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MTAPLLLRGVDLAALAVALVDRLRAAGVAVSAVGPSTLVAAMHVVAPVRRSQLYWAARLTLVSRAEDLPA FDGVFDAVFSDAVLGVDPPNLKRSQAPPGIPGQQYANGADSGESGDELPWTTRPASITAAAHPPAGSAIP DRAPSWLAGRTDESFDQFDQDDLHRLGTWLQGAEAHWPRRRTLRHRRHPSGRRIDLRETIRASRTTGWEP VRLARTRRRTRPRRVVLVCDVSGSMQPYAVVYLHLMRAAAVSRRGAAHPEVFAFATTLTRLTAALSHRSP EVAVTRANAKVHDRYGGTRLGRSIAALLAAPHGNLLRGAVVVIASDGWDADAPEVLRHAMSRLRRRAHLV VWLNPRAAAPGYEPLAGAMAAALPYCDHFLPAHTLTGLRELFDVLGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0751 | - | - | 100% (397) | hypothetical protein MSMEG_0751 |
| M. smegmatis MC2 155 | MSMEG_4582 | - | 2e-10 | 27.60% (221) | hypothetical protein MSMEG_4582 |
| M. smegmatis MC2 155 | MSMEG_6240 | - | 4e-08 | 26.00% (250) | hypothetical protein MSMEG_6240 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0375c | - | 1e-123 | 57.14% (399) | hypothetical protein Mb0375c |
| M. gilvum PYR-GCK | Mflv_2646 | - | 3e-10 | 28.57% (224) | VWA containing CoxE family protein |
| M. tuberculosis H37Rv | Rv0368c | - | 1e-122 | 57.14% (399) | hypothetical protein Rv0368c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1620 | - | 2e-08 | 30.60% (183) | hypothetical protein MAB_1620 |
| M. marinum M | MMAR_0662 | - | 1e-128 | 60.85% (401) | von Willebrand factor type A domain-containing protein |
| M. avium 104 | MAV_1749 | - | 3e-11 | 29.41% (221) | hypothetical protein MAV_1749 |
| M. thermoresistible (build 8) | TH_1639 | - | 1e-105 | 66.90% (284) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0110 | - | 1e-125 | 60.10% (401) | von Willebrand factor type A domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3932 | - | 3e-10 | 29.46% (224) | VWA containing CoxE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0375c|M.bovis_AF2122/97 ------MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQ
Rv0368c|M.tuberculosis_H37Rv ------MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQ
MMAR_0662|M.marinum_M ------MTAPLLLRGVDLAAFAAALVARLRGVGVLVSASGQANFVQAMRQ
MUL_0110|M.ulcerans_Agy99 ------MTAPLLLRGVDLAAFAAALVARLRGVGVLVSASGQANFVQAMRQ
TH_1639|M.thermoresistible__bu -----------------------------------VDAEG----------
MSMEG_0751|M.smegmatis_MC2_155 ------MTAPLLLRGVDLAALAVALVDRLRAAGVAVSAVGPSTLVAAMHV
Mflv_2646|M.gilvum_PYR-GCK MPPRR-TRPPQPPAPHGIPGHLVEFVEALRKQGIAVGPSETVDAGQVMAT
Mvan_3932|M.vanbaalenii_PYR-1 MPPRR-TRPPQPLAPHGIPGHLVEFVEALRGQGISVGPSETVDAGQVMAT
MAV_1749|M.avium_104 MATRR-IRPSRPLAPHGLPGHLVGFVEALRGAGISVGPSETVDAGRVMAT
MAB_1620|M.abscessus_ATCC_1997 MPPRKPPKAVLPLAPHGLPGHLVGFVEALREQGISVGPSETVDAGRVMTV
*..
Mb0375c|M.bovis_AF2122/97 LVPRTPAALYWGARLTLVSRVDELATFDAVFASLFGVFGSAEPDGANRPP
Rv0368c|M.tuberculosis_H37Rv LVPRTPAALYWGARLTLVSRVDELATFDAVFASLFGVFGSAEPDGANRPP
MMAR_0662|M.marinum_M LVPDSRSALYWAARLTLVNRMEDLVAFDLAFAAVFGALDAAGPEAADAAR
MUL_0110|M.ulcerans_Agy99 LVPDSRSALYWAARLTLVNRMEDLVAFDLAFAAVFGALDAAGPEAADAAR
TH_1639|M.thermoresistible__bu --------LPWATRPATVT--------------------ASADTGADTPT
MSMEG_0751|M.smegmatis_MC2_155 VAPVRRSQLYWAARLTLVSRAEDLPAFDGVFDAVF----SDAVLGVDPPN
Mflv_2646|M.gilvum_PYR-GCK LGLSDRNVLREGLACAVLRRSDHRETYDALFDLYFPAALGAKTVLDDDE-
Mvan_3932|M.vanbaalenii_PYR-1 LGLADRDVLREGLACAVLRRSDHRETYDALFDLYFPAALGSRTVLDDES-
MAV_1749|M.avium_104 LGLGNREVLREGLACAVLRRPDHRETYDAMFDLWFPAALGARAVVTDEDA
MAB_1620|M.abscessus_ATCC_1997 LGLQSRSELREGLACAVLRRADHRPTFDVLFDLWFPPALGARFVEVGEE-
* . : : . .
Mb0375c|M.bovis_AF2122/97 P---------------------------------------------PIAG
Rv0368c|M.tuberculosis_H37Rv P---------------------------------------------PIAG
MMAR_0662|M.marinum_M ----------------------------------------------PLPG
MUL_0110|M.ulcerans_Agy99 ----------------------------------------------PLPG
TH_1639|M.thermoresistible__bu --------------------------------------------------
MSMEG_0751|M.smegmatis_MC2_155 L---------------------------------------------KRSQ
Mflv_2646|M.gilvum_PYR-GCK ---DGE-GLPPEDIEALRSALVDLLADNEELANIDERLAAMIAQIVEAYG
Mvan_3932|M.vanbaalenii_PYR-1 ---DGESGLPPEDIEAMRQALLDMLTDNEELANLDERLAAMIAQIVEAYG
MAV_1749|M.avium_104 GPGSGEDALPPDDVEAMREMLLDLLTENPDLADMDERLVAMIARIVEAYG
MAB_1620|M.abscessus_ATCC_1997 -------GIDIDDIEQVRDELVDLLASDAG----DLPLNSLIAQIVEAYG
Mb0375c|M.bovis_AF2122/97 PRTPVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPSRTLPDVLP
Rv0368c|M.tuberculosis_H37Rv PRTPVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPSRTLPDVLP
MMAR_0662|M.marinum_M PKTPAAGIVHRNGGPSGAAGGQPLPWASR--IGDQDGSVRPSIQLPDLLP
MUL_0110|M.ulcerans_Agy99 PKTPAAGIVHRNGGPSGAAGGQPLPWASR--VGDQDGSVRPSIQLPDLLP
TH_1639|M.thermoresistible__bu -------------------------------------------RLPDLLP
MSMEG_0751|M.smegmatis_MC2_155 APPGIPGQQYANGADSGESGDE-LPWTTRPASITAAAHPPAGSAIPDRAP
Mflv_2646|M.gilvum_PYR-GCK RYNSSRGPSYSSYQALKAMSLDDLEGRLLAGLLAPYGDEP--TPTQEQIA
Mvan_3932|M.vanbaalenii_PYR-1 RYNSSRGPSYSSYQALKAMSLDDLEGRLLAGLLAPYGDEP--TPTQEQIA
MAV_1749|M.avium_104 KYSSSRGPSFSSYQALKAMALDELEGKLLAGLLAPYGDEP--TPTQEEIA
MAB_1620|M.abscessus_ATCC_1997 KYNSTRGTSYSAYQAMKSLSLDQIEAKLLTGLLGGGDEDSPVSPTDQAVA
: .
Mb0375c|M.bovis_AF2122/97 SRIVAR-----------------------------------ADEPFDQFD
Rv0368c|M.tuberculosis_H37Rv SRIVAR-----------------------------------ADEPFDQFD
MMAR_0662|M.marinum_M SRIAAL-----------------------------------AEEPFDQFD
MUL_0110|M.ulcerans_Agy99 SRIAAL-----------------------------------AEEPFDQFD
TH_1639|M.thermoresistible__bu SHITAR-----------------------------------ADEPFERFD
MSMEG_0751|M.smegmatis_MC2_155 SWLAGR-----------------------------------TDESFDQFD
Mflv_2646|M.gilvum_PYR-GCK KAIAAQRIAQLRKMVEGETKRRTAEQLGRDHVQMYGVPQLSENVEFLRAS
Mvan_3932|M.vanbaalenii_PYR-1 KAVAAQRIAALRKMVESETKRRTAEQLGRDHVQMYGVPQLAENVEFLRAS
MAV_1749|M.avium_104 KALAAQRITQLRKLVDAETKRRTAEQLGRDHVQMYGIPQLSENVEFLRAS
MAB_1620|M.abscessus_ATCC_1997 KAIAKERISKVRQLVEAETKRRTAEQLGRERVTAYGVPQLAENVEFLRAS
. :. : * : .
Mb0375c|M.bovis_AF2122/97 PDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWE
Rv0368c|M.tuberculosis_H37Rv PDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWE
MMAR_0662|M.marinum_M AEDLRRIGGWLESTVARWPRRRSLRFESSPHGKRIDLRATMNASRVTGWE
MUL_0110|M.ulcerans_Agy99 AEDLRRIGGWLESTVARWPRRRSLRFESSPHGKRIDLRATMNASRATGWE
TH_1639|M.thermoresistible__bu PDDLRLLGGWLEQAVAHWPRRRSLRRENHPHGKRIDLRETLRASRRTGFE
MSMEG_0751|M.smegmatis_MC2_155 QDDLHRLGTWLQGAEAHWPRRRTLRHRRHPSGRRIDLRETIRASRTTGWE
Mflv_2646|M.gilvum_PYR-GCK GEQLRQMRRVVGPLARTLATRLAARRRRSRAG-EIDLRKTLRKSMSTGGV
Mvan_3932|M.vanbaalenii_PYR-1 GEQLRQMRRVVGPLARTLATRLAARRRRSRAG-EIDLRKTLRKSMSTGGV
MAV_1749|M.avium_104 GEQLRQMQRVVAPLARTLATRLAARRRRSRAG-TIDLRKTLRKSMSTGGV
MAB_1620|M.abscessus_ATCC_1997 GEQLRNMRRVVHPLARMLASRLAARRRRAHTG-QIDLRRTLRKSMSTGGV
::*: : : . * : * . * **** *:. * **
Mb0375c|M.bovis_AF2122/97 SVLLARIRPRRRPRRVLLLCDVSRSMQPYAAIYLHLMRAAVLRR-----A
Rv0368c|M.tuberculosis_H37Rv SVLLARIRPRRRPRRVLLLCDVSRSMQPYAAIYLRLMRAAVLRR-----A
MMAR_0662|M.marinum_M AVRLARIRPRRRPRRVVLLCDVSRSMQPYAAIYLHLMRALVARQ-----P
MUL_0110|M.ulcerans_Agy99 AVRLARIRPRRRPRRVVLLCDVSRSMQPYAAIYLHLMRALVARQ-----P
TH_1639|M.thermoresistible__bu TLRLARTRPRRRDRPVVLICDVSRSMQPYTTVYLHLMRAAALHRNSRRRS
MSMEG_0751|M.smegmatis_MC2_155 PVRLARTRRRTRPRRVVLVCDVSGSMQPYAVVYLHLMRAAAVSR----RG
Mflv_2646|M.gilvum_PYR-GCK PIDVVLKKPHPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFS-----
Mvan_3932|M.vanbaalenii_PYR-1 PIDLVLKKPHPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFS-----
MAV_1749|M.avium_104 PIDVVLAKPRPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFS-----
MAB_1620|M.abscessus_ATCC_1997 PIDVVQKKPRPARPELVVLCDVSGSVAGFSHFTLLLVNALRQQFS-----
.: :. : : ::::**** *: :: . * *:.*
Mb0375c|M.bovis_AF2122/97 GGHPEVFAFSTSLTRLTSVLSHR---SAEMALHRANARVTDRYGGTFIGR
Rv0368c|M.tuberculosis_H37Rv GGHPEVFAFSTSLTRLTSVLSHR---SAEMALHRANARVTDRYGGTFIGR
MMAR_0662|M.marinum_M GIRPEVFAFSTSLTRLTPVLAHR---SAEVALDRANAKVADRYGGTFIGR
MUL_0110|M.ulcerans_Agy99 GIRPEVFAFSTSLTRLTPVLAHR---SAEVALDRANAKVADRYGGTFIGR
TH_1639|M.thermoresistible__bu GIRPEVFAFSTRLTRLTAVLAHR---SPEVARDRADAKVVDRYGGTHLGR
MSMEG_0751|M.smegmatis_MC2_155 AAHPEVFAFATTLTRLTAALSHR---SPEVAVTRANAKVHDRYGGTRLGR
Mflv_2646|M.gilvum_PYR-GCK --RVRVFAFIDTTDEVTELFGPDSDLAVAVQRITREAAVFTRDGHSDYGH
Mvan_3932|M.vanbaalenii_PYR-1 --RVRVFAFIDTTDEVTELFGPDADLAVAVQRITREAAVYTRDGHSDYGH
MAV_1749|M.avium_104 --RVRVFAFIDTTDEVTHMFGPEADLAVAIQRITREAGVYSRDGHSDYGN
MAB_1620|M.abscessus_ATCC_1997 --RVRVFAFIDTTDEVTHLFTPDTDLAEAIVRITREAQVFTGDGHSDYGH
: .**** .:* : : : :* * * : *.
Mb0375c|M.bovis_AF2122/97 SVAALLAPPHGNALRGAVVIIASDGWDSDPPDVLVHALTRVRRRAELLVW
Rv0368c|M.tuberculosis_H37Rv SVAALLAPPHGNALRGAVVIIASDGWDSDPPDVLVHALTRVRRRAELLVW
MMAR_0662|M.marinum_M SVGALLEAPHGNALRGAVVIIASDGWDSEAPEVLCHALARVRRRAQLLVW
MUL_0110|M.ulcerans_Agy99 SVGALLEPPHGNALRGAVVIIASDGWDSEAPKVLCHALARVRRRAQLLVC
TH_1639|M.thermoresistible__bu SLAELLASPHGNALRGAVVIIASDGWDSDPPELLGHTMARLRRRAQRVVW
MSMEG_0751|M.smegmatis_MC2_155 SIAALLAAPHGNLLRGAVVVIASDGWDADAPEVLRHAMSRLRRRAHLVVW
Mflv_2646|M.gilvum_PYR-GCK AFVSFLDKFPNVLSPRSSLLVLGDGR-NNYRNPETDLLAHMVNAARHAHW
Mvan_3932|M.vanbaalenii_PYR-1 AFVSFLDKFPNVLSPRSSLLVLGDGR-NNYRNPEAHLLAHMVNASRHAHW
MAV_1749|M.avium_104 AFASFEQKFPNVLSPRTSLLVLGDGR-TNYRNPEVELLSHMVTASRHAHW
MAB_1620|M.abscessus_ATCC_1997 AFKTFVEKFPTVLSPRSALLILGDGR-TNYRNPAVEVLSSMVSSSRHAHW
:. : : ::: .** : . . :: : :.
Mb0375c|M.bovis_AF2122/97 LNPRAAHPEFQPRASSMAAALPYCDLFLPAHSLAGLHQLLLALAGAR--
Rv0368c|M.tuberculosis_H37Rv LNPRAAHPEFQPRAGSMAAALPYCDLFLPAHSLAGLHQLLLALAGAR--
MMAR_0662|M.marinum_M LNPRAAQSDFEPLTGSMAAALPYCDLFLPAHSLTGVQQLLRALGGDLR-
MUL_0110|M.ulcerans_Agy99 LNPRAAQSDFEPLTGSMAAALPYCDLFLPAHSLTGVQQLLRALGGDLR-
TH_1639|M.thermoresistible__bu LNPRAGRPGFAPLTGAMAAALPYCDAMLPAHSLTALHEVFVTLANQ---
MSMEG_0751|M.smegmatis_MC2_155 LNPRAAAPGYEPLAGAMAAALPYCDHFLPAHTLTGLRELFDVLGA----
Mflv_2646|M.gilvum_PYR-GCK LNPEPKH-----LWGSGDSAVPRYQDVITMHECRSAKQLASVIDALLPV
Mvan_3932|M.vanbaalenii_PYR-1 LNPEPRH-----LWGSGDSAVPRYQDVITMHECRSAKQLASVIDALLPV
MAV_1749|M.avium_104 LNPEPKH-----LWGSGDSAVPRYQQVIPMHECRSAKQLAAVIDQLLPV
MAB_1620|M.abscessus_ATCC_1997 LNPEPKN-----HWGTGDSAAKRYQDAITMHECRSAKQLAAVIDNLLPV
***.. .: :* : :. * . ::: .: