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MGAIGKSKQSTARRGVGAMRAVSRRAWQGLALLMVALVLSSCGWRGISNVAIPGAPGTGKGSYTVYVQVP DTLAINGNSKVMVADVPVGSIRNIQLKNWVATLTLGIDQGVKLPKNALAKIGQTSLLGSQHVELAAPPNP SSQLLKNGDTIPLKNSSAYPNTEQTLASISLILRGGGIPNLEVLQNEVYDIFHGRGDQIRGFLTRLDTFT RQLNEQRDDITHAIDSTNRLMAYVGGRADVVDRALTDLPPLIKHFADTRDLLINAVNSVGQLSDVTGRYL SEARGNLHTDLQSLQCPLKELGRGSQYLIGALKLILTQPFDIDAVPKIFRGDYQNVSAALDVTFSAMDNA VLTGTGFSGALRALEQSFGLDPETMIPDVRYTPNPNDAPGGPLVERGDRQC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1066 | lprK | - | 100% (401) | MCE family lipoprotein LprK |
| M. ulcerans Agy99 | MUL_2866 | lprM | 1e-70 | 38.83% (376) | MCE family lipoprotein LprM |
| M. ulcerans Agy99 | MUL_3922 | lprM_1 | 7e-61 | 37.03% (343) | MCE family lipoprotein LprM |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 1e-168 | 75.46% (383) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0707 | - | 1e-129 | 58.53% (381) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0173 | lprK | 1e-168 | 75.46% (383) | MCE-family lipoprotein LprK |
| M. leprae Br4923 | MLBr_02593 | lprK | 1e-179 | 79.47% (380) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 1e-55 | 35.76% (344) | MCE-family protein LprN |
| M. marinum M | MMAR_0416 | lprK | 0.0 | 99.25% (401) | MCE family lipoprotein LprK |
| M. avium 104 | MAV_5011 | - | 0.0 | 80.83% (386) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0138 | - | 1e-138 | 63.47% (386) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2780 | - | 1e-133 | 60.00% (380) | PUTATIVE virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0138 | - | 1e-131 | 60.48% (377) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0707|M.gilvum_PYR-GCK -------------------------MS--RLGTLAKRAVALGAAALVLTS
Mvan_0138|M.vanbaalenii_PYR-1 -------------------------MG--KWTRLARRTVALAAAAVVLTS
TH_2780|M.thermoresistible__bu ---------------VTTVTTVTTVKR--TVTRATRRSLALLTIALVLTA
MSMEG_0138|M.smegmatis_MC2_155 ----------------MRLLKGFPKMR--NWTRVGRRTAVLAAVALVLTS
Mb0179|M.bovis_AF2122/97 ------------------MMSVLARMR--VMRHRAWQGLVLLVLALLLSS
Rv0173|M.tuberculosis_H37Rv ------------------MMSVLARMR--VMRHRAWQGLVLLVLALLLSS
MUL_1066|M.ulcerans_Agy99 -------MGAIGKSKQSTARRGVGAMR--AVSRRAWQGLALLMVALVLSS
MMAR_0416|M.marinum_M MRRGVSVMGAIGKSKQSAARRGVGAMR--AVSRRAWQGLALLMVALVLSS
MLBr_02593|M.leprae_Br4923 ------------------MRRAMSVVHTSRVRHQTWRGLVMLVAALLLSS
MAV_5011|M.avium_104 ----------------------MGALR--VIRRRSWQGLTLLVAAMVLTS
MAB_4149c|M.abscessus_ATCC_199 ------------------------------MSRNVLRAAVMGVGVAVVVS
: .: . :: :
Mflv_0707|M.gilvum_PYR-GCK CGSWKGIANIPLPGGPGTGSERTTIYVQMPDTLALNVNSRVRVADVYVGR
Mvan_0138|M.vanbaalenii_PYR-1 CGSWKGISNVPLPGGPGSGSERTTIYVQMPDTLALNVNSRVRVADVYVGR
TH_2780|M.thermoresistible__bu CGSWRGIANVPLPSGPGTGG-GMTIYVQMPDTLALNVNSRVRVADVEVGT
MSMEG_0138|M.smegmatis_MC2_155 CGQWRGIANVPLPGGPGTESGSMTLYVQMPETLALNANSRVRVRDVFVGR
Mb0179|M.bovis_AF2122/97 CG-WRGISNVAIPGGPGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGS
Rv0173|M.tuberculosis_H37Rv CG-WRGISNVAIPGGPGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGS
MUL_1066|M.ulcerans_Agy99 CG-WRGISNVAIPGAPGTGKGSYTVYVQVPDTLAINGNSKVMVADVPVGS
MMAR_0416|M.marinum_M CG-WRGISNVAIPGAPGTGKGSYTVYVQVPDTLAINGNSKVMVADVPVGS
MLBr_02593|M.leprae_Br4923 CG-WRGISNVSIPGGPGSGKGAYTIYVQVPDTLAINGNSKVMVADVTVGS
MAV_5011|M.avium_104 CG-WKGISNVSIPGGPGSGPNSYNIYVQVPDTLAINGNSKVMVADVFVGS
MAB_4149c|M.abscessus_ATCC_199 GCQFNGLNSLNLPGTAGHGSRSYTVTVELPDVTTLPQNSPVMVDDVTVGS
:.*: .: :*. .* .: *::*:. :: ** * * ** **
Mflv_0707|M.gilvum_PYR-GCK VRAIELRN-----WVATLTLDLEPNIALPVNTQAKIGQTSLLGSQHVQLD
Mvan_0138|M.vanbaalenii_PYR-1 VRAIELKN-----WIATLTLDLEPSVQLPVNTLARIGQTSLLGSQHVQLD
TH_2780|M.thermoresistible__bu VRRIELRD-----WTPVLTLALEPGIELPTNTIARIGQTSLLGSQHVELD
MSMEG_0138|M.smegmatis_MC2_155 VRKIELIN-----WVPTLTVDVEPGIKLPKNTLAKIGQTSLLGSQHVELN
Mb0179|M.bovis_AF2122/97 IRAIKLKN-----WVATLTLSLKKDVTLPKNATAKIGQTSLLGSQHVELA
Rv0173|M.tuberculosis_H37Rv IRAIKLKN-----WVATLTLSLKKDVTLPKNATAKIGQTSLLGSQHVELA
MUL_1066|M.ulcerans_Agy99 IRNIQLKN-----WVATLTLGIDQGVKLPKNALAKIGQTSLLGSQHVELA
MMAR_0416|M.marinum_M IRNIQLKN-----WVATLTLGIDQGVKLPKNALAKIGQTSLLGSQHVELA
MLBr_02593|M.leprae_Br4923 IRAINLKN-----WVATLTLGLNKDVQLPKNTTAKIGQTSLLGSQHVELA
MAV_5011|M.avium_104 IKAIQLKN-----WIATLTLGINKNVKLPKNATAKIGQTSLLGSQHVELA
MAB_4149c|M.abscessus_ATCC_199 VSGIDAFQKPDGSWYAGVKVSLEPEVHLPANAVAKVAQTSLLGSQHIELA
: *. : * . :.: :. : ** *: *::.*********::*
Mflv_0707|M.gilvum_PYR-GCK LPP-DPSPQRLESGDTITLENASAFPTTERVLASIASILTGGGVANLETI
Mvan_0138|M.vanbaalenii_PYR-1 LPP-DPSPQKLKSGDVIPLANASAFPTTERVLASISSILTGGGVANLETI
TH_2780|M.thermoresistible__bu PPD-DPSQQMLRDGDTIPLDQAEAFPTTERVLASVGTILTGGGIPNLEVI
MSMEG_0138|M.smegmatis_MC2_155 PPE-DPSSELLRDGDTIPLAQSSAYPTIERTLAGISGILTGGGIPNIEVI
Mb0179|M.bovis_AF2122/97 APP-DPSPVPLKDGDTIPLKRSSAYPTTEQTLASIATLLRGGGLVNLEGI
Rv0173|M.tuberculosis_H37Rv APP-DPSPVPLKDGDTIPLKRSSAYPTTEQTLASIATLLRGGGLVNLEGI
MUL_1066|M.ulcerans_Agy99 APP-NPSSQLLKNGDTIPLKNSSAYPNTEQTLASISLILRGGGIPNLEVL
MMAR_0416|M.marinum_M APP-NPSSQLLKNGDTIPLKNSSAYPNTEQTLASISLILRGGGIPNLEVL
MLBr_02593|M.leprae_Br4923 APA-NPSLELLKNGDTIPLKNSSVFPTTEQTLASLSLILRGGGIPNLETL
MAV_5011|M.avium_104 APP-NPSPELLKDGDTIPLKNSSSYPTTEQTLASLSLILRGGGIPNLEVL
MAB_4149c|M.abscessus_ATCC_199 APVGEPAVGKLTGGATIPLSRTGKYPSTEEVLSALSVVVNKGNLGALQDI
* :*: * .* .*.* .: :*. *..*:.:. :: *.: :: :
Mflv_0707|M.gilvum_PYR-GCK QSEVYNVLNGRADQIRDFLNQLDTFTAELNQQRDDITRAIDSTNRLLTIV
Mvan_0138|M.vanbaalenii_PYR-1 QTEIYNVLNGRADQIREFLGRLDTFTEELNRQRDDITRAIDSTNRLLAIV
TH_2780|M.thermoresistible__bu QTEVYNMLSGRAPQIRDFLTKLDTFTAELNAQRDDLTRAIDNSNELLTIV
MSMEG_0138|M.smegmatis_MC2_155 QTEVFNILNGRADQIREFLNQLDTFTDELNQQREEITRAIDSTNRLLNIV
Mb0179|M.bovis_AF2122/97 QQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAYV
Rv0173|M.tuberculosis_H37Rv QQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAYV
MUL_1066|M.ulcerans_Agy99 QNEVYDIFHGRGDQIRGFLTRLDTFTRQLNEQRDDITHAIDSTNRLMAYV
MMAR_0416|M.marinum_M QNEVYDIFHGRGDQIRGFLTRLDTFTRQLNEQRDDITHAIDSTNRLMAYV
MLBr_02593|M.leprae_Br4923 TNEVFNIFHGRADQIHAFLTKLDTFASQLNQQRDDITHAIDSTNRLLTYV
MAV_5011|M.avium_104 QNEVYNIFNGRGEAIRALLGKLDTFTNQLNQQRDDITHAIDSTNRLLTYV
MAB_4149c|M.abscessus_ATCC_199 TDETYNLFKGRTGNLTQVLPKLATLISSLNSQRDDIISAIEGIDKFSRVL
* :. ** : .* :* *: .** **::: **:. :.: :
Mflv_0707|M.gilvum_PYR-GCK AQRNETLDAVLTEFPPLIKHFADTRDLFGDAIESLGRISNAAVAALEPAN
Mvan_0138|M.vanbaalenii_PYR-1 GQRNQTLDAVLTEFPPLIQHFADTRDLFADAVESLGRISNAAVDALAPAS
TH_2780|M.thermoresistible__bu ANRESTLDRVLTEFPPLIEHFAETRDLFADAVLALGRVSEATDTYLGQAS
MSMEG_0138|M.smegmatis_MC2_155 SQRNDTLDRVLTEFPPLIQHFAETRDLFADAVTALGRLSAAADETLSGSN
Mb0179|M.bovis_AF2122/97 GGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAAR
Rv0173|M.tuberculosis_H37Rv GGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAAR
MUL_1066|M.ulcerans_Agy99 GGRADVVDRALTDLPPLIKHFADTRDLLINAVNSVGQLSDVTGRYLSEAR
MMAR_0416|M.marinum_M GGRADVVDRALTDLPPLIKHFADTRDLLINAVNSVGQLSDVTGRYLSEAR
MLBr_02593|M.leprae_Br4923 GGRSDVLDQILTDIPPLIKHFADTKNLLINAVGSVGQLSQAVDQYLSEAR
MAV_5011|M.avium_104 GGRADVVDRLLTDVPPLIKHFADTKQLLINAVDSVGRLSQAADQYLSEAR
MAB_4149c|M.abscessus_ATCC_199 AEHKESLGRAIDSIEPALKVLNENRANIIEAFRSVGNLAKITDRVLRTTK
. : . :. : .. * :: : :.: : :* ::*.:: . * :
Mflv_0707|M.gilvum_PYR-GCK GDMNQNLQNLQRPLRELGKSGPYLLGALKIFLTAPYSIENLPKAIRGDYV
Mvan_0138|M.vanbaalenii_PYR-1 DDINTNLANLQRPLRELGKSGPYLLGALKIFLTAPYNIENVPKAIRGDYI
TH_2780|M.thermoresistible__bu DPLHTNLQNLQRPLRELGRASPYLIGALKLMLTAPFNIENVPKVVRGDYI
MSMEG_0138|M.smegmatis_MC2_155 ANLHTNLQNLQRPLKQLGRAAPYLVGALKLILTVPFNIDNIPKAIRGDYI
Mb0179|M.bovis_AF2122/97 GDLHQDLQALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYM
Rv0173|M.tuberculosis_H37Rv GDLHQDLQALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYM
MUL_1066|M.ulcerans_Agy99 GNLHTDLQSLQCPLKELGRGSQYLIGALKLILTQPFDIDAVPKIFRGDYQ
MMAR_0416|M.marinum_M GNLHTDLQSLQCPLKELGRGSQYLIGALKLILTQPFDIDAVPKIFRGDYQ
MLBr_02593|M.leprae_Br4923 GPLHTDLQALACPLRELGRGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQ
MAV_5011|M.avium_104 GPLHTDLQALQCPLKELGKASPYLIGALKLILTQPFDIDTVPKIFRGDYI
MAB_4149c|M.abscessus_ATCC_199 DDIVADLKGLYPVVRALAENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYL
: :* * :: * . ::.::.:: * *:. . : : .****
Mflv_0707|M.gilvum_PYR-GCK NVSLTVDLTLSAIDNGFFSGTGISGMLRALEQAWGRD---PATMIPDVRF
Mvan_0138|M.vanbaalenii_PYR-1 NVSLTVDLTLSAIDNGFFSGTGISGMLRALEQAWGRD---PATMIPDVRF
TH_2780|M.thermoresistible__bu NVSLMLDLTLSAIDNGFLSGTGVAGMLRALEQAWGRD---PATMVPDTRF
MSMEG_0138|M.smegmatis_MC2_155 NVSLKLDLTLSSVDNAFLSGTGVSGMLRALEQAWGRD---PATMIPDVRF
Mb0179|M.bovis_AF2122/97 NLSLTLDLTYSAIDNAFLTGTGFSGALRALEQSFGRD---PETMIPDIRY
Rv0173|M.tuberculosis_H37Rv NLSLTLDLTYSAIDNAFLTGTGFSGALRALEQSFGRD---PETMIPDIRY
MUL_1066|M.ulcerans_Agy99 NVSAALDVTFSAMDNAVLTGTGFSGALRALEQSFGLD---PETMIPDVRY
MMAR_0416|M.marinum_M NVSATLDVTFSAMDNAVLTGTGFSGALRALEQSFGRD---PETMIPDVRY
MLBr_02593|M.leprae_Br4923 NVSLTLDVTYSAMDNAVLTGTGLSGALRALEQSFGRD---PETMIPDVRY
MAV_5011|M.avium_104 NISLTLDLTYSAVDNAFLTGTGLSGALRALEQSYGRD---PETMIPDVRY
MAB_4149c|M.abscessus_ATCC_199 NVFVTFDLTARRLGETLFTTSFFDPNMQHFNDVVNPPEWLIGSMANLNGK
*: .*:* :.: .:: : . :: ::: . :*
Mflv_0707|M.gilvum_PYR-GCK TPNPNSAPNGPLIERSE---------------------------------
Mvan_0138|M.vanbaalenii_PYR-1 TPNPNSVPGGPLIERSE---------------------------------
TH_2780|M.thermoresistible__bu TPNPNNVPGGPLIERAE---------------------------------
MSMEG_0138|M.smegmatis_MC2_155 TPNPHDAPGGPLVERGE---------------------------------
Mb0179|M.bovis_AF2122/97 TPNPNDAPGGPLVERGNRQC------------------------------
Rv0173|M.tuberculosis_H37Rv TPNPNDAPGGPLVERGNRQC------------------------------
MUL_1066|M.ulcerans_Agy99 TPNPNDAPGGPLVERGDRQC------------------------------
MMAR_0416|M.marinum_M TPNPNDAPGGPLVERGDRQC------------------------------
MLBr_02593|M.leprae_Br4923 TTNPNDAPGGPLVERADRRC------------------------------
MAV_5011|M.avium_104 TPNPNDAPGGPLVERGDRNCDSLRPTPTGRLRDPDRHLAARARHLLPADP
MAB_4149c|M.abscessus_ATCC_199 ETSPFDLPAPAAPQGGGR--------------------------------
..* . * . : .
Mflv_0707|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0138|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2780|M.thermoresistible__bu --------------------------------------------------
MSMEG_0138|M.smegmatis_MC2_155 --------------------------------------------------
Mb0179|M.bovis_AF2122/97 --------------------------------------------------
Rv0173|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1066|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0416|M.marinum_M --------------------------------------------------
MLBr_02593|M.leprae_Br4923 --------------------------------------------------
MAV_5011|M.avium_104 ELGGDRPVHAQGRAAGVGRPVPDGQRHLSRHHHRQGHRRRAHRARRRGDH
MAB_4149c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0707|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0138|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2780|M.thermoresistible__bu --------------------------------------------------
MSMEG_0138|M.smegmatis_MC2_155 --------------------------------------------------
Mb0179|M.bovis_AF2122/97 --------------------------------------------------
Rv0173|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1066|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0416|M.marinum_M --------------------------------------------------
MLBr_02593|M.leprae_Br4923 --------------------------------------------------
MAV_5011|M.avium_104 EHRQPLQDPDRRGGQRALGVGGRRAVPGPGVERKPGQVPVVRADHHQGHG
MAB_4149c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0707|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0138|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2780|M.thermoresistible__bu --------------------------------------------------
MSMEG_0138|M.smegmatis_MC2_155 --------------------------------------------------
Mb0179|M.bovis_AF2122/97 --------------------------------------------------
Rv0173|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1066|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0416|M.marinum_M --------------------------------------------------
MLBr_02593|M.leprae_Br4923 --------------------------------------------------
MAV_5011|M.avium_104 AGRDRAGPGHREPRAGGAAQGEDRPVARRDGAVRRRVGPQPAAAGRRHPG
MAB_4149c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0707|M.gilvum_PYR-GCK ------------------------------
Mvan_0138|M.vanbaalenii_PYR-1 ------------------------------
TH_2780|M.thermoresistible__bu ------------------------------
MSMEG_0138|M.smegmatis_MC2_155 ------------------------------
Mb0179|M.bovis_AF2122/97 ------------------------------
Rv0173|M.tuberculosis_H37Rv ------------------------------
MUL_1066|M.ulcerans_Agy99 ------------------------------
MMAR_0416|M.marinum_M ------------------------------
MLBr_02593|M.leprae_Br4923 ------------------------------
MAV_5011|M.avium_104 HRRRLQEPDHRRQRHHRALRAGDRQPGQIR
MAB_4149c|M.abscessus_ATCC_199 ------------------------------