVAVQRITREAEVFTRDGHSDYGHAFVSF
MAB_1620|M.abscessus_ATCC_1997 VFAFIDTTDEVTHLFTPDTDLAEAIVRITREAQVFTGDGHSDYGHAFKTF
******:*****.:* *::*** *: ****** *:: *******:** :*
Mb2449c|M.bovis_AF2122/97 MQGFPNVLSPRSSLLVLGDGRTNYRNPATDVLADMVTASRHAHWLNPEPK
Rv2425c|M.tuberculosis_H37Rv MQGFPNVLSPRSSLLVLGDGRTNYRNPATDVLADMVTASRHAHWLNPEPK
MMAR_3751|M.marinum_M MQGFPNVLSPRSSLLVLGDGRTNYRNPATDVLADMVTASRHAHWLNPEPQ
MUL_3694|M.ulcerans_Agy99 MQGFPNVLSPRSSLLVLGDGRTNYRNPATDVLADMVTASRHAHWLNPEPQ
MAV_1749|M.avium_104 EQKFPNVLSPRTSLLVLGDGRTNYRNPEVELLSHMVTASRHAHWLNPEPK
Mvan_3932|M.vanbaalenii_PYR-1 LDKFPNVLSPRSSLLVLGDGRNNYRNPEAHLLAHMVNASRHAHWLNPEPR
Mflv_2646|M.gilvum_PYR-GCK LDKFPNVLSPRSSLLVLGDGRNNYRNPETDLLAHMVNAARHAHWLNPEPK
MSMEG_4582|M.smegmatis_MC2_155 LDKYPNALSPRSSLLVLGDGRNNYRNPEAELLAHMVAASRHAHWLNPEPR
TH_0790|M.thermoresistible__bu LDKYPNALSPRSSLLILGDGRNNYRNPELELLERMVDASRHAHWLNPEPR
MAB_1620|M.abscessus_ATCC_1997 VEKFPTVLSPRSALLILGDGRTNYRNPAVEVLSSMVSSSRHAHWLNPEPK
: :*..****::**:*****.***** .:* ** ::**********:
Mb2449c|M.bovis_AF2122/97 HLWGSGDSAVPRYQEVITMHECRSAKQLATVIDQLLPV
Rv2425c|M.tuberculosis_H37Rv HLWGSGDSAVPRYQEVITMHECRSAKQLATVIDQLLPV
MMAR_3751|M.marinum_M HLWGSGDSAVPRYQEVIAMHECRSAKQLATVIDELLPV
MUL_3694|M.ulcerans_Agy99 HLWGSGDSAVPRYQEVIAMHECRSAKQLATVIDELLPV
MAV_1749|M.avium_104 HLWGSGDSAVPRYQQVIPMHECRSAKQLAAVIDQLLPV
Mvan_3932|M.vanbaalenii_PYR-1 HLWGSGDSAVPRYQDVITMHECRSAKQLASVIDALLPV
Mflv_2646|M.gilvum_PYR-GCK HLWGSGDSAVPRYQDVITMHECRSAKQLASVIDALLPV
MSMEG_4582|M.smegmatis_MC2_155 HLWGSGDSAVPKYQDIIPMHECRSAKQLAAVIDGLLPV
TH_0790|M.thermoresistible__bu HLWGSGDSAVPRYSEVITMHECRSAKQLAAVIDQLLPV
MAB_1620|M.abscessus_ATCC_1997 NHWGTGDSAAKRYQDAITMHECRSAKQLAAVIDNLLPV
: **:****. :*.: *.***********:*** ****